ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

901–920 of 2,768 studies

E2 ModerateBehavioralPEM not requiredObservational

Sleep education in primary school prevents future school refusal behavior.

Maeda, Tsutomu, Oniki, Kentaro, Miike, Teruhisa·Pediatrics international : official journal of the Japan Pediatric Society·2019

This study tested whether teaching primary school children about healthy sleep habits could prevent school refusal (persistent avoidance of attending school) later on. Researchers in Japan had students track their sleep for 2 weeks, gave them feedback, and taught them and their parents about the importance of regular sleep schedules. After the program started, school refusal rates dropped dramatically—from 10% of graduates in 2007 to 0% by 2012.

Sleep

E2 ModerateBehavioralPEM not requiredCross-Sectional

Hematological and Psychophysiological Correlates of Anomalous Information Reception in Mediums: A Preliminary Exploration.

Beischel, Julie, Tassone, Shawn, Boccuzzi, Mark·Explore (New York, N.Y.)·2019

This study looked at whether people who identify as mediums (those who report communicating with deceased individuals) experience more health problems than people who don't. Researchers found that mediums reported significantly more autoimmune diseases, sleep problems, gastrointestinal issues, and other symptoms compared to non-mediums. However, blood tests and heart rate measurements taken during mediumship sessions showed no unusual changes.

Sleep

E2 ModerateCohortPEM not requiredLongitudinal

Predictors of chronic fatigue in adolescents six months after acute Epstein-Barr virus infection: A prospective cohort study.

Pedersen, Maria, Asprusten, Tarjei Tørre, Godang, Kristin et al.·Brain, behavior, and immunity·2019

This study followed 200 teenagers who had an acute Epstein-Barr virus (EBV) infection to see which factors predicted who would develop lasting fatigue six months later. Researchers measured many baseline characteristics including pain sensitivity, mood, memory, physical activity level, and blood markers like vitamin B12 and inflammation levels. They found that fatigue six months after EBV was most strongly predicted by things like sensory sensitivity, pain, anxiety, and how active the teenager was—rather than by immune system markers alone.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

Associations Between Autonomic and Orthostatic Self-report and Physician Ratings of Orthostatic Intolerance in Youth.

Schultz, Katlin R, Katz, Ben Z, Bockian, Neil R et al.·Clinical therapeutics·2019

This study looked at whether what young people with ME/CFS report feeling about dizziness and heart symptoms matches what doctors measure during physical exams. Researchers compared answers from questionnaires with actual measurements of blood pressure and heart rate changes. They found that while patients reported these symptoms, the physical measurements didn't always show the same problems, suggesting current testing methods may miss real autonomic problems in young ME/CFS patients.

Autonomic Nervous System

E2 ModerateCohortPEM unclearLongitudinal

The Impact of a Structured Exercise Programme upon Cognitive Function in Chronic Fatigue Syndrome Patients.

Zalewski, Paweł, Kujawski, Sławomir, Tudorowska, Malwina et al.·Brain sciences·2019

This study tested whether a 16-week structured exercise program could help improve 'brain fog' and thinking problems that many people with ME/CFS experience. Of 53 patients who started the program, 34 completed it. Tests showed that those who finished the program had modest improvements in attention and processing speed, particularly in how quickly and accurately they could respond to visual tasks.

Cognitive Impairment

E2 ModerateCohortPEM requiredCross-Sectional

Systemic exertion intolerance disease/chronic fatigue syndrome is common in sleep centre patients with hypersomnolence: A retrospective pilot study.

Maness, Caroline, Saini, Prabhjyot, Bliwise, Donald L et al.·Journal of sleep research·2019

This study looked at people visiting sleep clinics who reported excessive daytime sleepiness and found that 21% of them also met criteria for ME/CFS (systemic exertion intolerance disease). People with both conditions reported more severe fatigue and were less likely to benefit from standard wake-promoting medications compared to those with only sleep disorders. The findings suggest that ME/CFS frequently occurs alongside sleep disorders and may make treatment more difficult.

Post-Exertional Malaise

E2 ModerateCohortPEM requiredObservational

Post-Exertional Malaise Is Associated with Hypermetabolism, Hypoacetylation and Purine Metabolism Deregulation in ME/CFS Cases.

McGregor, Neil R, Armstrong, Christopher W, Lewis, Donald P et al.·Diagnostics (Basel, Switzerland)·2019

This study looked at what happens in the body during post-exertional malaise (PEM)—the exhaustion and worsening of symptoms that ME/CFS patients experience after physical or mental activity. Researchers measured chemical changes in blood and urine over 7 days in 35 ME/CFS patients who reported PEM and compared them to healthy controls. They found that during PEM, the body shows signs of increased metabolism (burning energy faster), low levels of a molecule called hypoxanthine, and problems with how cells use and process energy, along with evidence that the body is breaking down muscle protein.

Post-Exertional Malaise

E2 ModerateMechanismPEM not requiredMechanistic

Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of Gene-expression Modules.

