ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1761–1780 of 2,420 studies

E3 PreliminaryCohortPEM not requiredCase-Control

Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome.

Kerr, J R, Cunniffe, V S, Kelleher, P et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2003

This study looked at three patients whose chronic fatigue syndrome (ME/CFS) appeared to start after they were infected with parvovirus B19, a common virus. These patients were treated with intravenous immunoglobulin (IVIG), a therapy that contains antibodies from donated blood. All three patients improved significantly, with their symptoms resolving and their ability to function returning to normal.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Glucocorticoids and glucocorticoid receptors: mediators of fatigue?

Cleare, A J·Acta neuropsychiatrica·2003

This study looks at whether a hormone system called the HPA axis—which controls stress responses and cortisol production—might explain why people with ME/CFS experience severe fatigue. Researchers found that some patients have lower cortisol levels and changes in how their bodies respond to stress, and that giving cortisol replacement therapy in some cases improved fatigue. However, the changes weren't the same in all patients, suggesting multiple different factors may be contributing to fatigue rather than one single problem.

Endocrine Disruption

E3 PreliminaryBehavioralPEM not requiredCase-Control

Acute parvovirus B19 infection mimicking chronic fatigue syndrome.

Matano, Sadaya, Kinoshita, Hiroya, Tanigawa, Kiyoaki et al.·Internal medicine (Tokyo, Japan)·2003

This case study describes a woman in Japan who developed severe fatigue, pain, sleep problems, and other symptoms lasting two months that resembled ME/CFS. Blood tests showed she had a parvovirus B19 infection (a common virus), and she was also diagnosed with depression. Her symptoms improved after taking antidepressant medication and herbal treatments, even though the virus remained detectable in her blood for months. This case suggests that parvovirus B19 infection can sometimes produce symptoms similar to ME/CFS, especially in people who have experienced significant stress.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Chronic phase lipids in sera of chronic fatigue syndrome (CFS), chronic ciguatera fish poisoning (CCFP), hepatitis B, and cancer with antigenic epitope resembling ciguatoxin, as assessed with MAb-CTX.

Hokama, Y, Uto, G A, Palafox, N A et al.·Journal of clinical laboratory analysis·2003

Researchers found that people with ME/CFS have unusual lipids (fatty substances) in their blood that react similarly to toxins found in certain poisoned fish. The study tested blood samples from ME/CFS patients and compared them to healthy people and patients with other diseases. About 96% of ME/CFS patients showed high levels of these lipids, suggesting they may be a distinctive feature of the condition.

Biomarkers

E3 PreliminaryMechanismPEM not requiredLongitudinal

Deficit in motor performance correlates with changed corticospinal excitability in patients with chronic fatigue syndrome.

Davey, N J, Puri, B K, Catley, M et al.·International journal of clinical practice·2003

This study looked at whether the slowness people with ME/CFS experience in reacting and moving is connected to changes in how their brain controls muscles. Researchers tested 10 ME/CFS patients twice over up to two years, measuring reaction times, movement speed, and brain signals using magnetic stimulation. They found that when patients' symptoms changed, their brain's ability to control movements changed in a similar way, suggesting the slowness has a real physical basis in the brain rather than being purely psychological.

E3 PreliminaryReviewPEM unclearReview-Narrative

An overview of chronic fatigue syndrome.

Jackson, Elizabeth·Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2003

This article reviews what we know about ME/CFS, including the symptoms people commonly experience and how they can be treated. The author describes a new model of patient care that was tested in the community, which combines several different therapeutic approaches to help manage the condition.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome or myalgic encephalomyelitis in children and adolescents.

Chatterjee, Tapabrata·Journal of the Indian Medical Association·2003

This article reviews how ME/CFS affects children and teens, a group that is often overlooked in medical research. The authors explain the current diagnostic criteria used to identify the condition and discuss available treatments, though they note that how well these treatments work and what happens to patients over time remains unclear.

Diagnostics

E3 PreliminaryCohortPEM not requiredCase-Control

Case reports and review of Postural Orthostatic Tachycardia syndrome (POTS).

Carothers, Becky, Schmidt, Lori, Puri, Vinay·The Journal of the Kentucky Medical Association·2003

POTS is a condition where your heart rate increases too much when you stand up, and less blood flows to your brain, causing dizziness and fainting. This paper describes two patients with POTS who needed different levels of treatment—one managed at home and one needing hospital care. The authors point out that POTS is probably more common than doctors realize and is sometimes mistaken for chronic fatigue syndrome or other conditions.

