ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

861–880 of 2,807 studies

E2 ModerateCohortPEM unclearObservational

Healthcare Utilization in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Analysis of US Ambulatory Healthcare Data, 2000-2009.

Bae, Jaeyong, Lin, Jin-Mann S·Frontiers in pediatrics·2019

This study examined how often people with ME/CFS visited doctors in the United States between 2000 and 2009. Researchers found that about 2.9 million visits were coded as ME/CFS-related during this period, with most patients being women in their 40s and 50s. Many patients with ME/CFS also had other health conditions like depression, high blood pressure, and diabetes, making their care more complicated.

Diagnostics

E2 ModerateCohortPEM not requiredCase-Control

MicroRNAs as Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome.

Al-Rawaf, Hadeel A, Alghadir, Ahmad H, Gabr, Sami A·Pain practice : the official journal of World Institute of Pain·2019

This study looked at tiny molecules called microRNAs in the blood of adolescents with ME/CFS to see if they could help explain why these patients experience pain. Researchers found that five specific microRNAs were lower in ME/CFS patients compared to healthy teens, and these changes were linked to higher levels of inflammatory chemicals that are known to cause pain. Interestingly, girls with ME/CFS had even lower microRNA levels and higher inflammation markers than boys with the condition.

BiomarkersImmune System

E2 ModerateCohortPEM unclearObservational

MtDNA population variation in Myalgic encephalomyelitis/Chronic fatigue syndrome in two populations: a study of mildly deleterious variants.

Venter, Marianne, Tomas, Cara, Pienaar, Ilse S et al.·Scientific reports·2019

This study looked at mitochondrial DNA (the genetic material in the energy-producing parts of our cells) in people with ME/CFS to see if differences in this DNA might help explain the condition. Researchers compared DNA samples from ME/CFS patients in the UK and South Africa to look for variations. Interestingly, they found that ME/CFS patients were less likely to have certain common genetic variations that most people carry, but they did not find any confirmed disease-causing mutations.

Energy Metabolism

E2 ModerateCohortPEM unclearCross-Sectional

Searching for Serum Antibodies to Neuronal Proteins in Patients With Myalgic Encephalopathy/Chronic Fatigue Syndrome.

Giannoccaro, Maria Pia, Cossins, Judith, Sørland, Kari et al.·Clinical therapeutics·2019

Researchers tested blood samples from 50 ME/CFS patients and 50 healthy people to see if ME/CFS patients had unusual antibodies (immune proteins) that attack nerve cells. While a small number of both patients and healthy people had some immune activity toward nerve proteins, only one ME/CFS patient had a specific antibody that could be clearly identified. Interestingly, the patients who did have these antibodies tended to have more severe symptoms and had become ill more recently.

Immune System

E2 ModerateBehavioralPEM not requiredCase-Control

Depressive symptoms in adolescents with chronic fatigue syndrome (CFS): Are rates higher than in controls and do depressive symptoms affect outcome?

Loades, Maria Elizabeth, Rimes, Katharine A, Ali, Sheila et al.·Clinical child psychology and psychiatry·2019

This study compared depression symptoms in adolescents with ME/CFS to healthy teenagers and teenagers with asthma. Young people with ME/CFS had significantly higher depression scores than both groups. While depression symptoms were linked to some worsening of fatigue over time, they were a stronger predictor of future depression itself, suggesting depression may be a separate concern that needs its own treatment approach.

E2 ModerateDiagnosticPEM unclearCross-Sectional

Myalgic encephalomyelitis and chronic fatigue syndrome case definitions: effects of requiring a substantial reduction in functioning.

Scartozzi, Samantha, Sunnquist, Madison, Jason, Leonard A·Fatigue : biomedicine, health & behavior·2019

ME/CFS diagnoses require doctors to confirm that patients have a significant drop in their ability to function compared to before they got sick. However, there's no clear agreement on how much of a drop counts as 'significant.' This study looked at over 1,000 people with ME/CFS to see whether this requirement actually helps doctors identify who has the illness. The researchers found that when diagnostic criteria clearly describe which symptoms to look for and how severe they should be, the 'significant drop in functioning' requirement may not be necessary.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

Adolescent and parent factors related to fatigue in paediatric multiple sclerosis and chronic fatigue syndrome: A comparative study.

Carroll, Susan, Chalder, Trudie, Hemingway, Cheryl et al.·European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2019

This study compared teenagers with multiple sclerosis (MS) who experienced fatigue, teenagers with ME/CFS, and healthy teenagers to understand what factors contribute to severe fatigue. Researchers found that teenagers with MS who were fatigued and teenagers with ME/CFS had very similar patterns of fatigue and unhelpful thinking patterns about their symptoms, but teenagers with ME/CFS had normal brain function while those with MS had some cognitive difficulties. The study suggests that psychological approaches used successfully in ME/CFS might also help teenagers with MS who experience fatigue.

Cognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

Psychometric properties of the PROMIS® Fatigue Short Form 7a among adults with myalgic encephalomyelitis/chronic fatigue syndrome.

