ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1401–1420 of 2,423 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

[Functional somatic syndrome in dental practice].

Inamitsu, Tetsuaki·Nihon rinsho. Japanese journal of clinical medicine·2009

Many people experience pain and discomfort in their face, jaw, and mouth that doctors and dentists cannot easily explain with standard tests. This review discusses how conditions like temporomandibular disorder (jaw pain), burning mouth syndrome, and facial pain are related to each other and to broader conditions like fibromyalgia and chronic fatigue syndrome. These conditions often occur alongside anxiety, depression, and other mental health challenges, and treating them effectively requires a team approach including medication, physical therapy, and counseling.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredCross-Sectional

A gene signature for post-infectious chronic fatigue syndrome.

Gow, John W, Hagan, Suzanne, Herzyk, Pawel et al.·BMC medical genomics·2009

This study looked at whether certain genes are turned on or off differently in people with ME/CFS compared to healthy people. Researchers examined blood cells from 8 men with post-infectious ME/CFS and 7 healthy men, testing the activity of nearly 39,000 genes. They found that 366 genes were expressed differently between the two groups, particularly in areas related to immune function, oxidative stress, and cell death.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations.

Kumar, Anil, Garg, Ruchika·Fundamental & clinical pharmacology·2009

Researchers tested whether three common antidepressant medications could help reduce fatigue-like symptoms and improve mood and activity levels in mice subjected to repeated stress. All three medications tested—imipramine, desipramine, and citalopram—reduced immobility (fatigue-like behavior), improved movement and activity, decreased anxiety, and reduced markers of cellular damage caused by oxidative stress in the stressed mice.

E3 PreliminaryReviewPEM unclearReview-Narrative

Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you: disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways may explain cardiovascular disorders in ME/CFS.

Maes, Michael, Twisk, Frank Nm·Neuro endocrinology letters·2009

This review examines why people with ME/CFS may develop heart problems earlier than others. The researchers found that ME/CFS involves abnormal inflammation and oxidative stress (damage from harmful molecules in the body), along with low levels of protective antioxidants. These biological changes can damage the heart and blood vessels, potentially explaining why some ME/CFS patients experience heart failure at much younger ages than the general population.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

An integrated approach to infer causal associations among gene expression, genotype variation, and disease.

Lee, Eunjee, Cho, Seoae, Kim, Kyunga et al.·Genomics·2009

Researchers developed a new method to find which genes might cause ME/CFS by combining three types of medical data: genetic variations people are born with, how active those genes are in the body, and whether someone has the disease. When they tested this method on ME/CFS patients, they found that certain genes—especially one called NR3C1—appear to influence disease risk, and that patients with ME/CFS plus depression may have different genetic causes than those with ME/CFS alone.

E3 PreliminaryBehavioralPEM not requiredCase-Control

Fixed belief in cognitive dysfunction despite normal neuropsychological scores: neurocognitive hypochondriasis?

Boone, Kyle Brauer·The Clinical neuropsychologist·2009

Some people with ME/CFS report serious cognitive problems in their daily life, but when given standard memory and thinking tests, their scores are completely normal. This study presents one case and suggests that some patients may worry excessively about cognitive problems that aren't actually measurable on formal tests—a condition the author calls 'neurocognitive hypochondriasis.' The study notes this pattern may occur in ME/CFS and several other conditions.

Cognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia: pathogenetic, diagnostic and therapeutic concerns.

Podolecki, Tomasz, Podolecki, Andrzej, Hrycek, Antoni·Polskie Archiwum Medycyny Wewnetrznej·2009

Fibromyalgia is a condition causing widespread muscle and joint pain that affects many people worldwide. This review examines what we know about fibromyalgia's causes, how doctors diagnose it, and how it can be treated. The authors note that fibromyalgia likely results from multiple factors involving the nervous system, brain chemistry, and immune function, and that treatment typically involves antidepressants, therapy, and other approaches.

Pain and SensitizationDiagnostics

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

Autoantibodies to lens epithelium-derived growth factor/transcription co-activator P75 (LEDGF/P75) in children with chronic nonspecific complaints and with positive antinuclear antibodies.

