ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2795 studies

961–980 of 2,795 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Emotional Regulation in Women with Chronic Fatigue Syndrome and Depression: Internal Representations and Adaptive Defenses.

Bram, Anthony D, Gottschalk, Kiley A, Leeds, William M·Journal of the American Psychoanalytic Association·2018

This study looked at how women with ME/CFS and depression process and manage their emotions differently than healthy women. Researchers tested 186 women in four groups—those with ME/CFS and high depression, ME/CFS with lower depression, depression alone, and healthy controls—to see if difficulty expressing emotions psychologically might lead to more physical symptoms. The findings suggest that some people with ME/CFS, particularly those with both ME/CFS and depression, may have more trouble managing emotions, but not all patients show this pattern.

E2 ModerateCohortPEM unclearCross-Sectional

Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.

Nagy-Szakal, Dorottya, Barupal, Dinesh K, Lee, Bohyun et al.·Scientific reports·2018

Researchers studied blood and gut bacteria samples from 50 people with ME/CFS and 50 healthy people to find biological markers of the disease. They found that people with ME/CFS have abnormal levels of certain substances in their blood called metabolites, particularly a fatty molecule called ceramide in those who also have irritable bowel syndrome. When scientists combined information about both blood metabolites and gut bacteria, they could identify ME/CFS patients more accurately than using either test alone.

Biomarkers

E2 ModerateCohortPEM requiredCross-Sectional

Association of chronic fatigue syndrome with premature telomere attrition.

Rajeevan, Mangalathu S, Murray, Janna, Oakley, Lisa et al.·Journal of translational medicine·2018

This study compared telomere length—the protective caps at the ends of our DNA—between people with ME/CFS and healthy controls. Researchers found that people with ME/CFS had shorter telomeres, suggesting their cells may be aging faster than expected. The effect was strongest in women under 45 years old with ME/CFS, who showed signs of aging equivalent to 10-20 years beyond their actual age.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Circadian rhythm abnormalities and autonomic dysfunction in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Cambras, Trinitat, Castro-Marrero, Jesús, Zaragoza, Maria Cleofé et al.·PloS one·2018

This study compared daily activity patterns and skin temperature regulation in 10 women with ME/CFS and 10 healthy women over a week in both winter and summer. While sleep patterns were similar between groups, people with ME/CFS had lower overall daily activity levels and their bodies showed weaker responses to the normal daily rhythm patterns that healthy people display (like a post-lunch energy dip). The findings suggest that ME/CFS may involve problems with how the body's internal clock and temperature regulation systems work.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in chronic fatigue syndrome.

Barnden, Leighton R, Shan, Zack Y, Staines, Donald R et al.·NeuroImage. Clinical·2018

Researchers used advanced MRI scans to compare the brains of 43 people with ME/CFS and 27 healthy people. They found that people with ME/CFS had different patterns in their brainstem (the base of the brain that controls basic functions) and in the sensorimotor areas (parts that control movement and sensation). The study suggests that the body may be compensating for problems in the brainstem by increasing protective coating around nerve fibers in motor control areas.

Neuroinflammation

E2 ModerateCohortPEM unclearCase-Control

Humoral Immunity Profiling of Subjects with Myalgic Encephalomyelitis Using a Random Peptide Microarray Differentiates Cases from Controls with High Specificity and Sensitivity.

Singh, Sahajpreet, Stafford, Phillip, Schlauch, Karen A et al.·Molecular neurobiology·2018

Researchers tested blood samples from 21 people with ME and 21 healthy controls to look for distinctive antibody patterns that could serve as a diagnostic test. Using a high-tech screening tool that checks for antibodies against thousands of different peptides, they found 25 unique patterns that could reliably distinguish people with ME from those without the disease. The antibodies appeared to target the person's own proteins and certain virus-like sequences found in human DNA.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

The presence of co-morbid mental health problems in a cohort of adolescents with chronic fatigue syndrome.

Loades, Maria Elizabeth, Rimes, Katharine A, Ali, Sheila et al.·Clinical child psychology and psychiatry·2018

This study looked at mental health problems in 52 teenagers with ME/CFS to see how common depression and anxiety are in this group. About one-third of the teenagers had depression, and over a quarter had anxiety disorders. Teenagers with depression reported more difficulty with school and social life. The researchers found that using a proper psychiatric interview was better than just asking teenagers to fill out questionnaires for identifying these mental health conditions.

E2 ModerateCohortPEM unclearCross-Sectional

Decreased Connectivity and Increased Blood Oxygenation Level Dependent Complexity in the Default Mode Network in Individuals with Chronic Fatigue Syndrome.

Shan, Zack Y, Finegan, Kevin, Bhuta, Sandeep et al.·Brain connectivity·2018

This study used brain imaging to look at how a specific network in the brain (called the default mode network) works differently in people with ME/CFS compared to healthy people. Researchers found that in ME/CFS patients, this brain network shows more chaotic activity and weaker communication between different regions. These differences might one day help doctors diagnose ME/CFS using brain scans.

