ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1261–1280 of 2,423 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Regulatory T-cells: modern approaches to optimization of their numbers].

Pukhal'skiĭ, A L, Shmarina, G V, Aleshkin, V A·Vestnik Rossiiskoi akademii meditsinskikh nauk·2011

Your body has special immune cells called regulatory T-cells (Tregs) that normally help control inflammation and keep your immune system balanced. This article explains how long-term stress and aging can disrupt this balance—either causing too many Tregs to build up or too few to develop properly. The authors suggest that when Tregs become imbalanced, it may contribute to conditions like chronic fatigue syndrome, while also affecting allergy and cancer risk.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue?

Hoeck, Anna Dorothea, Pall, Martin L·Medical hypotheses·2011

This paper proposes that low vitamin D levels may contribute to ME/CFS by allowing harmful inflammatory processes to continue unchecked in the body. Vitamin D normally acts as a brake on inflammation, but only when levels are adequate. The authors suggest that fixing vitamin D deficiency through supplementation might help reduce fatigue and inflammation in ME/CFS, though they acknowledge this theory needs to be tested in actual clinical trials.

Immune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

PCR master mixes harbour murine DNA sequences. Caveat emptor!

Tuke, Philip W, Tettmar, Kate I, Tamuri, Asif et al.·PloS one·2011

This study found that the laboratory chemicals used to detect viruses in blood samples may themselves contain mouse virus DNA, which can contaminate test results. When researchers tested water samples (with no actual virus present) using common laboratory kits, they still found mouse virus sequences—the same sequences that had been previously reported in ME/CFS patients. This suggests that previous findings of these viruses in ME/CFS patients may have been false positives caused by contaminated testing materials rather than actual infections.

E3 PreliminaryMechanismPEM not requiredMechanistic

Antibody responses against xenotropic murine leukemia virus-related virus envelope in a murine model.

Makarova, Natalia, Zhao, Chunxia, Zhang, Yuanyuan et al.·PloS one·2011

Researchers created a vaccine to test whether the body can develop antibodies (immune proteins) against XMRV, a virus that was proposed to be associated with ME/CFS. Mice given the vaccine did produce antibodies against the virus, but these antibodies disappeared quickly—within three weeks. This short-lived immune response might help explain why different studies have found different rates of XMRV in ME/CFS patients.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Sleep disorders, medical conditions, and road accident risk.

Smolensky, Michael H, Di Milia, Lee, Ohayon, Maurice M et al.·Accident; analysis and prevention·2011

This review examined how sleep disorders and medical conditions—including ME/CFS, sleep apnea, insomnia, and others—may increase the risk of car accidents caused by drowsiness and fatigue. The authors found that while these conditions clearly cause tiredness and poor sleep, very few studies have actually looked at whether they make people more likely to have driving accidents. They call for better research to understand this connection and test whether treating these conditions reduces crash risk.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

Systemic nickel hypersensitivity and diet: myth or reality?

Pizzutelli, S·European annals of allergy and clinical immunology·2011

This review examines whether eating foods containing nickel causes widespread symptoms in people with nickel allergies. While nickel allergies from skin contact are well-established, the evidence that eating nickel-containing foods causes systemic symptoms—like fatigue, digestive problems, or neurological issues—is unclear and unproven. The authors conclude that current scientific evidence is not strong enough to recommend low-nickel diets as a treatment.

E3 PreliminaryMechanismPEM not requiredMechanistic

Resveratrol improves hippocampal atrophy in chronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cells.

Moriya, Junji, Chen, Rui, Yamakawa, Jun-ichi et al.·Biological & pharmaceutical bulletin·2011

Researchers created mice with chronic fatigue by repeatedly exposing them to a bacterial antigen, which caused them to move less and their brains to shrink in a region called the hippocampus. When they gave these mice resveratrol (a compound found in red grapes), the mice became more active and their hippocampus enlarged. The treatment appeared to work by reducing brain cell death and promoting the growth of new brain cells.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

Evidence and controversies on the role of XMRV in prostate cancer and chronic fatigue syndrome.