Kuwabara, Natsuko, Itoh, Yasuhiko, Igarshi, Tohru et al.·Autoimmunity·2009

This study found that a specific antibody called anti-Sa, detected in people with chronic fatigue and positive autoimmune markers, is actually targeting a protein called LEDGF/p75. Researchers developed a simple blood test (ELISA) to detect this antibody more accurately than previous methods. This new test could help doctors identify which patients with chronic fatigue may have an autoimmune component to their illness.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series.

Fluge, Øystein, Mella, Olav·BMC neurology·2009

This study examined whether a drug called rituximab, which reduces B cells (a type of immune cell), could help ME/CFS patients. Three ME/CFS patients received rituximab infusions and all experienced significant symptom improvement lasting several months. When symptoms returned, patients were retreated and improved again, suggesting that B cells may play a role in ME/CFS for at least some patients.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Continuing medical education challenges in chronic fatigue syndrome.

Brimmer, Dana J, McCleary, K Kimberly, Lupton, Teresa A et al.·BMC medical education·2009

Most doctors don't know much about ME/CFS, which means many patients don't get diagnosed or treated. Researchers created an educational program to teach healthcare providers about ME/CFS between 2000 and 2006. They found that online courses were much more popular than printed materials, and that targeting specific audiences at smaller conferences was most effective at spreading information.

E3 PreliminaryBehavioralPEM unclear

Acupuncture treatment of chronic fatigue syndrome.

Hui, Jin-Sheng·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2009

This study looked at whether acupuncture, a traditional Chinese medicine treatment involving thin needles placed on the skin, might help people with ME/CFS. The researchers compared a group of patients who received acupuncture treatment with a control group to see if there were differences in their symptoms and fatigue levels.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome--more than just chronic fatigue].

Forstenius, Lisa, Helmfrid, Sten·Lakartidningen·2009

This article explains that ME/CFS is much more than simply feeling tired all the time. The authors describe how the condition affects multiple body systems and causes real, measurable problems with energy, cognition, and physical function. The paper emphasizes that ME/CFS is a serious medical condition deserving proper recognition and treatment.

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic fatigue syndrome: a hormonal origin? A rare case of dysmenorrhea membranacea.

Veldman, Joan, Van Houdenhove, Boudewijn, Verguts, Jasper·Archives of gynecology and obstetrics·2009

This case describes a woman with chronic fatigue syndrome who developed a rare condition called membranous dysmenorrhea (where the uterine lining sheds in one piece) after starting a hormonal birth control pill. Interestingly, when she stopped the medication and the tissue was expelled, her fatigue symptoms completely disappeared and she was able to return to work. While this is just one patient's experience, it raises the possibility that hormone imbalances might contribute to chronic fatigue in some cases.

E3 PreliminaryBehavioralPEM not requiredCase-Control

Cognitive-behavior therapy in chronic fatigue syndrome: is improvement related to increased physical activity?

Friedberg, Fred, Sohl, Stephanie·Journal of clinical psychology·2009

This study looked at whether cognitive-behavioral therapy (CBT)—a type of talk therapy combined with gradually increasing physical activity—helped 11 people with ME/CFS feel better. While most patients reported feeling improved, the researchers found something surprising: some patients who felt better had actually increased their activity levels (shown by motion sensors), while others had decreased their activity levels. This suggests that improvement in ME/CFS may not work the same way the standard CBT model predicts.

E3 PreliminaryReviewPEM unclearReview-Narrative

Immunological aspects of chronic fatigue syndrome.

Lorusso, Lorenzo, Mikhaylova, Svetlana V, Capelli, Enrica et al.·Autoimmunity reviews·2009

This review examines how the immune system may be involved in ME/CFS. Researchers have found that people with ME/CFS often have unusual patterns in immune cells and signaling molecules called cytokines, particularly higher levels of inflammatory markers. These immune system changes might explain some of the main symptoms, like fatigue and flu-like feelings, though the exact role these changes play in causing the disease remains unclear.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

A comparison of classification methods for predicting Chronic Fatigue Syndrome based on genetic data.

Huang, Lung-Cheng, Hsu, Sen-Yen, Lin, Eugene·Journal of translational medicine·2009

Researchers used computer algorithms to analyze genetic variations (called SNPs) in people with ME/CFS to see if they could predict who has the disease. They tested different mathematical approaches to find the most important genes linked to ME/CFS. Their best-performing method combined a technique called naive Bayes with a process that identified the most relevant genetic markers, suggesting this approach could help identify genetic patterns in ME/CFS.

