ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

841–860 of 2,807 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Associations of occupational stress, workplace violence, and organizational support on chronic fatigue syndrome among nurses.

Li, Mengyao, Shu, Qianyi, Huang, Hao et al.·Journal of advanced nursing·2020

This study examined whether workplace stress, violence, and lack of organizational support increase the risk of ME/CFS in nurses. Researchers surveyed 1,080 Chinese nurses and found that those experiencing high levels of overcommitment, workplace violence, and little support from their employers were significantly more likely to have ME/CFS. The findings suggest that improving workplace safety, support, and reducing internal stress could help prevent ME/CFS in this high-risk group.

SleepCognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Cortisol levels in chronic fatigue syndrome and atypical depression measured using hair and saliva specimens.

Herane-Vives, Andres, Papadopoulos, Andrew, de Angel, Valeria et al.·Journal of affective disorders·2020

This study compared stress hormone (cortisol) levels in people with ME/CFS and people with a specific type of depression called atypical depression, both with and without fatigue. Researchers measured cortisol in two ways: through hair samples (showing levels over 3 months) and saliva samples (showing daily patterns). Both ME/CFS and atypical depression groups had lower daily cortisol output than healthy people, but normal cortisol levels when measured over longer periods, suggesting the low levels might be temporary or related to how the body's rhythm changes.

Endocrine Disruption

E2 ModerateCohortPEM requiredCase-Control

Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Lande, Asgeir, Fluge, Øystein, Strand, Elin B et al.·Scientific reports·2020

Researchers studied immune system markers called HLA alleles in 426 Norwegian ME/CFS patients and compared them to healthy controls. They found that two specific immune markers (HLA-C*07:04 and HLA-DQB1*03:03) were more common in ME/CFS patients than in healthy people, suggesting the immune system may play a role in developing ME/CFS. About 1 in 5 ME/CFS patients carried one or both of these markers, compared to 1 in 8 healthy people.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Cardiac Dimensions and Function Are Not Altered among Females with the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Iversen, Per Ole, von Lueder, Thomas Gero, Kardel, Kristin Reimers et al.·Healthcare (Basel, Switzerland)·2020

Researchers used heart ultrasounds to check if the hearts of people with ME/CFS were structurally different or working differently than healthy people's hearts. They found no significant differences in heart size or function between the 16 women with ME/CFS and 10 healthy women they studied. This suggests that ME/CFS exercise intolerance and lactate buildup may not be caused by problems with how the heart itself is structured or functioning.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearObservational

Pressure Point Thresholds and ME/CFS Comorbidity as Indicators of Patient's Response to Manual Physiotherapy in Fibromyalgia.

Falaguera-Vera, Francisco Javier, Garcia-Escudero, María, Bonastre-Férez, Javier et al.·International journal of environmental research and public health·2020

This study tested whether hands-on physiotherapy (manual therapy) could help people with fibromyalgia (FM) by reducing pain sensitivity and improving quality of life. Researchers measured pain sensitivity before and after treatment using a special device called an algometer. The main finding was that people with fibromyalgia alone responded better to the therapy than those who had both fibromyalgia and ME/CFS.

Pain and Sensitization

E2 ModerateCohortPEM unclearCross-Sectional

Comprehensive Circulatory Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids.

Germain, Arnaud, Barupal, Dinesh K, Levine, Susan M et al.·Metabolites·2020

Researchers studied the chemicals in blood samples from 26 ME/CFS patients and 26 healthy controls to understand what might be different in ME/CFS. They found that ME/CFS patients have lower levels of certain fats (especially acyl cholines) and hormones (including some involved in stress response and reproduction) compared to healthy people. These chemical differences might help explain why ME/CFS causes such widespread symptoms affecting many body systems.

Energy Metabolism

E2 ModerateCohortPEM not requiredCase-Control

Sleep problems in adolescents with CFS: A case-control study nested within a prospective clinical cohort.

Loades, Maria Elizabeth, Rimes, Katharine A, Chalder, Trudie·Clinical child psychology and psychiatry·2020

This study looked at sleep problems in teenagers with ME/CFS compared to healthy teenagers and those with asthma. Teenagers with ME/CFS reported significantly more sleep difficulties than both comparison groups. When researchers checked in 3 months later without any treatment, sleep problems remained largely unchanged, suggesting that sleep issues in ME/CFS don't improve on their own and may need specific attention during treatment.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

MCP-1 is increased in patients with CFS and FM, whilst several other immune markers are significantly lower than healthy controls.

Groven, Nina, Fors, Egil Andreas, Stunes, Astrid Kamilla et al.·Brain, behavior, & immunity - health·2020

This study looked at immune system markers in the blood of people with ME/CFS and fibromyalgia compared to healthy people. Researchers found that one immune marker called MCP-1 was higher in patients, while many other immune markers were actually lower than in healthy controls. This suggests the immune system may work differently in these conditions, though the exact meaning of these differences is still unclear.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients - A validation study in plasma and cerebrospinal fluid from two Swedish cohorts.

