ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1761–1780 of 2,422 studies

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution.

Reeves, William C, Lloyd, Andrew, Vernon, Suzanne D et al.·BMC health services research·2003

This study brought together experienced ME/CFS researchers from around the world to identify problems and confusing parts of the official definition used to diagnose ME/CFS in research studies. The team worked together in workshops over three years to find ways to make the diagnosis more consistent and accurate across different research sites, so that patients are identified the same way no matter where they're studied.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Isoprenoid pathway dysfunction in chronic fatigue syndrome.

Kurup, Ravi Kumar, Kurup, Parameswara Achutha·Acta neuropsychiatrica·2003

This study looked at a set of chemical processes in the body called the isoprenoid pathway in 15 people with ME/CFS. Researchers found that several key molecules and minerals were out of balance in ME/CFS patients compared to expected levels, including low magnesium, low energy-producing compounds in cells, and imbalanced brain chemicals. These patterns were associated with increased oxidative stress (cellular damage from unstable molecules) and problems with how the immune system presents viral antigens.

Energy Metabolism

E3 PreliminaryBehavioralPEM not requiredCase-Control

Phantom lymphadenopathy. An association with chronic fatigue syndrome.

Shee, C D·Postgraduate medical journal·2003

This study looked at 10 patients who thought they had swollen lymph nodes in their neck and other areas. However, when doctors carefully examined them, the swelling wasn't actually there. All of these patients had ME/CFS and experienced severe fatigue, body aches, and various other symptoms. The researchers suggest that some people with ME/CFS may feel like their lymph nodes are enlarged even when they aren't, a phenomenon they call 'phantom lymphadenopathy.'

E3 PreliminaryCommentaryPEM not requiredEditorial

Type I interferons induce proteins susceptible to act as thyroid receptor (TR) corepressors and to signal the TR for destruction by the proteasome: possible etiology for unexplained chronic fatigue.

Englebienne, P, Verhas, M, Herst, C V et al.·Medical hypotheses·2003

This study proposes a potential explanation for why some ME/CFS patients experience severe fatigue despite having normal thyroid blood tests. The researchers suggest that certain immune proteins called interferons may trigger the production of other proteins that interfere with thyroid hormone function at the cellular level, making the body behave as if it has low thyroid activity even though standard thyroid tests appear normal.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Atypical depression spectrum disorder - neurobiology and treatment.

Murck, Harald·Acta neuropsychiatrica·2003

This article explores a type of depression with unusual symptoms—like eating more and sleeping more instead of less—that is often overlooked in standard depression assessments. The author suggests this pattern of depression shares biological similarities with chronic fatigue syndrome, fibromyalgia, and other related conditions, and that all of these may involve a common problem with how the body regulates stress hormones. Different medications may work better for this type of depression than those typically used for other forms.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic diffuse musculoskeletal pain, fibromyalgia and co-morbid unexplained clinical conditions.

Aaron, Leslie A, Buchwald, Dedra·Best practice & research. Clinical rheumatology·2003

Many people with fibromyalgia also experience other chronic conditions like ME/CFS, irritable bowel syndrome, and jaw pain. This review examines how often these conditions occur together and suggests that doctors should check for multiple conditions when treating fibromyalgia patients. Treatment works better when it addresses all of a patient's overlapping symptoms, not just one condition.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Glucocorticoids and glucocorticoid receptors: mediators of fatigue?

Cleare, A J·Acta neuropsychiatrica·2003

This study looks at whether a hormone system called the HPA axis—which controls stress responses and cortisol production—might explain why people with ME/CFS experience severe fatigue. Researchers found that some patients have lower cortisol levels and changes in how their bodies respond to stress, and that giving cortisol replacement therapy in some cases improved fatigue. However, the changes weren't the same in all patients, suggesting multiple different factors may be contributing to fatigue rather than one single problem.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients.

