ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1401–1420 of 2,422 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Inflammatory and oxidative and nitrosative stress pathways underpinning chronic fatigue, somatization and psychosomatic symptoms.

Maes, Michael·Current opinion in psychiatry·2009

This review examines how inflammation and stress on cells (caused by harmful molecules) may explain ME/CFS symptoms. The authors argue that various triggers—like infections, stress, intense exercise, and a 'leaky gut'—can activate these inflammatory pathways inside cells, leading to the pain, fatigue, muscle tension, and other symptoms that ME/CFS patients experience. They suggest that treating these inflammatory pathways could help develop new medicines for ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Postulated vasoactive neuropeptide immunopathology affecting the blood-brain/blood-spinal barrier in certain neuropsychiatric fatigue-related conditions: A role for phosphodiesterase inhibitors in treatment?

Staines, Donald R, Brenu, Ekua W, Marshall-Gradisnik, Sonya·Neuropsychiatric disease and treatment·2009

This paper proposes that ME/CFS, along with MS, Parkinson's disease, and ALS, may involve immune system problems affecting the protective barriers around the brain and spinal cord. Specifically, the authors suggest that certain signaling molecules called PACAP and VIP, which normally help maintain these barriers, may become targets of autoimmune attack. They propose that a class of drugs called phosphodiesterase inhibitors might help restore normal function by boosting protective immune responses.

NeuroinflammationImmune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Sensitive, qualitative detection of human herpesvirus-6 and simultaneous differentiation of variants A and B.

Li, Haijing, Meng, Shufang, Levine, Susan M et al.·Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2009

Researchers developed a new test to detect human herpesvirus-6 (HHV-6) in patient samples, even when the virus is present in very small amounts. The test can also tell the difference between two types of HHV-6 (called variant A and B). When tested on urine samples from people with and without chronic fatigue syndrome, the test successfully detected the virus in a small number of patients.

E3 PreliminaryMechanismPEM not requiredMechanistic

[Activity of hypotnalamic-pituitary-adrenal axis by induction of experimental chronic fatigue syndrom].

Fomicheva, E E, Filatenkova, T A, Rybakina, E G·Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova·2009

Researchers used an animal model to study how ME/CFS might affect the stress hormone system in the body. They gave rats a substance that mimics a viral infection, then tested whether the animals' adrenal glands (which produce cortisol, the main stress hormone) still responded normally. They found that the stress hormone system became less responsive, suggesting that an infection-like trigger could disrupt how the body regulates stress hormones.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects.

Light, Alan R, White, Andrea T, Hughen, Ronald W et al.·The journal of pain·2009

This study examined blood cells from ME/CFS patients and healthy people before and after moderate exercise. Researchers found that ME/CFS patients showed much larger changes in genes related to pain sensation, stress response, and immune function after exercise compared to healthy controls. These gene changes lasted from 30 minutes to 2 days and correlated with patients' fatigue and pain symptoms.

Immune SystemPost-Exertional Malaise

E3 PreliminaryBehavioralPEM not required

Using a DVD to help people with chronic fatigue syndrome learn the technique of pacing.

Weston, Sarah, Townsend, Stella·Nursing times·2009

A specialist rehabilitation team in Shropshire created a DVD and booklet to teach people with ME/CFS about pacing—a technique that involves carefully balancing rest and activity to manage fatigue. This resource was designed to help patients better understand and practice pacing in their daily lives. The team found that these educational materials helped them support their patients more effectively.

E3 PreliminaryMechanismPEM not requiredMechanistic

The role of antioxidant properties of Nardostachys jatamansi in alleviation of the symptoms of the chronic fatigue syndrome.

Lyle, Nazmun, Gomes, Antony, Sur, Tapas et al.·Behavioural brain research·2009

Researchers used rats to test whether an herbal extract from Nardostachys jatamansi (a plant used in traditional medicine) could help with fatigue-like symptoms and stress. Rats that were forced to swim daily for three weeks developed behaviors similar to depression and anxiety, along with signs of cellular damage from oxidative stress. The herbal extract appeared to reduce these symptoms and restore balance to the rats' stress-fighting systems.

E3 PreliminaryReviewPEM unclearReview-Narrative

Are chronic fatigue syndrome and fibromyalgia the same? Implications for the provision of appropriate mental health intervention.

