ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1741–1760 of 2,423 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Modification of the functional capacity of sarcoplasmic reticulum membranes in patients suffering from chronic fatigue syndrome.

Fulle, Stefania, Belia, Silvia, Vecchiet, Jacopo et al.·Neuromuscular disorders : NMD·2003

This study examined muscle cell structures called sarcoplasmic reticulum, which are responsible for controlling muscle contractions. Researchers found that in ME/CFS patients, these structures show signs of damage from oxidative stress, which may interfere with how muscles contract and relax. The damage appears to affect how calcium moves in and out of muscle cells, potentially explaining why patients experience fatigue.

E3 PreliminaryReviewPEM unclearReview-Narrative

The head-up tilt test in the diagnosis and management of chronic fatigue syndrome.

Naschitz, Jochanan E, Sabo, Edmond, Dreyfuss, Daniel et al.·The Israel Medical Association journal : IMAJ·2003

This review examines how a simple test called the head-up tilt test might help diagnose and manage ME/CFS. In this test, a patient lies flat and is then tilted upright while doctors measure heart rate and blood pressure changes. The review discusses whether these measurements could reveal problems with how the body controls blood pressure and heart function in ME/CFS patients.

Autonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

An occupational therapy approach to persons with chronic fatigue syndrome: part two, assessment and intervention.

Taylor, Renee R, Kielhofner, Gary W·Occupational therapy in health care·2003

This study explains how occupational therapists can better help people with ME/CFS by using a structured approach called the Model of Human Occupation. This framework helps therapists understand how the condition affects a person's motivation, daily habits, roles, and ability to do activities they care about. The paper provides practical guidance and a real-world example of how to assess and treat ME/CFS patients using this approach.

E3 PreliminaryReviewPEM unclearReview-Narrative

An overview of chronic fatigue syndrome.

Jackson, Elizabeth·Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2003

This article reviews what we know about ME/CFS, including the symptoms people commonly experience and how they can be treated. The author describes a new model of patient care that was tested in the community, which combines several different therapeutic approaches to help manage the condition.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic diffuse musculoskeletal pain, fibromyalgia and co-morbid unexplained clinical conditions.

Aaron, Leslie A, Buchwald, Dedra·Best practice & research. Clinical rheumatology·2003

Many people with fibromyalgia also experience other chronic conditions like ME/CFS, irritable bowel syndrome, and jaw pain. This review examines how often these conditions occur together and suggests that doctors should check for multiple conditions when treating fibromyalgia patients. Treatment works better when it addresses all of a patient's overlapping symptoms, not just one condition.

E3 PreliminaryCohortPEM not requiredObservational

Immunological anomalies and thrombocytopenia in 117 dogs and cats diagnosed with chronic fatigue syndrome (CFS).

Tarello, W·Acta veterinaria Hungarica·2003

This study looked at blood test results from 117 pets (dogs and cats) diagnosed with a fatigue syndrome similar to ME/CFS in humans. The researchers found that many of these animals had low blood cell counts and low platelets, along with high muscle enzyme levels and unusual bacteria-like organisms in their blood. When treated with a specific arsenic-based medication, all the animals recovered completely and their immune systems improved.

Immune System

E3 PreliminaryGuidelinePEM not requiredEditorial

An approach to chronic fatigue syndrome in adults.

Sabin, Thomas D·The neurologist·2003

This paper helps doctors, especially neurologists, understand how to properly evaluate patients who are experiencing severe fatigue. The author emphasizes that while ME/CFS is a real condition, it's important to rule out other medical problems that can cause similar symptoms before confirming an ME/CFS diagnosis. Since there is no blood test or scan that can definitively diagnose ME/CFS, careful evaluation and questioning of patients is essential.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Single-photon emission computerized tomography and neurocognitive function in patients with chronic fatigue syndrome.

Schmaling, Karen B, Lewis, David H, Fiedelak, Jessica I et al.·Psychosomatic medicine·2003

Researchers used brain imaging scans to compare how the brains of people with ME/CFS and healthy people work during a challenging listening and memory task. People with ME/CFS performed just as well on the task as healthy people, but reported feeling like they had to work much harder mentally. The brain scans showed that people with ME/CFS had a different pattern of brain activity—more spread out rather than focused in specific areas—suggesting their brains may be working less efficiently.