Smirnova, Iva V, Pall, Martin L·Molecular and cellular biochemistry·2003

This study measured a specific type of damage to proteins in the blood of ME/CFS patients compared to healthy people. Researchers found that ME/CFS patients had significantly higher levels of this protein damage, suggesting their cells may be experiencing more oxidative stress—a type of cellular damage similar to rust forming on metal. This finding supports the idea that oxidative stress may be involved in ME/CFS.

E3 PreliminaryCohortPEM not requiredCase-Control

Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome.

Kerr, J R, Cunniffe, V S, Kelleher, P et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2003

This study looked at three patients whose chronic fatigue syndrome (ME/CFS) appeared to start after they were infected with parvovirus B19, a common virus. These patients were treated with intravenous immunoglobulin (IVIG), a therapy that contains antibodies from donated blood. All three patients improved significantly, with their symptoms resolving and their ability to function returning to normal.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome.

Chaudhuri, A, Condon, B R, Gow, J W et al.·Neuroreport·2003

This study used a specialized brain imaging technique called MR spectroscopy to look at a part of the brain called the basal ganglia in people with ME/CFS. The researchers found that people with ME/CFS had significantly higher levels of choline (a compound involved in cell membranes) in this brain region compared to healthy people. This suggests that the fatigue in ME/CFS may involve changes in how brain cells are functioning and communicating.

E3 PreliminaryReviewPEM unclearReview-Narrative

An overview of chronic fatigue syndrome.

Jackson, Elizabeth·Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2003

This article reviews what we know about ME/CFS, including the symptoms people commonly experience and how they can be treated. The author describes a new model of patient care that was tested in the community, which combines several different therapeutic approaches to help manage the condition.

Interventions

E3 PreliminaryMechanismPEM not requiredMechanistic

Integration of gene expression, clinical, and epidemiologic data to characterize Chronic Fatigue Syndrome.

Whistler, Toni, Unger, Elizabeth R, Nisenbaum, Rosane et al.·Journal of translational medicine·2003

This study looked at blood samples from people with ME/CFS to see if the disease might actually be several different conditions rather than one. Researchers found that when they grouped patients by how their illness started, certain genes were turned on or off differently. These genes are involved in how the body produces energy, particularly through breaking down sugars and other molecules. This suggests that ME/CFS patients may have different underlying problems with their body's energy production systems.

Energy Metabolism

E3 PreliminaryReviewPEM not requiredReview-Narrative

The radicalized self: the impact on the self of the contested nature of the diagnosis of chronic fatigue syndrome.

Clarke, Juanne N, James, Susan·Social science & medicine (1982)·2003

This study explores how people with ME/CFS cope with the challenge that their illness is not universally accepted by doctors and society. Patients experience both the physical burden of the disease and the emotional strain of having their condition disputed or questioned. The research found that people with ME/CFS often develop new ways of understanding themselves and their identity as a way to cope with this lack of recognition.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Cerebral and systemic hemodynamics changes during upright tilt in chronic fatigue syndrome.

Razumovsky, Alexander Y, DeBusk, Karen, Calkins, Hugh et al.·Journal of neuroimaging : official journal of the American Society of Neuroimaging·2003

When people with ME/CFS stand up quickly, they often experience dizziness and fainting. This study used ultrasound to measure blood flow in the brain during a tilt test and compared it between ME/CFS patients and healthy people. The researchers found that blood flow patterns in the brain were actually similar between the two groups, even though ME/CFS patients felt symptoms faster.

Autonomic Nervous System

E3 PreliminaryMechanismPEM unclearMechanistic

Hypothalamic digoxin, cerebral chemical dominance and myalgic encephalomyelitis.

Kurup, Ravi Kumar, Kurup, Parameswara Achutha·The International journal of neuroscience·2003

This study examined chemical pathways in the brains of 15 ME/CFS patients, focusing on how the body produces energy and manages stress. Researchers found that people with ME/CFS had lower levels of important protective molecules and higher levels of harmful byproducts, along with imbalances in brain chemicals that affect mood, energy, and pain. The study suggests these biochemical problems may be linked to how the brain is organized in people with ME/CFS.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome or myalgic encephalomyelitis in children and adolescents.