Autonomic Nervous System

E3 PreliminaryMechanismPEM unclearMechanistic

Hypothalamic digoxin, cerebral chemical dominance and myalgic encephalomyelitis.

Kurup, Ravi Kumar, Kurup, Parameswara Achutha·The International journal of neuroscience·2003

This study examined chemical pathways in the brains of 15 ME/CFS patients, focusing on how the body produces energy and manages stress. Researchers found that people with ME/CFS had lower levels of important protective molecules and higher levels of harmful byproducts, along with imbalances in brain chemicals that affect mood, energy, and pain. The study suggests these biochemical problems may be linked to how the brain is organized in people with ME/CFS.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredMechanistic

Chronic fatigue syndrome: new evidence for a central fatigue disorder.

Georgiades, Evelina, Behan, Wilhelmina M H, Kilduff, Liam P et al.·Clinical science (London, England : 1979)·2003

This study investigated whether ME/CFS involves problems with how the brain regulates energy and effort perception. Researchers compared 12 ME/CFS patients and 11 healthy controls during exercise, measuring chemicals in the blood that help the brain function. ME/CFS patients felt more exhausted at every stage and had different levels of brain chemicals, particularly those related to serotonin and dopamine—systems that regulate mood, motivation, and perception of effort.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

An occupational therapy approach to persons with chronic fatigue syndrome: part two, assessment and intervention.

Taylor, Renee R, Kielhofner, Gary W·Occupational therapy in health care·2003

This study explains how occupational therapists can better help people with ME/CFS by using a structured approach called the Model of Human Occupation. This framework helps therapists understand how the condition affects a person's motivation, daily habits, roles, and ability to do activities they care about. The paper provides practical guidance and a real-world example of how to assess and treat ME/CFS patients using this approach.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: the nurse's role.

Aylett, Elizabeth, Fawcett, Tonks N·Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2003

This article discusses what ME/CFS is and how nurses can help patients manage this exhausting illness. The authors argue that nurses are well-suited to be the main healthcare provider coordinating care for ME/CFS patients, because they can build strong relationships with patients and help them feel heard and supported.

E3 PreliminaryReviewPEM unclearReview-Narrative

Q fever as a biological weapon.

Kagawa, Frank T, Wehner, John H, Mohindra, Vibha·Seminars in respiratory infections·2003

Q fever is a rare bacterial infection that can be caught from animals and is highly contagious. Most people who catch it have no symptoms or mild flu-like illness, but some develop serious complications like pneumonia or inflammation of the heart. Importantly, a small number of people develop chronic Q fever, which can cause long-term fatigue similar to ME/CFS.

E3 PreliminaryCohortPEM not requiredCase-Control

Efficacy of a half dose of oral pyridostigmine in the treatment of chronic fatigue syndrome: three case reports.

Kawamura, Yasuo, Kihara, Mikihiro, Nishimoto, Kazuhiro et al.·Pathophysiology : the official journal of the International Society for Pathophysiology·2003

This small study looked at three ME/CFS patients who had problems with both nerve-muscle communication and autonomic nervous system dysfunction (how the body regulates heart rate, sweating, and other automatic functions). All three patients improved significantly when given low doses of a medication called pyridostigmine, which helps acetylcholine (a chemical messenger in the nervous system) work better. The authors suggest that some ME/CFS fatigue might be caused by a combination of these two problems working together.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Lessons from macrophagic myofasciitis: towards definition of a vaccine adjuvant-related syndrome].

Gherardi, R K·Revue neurologique·2003

This review examines macrophagic myofasciitis, a condition where aluminum from vaccine adjuvants persists in muscle tissue and may trigger long-lasting immune activation. About half of patients develop fatigue and muscle pain that meet ME/CFS criteria, and some develop autoimmune diseases. The authors suggest that persistent immune stimulation from the aluminum depot could explain both this vaccine-related condition and possibly other forms of ME/CFS.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Modification of the functional capacity of sarcoplasmic reticulum membranes in patients suffering from chronic fatigue syndrome.

