ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1761–1780 of 2,423 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Atypical depression spectrum disorder - neurobiology and treatment.

Murck, Harald·Acta neuropsychiatrica·2003

This article explores a type of depression with unusual symptoms—like eating more and sleeping more instead of less—that is often overlooked in standard depression assessments. The author suggests this pattern of depression shares biological similarities with chronic fatigue syndrome, fibromyalgia, and other related conditions, and that all of these may involve a common problem with how the body regulates stress hormones. Different medications may work better for this type of depression than those typically used for other forms.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

Glucocorticoids and glucocorticoid receptors: mediators of fatigue?

Cleare, A J·Acta neuropsychiatrica·2003

This study looks at whether a hormone system called the HPA axis—which controls stress responses and cortisol production—might explain why people with ME/CFS experience severe fatigue. Researchers found that some patients have lower cortisol levels and changes in how their bodies respond to stress, and that giving cortisol replacement therapy in some cases improved fatigue. However, the changes weren't the same in all patients, suggesting multiple different factors may be contributing to fatigue rather than one single problem.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

Cytokines in parvovirus B19 infection as an aid to understanding chronic fatigue syndrome.

Kerr, Jonathan R, Tyrrell, David A J·Current pain and headache reports·2003

This study examined how parvovirus B19 (a common virus) can trigger ME/CFS in some people. The researchers found that patients who developed ME/CFS after B19 infection had abnormal levels of immune signaling chemicals in their blood (specifically TNF-alpha, interferon-gamma, and MCP-1). Importantly, some patients improved when treated with intravenous immunoglobulin therapy, suggesting B19-triggered ME/CFS may be treatable.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The head-up tilt test in the diagnosis and management of chronic fatigue syndrome.

Naschitz, Jochanan E, Sabo, Edmond, Dreyfuss, Daniel et al.·The Israel Medical Association journal : IMAJ·2003

This review examines how a simple test called the head-up tilt test might help diagnose and manage ME/CFS. In this test, a patient lies flat and is then tilted upright while doctors measure heart rate and blood pressure changes. The review discusses whether these measurements could reveal problems with how the body controls blood pressure and heart function in ME/CFS patients.

Autonomic Nervous System

E3 PreliminaryCohortPEM not requiredCase-Control

Case reports and review of Postural Orthostatic Tachycardia syndrome (POTS).

Carothers, Becky, Schmidt, Lori, Puri, Vinay·The Journal of the Kentucky Medical Association·2003

POTS is a condition where your heart rate increases too much when you stand up, and less blood flows to your brain, causing dizziness and fainting. This paper describes two patients with POTS who needed different levels of treatment—one managed at home and one needing hospital care. The authors point out that POTS is probably more common than doctors realize and is sometimes mistaken for chronic fatigue syndrome or other conditions.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredMechanistic

Modification of the functional capacity of sarcoplasmic reticulum membranes in patients suffering from chronic fatigue syndrome.

Fulle, Stefania, Belia, Silvia, Vecchiet, Jacopo et al.·Neuromuscular disorders : NMD·2003

This study examined muscle cell structures called sarcoplasmic reticulum, which are responsible for controlling muscle contractions. Researchers found that in ME/CFS patients, these structures show signs of damage from oxidative stress, which may interfere with how muscles contract and relax. The damage appears to affect how calcium moves in and out of muscle cells, potentially explaining why patients experience fatigue.

E3 PreliminaryGuidelinePEM not requiredEditorial

An approach to chronic fatigue syndrome in adults.

Sabin, Thomas D·The neurologist·2003

This paper helps doctors, especially neurologists, understand how to properly evaluate patients who are experiencing severe fatigue. The author emphasizes that while ME/CFS is a real condition, it's important to rule out other medical problems that can cause similar symptoms before confirming an ME/CFS diagnosis. Since there is no blood test or scan that can definitively diagnose ME/CFS, careful evaluation and questioning of patients is essential.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Q fever as a biological weapon.

Kagawa, Frank T, Wehner, John H, Mohindra, Vibha·Seminars in respiratory infections·2003

Q fever is a rare bacterial infection that can be caught from animals and is highly contagious. Most people who catch it have no symptoms or mild flu-like illness, but some develop serious complications like pneumonia or inflammation of the heart. Importantly, a small number of people develop chronic Q fever, which can cause long-term fatigue similar to ME/CFS.

E3 PreliminaryCohortPEM not requiredObservational

Immunological anomalies and thrombocytopenia in 117 dogs and cats diagnosed with chronic fatigue syndrome (CFS).