Yang, Manshu, Keller, San, Lin, Jin-Mann S·Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2019

Researchers tested whether a short questionnaire called PROMIS Fatigue (7 questions) accurately measures fatigue in people with ME/CFS. They found that the questionnaire reliably captures how tired ME/CFS patients feel, works the same way for different ages and genders, and can detect when fatigue changes over time. This tool may help doctors and researchers measure whether new treatments for ME/CFS actually work.

E2 ModerateCohortPEM not requiredCross-Sectional

Factors associated with work status in chronic fatigue syndrome.

Stevelink, S A M, Fear, N T, Hotopf, M et al.·Occupational medicine (Oxford, England)·2019

This study looked at how ME/CFS affects people's ability to work. Researchers surveyed 507 patients and found that about half were still working, while nearly one-third had stopped working completely. People who were older, had more severe symptoms, or felt depressed were more likely to have left work, while those with higher education or strong relationships were more likely to still be employed.

E2 ModerateCohortPEM unclearCross-Sectional

Brain abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome: Evaluation by diffusional kurtosis imaging and neurite orientation dispersion and density imaging.

Kimura, Yukio, Sato, Noriko, Ota, Miho et al.·Journal of magnetic resonance imaging : JMRI·2019

Researchers used advanced brain imaging to examine 20 ME/CFS patients and 23 healthy people. The imaging revealed that people with ME/CFS had subtle structural differences in specific brain regions involved in communication, thinking, and sensation. These differences were not visible on standard brain scans but were detected using newer, more detailed imaging techniques.

E2 ModerateBehavioralPEM unclearLongitudinal

Psychological and demographic factors associated with fatigue and social adjustment in young people with severe chronic fatigue syndrome/myalgic encephalomyelitis: a preliminary mixed-methods study.

Ali, Sheila, Adamczyk, Lucy, Burgess, Mary et al.·Journal of behavioral medicine·2019

This study followed 51 young people (aged 12-25) with severe ME/CFS over about 5 months to understand what affects their fatigue and ability to attend school or work. Researchers found that young people who were more afraid of activity and worried about making their symptoms worse tended to have higher fatigue levels and struggled more with social life. Interestingly, girls were less likely to attend school or work, but this wasn't connected to having worse fatigue or social problems.

E2 ModerateCohortPEM requiredObservational

Abnormal blood lactate accumulation during repeated exercise testing in myalgic encephalomyelitis/chronic fatigue syndrome.

Lien, Katarina, Johansen, Bjørn, Veierød, Marit B et al.·Physiological reports·2019

This study looked at how the bodies of ME/CFS patients handle repeated exercise tests done 24 hours apart. Researchers measured how much oxygen patients used and tracked a substance called lactate in their blood during exercise. They found that ME/CFS patients performed worse on the second test and had higher lactate levels, opposite to what happened in healthy people, whose bodies actually recovered better the second time.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredObservational

Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome.

Nguyen, Chinh Bkrong, Kumar, Surendra, Zucknick, Manuela et al.·Brain, behavior, and immunity·2019

This study looked at blood samples from teenagers with ME/CFS to understand how their immune systems and stress-response chemicals differ from healthy teenagers. Researchers found two distinct subgroups of ME/CFS patients based on immune activity and a stress hormone called norepinephrine. Patients with lower norepinephrine levels had more severe fatigue, while those with higher levels showed different patterns of immune dysfunction.

BiomarkersImmune System

E2 ModerateCohortPEM not requiredCross-Sectional

Musculoskeletal Pain in Individuals With Inflammatory Bowel Disease Reflects Three Distinct Profiles.

Falling, Carrie, Stebbings, Simon, Baxter, George D et al.·The Clinical journal of pain·2019

Most people with inflammatory bowel disease (IBD) experience muscle and joint pain, but the pain works differently in different people. This study found three distinct groups: one with mixed types of pain, one with pain driven by nervous system sensitivity, and one with pain in specific areas that improves when the IBD is under control. The group with nervous system-driven pain had higher rates of depression, anxiety, and chronic fatigue syndrome.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Assessing chronic fatigue syndrome: Self-reported physical functioning and correlations with physical testing.

Eyskens, Jan B, Illegems, Jela, De Nil, Luc et al.·Journal of bodywork and movement therapies·2019

This study tested whether two simple physical tests could help diagnose ME/CFS and match how tired patients feel. Researchers had 27 women with ME/CFS do a standing endurance test and a balance-while-thinking test, then compared the results to questionnaires about fatigue and daily functioning. Only the standing test correlated with how patients rated their physical abilities.

E2 ModerateCohortPEM unclearCross-Sectional

A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy.

Xu, Jiabao, Potter, Michelle, Tomas, Cara et al.·The Analyst·2019

Researchers used a new scanning technology called Raman spectroscopy to look at individual cells from ME/CFS patients and healthy people. They found that cells from ME/CFS patients had higher levels of a protein building block called phenylalanine, similar to cells with broken energy-producing structures (mitochondria). Using computer learning, they could identify ME/CFS patient cells with 98% accuracy based on this signature.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

Clinical symptoms and markers of disease mechanisms in adolescent chronic fatigue following Epstein-Barr virus infection: An exploratory cross-sectional study.