Menéndez-Arias, Luis·Reviews in medical virology·2011

Researchers discovered a virus called XMRV in some people with prostate cancer and ME/CFS, which generated significant interest. However, other studies have not been able to confirm this finding, leaving uncertainty about whether XMRV actually causes disease in humans. This review examines what we know and don't know about XMRV's role in these conditions.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fatigue and chronic fatigue in the elderly: definitions, diagnoses, and treatments.

Morelli, Vincent·Clinics in geriatric medicine·2011

This review article helps doctors understand fatigue in older adults by explaining three types: fatigue that comes on recently, fatigue that lasts a long time, and chronic fatigue syndrome. The article discusses how doctors can evaluate fatigue and offers both medication and non-medication treatments like exercise, vitamins, diet changes, and behavioral strategies.

Diagnostics

E3 PreliminaryCohortPEM unclearCross-Sectional

Patients' hopes and expectations of a specialist chronic fatigue syndrome/ME service: a qualitative study.

McDermott, C, Lynch, J, Leydon, G M·Family practice·2011

This study asked 20 newly referred ME/CFS patients what they hoped to gain from visiting a specialist service. Patients most wanted a clear diagnosis, better understanding of their illness, practical guidance on managing it, and hope for the future. Most patients felt uncertain about ME/CFS and wanted more information earlier in their illness journey, rather than waiting to see a specialist.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

How to care for patients with chronic fatigue syndrome/ME.

McGough, Amanda·Nursing times·2011

This article provides practical guidance for nurses and healthcare professionals on how to care for patients with ME/CFS. It focuses on managing symptoms, supporting patients through their illness, and improving the quality of care these patients receive in clinical settings.

E3 PreliminaryReviewPEM unclearReview-Narrative

Kynurenine pathway Hypothesis: The nature of the chronic Fatigue syndrome (cFs) Revisited.

Blankfield, Adele·International journal of tryptophan research : IJTR·2011

This study examines a theory that ME/CFS might be related to problems with how the body processes an amino acid called tryptophan. The body normally breaks down tryptophan through a pathway called the kynurenine pathway, and the researchers suggest that abnormalities in this process could contribute to the symptoms of chronic fatigue syndrome.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

The sick building syndrome as a part of the autoimmune (auto-inflammatory) syndrome induced by adjuvants.

Israeli, Eitan, Pardo, Asher·Modern rheumatology·2011

This review paper proposes that sick building syndrome—a collection of unexplained symptoms people develop from spending time in certain buildings—may be part of a larger group of related conditions. The authors suggest that sick building syndrome shares many symptoms with other post-exposure illnesses like Gulf War syndrome and chronic fatigue syndrome, and may all stem from similar immune system problems triggered by specific substances.

E3 PreliminaryReviewPEM unclearReview-Narrative

Structural integration, an alternative method of manual therapy and sensorimotor education.

Jacobson, Eric·Journal of alternative and complementary medicine (New York, N.Y.)·2011

Structural Integration (SI) is a hands-on therapy that focuses on improving how your body moves and holds itself, rather than treating specific symptoms. This review looked at what we know about how SI might work—such as making muscles and connective tissues more flexible and improving how your nervous system processes movement and stress—and found that small studies have reported improvements in pain, movement, balance, and well-being in some conditions including chronic fatigue.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Treatment of central sensitization in patients with 'unexplained' chronic pain: what options do we have?

Nijs, Jo, Meeus, Mira, Van Oosterwijck, Jessica et al.·Expert opinion on pharmacotherapy·2011

This review examines how the nervous system can become overly sensitive to pain signals, a condition called central sensitization that occurs in many chronic pain disorders including ME/CFS. The authors summarize different treatment approaches—including medications, physical therapy, brain stimulation, and stress management—that may help calm down an overactive pain processing system in the brain and spinal cord.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredMechanistic

A Chinese herbal decoction, Danggui Buxue Tang, improves chronic fatigue syndrome induced by food restriction and forced swimming in rats.

Liu, Ya, Zhang, Hai-Gang, Li, Xiao-Hui·Phytotherapy research : PTR·2011

Researchers tested a traditional Chinese herbal mixture called Danggui Buxue Tang on rats engineered to have chronic fatigue-like symptoms. Rats treated with the herb showed improvements in body weight, physical endurance, and markers of immune function, suggesting the herbal mixture might help reduce fatigue by calming overactive immune responses.