E2 ModerateCohortPEM not requiredCross-Sectional

How to Distinguish Patients with pSS among Individuals with Dryness without Invasive Diagnostic Studies.

Sebastian, Agata, Sebastian, Maciej, Misterska-Skóra, Maria et al.·Journal of immunology research·2018

This study looked at whether doctors can tell the difference between primary Sjögren's syndrome (pSS)—an autoimmune disease that damages moisture-producing glands—and simple dryness caused by other reasons, without needing invasive tests like biopsies. The researchers found that certain blood markers and symptoms like fatigue, swollen lymph nodes, and specific antibodies were much more common in pSS patients than in people with dryness alone.

Immune System

E2 ModerateCohortPEM unclearObservational

Effects of a short-term aquatic exercise intervention on symptoms and exercise capacity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis: a pilot study.

Broadbent, Suzanne, Coetzee, Sonja, Beavers, Rosalind·European journal of applied physiology·2018

This small study looked at whether exercising in water could help women with ME/CFS. Eleven women did gentle water exercise twice a week for 4 weeks, and researchers measured their strength, fitness, and fatigue levels before and after. The women were able to walk farther, felt less tired and had less pain after the program, and nobody reported feeling worse from the exercise.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

The etiologic relation between disequilibrium and orthostatic intolerance in patients with myalgic encephalomyelitis (chronic fatigue syndrome).

Miwa, Kunihisa, Inoue, Yukichi·Journal of cardiology·2018

This study looked at 44 ME/CFS patients to understand why they struggle to stay upright (orthostatic intolerance). Researchers found that balance problems—difficulty staying steady when standing with eyes closed—were common and seemed to make orthostatic intolerance worse. Patients with balance problems were more likely to have trouble completing a 10-minute standing test than those with only heart rate changes, suggesting balance issues may be just as important as blood pressure and heart rate problems in ME/CFS.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

In Schizophrenia, Depression, Anxiety, and Physiosomatic Symptoms Are Strongly Related to Psychotic Symptoms and Excitation, Impairments in Episodic Memory, and Increased Production of Neurotoxic Tryptophan Catabolites: a Multivariate and Machine Learning Study.

Kanchanatawan, Buranee, Thika, Supaksorn, Sirivichayakul, Sunee et al.·Neurotoxicity research·2018

This study examined 80 people with schizophrenia and 40 healthy controls to understand why schizophrenia patients often experience depression, anxiety, and physical symptoms like those seen in chronic fatigue. The researchers found that these symptoms were linked to changes in how the body breaks down tryptophan (an amino acid), problems with memory, and the severity of psychotic symptoms. The findings suggest that toxic byproducts from tryptophan metabolism may contribute to depression, anxiety, and physical symptoms in schizophrenia.

Neuroinflammation

E2 ModerateCohortPEM not requiredCross-Sectional

Sleep patterns among patients with chronic fatigue: A polysomnography-based study.

Pajediene, Evelina, Bileviciute-Ljungar, Indre, Friberg, Danielle·The clinical respiratory journal·2018

This study looked at sleep problems in people with chronic fatigue by using a sleep monitoring test called polysomnography. Researchers found that more than half of the fatigued patients who also felt excessively sleepy had treatable sleep disorders like sleep apnea, restless legs, or periodic leg movements. The authors suggest that people with these symptoms should be tested for sleep disorders and treated before being diagnosed with ME/CFS, since fixing the sleep problem might help with fatigue.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Adolescent's descriptions of fatigue, fluctuation and payback in chronic fatigue syndrome/myalgic encephalopathy (CFS/ME): interviews with adolescents and parents.

Parslow, Roxanne M, Anderson, Nina, Byrne, Danielle et al.·BMJ paediatrics open·2018

Researchers interviewed 21 teenagers with ME/CFS and their parents to understand how they experience fatigue and symptoms. All the teenagers described fatigue, good days and bad days, and getting worse after activity (called payback). However, each teenager's experience was different—some felt constantly tired while others had more variable symptoms, and the impact on their daily lives ranged from minor activity limitations to being mostly sedentary.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Grey and white matter differences in Chronic Fatigue Syndrome - A voxel-based morphometry study.

Finkelmeyer, Andreas, He, Jiabao, Maclachlan, Laura et al.·NeuroImage. Clinical·2018

Researchers used advanced brain imaging (MRI) to compare the brains of 42 people with ME/CFS to 30 healthy people. They found differences in how much grey matter and white matter the ME/CFS patients had in certain brain regions. Specifically, people with ME/CFS had more grey matter in areas that process internal body signals and stress, but less white matter in regions involved in the brainstem and midbrain.

E2 ModerateCohortPEM not requiredLongitudinal

Longitudinal associations of lymphocyte subsets with clinical outcomes in chronic fatigue syndrome.

Mehalick, Melissa L, Schmaling, Karen B, Sabath, Daniel E et al.·Fatigue : biomedicine, health & behavior·2018

This study looked at how different types of immune cells (called lymphocytes) change over 18 months in people with ME/CFS and whether these changes connected to symptom severity and physical ability. Researchers tracked three types of immune cells in 93 ME/CFS patients and measured their fatigue, physical functioning, and energy levels over time. They found that certain immune cell patterns were linked to worse physical function and more symptoms, suggesting the immune system may play a role in ME/CFS severity.