Kristiansen, Miriam Skjerven, Stabursvik, Julie, O'Leary, Elise Catriona et al.·Brain, behavior, and immunity·2019

This study looked at adolescents who had Epstein-Barr virus (EBV) infection and tracked whether they developed chronic fatigue 6 months later. Researchers found that those with ongoing fatigue had more symptoms overall, but blood tests and heart-monitoring showed only small differences compared to those who recovered—mainly slightly higher inflammation markers and changes in nervous system activity. The study suggests that post-EBV fatigue in teenagers involves subtle changes in the body's stress and immune systems, even though the virus itself had cleared.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

[Fatigue among working and non-working students: a sociological analysis of the environmental determinants of its level].

Kutyło, Łukasz, Łaska-Formejster, Alicja Barbara, Ober-Domagalska, Barbara·Medycyna pracy·2019

This study compared fatigue levels in 298 college students, some who worked while studying and some who did not. Interestingly, non-working students reported significantly more fatigue than working students. The researchers found that students who were less satisfied with their classes, teachers, or peer relationships tended to feel more tired.

E2 ModerateCohortPEM not requiredCross-Sectional

Evidence for similarity in symptoms and mechanism: The extra-pulmonary symptoms of severe asthma and the polysymptomatic presentation of fibromyalgia.

Hyland, Michael E, Lanario, Joseph W, Wei, Yinghui et al.·Immunity, inflammation and disease·2019

This study found that people with severe asthma report many symptoms beyond breathing problems—such as fatigue, pain, and digestive issues—that are very similar to symptoms seen in fibromyalgia and chronic fatigue syndrome. The researchers compared symptom patterns between asthma patients and people with various functional disorders, finding that asthma and fibromyalgia symptoms were 75% similar in type and pattern. This suggests these conditions may share common underlying mechanisms related to how the body's systems interact.

E2 ModerateBehavioralPEM not requiredLongitudinal

Fatigue in Epstein-Barr virus infected adolescents and healthy controls: A prospective multifactorial association study.

Pedersen, Maria, Asprusten, Tarjei Tørre, Godang, Kristin et al.·Journal of psychosomatic research·2019

This study followed teenagers with acute Epstein-Barr virus (EBV) infection and compared them to healthy teenagers to understand what causes fatigue. Researchers measured 148 different factors including symptoms, quality of life, sleep, emotions, immune markers, and heart rate control at the start of infection and again six months later. They found that fatigue was consistently linked to sleep problems, negative emotions, and poor quality of life, but surprisingly, markers of active infection were not associated with how tired people felt.

SleepAutonomic Nervous System

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Evidence browser

Healthcare Utilization in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Analysis of US Ambulatory Healthcare Data, 2000-2009.

MicroRNAs as Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome.

MtDNA population variation in Myalgic encephalomyelitis/Chronic fatigue syndrome in two populations: a study of mildly deleterious variants.

Searching for Serum Antibodies to Neuronal Proteins in Patients With Myalgic Encephalopathy/Chronic Fatigue Syndrome.

Depressive symptoms in adolescents with chronic fatigue syndrome (CFS): Are rates higher than in controls and do depressive symptoms affect outcome?

Myalgic encephalomyelitis and chronic fatigue syndrome case definitions: effects of requiring a substantial reduction in functioning.

Adolescent and parent factors related to fatigue in paediatric multiple sclerosis and chronic fatigue syndrome: A comparative study.

Psychometric properties of the PROMIS® Fatigue Short Form 7a among adults with myalgic encephalomyelitis/chronic fatigue syndrome.

Factors associated with work status in chronic fatigue syndrome.

Brain abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome: Evaluation by diffusional kurtosis imaging and neurite orientation dispersion and density imaging.

Psychological and demographic factors associated with fatigue and social adjustment in young people with severe chronic fatigue syndrome/myalgic encephalomyelitis: a preliminary mixed-methods study.

Abnormal blood lactate accumulation during repeated exercise testing in myalgic encephalomyelitis/chronic fatigue syndrome.

Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome.

Musculoskeletal Pain in Individuals With Inflammatory Bowel Disease Reflects Three Distinct Profiles.

Assessing chronic fatigue syndrome: Self-reported physical functioning and correlations with physical testing.

A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy.

Clinical symptoms and markers of disease mechanisms in adolescent chronic fatigue following Epstein-Barr virus infection: An exploratory cross-sectional study.

[Fatigue among working and non-working students: a sociological analysis of the environmental determinants of its level].

Evidence for similarity in symptoms and mechanism: The extra-pulmonary symptoms of severe asthma and the polysymptomatic presentation of fibromyalgia.

Fatigue in Epstein-Barr virus infected adolescents and healthy controls: A prospective multifactorial association study.

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