Jeffrey, Mary G, Nathanson, Lubov, Aenlle, Kristina et al.·Clinical therapeutics·2019

Researchers studied blood samples from 33 ME/CFS patients and 21 healthy people to look for differences in how their genes were working. They found that ME/CFS appears to involve problems with the immune system (the body's defense mechanism) and how cells produce energy. By matching these gene differences with existing FDA-approved drugs, they identified immunosuppressant medications as potential candidates that might help reduce ME/CFS symptoms.

Immune System

E2 ModerateReviewPEM not requiredMeta-Analysis

Self-Compassion and Adherence in Five Medical Samples: the Role of Stress.

Sirois, Fuschia M, Hirsch, Jameson K·Mindfulness·2019

This study looked at whether being kind and compassionate to yourself helps people with chronic illnesses—including ME/CFS—stick to their medical treatments. Researchers surveyed 709 patients across five different conditions and found that people who naturally practice self-compassion do tend to follow their treatment plans better. They also discovered that part of this benefit happens because self-compassion helps reduce stress.

E2 ModerateBehavioralPEM not requiredObservational

A 4-Day Mindfulness-Based Cognitive Behavioral Intervention Program for CFS/ME. An Open Study, With 1-Year Follow-Up.

Stubhaug, Bjarte, Lier, Haldis O, Aßmus, Jörg et al.·Frontiers in psychiatry·2018

This study tested whether a 4-day treatment program combining education, cognitive therapy, mindfulness, physical activity, and writing could help people with ME/CFS. Over 300 patients participated and were followed for one year. About 80% of patients showed meaningful improvement in fatigue and physical functioning that lasted throughout the year, and nearly all patients were satisfied with the program.

E2 ModerateCohortPEM not requiredCross-Sectional

Comparison of Fatigue Severity and Quality of Life between Unexplained Fatigue Patients and Explained Fatigue Patients.

Yoo, Eun Hae, Choi, Eun Sil, Cho, Soo Hyun et al.·Korean journal of family medicine·2018

This study compared fatigue and quality of life in 200 Korean adults with fatigue. Researchers divided participants into two groups: those whose fatigue had a clear medical explanation (like anemia or thyroid disease) and those whose fatigue remained unexplained after testing. People with unexplained fatigue reported significantly lower quality of life, especially in physical functioning, compared to those with explained fatigue.

Diagnostics

E2 ModerateCohortPEM unclearObservational

Verification of exercise-induced transient postural tachycardia phenotype in Gulf War Illness.

Garner, Richard S, Rayhan, Rakib U, Baraniuk, James N·American journal of translational research·2018

Researchers found that about one-fourth of Gulf War Illness patients developed an unusual heart rate response after exercise: their heart raced when they stood up, even though this didn't happen before exercise. This temporary condition, called the START phenotype, appeared around 2 hours after exercise and was different from a similar condition called POTS that some patients had continuously. This discovery suggests that exercise can trigger a specific cardiovascular problem in some Gulf War Illness patients.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCross-Sectional

Hand Grip Strength as a Clinical Biomarker for ME/CFS and Disease Severity.

Nacul, Luis Carlos, Mudie, Kathleen, Kingdon, Caroline C et al.·Frontiers in neurology·2018

Researchers tested whether hand grip strength could be a useful tool for diagnosing ME/CFS and measuring how severe the condition is. They found that people with ME/CFS—especially those with severe disease—have noticeably weaker grip strength compared to healthy people, and their grip strength drops more across repeated tests. This simple, objective test may help doctors better diagnose ME/CFS and track how patients are doing over time.

Biomarkers

E2 ModerateBehavioralPEM not requiredCross-Sectional

A test of the adaptive network explanation of functional disorders using a machine learning analysis of symptoms.

Melidis, Christos, Denham, Susan L, Hyland, Michael E·Bio Systems·2018

This study looked at whether ME/CFS, fibromyalgia, and IBS might result from the body's biological systems becoming overly adapted in ways that backfire. Researchers surveyed 1,751 people with these conditions about their symptoms and used computer analysis to identify patterns. They found that as symptoms become more severe and widespread, the differences between these three conditions blur, suggesting they may share common underlying mechanisms.

E2 ModerateCohortPEM unclearCross-Sectional

Poor self-reported sleep quality and health-related quality of life in patients with chronic fatigue syndrome/myalgic encephalomyelitis.

Castro-Marrero, Jesús, Zaragozá, Maria C, González-Garcia, Sergio et al.·Journal of sleep research·2018

This study looked at sleep problems in 1,455 Spanish ME/CFS patients and found that nearly all of them reported poor sleep quality that wasn't refreshing, even when they slept. The researchers discovered that poor sleep was strongly linked to worse pain, fatigue, anxiety, depression, and lower quality of life overall. Several factors—including pain intensity, mood problems, fibromyalgia, and autonomic nervous system dysfunction—were particularly associated with sleep difficulties.

Pain and SensitizationSleepAutonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Reduction of Glucocorticoid Receptor Function in Chronic Fatigue Syndrome.