E3 PreliminaryCohortPEM not requiredCase-Control

A role for the body burden of aluminium in vaccine-associated macrophagic myofasciitis and chronic fatigue syndrome.

Exley, Christopher, Swarbrick, Louise, Gherardi, Rhomain K et al.·Medical hypotheses·2009

This study describes one patient who developed both chronic fatigue syndrome (ME/CFS) and a muscle condition called macrophagic myofasciitis after receiving vaccines containing aluminum adjuvants, and who also had high levels of aluminum in their body. The researchers propose that aluminum accumulation from vaccines might trigger immune system problems that lead to these conditions. This is a single case report rather than a broad study of many patients.

Immune System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Promising outcomes of an adolescent chronic fatigue syndrome inpatient programme.

Gordon, Brett, Lubitz, Lionel·Journal of paediatrics and child health·2009

This study looked at 16 teenagers with ME/CFS who participated in a 4-week inpatient program that included carefully supervised exercise training tailored to each person's abilities. Teenagers who completed the program showed improvements in physical fitness (18% longer time before fatigue, 17% better oxygen uptake), strength (70% more push-ups), fatigue severity (13% improvement), and depression symptoms (42% improvement). These improvements helped many teenagers return to school, social activities, and family life.

E3 PreliminaryMechanismPEM requiredMechanistic

Transcriptional control of complement activation in an exercise model of chronic fatigue syndrome.

Sorensen, Bristol, Jones, James F, Vernon, Suzanne D et al.·Molecular medicine (Cambridge, Mass.)·2009

After exercise, people with ME/CFS show higher levels of certain immune molecules (particularly C4a) that may contribute to their post-exercise symptoms. This study looked at which genes were turned on or off in immune cells after exercise and found that people with ME/CFS activated different immune pathways than healthy people—specifically, a pathway called the lectin pathway responded differently. This suggests their immune system may be producing excess inflammatory signals after physical activity.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCross-Sectional

Secondary structural changes of proteins in fingernails of chronic fatigue syndrome patients from Fourier-transform infrared spectra.

Sakudo, Akikazu, Kuratsune, Hirohiko, Kato, Yukiko Hakariya et al.·Clinica chimica acta; international journal of clinical chemistry·2009

Researchers used a special infrared scanner to examine fingernails from people with ME/CFS and compared them to healthy people's nails. They found that the proteins in ME/CFS patients' nails had different structures—specifically, the nails showed less of a protein structure called alpha-helix and more of a structure called beta-sheet. This suggests that ME/CFS may cause measurable changes in nail composition that could potentially be detected with this scanning technology.

Biomarkers

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[Functional somatic syndrome in dental practice].

A gene signature for post-infectious chronic fatigue syndrome.

Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations.

Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you: disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways may explain cardiovascular disorders in ME/CFS.

An integrated approach to infer causal associations among gene expression, genotype variation, and disease.

Fixed belief in cognitive dysfunction despite normal neuropsychological scores: neurocognitive hypochondriasis?

Fibromyalgia: pathogenetic, diagnostic and therapeutic concerns.

Autoantibodies to lens epithelium-derived growth factor/transcription co-activator P75 (LEDGF/P75) in children with chronic nonspecific complaints and with positive antinuclear antibodies.

Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series.

Continuing medical education challenges in chronic fatigue syndrome.

Acupuncture treatment of chronic fatigue syndrome.

[Chronic fatigue syndrome--more than just chronic fatigue].

Chronic fatigue syndrome: a hormonal origin? A rare case of dysmenorrhea membranacea.

Cognitive-behavior therapy in chronic fatigue syndrome: is improvement related to increased physical activity?

Immunological aspects of chronic fatigue syndrome.

A comparison of classification methods for predicting Chronic Fatigue Syndrome based on genetic data.

A role for the body burden of aluminium in vaccine-associated macrophagic myofasciitis and chronic fatigue syndrome.

Promising outcomes of an adolescent chronic fatigue syndrome inpatient programme.

Transcriptional control of complement activation in an exercise model of chronic fatigue syndrome.

Secondary structural changes of proteins in fingernails of chronic fatigue syndrome patients from Fourier-transform infrared spectra.

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