Tarello, W·Acta veterinaria Hungarica·2003

This study looked at blood test results from 117 pets (dogs and cats) diagnosed with a fatigue syndrome similar to ME/CFS in humans. The researchers found that many of these animals had low blood cell counts and low platelets, along with high muscle enzyme levels and unusual bacteria-like organisms in their blood. When treated with a specific arsenic-based medication, all the animals recovered completely and their immune systems improved.

Immune System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Phantom lymphadenopathy. An association with chronic fatigue syndrome.

Shee, C D·Postgraduate medical journal·2003

This study looked at 10 patients who thought they had swollen lymph nodes in their neck and other areas. However, when doctors carefully examined them, the swelling wasn't actually there. All of these patients had ME/CFS and experienced severe fatigue, body aches, and various other symptoms. The researchers suggest that some people with ME/CFS may feel like their lymph nodes are enlarged even when they aren't, a phenomenon they call 'phantom lymphadenopathy.'

E3 PreliminaryMechanismPEM not requiredLongitudinal

Deficit in motor performance correlates with changed corticospinal excitability in patients with chronic fatigue syndrome.

Davey, N J, Puri, B K, Catley, M et al.·International journal of clinical practice·2003

This study looked at whether the slowness people with ME/CFS experience in reacting and moving is connected to changes in how their brain controls muscles. Researchers tested 10 ME/CFS patients twice over up to two years, measuring reaction times, movement speed, and brain signals using magnetic stimulation. They found that when patients' symptoms changed, their brain's ability to control movements changed in a similar way, suggesting the slowness has a real physical basis in the brain rather than being purely psychological.

E3 PreliminaryCommentaryPEM not requiredEditorial

Type I interferons induce proteins susceptible to act as thyroid receptor (TR) corepressors and to signal the TR for destruction by the proteasome: possible etiology for unexplained chronic fatigue.

Englebienne, P, Verhas, M, Herst, C V et al.·Medical hypotheses·2003

This study proposes a potential explanation for why some ME/CFS patients experience severe fatigue despite having normal thyroid blood tests. The researchers suggest that certain immune proteins called interferons may trigger the production of other proteins that interfere with thyroid hormone function at the cellular level, making the body behave as if it has low thyroid activity even though standard thyroid tests appear normal.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Chronic phase lipids in sera of chronic fatigue syndrome (CFS), chronic ciguatera fish poisoning (CCFP), hepatitis B, and cancer with antigenic epitope resembling ciguatoxin, as assessed with MAb-CTX.

Hokama, Y, Uto, G A, Palafox, N A et al.·Journal of clinical laboratory analysis·2003

Researchers found that people with ME/CFS have unusual lipids (fatty substances) in their blood that react similarly to toxins found in certain poisoned fish. The study tested blood samples from ME/CFS patients and compared them to healthy people and patients with other diseases. About 96% of ME/CFS patients showed high levels of these lipids, suggesting they may be a distinctive feature of the condition.

Biomarkers

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Psychometric properties of the Dutch Chronic Fatigue Syndrome--Activities and Participation Questionnaire (CFS-APQ).

Nijs, Jo, Vaes, Peter, McGregor, Neil et al.·Physical therapy·2003

Researchers tested a questionnaire designed to measure how ME/CFS affects daily activities and participation in normal life. The Dutch version of this questionnaire was given to people with ME/CFS, and the researchers found it reliably measured activity limitations and correlated well with patients' reports of pain and fatigue. This suggests the questionnaire is a useful tool for tracking how the disease impacts everyday functioning.

E3 PreliminaryReviewPEM not requiredReview-Narrative

An occupational therapy approach to persons with chronic fatigue syndrome: part two, assessment and intervention.

Taylor, Renee R, Kielhofner, Gary W·Occupational therapy in health care·2003

This study explains how occupational therapists can better help people with ME/CFS by using a structured approach called the Model of Human Occupation. This framework helps therapists understand how the condition affects a person's motivation, daily habits, roles, and ability to do activities they care about. The paper provides practical guidance and a real-world example of how to assess and treat ME/CFS patients using this approach.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Lessons from macrophagic myofasciitis: towards definition of a vaccine adjuvant-related syndrome].