McKay, P G, Duffy, T, Martin, C R·Journal of psychiatric and mental health nursing·2009

This review examines whether ME/CFS and fibromyalgia are actually the same condition or two different diseases. Both conditions cause fatigue and pain, and both often come with mental health challenges like depression or anxiety. The authors suggest that these conditions might share the same root cause, yet doctors currently treat them quite differently, which could affect the mental health support patients receive.

E3 PreliminaryGuidelinePEM not requiredGuideline

Chronic fatigue syndrome: aetiology, diagnosis and treatment.

Avellaneda Fernández, Alfredo, Pérez Martín, Alvaro, Izquierdo Martínez, Maravillas et al.·BMC psychiatry·2009

ME/CFS is a serious condition marked by extreme exhaustion that lasts at least six months and doesn't improve with rest. The fatigue is so severe that it can force people to reduce their daily activities by half or more. Doctors don't yet have a single test to diagnose it, so they diagnose it by ruling out other illnesses. There is currently no cure, but treatment works best when doctors, mental health professionals, and social support services work together to help patients.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM unclearCross-Sectional

An in vivo proton neurospectroscopy study of cerebral oxidative stress in myalgic encephalomyelitis (chronic fatigue syndrome).

Puri, B K, Agour, M, Gunatilake, K D R et al.·Prostaglandins, leukotrienes, and essential fatty acids·2009

This study used brain imaging to measure levels of a protective molecule called glutathione in the brains of people with ME/CFS. Researchers had expected glutathione levels to be lower in ME/CFS patients because it was reduced in their blood, but surprisingly, the brain levels were similar between patients and healthy controls. The study found no evidence that taking glutathione supplements would help with ME/CFS brain-related symptoms.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Immunologic disturbances can explain chronic fatigue syndrome. Biological findings point towards somatogenesis].

Gottfries, Carl-Gerhard, Matousek, Michael, Zachrisson, Olof·Lakartidningen·2009

This review article examines how problems with the immune system may explain why people with ME/CFS experience persistent fatigue and other symptoms. The authors argue that biological evidence supports the idea that ME/CFS is a real physical illness rather than a psychological one, with immune system disturbances playing a central role in the condition.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Continuing medical education challenges in chronic fatigue syndrome.

Brimmer, Dana J, McCleary, K Kimberly, Lupton, Teresa A et al.·BMC medical education·2009

Most doctors don't know much about ME/CFS, which means many patients don't get diagnosed or treated. Researchers created an educational program to teach healthcare providers about ME/CFS between 2000 and 2006. They found that online courses were much more popular than printed materials, and that targeting specific audiences at smaller conferences was most effective at spreading information.

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

Autoantibodies to lens epithelium-derived growth factor/transcription co-activator P75 (LEDGF/P75) in children with chronic nonspecific complaints and with positive antinuclear antibodies.

Kuwabara, Natsuko, Itoh, Yasuhiko, Igarshi, Tohru et al.·Autoimmunity·2009

This study found that a specific antibody called anti-Sa, detected in people with chronic fatigue and positive autoimmune markers, is actually targeting a protein called LEDGF/p75. Researchers developed a simple blood test (ELISA) to detect this antibody more accurately than previous methods. This new test could help doctors identify which patients with chronic fatigue may have an autoimmune component to their illness.

Immune System

E3 PreliminaryBehavioralPEM unclear

Acupuncture treatment of chronic fatigue syndrome.

Hui, Jin-Sheng·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2009

This study looked at whether acupuncture, a traditional Chinese medicine treatment involving thin needles placed on the skin, might help people with ME/CFS. The researchers compared a group of patients who received acupuncture treatment with a control group to see if there were differences in their symptoms and fatigue levels.

E3 PreliminaryBehavioralPEM not requiredCase-Control

Fixed belief in cognitive dysfunction despite normal neuropsychological scores: neurocognitive hypochondriasis?

Boone, Kyle Brauer·The Clinical neuropsychologist·2009

Some people with ME/CFS report serious cognitive problems in their daily life, but when given standard memory and thinking tests, their scores are completely normal. This study presents one case and suggests that some patients may worry excessively about cognitive problems that aren't actually measurable on formal tests—a condition the author calls 'neurocognitive hypochondriasis.' The study notes this pattern may occur in ME/CFS and several other conditions.

Cognitive Impairment

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic fatigue syndrome: a hormonal origin? A rare case of dysmenorrhea membranacea.