Immune System

E2 ModeratePEM not requiredRegistry-Resource

Improvement in mood, oxidative stress, fatigue, and insomnia following supplementary management with Robuvit®.

Belcaro, Gianni, Saggino, Aristide, Cornelli, Umberto et al.·Journal of neurosurgical sciences·2018

This study tested whether a supplement made from French oak wood called Robuvit® could help people with ME/CFS who experience fatigue, sleep problems, mood difficulties, and high levels of oxidative stress (cellular damage). Eighteen patients took 300 mg of Robuvit® daily for 8 weeks, while 22 others received standard care. The Robuvit® group showed significant improvements in mood, fatigue, sleep, and oxidative stress levels, with no safety concerns reported.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Association between cytokines and psychiatric symptoms in chronic fatigue syndrome and healthy controls.

Groven, Nina, Fors, Egil A, Iversen, Valentina C et al.·Nordic journal of psychiatry·2018

This study looked at immune system markers called cytokines in people with ME/CFS compared to healthy people, and how these markers related to mood and anxiety symptoms. Researchers found that people with ME/CFS had slightly higher levels of one immune marker (TNF-α) and discovered different patterns of how immune markers connected to psychiatric symptoms in ME/CFS patients versus healthy controls. The findings suggest that immune system activity may work differently in ME/CFS, which could help explain some symptoms and guide future treatments.

Immune System

E2 ModeratePEM not requiredRegistry-Resource

Supplementation with Robuvit® in subjects with burnout associated to high oxidative stress.

Belcaro, Gianni, Hosoi, Morio, Feragalli, Beatrice et al.·Minerva medica·2018

This study tested whether a supplement called Robuvit® (made from French oak wood) could help people with burnout syndrome who experience severe fatigue and high oxidative stress (a type of cellular damage). Over 4 weeks, people taking Robuvit® showed improvements in emotional exhaustion, job satisfaction, and stress levels compared to those receiving standard treatment alone. The supplement also reduced markers of oxidative stress in the blood.

E2 ModerateCohortPEM not requiredCross-Sectional

Structural brain changes versus self-report: machine-learning classification of chronic fatigue syndrome patients.

Sevel, Landrew S, Boissoneault, Jeff, Letzen, Janelle E et al.·Experimental brain research·2018

Researchers compared two methods for identifying ME/CFS patients: looking at structural brain changes on MRI scans versus asking patients to rate their symptoms like fatigue, pain, and sleep quality. While brain imaging showed some useful differences between ME/CFS patients and healthy people, patients' own descriptions of their symptoms were actually better at identifying who had ME/CFS.

Biomarkers

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Emotional Regulation in Women with Chronic Fatigue Syndrome and Depression: Internal Representations and Adaptive Defenses.

Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.

Association of chronic fatigue syndrome with premature telomere attrition.

Circadian rhythm abnormalities and autonomic dysfunction in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in chronic fatigue syndrome.

Humoral Immunity Profiling of Subjects with Myalgic Encephalomyelitis Using a Random Peptide Microarray Differentiates Cases from Controls with High Specificity and Sensitivity.

The presence of co-morbid mental health problems in a cohort of adolescents with chronic fatigue syndrome.

Decreased Connectivity and Increased Blood Oxygenation Level Dependent Complexity in the Default Mode Network in Individuals with Chronic Fatigue Syndrome.

How to Distinguish Patients with pSS among Individuals with Dryness without Invasive Diagnostic Studies.

Effects of a short-term aquatic exercise intervention on symptoms and exercise capacity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis: a pilot study.

The etiologic relation between disequilibrium and orthostatic intolerance in patients with myalgic encephalomyelitis (chronic fatigue syndrome).

In Schizophrenia, Depression, Anxiety, and Physiosomatic Symptoms Are Strongly Related to Psychotic Symptoms and Excitation, Impairments in Episodic Memory, and Increased Production of Neurotoxic Tryptophan Catabolites: a Multivariate and Machine Learning Study.

Sleep patterns among patients with chronic fatigue: A polysomnography-based study.

Adolescent's descriptions of fatigue, fluctuation and payback in chronic fatigue syndrome/myalgic encephalopathy (CFS/ME): interviews with adolescents and parents.

Grey and white matter differences in Chronic Fatigue Syndrome - A voxel-based morphometry study.

Longitudinal associations of lymphocyte subsets with clinical outcomes in chronic fatigue syndrome.

Improvement in mood, oxidative stress, fatigue, and insomnia following supplementary management with Robuvit®.

Association between cytokines and psychiatric symptoms in chronic fatigue syndrome and healthy controls.

Supplementation with Robuvit® in subjects with burnout associated to high oxidative stress.

Structural brain changes versus self-report: machine-learning classification of chronic fatigue syndrome patients.

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Biomarkers

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