Cognitive Impairment

E3 PreliminaryMechanismPEM unclearMechanistic

Hypothalamic digoxin, cerebral chemical dominance and myalgic encephalomyelitis.

Kurup, Ravi Kumar, Kurup, Parameswara Achutha·The International journal of neuroscience·2003

This study examined chemical pathways in the brains of 15 ME/CFS patients, focusing on how the body produces energy and manages stress. Researchers found that people with ME/CFS had lower levels of important protective molecules and higher levels of harmful byproducts, along with imbalances in brain chemicals that affect mood, energy, and pain. The study suggests these biochemical problems may be linked to how the brain is organized in people with ME/CFS.

Energy Metabolism

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: the nurse's role.

Aylett, Elizabeth, Fawcett, Tonks N·Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2003

This article discusses what ME/CFS is and how nurses can help patients manage this exhausting illness. The authors argue that nurses are well-suited to be the main healthcare provider coordinating care for ME/CFS patients, because they can build strong relationships with patients and help them feel heard and supported.

E3 PreliminaryReviewPEM unclearReview-Narrative

Atypical depression spectrum disorder - neurobiology and treatment.

Murck, Harald·Acta neuropsychiatrica·2003

This article explores a type of depression with unusual symptoms—like eating more and sleeping more instead of less—that is often overlooked in standard depression assessments. The author suggests this pattern of depression shares biological similarities with chronic fatigue syndrome, fibromyalgia, and other related conditions, and that all of these may involve a common problem with how the body regulates stress hormones. Different medications may work better for this type of depression than those typically used for other forms.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome or myalgic encephalomyelitis in children and adolescents.

Chatterjee, Tapabrata·Journal of the Indian Medical Association·2003

This article reviews how ME/CFS affects children and teens, a group that is often overlooked in medical research. The authors explain the current diagnostic criteria used to identify the condition and discuss available treatments, though they note that how well these treatments work and what happens to patients over time remains unclear.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution.

Reeves, William C, Lloyd, Andrew, Vernon, Suzanne D et al.·BMC health services research·2003

This study brought together experienced ME/CFS researchers from around the world to identify problems and confusing parts of the official definition used to diagnose ME/CFS in research studies. The team worked together in workshops over three years to find ways to make the diagnosis more consistent and accurate across different research sites, so that patients are identified the same way no matter where they're studied.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome.

Chaudhuri, A, Condon, B R, Gow, J W et al.·Neuroreport·2003

This study used a specialized brain imaging technique called MR spectroscopy to look at a part of the brain called the basal ganglia in people with ME/CFS. The researchers found that people with ME/CFS had significantly higher levels of choline (a compound involved in cell membranes) in this brain region compared to healthy people. This suggests that the fatigue in ME/CFS may involve changes in how brain cells are functioning and communicating.

E3 PreliminaryCommentaryPEM not requiredEditorial

Type I interferons induce proteins susceptible to act as thyroid receptor (TR) corepressors and to signal the TR for destruction by the proteasome: possible etiology for unexplained chronic fatigue.

Englebienne, P, Verhas, M, Herst, C V et al.·Medical hypotheses·2003

This study proposes a potential explanation for why some ME/CFS patients experience severe fatigue despite having normal thyroid blood tests. The researchers suggest that certain immune proteins called interferons may trigger the production of other proteins that interfere with thyroid hormone function at the cellular level, making the body behave as if it has low thyroid activity even though standard thyroid tests appear normal.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Cerebral and systemic hemodynamics changes during upright tilt in chronic fatigue syndrome.

Razumovsky, Alexander Y, DeBusk, Karen, Calkins, Hugh et al.·Journal of neuroimaging : official journal of the American Society of Neuroimaging·2003

When people with ME/CFS stand up quickly, they often experience dizziness and fainting. This study used ultrasound to measure blood flow in the brain during a tilt test and compared it between ME/CFS patients and healthy people. The researchers found that blood flow patterns in the brain were actually similar between the two groups, even though ME/CFS patients felt symptoms faster.

Autonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Glucocorticoids and glucocorticoid receptors: mediators of fatigue?

Cleare, A J·Acta neuropsychiatrica·2003

This study looks at whether a hormone system called the HPA axis—which controls stress responses and cortisol production—might explain why people with ME/CFS experience severe fatigue. Researchers found that some patients have lower cortisol levels and changes in how their bodies respond to stress, and that giving cortisol replacement therapy in some cases improved fatigue. However, the changes weren't the same in all patients, suggesting multiple different factors may be contributing to fatigue rather than one single problem.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Assessment of cortisol response with low-dose and high-dose ACTH in patients with chronic fatigue syndrome and healthy comparison subjects.

Gaab, Jens, Hüster, D, Peisen, R et al.·Psychosomatics·2003

This study tested whether ME/CFS patients have problems with cortisol, a stress hormone made by the adrenal glands. Researchers gave 18 ME/CFS patients and 18 healthy people a hormone called ACTH (in both low and high doses) to stimulate cortisol production. The results showed no difference between the two groups, suggesting that ME/CFS is unlikely caused by faulty adrenal glands.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredMechanistic

Identification of novel expressed sequences, up-regulated in the leucocytes of chronic fatigue syndrome patients.

Powell, R, Ren, J, Lewith, G et al.·Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2003

This study looked for differences in how genes are turned on or off in immune cells from ME/CFS patients compared to healthy people. Researchers found 12 genes that were more active in ME/CFS patients' immune cells, including two genes known to be involved when immune cells become activated. This supports the idea that ME/CFS may involve immune system changes.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Chronic phase lipids in sera of chronic fatigue syndrome (CFS), chronic ciguatera fish poisoning (CCFP), hepatitis B, and cancer with antigenic epitope resembling ciguatoxin, as assessed with MAb-CTX.

Hokama, Y, Uto, G A, Palafox, N A et al.·Journal of clinical laboratory analysis·2003

Researchers found that people with ME/CFS have unusual lipids (fatty substances) in their blood that react similarly to toxins found in certain poisoned fish. The study tested blood samples from ME/CFS patients and compared them to healthy people and patients with other diseases. About 96% of ME/CFS patients showed high levels of these lipids, suggesting they may be a distinctive feature of the condition.

Biomarkers

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Modification of the functional capacity of sarcoplasmic reticulum membranes in patients suffering from chronic fatigue syndrome.

The head-up tilt test in the diagnosis and management of chronic fatigue syndrome.

An occupational therapy approach to persons with chronic fatigue syndrome: part two, assessment and intervention.

An overview of chronic fatigue syndrome.

Chronic diffuse musculoskeletal pain, fibromyalgia and co-morbid unexplained clinical conditions.

Immunological anomalies and thrombocytopenia in 117 dogs and cats diagnosed with chronic fatigue syndrome (CFS).

An approach to chronic fatigue syndrome in adults.

Single-photon emission computerized tomography and neurocognitive function in patients with chronic fatigue syndrome.

Hypothalamic digoxin, cerebral chemical dominance and myalgic encephalomyelitis.

Chronic fatigue syndrome: the nurse's role.

Atypical depression spectrum disorder - neurobiology and treatment.

Chronic fatigue syndrome or myalgic encephalomyelitis in children and adolescents.

Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution.

Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome.

Type I interferons induce proteins susceptible to act as thyroid receptor (TR) corepressors and to signal the TR for destruction by the proteasome: possible etiology for unexplained chronic fatigue.

Cerebral and systemic hemodynamics changes during upright tilt in chronic fatigue syndrome.

Glucocorticoids and glucocorticoid receptors: mediators of fatigue?

Assessment of cortisol response with low-dose and high-dose ACTH in patients with chronic fatigue syndrome and healthy comparison subjects.

Identification of novel expressed sequences, up-regulated in the leucocytes of chronic fatigue syndrome patients.

Chronic phase lipids in sera of chronic fatigue syndrome (CFS), chronic ciguatera fish poisoning (CCFP), hepatitis B, and cancer with antigenic epitope resembling ciguatoxin, as assessed with MAb-CTX.

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Biomarkers

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