ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1781–1800 of 2,423 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Cytokines in parvovirus B19 infection as an aid to understanding chronic fatigue syndrome.

Kerr, Jonathan R, Tyrrell, David A J·Current pain and headache reports·2003

This study examined how parvovirus B19 (a common virus) can trigger ME/CFS in some people. The researchers found that patients who developed ME/CFS after B19 infection had abnormal levels of immune signaling chemicals in their blood (specifically TNF-alpha, interferon-gamma, and MCP-1). Importantly, some patients improved when treated with intravenous immunoglobulin therapy, suggesting B19-triggered ME/CFS may be treatable.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Case reports and review of Postural Orthostatic Tachycardia syndrome (POTS).

Carothers, Becky, Schmidt, Lori, Puri, Vinay·The Journal of the Kentucky Medical Association·2003

POTS is a condition where your heart rate increases too much when you stand up, and less blood flows to your brain, causing dizziness and fainting. This paper describes two patients with POTS who needed different levels of treatment—one managed at home and one needing hospital care. The authors point out that POTS is probably more common than doctors realize and is sometimes mistaken for chronic fatigue syndrome or other conditions.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredObservational

The effect of granisetron, a 5-HT3 receptor antagonist, in the treatment of chronic fatigue syndrome patients--a pilot study.

The, G K H, Prins, J, Bleijenberg, G et al.·The Netherlands journal of medicine·2003

Researchers tested whether a medication called granisetron, which affects a brain chemical involved in nausea and other functions, might help ME/CFS patients feel less fatigued. Five women with ME/CFS took the medication for one month and reported significant improvements in how tired they felt and how much they could do. However, this was a very small study without a comparison group, so much more research is needed to confirm these results.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome or myalgic encephalomyelitis in children and adolescents.

Chatterjee, Tapabrata·Journal of the Indian Medical Association·2003

This article reviews how ME/CFS affects children and teens, a group that is often overlooked in medical research. The authors explain the current diagnostic criteria used to identify the condition and discuss available treatments, though they note that how well these treatments work and what happens to patients over time remains unclear.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

An approach to persons with chronic fatigue syndrome based on the model of human occupation: part one, impact on occupational performance and participation.

Taylor, Renee R, Kielhofner, Gary W, Abelenda, Judith et al.·Occupational therapy in health care·2003

This study looked at how ME/CFS affects people's ability to work, study, and participate in daily life. The researchers used a framework called the Model of Human Occupation to understand how motivation, habits, physical abilities, and surroundings all work together to influence how people with ME/CFS manage their daily activities. The paper draws on real examples from patients' experiences and clinical practice to show the many ways this illness disrupts normal life.

E3 PreliminaryCommentaryPEM not requiredEditorial

Identification of masqueraders of autoimmune disease in the office.

Frieri, Marianne·Allergy and asthma proceedings·2003

This article discusses how several autoimmune and rheumatologic diseases can look like allergies or other conditions, making them easy to miss in a doctor's office. The author reviews nine conditions—including ME/CFS and fibromyalgia—that are often confused with other illnesses and explains how doctors can use blood tests and other tools to correctly identify them.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Small adrenal glands in cats with feline interstitial cystitis.

Westropp, Jodi L, Welk, Kristin A, Buffington, C A Tony·The Journal of urology·2003

This study found that cats with a painful bladder condition called feline interstitial cystitis had smaller adrenal glands (organs that make stress hormones) and produced less cortisol when stimulated compared to healthy cats. The researchers suggest this might indicate a mild form of adrenal insufficiency, similar to what has been observed in some people with chronic fatigue syndrome.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredLongitudinal

Deficit in motor performance correlates with changed corticospinal excitability in patients with chronic fatigue syndrome.

Davey, N J, Puri, B K, Catley, M et al.·International journal of clinical practice·2003

This study looked at whether the slowness people with ME/CFS experience in reacting and moving is connected to changes in how their brain controls muscles. Researchers tested 10 ME/CFS patients twice over up to two years, measuring reaction times, movement speed, and brain signals using magnetic stimulation. They found that when patients' symptoms changed, their brain's ability to control movements changed in a similar way, suggesting the slowness has a real physical basis in the brain rather than being purely psychological.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome: the point of view of the internist].