Chatterjee, Tapabrata·Journal of the Indian Medical Association·2003

This article reviews how ME/CFS affects children and teens, a group that is often overlooked in medical research. The authors explain the current diagnostic criteria used to identify the condition and discuss available treatments, though they note that how well these treatments work and what happens to patients over time remains unclear.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Mycoplasma blood infection in chronic fatigue and fibromyalgia syndromes.

Endresen, Gerhard K M·Rheumatology international·2003

This review looked at whether a type of bacteria called mycoplasma might be found in the blood of people with ME/CFS and fibromyalgia. Researchers found mycoplasma in about half of patients with these conditions, compared to only 10% of healthy people. Some patients who received long-term antibiotic treatment appeared to recover completely, suggesting mycoplasma infection might be treatable in certain cases.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Fibromyalgia syndrome].

Siegmeth, Walter·Wiener medizinische Wochenschrift (1946)·2003

Fibromyalgia syndrome (FMS) is a real medical condition that causes widespread pain and should be diagnosed using clear, established criteria. Research suggests it may involve problems with the nervous system, hormonal systems, and pain control pathways in the brain. Treatment works best when it combines information and education, physical therapy, and sometimes medication, rather than relying on drugs alone.

Sleep

E3 PreliminaryBehavioralPEM unclearCross-Sectional

Ideal versus reality: physicians perspectives on patients with chronic fatigue syndrome (CFS) and fibromyalgia.

Asbring, Pia, Närvänen, Anna-Liisa·Social science & medicine (1982)·2003

This study asked 26 Swedish doctors about their experiences caring for patients with ME/CFS and fibromyalgia. The researchers found that many doctors feel uncertain and uncomfortable treating these conditions, partly because they're not fully understood. Some doctors were skeptical about whether these illnesses were real, and patients often weren't treated with the same respect as those with clearly defined diseases.

E3 PreliminaryMechanismPEM not requiredMechanistic

Identification of novel expressed sequences, up-regulated in the leucocytes of chronic fatigue syndrome patients.

Powell, R, Ren, J, Lewith, G et al.·Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2003

This study looked for differences in how genes are turned on or off in immune cells from ME/CFS patients compared to healthy people. Researchers found 12 genes that were more active in ME/CFS patients' immune cells, including two genes known to be involved when immune cells become activated. This supports the idea that ME/CFS may involve immune system changes.

Immune System

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Evidence browser

Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution.

Isoprenoid pathway dysfunction in chronic fatigue syndrome.

Phantom lymphadenopathy. An association with chronic fatigue syndrome.

Type I interferons induce proteins susceptible to act as thyroid receptor (TR) corepressors and to signal the TR for destruction by the proteasome: possible etiology for unexplained chronic fatigue.

Atypical depression spectrum disorder - neurobiology and treatment.

Chronic diffuse musculoskeletal pain, fibromyalgia and co-morbid unexplained clinical conditions.

Glucocorticoids and glucocorticoid receptors: mediators of fatigue?

Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients.

Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome.

Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome.

An overview of chronic fatigue syndrome.

Integration of gene expression, clinical, and epidemiologic data to characterize Chronic Fatigue Syndrome.

The radicalized self: the impact on the self of the contested nature of the diagnosis of chronic fatigue syndrome.

Cerebral and systemic hemodynamics changes during upright tilt in chronic fatigue syndrome.

Hypothalamic digoxin, cerebral chemical dominance and myalgic encephalomyelitis.

Chronic fatigue syndrome or myalgic encephalomyelitis in children and adolescents.

Mycoplasma blood infection in chronic fatigue and fibromyalgia syndromes.

[Fibromyalgia syndrome].

Ideal versus reality: physicians perspectives on patients with chronic fatigue syndrome (CFS) and fibromyalgia.

Identification of novel expressed sequences, up-regulated in the leucocytes of chronic fatigue syndrome patients.

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