Gherardi, R K·Revue neurologique·2003

This review examines macrophagic myofasciitis, a condition where aluminum from vaccine adjuvants persists in muscle tissue and may trigger long-lasting immune activation. About half of patients develop fatigue and muscle pain that meet ME/CFS criteria, and some develop autoimmune diseases. The authors suggest that persistent immune stimulation from the aluminum depot could explain both this vaccine-related condition and possibly other forms of ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic diffuse musculoskeletal pain, fibromyalgia and co-morbid unexplained clinical conditions.

Aaron, Leslie A, Buchwald, Dedra·Best practice & research. Clinical rheumatology·2003

Many people with fibromyalgia also experience other chronic conditions like ME/CFS, irritable bowel syndrome, and jaw pain. This review examines how often these conditions occur together and suggests that doctors should check for multiple conditions when treating fibromyalgia patients. Treatment works better when it addresses all of a patient's overlapping symptoms, not just one condition.

E3 PreliminaryBehavioralPEM not requiredCase-Control

Acute parvovirus B19 infection mimicking chronic fatigue syndrome.

Matano, Sadaya, Kinoshita, Hiroya, Tanigawa, Kiyoaki et al.·Internal medicine (Tokyo, Japan)·2003

This case study describes a woman in Japan who developed severe fatigue, pain, sleep problems, and other symptoms lasting two months that resembled ME/CFS. Blood tests showed she had a parvovirus B19 infection (a common virus), and she was also diagnosed with depression. Her symptoms improved after taking antidepressant medication and herbal treatments, even though the virus remained detectable in her blood for months. This case suggests that parvovirus B19 infection can sometimes produce symptoms similar to ME/CFS, especially in people who have experienced significant stress.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: the nurse's role.

Aylett, Elizabeth, Fawcett, Tonks N·Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2003

This article discusses what ME/CFS is and how nurses can help patients manage this exhausting illness. The authors argue that nurses are well-suited to be the main healthcare provider coordinating care for ME/CFS patients, because they can build strong relationships with patients and help them feel heard and supported.

E3 PreliminaryReviewPEM not requiredReview-Narrative

An approach to persons with chronic fatigue syndrome based on the model of human occupation: part one, impact on occupational performance and participation.

Taylor, Renee R, Kielhofner, Gary W, Abelenda, Judith et al.·Occupational therapy in health care·2003

This study looked at how ME/CFS affects people's ability to work, study, and participate in daily life. The researchers used a framework called the Model of Human Occupation to understand how motivation, habits, physical abilities, and surroundings all work together to influence how people with ME/CFS manage their daily activities. The paper draws on real examples from patients' experiences and clinical practice to show the many ways this illness disrupts normal life.

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Evidence browser

Atypical depression spectrum disorder - neurobiology and treatment.

Glucocorticoids and glucocorticoid receptors: mediators of fatigue?

Cytokines in parvovirus B19 infection as an aid to understanding chronic fatigue syndrome.

The head-up tilt test in the diagnosis and management of chronic fatigue syndrome.

Case reports and review of Postural Orthostatic Tachycardia syndrome (POTS).

Modification of the functional capacity of sarcoplasmic reticulum membranes in patients suffering from chronic fatigue syndrome.

An approach to chronic fatigue syndrome in adults.

Q fever as a biological weapon.

Immunological anomalies and thrombocytopenia in 117 dogs and cats diagnosed with chronic fatigue syndrome (CFS).

Phantom lymphadenopathy. An association with chronic fatigue syndrome.

Deficit in motor performance correlates with changed corticospinal excitability in patients with chronic fatigue syndrome.

Type I interferons induce proteins susceptible to act as thyroid receptor (TR) corepressors and to signal the TR for destruction by the proteasome: possible etiology for unexplained chronic fatigue.

Chronic phase lipids in sera of chronic fatigue syndrome (CFS), chronic ciguatera fish poisoning (CCFP), hepatitis B, and cancer with antigenic epitope resembling ciguatoxin, as assessed with MAb-CTX.

Psychometric properties of the Dutch Chronic Fatigue Syndrome--Activities and Participation Questionnaire (CFS-APQ).

An occupational therapy approach to persons with chronic fatigue syndrome: part two, assessment and intervention.

[Lessons from macrophagic myofasciitis: towards definition of a vaccine adjuvant-related syndrome].

Chronic diffuse musculoskeletal pain, fibromyalgia and co-morbid unexplained clinical conditions.

Acute parvovirus B19 infection mimicking chronic fatigue syndrome.

Chronic fatigue syndrome: the nurse's role.

An approach to persons with chronic fatigue syndrome based on the model of human occupation: part one, impact on occupational performance and participation.

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