Immune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Detection of murine leukemia virus or mouse DNA in commercial RT-PCR reagents and human DNAs.

Zheng, HaoQiang, Jia, Hongwei, Shankar, Anupama et al.·PloS one·2011

Scientists tested commercial laboratory reagents and DNA samples commonly used in medical research and found that many contained mouse virus sequences (MLV). These contaminations appear to come from the manufacturing process and could produce false-positive test results if not properly identified. This discovery is important because earlier ME/CFS studies reporting MLV detection may have been affected by these contaminated supplies rather than finding a real virus in patients.

E3 PreliminaryCohortPEM not requiredCase-Control

Adrenal histoplasmosis: a case series and review of the literature.

Larbcharoensub, Noppadol, Boonsakan, Paisarn, Aroonroch, Rangsima et al.·The Southeast Asian journal of tropical medicine and public health·2011

This study describes seven cases of a rare fungal infection (histoplasmosis) that affected the adrenal glands—small organs that help manage stress and energy in the body. All patients experienced chronic fatigue as their main symptom, and most recovered after treatment. While this infection is uncommon, it shows that certain fungal infections can cause fatigue-like illness and should be considered when evaluating patients with unexplained chronic tiredness.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Classifying medication use in clinical research.

Rizzo, Dorrie, Creti, Laura, Bailes, Sally et al.·Journal of primary care & community health·2011

Researchers created a simple system for organizing and grouping the medicines that patients take during medical studies. They tested this organizational method on patients with ME/CFS and sleep apnea to see if different groups of patients tend to take different combinations of medications. They found five main medicine categories, and importantly, the pattern of medicines taken by ME/CFS patients was quite different from sleep apnea patients, possibly reflecting different views about what causes these conditions.

E3 PreliminaryBehavioralPEM not requiredCase-Control

Pain neurophysiology education improves cognitions, pain thresholds, and movement performance in people with chronic whiplash: a pilot study.

Van Oosterwijck, Jessica, Nijs, Jo, Meeus, Mira et al.·Journal of rehabilitation research and development·2011

This small study tested whether teaching patients with chronic neck pain from whiplash about how pain works in the body could help them feel better. Six patients received this education, and researchers found that afterward, patients had less fear of movement, used healthier coping strategies, reported less disability, and could move their necks with less pain.

Pain and Sensitization

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Evidence browser

[Regulatory T-cells: modern approaches to optimization of their numbers].

Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue?

PCR master mixes harbour murine DNA sequences. Caveat emptor!

Antibody responses against xenotropic murine leukemia virus-related virus envelope in a murine model.

Sleep disorders, medical conditions, and road accident risk.

Systemic nickel hypersensitivity and diet: myth or reality?

Resveratrol improves hippocampal atrophy in chronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cells.

Evidence and controversies on the role of XMRV in prostate cancer and chronic fatigue syndrome.

Fatigue and chronic fatigue in the elderly: definitions, diagnoses, and treatments.

Patients' hopes and expectations of a specialist chronic fatigue syndrome/ME service: a qualitative study.

How to care for patients with chronic fatigue syndrome/ME.

Kynurenine pathway Hypothesis: The nature of the chronic Fatigue syndrome (cFs) Revisited.

The sick building syndrome as a part of the autoimmune (auto-inflammatory) syndrome induced by adjuvants.

Structural integration, an alternative method of manual therapy and sensorimotor education.

Treatment of central sensitization in patients with 'unexplained' chronic pain: what options do we have?

A Chinese herbal decoction, Danggui Buxue Tang, improves chronic fatigue syndrome induced by food restriction and forced swimming in rats.

Detection of murine leukemia virus or mouse DNA in commercial RT-PCR reagents and human DNAs.

Adrenal histoplasmosis: a case series and review of the literature.

Classifying medication use in clinical research.

Pain neurophysiology education improves cognitions, pain thresholds, and movement performance in people with chronic whiplash: a pilot study.

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