Veldman, Joan, Van Houdenhove, Boudewijn, Verguts, Jasper·Archives of gynecology and obstetrics·2009

This case describes a woman with chronic fatigue syndrome who developed a rare condition called membranous dysmenorrhea (where the uterine lining sheds in one piece) after starting a hormonal birth control pill. Interestingly, when she stopped the medication and the tissue was expelled, her fatigue symptoms completely disappeared and she was able to return to work. While this is just one patient's experience, it raises the possibility that hormone imbalances might contribute to chronic fatigue in some cases.

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia: pathogenetic, diagnostic and therapeutic concerns.

Podolecki, Tomasz, Podolecki, Andrzej, Hrycek, Antoni·Polskie Archiwum Medycyny Wewnetrznej·2009

Fibromyalgia is a condition causing widespread muscle and joint pain that affects many people worldwide. This review examines what we know about fibromyalgia's causes, how doctors diagnose it, and how it can be treated. The authors note that fibromyalgia likely results from multiple factors involving the nervous system, brain chemistry, and immune function, and that treatment typically involves antidepressants, therapy, and other approaches.

Pain and SensitizationDiagnostics

E3 PreliminaryCohortPEM not requiredCase-Control

Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series.

Fluge, Øystein, Mella, Olav·BMC neurology·2009

This study examined whether a drug called rituximab, which reduces B cells (a type of immune cell), could help ME/CFS patients. Three ME/CFS patients received rituximab infusions and all experienced significant symptom improvement lasting several months. When symptoms returned, patients were retreated and improved again, suggesting that B cells may play a role in ME/CFS for at least some patients.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome--more than just chronic fatigue].

Forstenius, Lisa, Helmfrid, Sten·Lakartidningen·2009

This article explains that ME/CFS is much more than simply feeling tired all the time. The authors describe how the condition affects multiple body systems and causes real, measurable problems with energy, cognition, and physical function. The paper emphasizes that ME/CFS is a serious medical condition deserving proper recognition and treatment.

E3 PreliminaryReviewPEM unclearReview-Narrative

Immunological aspects of chronic fatigue syndrome.

Lorusso, Lorenzo, Mikhaylova, Svetlana V, Capelli, Enrica et al.·Autoimmunity reviews·2009

This review examines how the immune system may be involved in ME/CFS. Researchers have found that people with ME/CFS often have unusual patterns in immune cells and signaling molecules called cytokines, particularly higher levels of inflammatory markers. These immune system changes might explain some of the main symptoms, like fatigue and flu-like feelings, though the exact role these changes play in causing the disease remains unclear.

Immune System

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Inflammatory and oxidative and nitrosative stress pathways underpinning chronic fatigue, somatization and psychosomatic symptoms.

Postulated vasoactive neuropeptide immunopathology affecting the blood-brain/blood-spinal barrier in certain neuropsychiatric fatigue-related conditions: A role for phosphodiesterase inhibitors in treatment?

Sensitive, qualitative detection of human herpesvirus-6 and simultaneous differentiation of variants A and B.

[Activity of hypotnalamic-pituitary-adrenal axis by induction of experimental chronic fatigue syndrom].

Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects.

Using a DVD to help people with chronic fatigue syndrome learn the technique of pacing.

The role of antioxidant properties of Nardostachys jatamansi in alleviation of the symptoms of the chronic fatigue syndrome.

Are chronic fatigue syndrome and fibromyalgia the same? Implications for the provision of appropriate mental health intervention.

Chronic fatigue syndrome: aetiology, diagnosis and treatment.

An in vivo proton neurospectroscopy study of cerebral oxidative stress in myalgic encephalomyelitis (chronic fatigue syndrome).

[Immunologic disturbances can explain chronic fatigue syndrome. Biological findings point towards somatogenesis].

Continuing medical education challenges in chronic fatigue syndrome.

Autoantibodies to lens epithelium-derived growth factor/transcription co-activator P75 (LEDGF/P75) in children with chronic nonspecific complaints and with positive antinuclear antibodies.

Acupuncture treatment of chronic fatigue syndrome.

Fixed belief in cognitive dysfunction despite normal neuropsychological scores: neurocognitive hypochondriasis?

Chronic fatigue syndrome: a hormonal origin? A rare case of dysmenorrhea membranacea.

Fibromyalgia: pathogenetic, diagnostic and therapeutic concerns.

Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series.

[Chronic fatigue syndrome--more than just chronic fatigue].

Immunological aspects of chronic fatigue syndrome.

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