Fulle, Stefania, Belia, Silvia, Vecchiet, Jacopo et al.·Neuromuscular disorders : NMD·2003

This study examined muscle cell structures called sarcoplasmic reticulum, which are responsible for controlling muscle contractions. Researchers found that in ME/CFS patients, these structures show signs of damage from oxidative stress, which may interfere with how muscles contract and relax. The damage appears to affect how calcium moves in and out of muscle cells, potentially explaining why patients experience fatigue.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Psychometric properties of the Dutch Chronic Fatigue Syndrome--Activities and Participation Questionnaire (CFS-APQ).

Nijs, Jo, Vaes, Peter, McGregor, Neil et al.·Physical therapy·2003

Researchers tested a questionnaire designed to measure how ME/CFS affects daily activities and participation in normal life. The Dutch version of this questionnaire was given to people with ME/CFS, and the researchers found it reliably measured activity limitations and correlated well with patients' reports of pain and fatigue. This suggests the questionnaire is a useful tool for tracking how the disease impacts everyday functioning.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Single-photon emission computerized tomography and neurocognitive function in patients with chronic fatigue syndrome.

Schmaling, Karen B, Lewis, David H, Fiedelak, Jessica I et al.·Psychosomatic medicine·2003

Researchers used brain imaging scans to compare how the brains of people with ME/CFS and healthy people work during a challenging listening and memory task. People with ME/CFS performed just as well on the task as healthy people, but reported feeling like they had to work much harder mentally. The brain scans showed that people with ME/CFS had a different pattern of brain activity—more spread out rather than focused in specific areas—suggesting their brains may be working less efficiently.

Cognitive Impairment

E3 PreliminaryGuidelinePEM not requiredEditorial

An approach to chronic fatigue syndrome in adults.

Sabin, Thomas D·The neurologist·2003

This paper helps doctors, especially neurologists, understand how to properly evaluate patients who are experiencing severe fatigue. The author emphasizes that while ME/CFS is a real condition, it's important to rule out other medical problems that can cause similar symptoms before confirming an ME/CFS diagnosis. Since there is no blood test or scan that can definitively diagnose ME/CFS, careful evaluation and questioning of patients is essential.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Cytokines in parvovirus B19 infection as an aid to understanding chronic fatigue syndrome.

Kerr, Jonathan R, Tyrrell, David A J·Current pain and headache reports·2003

This study examined how parvovirus B19 (a common virus) can trigger ME/CFS in some people. The researchers found that patients who developed ME/CFS after B19 infection had abnormal levels of immune signaling chemicals in their blood (specifically TNF-alpha, interferon-gamma, and MCP-1). Importantly, some patients improved when treated with intravenous immunoglobulin therapy, suggesting B19-triggered ME/CFS may be treatable.

Immune System

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Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome.

Glucocorticoids and glucocorticoid receptors: mediators of fatigue?

Acute parvovirus B19 infection mimicking chronic fatigue syndrome.

Chronic phase lipids in sera of chronic fatigue syndrome (CFS), chronic ciguatera fish poisoning (CCFP), hepatitis B, and cancer with antigenic epitope resembling ciguatoxin, as assessed with MAb-CTX.

Deficit in motor performance correlates with changed corticospinal excitability in patients with chronic fatigue syndrome.

An overview of chronic fatigue syndrome.

Chronic fatigue syndrome or myalgic encephalomyelitis in children and adolescents.

Case reports and review of Postural Orthostatic Tachycardia syndrome (POTS).

Hypothalamic digoxin, cerebral chemical dominance and myalgic encephalomyelitis.

Chronic fatigue syndrome: new evidence for a central fatigue disorder.

An occupational therapy approach to persons with chronic fatigue syndrome: part two, assessment and intervention.

Chronic fatigue syndrome: the nurse's role.

Q fever as a biological weapon.

Efficacy of a half dose of oral pyridostigmine in the treatment of chronic fatigue syndrome: three case reports.

[Lessons from macrophagic myofasciitis: towards definition of a vaccine adjuvant-related syndrome].

Modification of the functional capacity of sarcoplasmic reticulum membranes in patients suffering from chronic fatigue syndrome.

Psychometric properties of the Dutch Chronic Fatigue Syndrome--Activities and Participation Questionnaire (CFS-APQ).

Single-photon emission computerized tomography and neurocognitive function in patients with chronic fatigue syndrome.

An approach to chronic fatigue syndrome in adults.

Cytokines in parvovirus B19 infection as an aid to understanding chronic fatigue syndrome.

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