Bynke, Annie, Julin, Per, Gottfries, Carl-Gerhard et al.·Brain, behavior, & immunity - health·2020

Researchers tested blood and spinal fluid samples from ME/CFS patients and healthy people to look for certain antibodies (immune proteins) that mistakenly attack nerve receptors in the body. They found higher levels of some of these antibodies in ME/CFS patients compared to healthy controls, particularly antibodies targeting muscarinic receptors (involved in nerve signaling). However, the amount of these antibodies did not match how severe patients' symptoms were.

Immune System

E2 ModerateCohortPEM unclearObservational

Rituximab Serum Concentrations and Anti-Rituximab Antibodies During B-Cell Depletion Therapy for Myalgic Encephalopathy/Chronic Fatigue Syndrome.

Rekeland, Ingrid G, Fluge, Øystein, Alme, Kine et al.·Clinical therapeutics·2019

This study looked at whether the amount of a drug called rituximab in patients' blood predicted whether they would improve from ME/CFS symptoms. The researchers measured rituximab levels in 23 patients and found no clear connection between how much drug was in the blood and who felt better. Interestingly, none of the patients developed antibodies against the drug, which was a potential concern.

Immune System

E2 ModerateCohortPEM not requiredLongitudinal

Increased risk of chronic fatigue syndrome following psoriasis: a nationwide population-based cohort study.

Tsai, Shin-Yi, Chen, Hsuan-Ju, Chen, Chi et al.·Journal of translational medicine·2019

This study found that people with psoriasis (a skin condition involving immune system dysfunction) have a higher chance of developing ME/CFS compared to people without psoriasis. Researchers followed over 13,000 people in Taiwan for several years and found that those with psoriasis were about 1.5 times more likely to develop ME/CFS. Interestingly, people who received certain psoriasis treatments appeared to have a lower risk of developing ME/CFS.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy.

Xu, Jiabao, Potter, Michelle, Tomas, Cara et al.·The Analyst·2019

Researchers used a new scanning technology called Raman spectroscopy to look at individual cells from ME/CFS patients and healthy people. They found that cells from ME/CFS patients had higher levels of a protein building block called phenylalanine, similar to cells with broken energy-producing structures (mitochondria). Using computer learning, they could identify ME/CFS patient cells with 98% accuracy based on this signature.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

Clinical symptoms and markers of disease mechanisms in adolescent chronic fatigue following Epstein-Barr virus infection: An exploratory cross-sectional study.

Kristiansen, Miriam Skjerven, Stabursvik, Julie, O'Leary, Elise Catriona et al.·Brain, behavior, and immunity·2019

This study looked at adolescents who had Epstein-Barr virus (EBV) infection and tracked whether they developed chronic fatigue 6 months later. Researchers found that those with ongoing fatigue had more symptoms overall, but blood tests and heart-monitoring showed only small differences compared to those who recovered—mainly slightly higher inflammation markers and changes in nervous system activity. The study suggests that post-EBV fatigue in teenagers involves subtle changes in the body's stress and immune systems, even though the virus itself had cleared.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Cerebral blood flow and heart rate variability predict fatigue severity in patients with chronic fatigue syndrome.

Boissoneault, Jeff, Letzen, Janelle, Robinson, Michael et al.·Brain imaging and behavior·2019

This study looked at blood flow in the brain and heart rate patterns in women with ME/CFS compared to healthy women. The researchers found that women with ME/CFS who had better blood flow to the brain and more variable heart rates tended to have less severe fatigue. These findings suggest that how well the body's circulatory and nervous systems are working may be connected to how tired people with ME/CFS feel.

E2 ModerateCohortPEM not requiredObservational

Can a Chronic BPPV With a History of Trauma be the Trigger of Symptoms in Vestibular Migraine, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), and Whiplash Associated Disorders (WAD)? A Retrospective Cohort Study.

Tjell, Carsten, Iglebekk, Wenche, Borenstein, Peter·Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2019

This study looked at patients with a condition called chronic BPPV (a type of inner ear problem that causes dizziness), many of whom had experienced head or neck trauma. The researchers found that treating this inner ear condition improved symptoms in about 90% of patients. Interestingly, the patients' symptoms overlapped with ME/CFS, migraine, and whiplash-related disorders, raising the question of whether the inner ear problem might be triggering or contributing to these conditions.

E2 ModerateCohortPEM requiredCross-Sectional

Elevated blood lactate in resting conditions correlate with post-exertional malaise severity in patients with Myalgic encephalomyelitis/Chronic fatigue syndrome.

Ghali, Alaa, Lacout, Carole, Ghali, Maria et al.·Scientific reports·2019

This study looked at lactate levels (a substance produced by muscles) in the blood of ME/CFS patients who were at rest. Researchers found that about 45% of patients had higher-than-normal lactate levels even when not exercising. Importantly, patients with elevated resting lactate tended to experience more severe post-exertional malaise (the symptom flare-ups that follow physical activity).