Lynn, Megan, Maclachlan, Laura, Finkelmeyer, Andreas et al.·Mediators of inflammation·2018

This study looked at how the body's stress hormone system (glucocorticoid receptor) works in ME/CFS patients compared to healthy people. Researchers took blood samples and tested how well a stress hormone called dexamethasone could reduce inflammation markers. They found that ME/CFS patients had some differences in how their immune system responded, but the stress hormone system itself seemed to work similarly to healthy controls.

Immune System

E2 ModerateCohortPEM requiredLongitudinal

Chronic fatigue syndrome (CFS/ME) symptom-based phenotypes and 1-year treatment outcomes in two clinical cohorts of adult patients in the UK and The Netherlands.

Collin, Simon M, Heron, Jon, Nikolaus, Stephanie et al.·Journal of psychosomatic research·2018

This study looked at different patterns of ME/CFS symptoms in nearly 2,300 patients across the UK and Netherlands to see if the types of symptoms people have when they first seek treatment predict how well they'll improve. Researchers found three main symptom patterns: patients with few extra symptoms, patients with multiple symptoms, and patients with mainly pain symptoms. After one year of treatment, patients who started with fewer symptoms were significantly more likely to feel much better, while those with many symptoms or pain-focused symptoms were less likely to improve.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredObservational

The effects of warm water immersion on blood pressure, heart rate and heart rate variability in people with chronic fatigue syndrome.

Parker, Romy, Higgins, Zeenath, Mlombile, Zandiswa N P et al.·The South African journal of physiotherapy·2018

This study looked at how warm water bathing affects heart function in people with ME/CFS compared to healthy people. Researchers found that people with ME/CFS had less stable heart rate patterns before entering warm water, but this improved during the water immersion. The heart rate stayed slightly elevated in the ME/CFS group even after leaving the water. Overall, warm water immersion appeared safe and may help with managing ME/CFS symptoms.

Autonomic Nervous System

E2 ModerateCohortPEM unclearObservational

Estimating Prevalence, Demographics, and Costs of ME/CFS Using Large Scale Medical Claims Data and Machine Learning.

Valdez, Ashley R, Hancock, Elizabeth E, Adebayo, Seyi et al.·Frontiers in pediatrics·2018

Researchers used insurance billing records and computer analysis to estimate how many Americans have ME/CFS. They found that between 1.7 and 3.4 million people in the U.S. may have been diagnosed with ME/CFS, making it more common than many people realize. The study also showed that ME/CFS costs patients far more in medical expenses than other serious diseases like lupus or multiple sclerosis.

E2 ModerateCohortPEM unclearCross-Sectional

Restricted Spatial Windows of Visibility in Myalgic Encephalomyelitis (ME).

Ahmed, Nadia S, Gottlob, Irene, Proudlock, Frank A et al.·Vision (Basel, Switzerland)·2018

This study looked at how ME affects vision by testing how well people can see contrast (the difference between light and dark areas). Researchers tested 19 people with ME and 19 healthy people by asking them to identify faint striped patterns. People with ME had more difficulty seeing these patterns, especially at lower levels of detail, suggesting that ME may affect how the eyes and brain process visual information.

Biomarkers

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Sleep education in primary school prevents future school refusal behavior.

Hematological and Psychophysiological Correlates of Anomalous Information Reception in Mediums: A Preliminary Exploration.

Predictors of chronic fatigue in adolescents six months after acute Epstein-Barr virus infection: A prospective cohort study.

Associations Between Autonomic and Orthostatic Self-report and Physician Ratings of Orthostatic Intolerance in Youth.

The Impact of a Structured Exercise Programme upon Cognitive Function in Chronic Fatigue Syndrome Patients.

Systemic exertion intolerance disease/chronic fatigue syndrome is common in sleep centre patients with hypersomnolence: A retrospective pilot study.

Post-Exertional Malaise Is Associated with Hypermetabolism, Hypoacetylation and Purine Metabolism Deregulation in ME/CFS Cases.

Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of Gene-expression Modules.

Self-Compassion and Adherence in Five Medical Samples: the Role of Stress.

A 4-Day Mindfulness-Based Cognitive Behavioral Intervention Program for CFS/ME. An Open Study, With 1-Year Follow-Up.

Comparison of Fatigue Severity and Quality of Life between Unexplained Fatigue Patients and Explained Fatigue Patients.

Verification of exercise-induced transient postural tachycardia phenotype in Gulf War Illness.

Hand Grip Strength as a Clinical Biomarker for ME/CFS and Disease Severity.

A test of the adaptive network explanation of functional disorders using a machine learning analysis of symptoms.

Poor self-reported sleep quality and health-related quality of life in patients with chronic fatigue syndrome/myalgic encephalomyelitis.

Reduction of Glucocorticoid Receptor Function in Chronic Fatigue Syndrome.

Chronic fatigue syndrome (CFS/ME) symptom-based phenotypes and 1-year treatment outcomes in two clinical cohorts of adult patients in the UK and The Netherlands.

The effects of warm water immersion on blood pressure, heart rate and heart rate variability in people with chronic fatigue syndrome.

Estimating Prevalence, Demographics, and Costs of ME/CFS Using Large Scale Medical Claims Data and Machine Learning.

Restricted Spatial Windows of Visibility in Myalgic Encephalomyelitis (ME).

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

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