Energy MetabolismPost-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

A laboratory approach for characterizing chronic fatigue: what does metabolomics tell us?

Erasmus, Elardus, Mason, Shayne, van Reenen, Mari et al.·Metabolomics : Official journal of the Metabolomic Society·2019

This study looked at whether a simple urine test could help measure fatigue severity in ME/CFS patients. Researchers used a specialized scanning technique (NMR) to analyze urine samples from 578 women with chronic fatigue before and after a detoxification challenge, finding that the fatigue group showed different metabolite patterns compared to controls. While the study didn't identify a single reliable biomarker for fatigue, it suggests that fatigue may be connected to how the body processes toxins.

Biomarkers

E2 ModerateCohortPEM not requiredCase-Control

Silicone breast implants and depression, fibromyalgia and chronic fatigue syndrome in a rheumatology clinic population.

Khoo, Thomas, Proudman, Susanna, Limaye, Vidya·Clinical rheumatology·2019

This study looked at whether silicone breast implants are linked to depression, fibromyalgia, or ME/CFS in women visiting a rheumatology clinic. Researchers compared 30 women with breast implants to similar women without implants, some of whom had other autoimmune diseases. They found that fibromyalgia and ME/CFS were slightly more common in women with implants compared to those with systemic sclerosis, but not compared to those with lupus.

E2 ModerateCohortPEM unclearObservational

Healthcare Utilization in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Analysis of US Ambulatory Healthcare Data, 2000-2009.

Bae, Jaeyong, Lin, Jin-Mann S·Frontiers in pediatrics·2019

This study examined how often people with ME/CFS visited doctors in the United States between 2000 and 2009. Researchers found that about 2.9 million visits were coded as ME/CFS-related during this period, with most patients being women in their 40s and 50s. Many patients with ME/CFS also had other health conditions like depression, high blood pressure, and diabetes, making their care more complicated.

Diagnostics

E2 ModerateBehavioralPEM not requiredCase-Control

Perfectionism and beliefs about emotions in adolescents with chronic fatigue syndrome and their parents: a preliminary investigation in a case control study nested within a cohort.

Loades, Maria E, Rimes, Katharine A, Lievesley, Kate et al.·Psychology & health·2019

This study looked at whether perfectionism and unhelpful ways of thinking about emotions might be connected to ME/CFS in teenagers and their parents. Researchers compared 121 adolescents with ME/CFS to teenagers with asthma and healthy teenagers, measuring their perfectionism and attitudes toward emotions. Interestingly, teenagers with ME/CFS did not show significantly more perfectionism than the other groups, but the study did find that when mothers had unhelpful beliefs about emotions, their teenagers were more likely to have similar beliefs.

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Associations of occupational stress, workplace violence, and organizational support on chronic fatigue syndrome among nurses.

Cortisol levels in chronic fatigue syndrome and atypical depression measured using hair and saliva specimens.

Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Cardiac Dimensions and Function Are Not Altered among Females with the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Pressure Point Thresholds and ME/CFS Comorbidity as Indicators of Patient's Response to Manual Physiotherapy in Fibromyalgia.

Comprehensive Circulatory Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids.

Sleep problems in adolescents with CFS: A case-control study nested within a prospective clinical cohort.

MCP-1 is increased in patients with CFS and FM, whilst several other immune markers are significantly lower than healthy controls.

Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients - A validation study in plasma and cerebrospinal fluid from two Swedish cohorts.

Rituximab Serum Concentrations and Anti-Rituximab Antibodies During B-Cell Depletion Therapy for Myalgic Encephalopathy/Chronic Fatigue Syndrome.

Increased risk of chronic fatigue syndrome following psoriasis: a nationwide population-based cohort study.

A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy.

Clinical symptoms and markers of disease mechanisms in adolescent chronic fatigue following Epstein-Barr virus infection: An exploratory cross-sectional study.

Cerebral blood flow and heart rate variability predict fatigue severity in patients with chronic fatigue syndrome.

Can a Chronic BPPV With a History of Trauma be the Trigger of Symptoms in Vestibular Migraine, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), and Whiplash Associated Disorders (WAD)? A Retrospective Cohort Study.

Elevated blood lactate in resting conditions correlate with post-exertional malaise severity in patients with Myalgic encephalomyelitis/Chronic fatigue syndrome.

A laboratory approach for characterizing chronic fatigue: what does metabolomics tell us?

Silicone breast implants and depression, fibromyalgia and chronic fatigue syndrome in a rheumatology clinic population.

Healthcare Utilization in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Analysis of US Ambulatory Healthcare Data, 2000-2009.

Perfectionism and beliefs about emotions in adolescents with chronic fatigue syndrome and their parents: a preliminary investigation in a case control study nested within a cohort.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research