Cogan, E·Revue medicale de Bruxelles·2002

This review examines how doctors approach patients with chronic fatigue. The authors note that most chronic fatigue cases stem from psychiatric conditions like depression and anxiety. A small group of patients have ME/CFS, which involves fatigue, mood and thinking problems, and various other physical symptoms—but doctors still don't know what causes it. Current treatments with limited evidence include antidepressants, talk therapy, and graded exercise programs.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

The case definition of chronic fatigue syndrome.

Tan, Eng M, Sugiura, Kazumitsu, Gupta, Sudhir·Journal of clinical immunology·2002

This review discusses how ME/CFS is currently diagnosed using symptom-based criteria from 1994, which doesn't account for the fact that different patients have very different experiences. The authors suggest that ME/CFS might actually be four distinct subtypes based on which body system is most affected: nervous system (memory problems, headaches), endocrine system (poor sleep, post-exertion crashes), musculoskeletal system (muscle and joint pain), or immune/infection-related (sore throat, swollen lymph nodes). If researchers studied more similar groups of patients separately instead of mixing everyone together, they might get clearer and more consistent results.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredCase-Control

Using an interleukin-6 challenge to evaluate neuropsychological performance in chronic fatigue syndrome.

Arnold, M C, Papanicolaou, D A, O'Grady, J A et al.·Psychological medicine·2002

Researchers gave ME/CFS patients and healthy people a substance called interleukin-6 to temporarily trigger flu-like symptoms. They then tested how well both groups could think and remember during this induced illness. ME/CFS patients reported more overall sickness symptoms, but surprisingly, both groups performed equally well on memory and thinking tests, suggesting that the temporary immune activation didn't impair cognitive abilities in either group.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Peripheral vestibular dysfunction in chronic fatigue syndrome.

Palaniappan, Rudrapathy, Sirimanna, Tony·International journal of pediatric otorhinolaryngology·2002

This study describes a 12-year-old boy with ME/CFS who experienced dizziness caused by a problem with the balance system in his inner ear (his left vestibular system). The doctors found that specific tests could identify this balance problem, and that exercises designed to help retrain the balance system were an effective treatment. This case suggests that some people with ME/CFS who have dizziness might benefit from checking their balance system and doing targeted exercises.

E3 PreliminaryMechanismPEM unclearObservational

[Role of pathological delayed-type hypersensitivity in chronic fatigue syndrome: importance of the evaluation of lymphocyte activation by flow cytometry and the measurement of urinary neopterin].

Brunet, J L, Fatoohi, F, Liaudet, A Perret et al.·Allergie et immunologie·2002

This study investigated whether ME/CFS patients have exaggerated immune reactions to common fungi and bacteria that normally live on or around our bodies. Researchers tested this by placing small amounts of Candida (a common yeast) under the skin and watching for delayed reactions. They found that about half of ME/CFS patients showed these heightened reactions, and they developed methods to measure immune cell activation in the lab that matched what they saw on the skin.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

A computational analysis of Canale-Smith syndrome: chronic lymphadenopathy simulating malignant lymphoma.

Krueger, Gerhard R F, Brandt, Michael E, Wang, Guanyu et al.·Anticancer research·2002

Researchers used a computer model to simulate how the immune system changes when infected with a virus called HHV-6. They found that a chronic (long-lasting) simulated infection produced immune cell patterns similar to what is seen in ME/CFS patients, suggesting that persistent viral infection might be connected to the disease.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Psychiatric management of severe somatoform disorders in childhood and adolescence.

Garralda, M Elena·Acta neuropsychiatrica·2002

This review examined how doctors can help children with unexplained medical symptoms, including chronic fatigue syndrome. The authors looked at different treatment approaches, particularly psychological and behavioral therapies, and found that many children improved with these methods. However, they note that more rigorous research is needed to confirm which treatments work best.

E3 PreliminaryCommentaryPEM unclearEditorial

Chronopathological forms of magnesium depletion with hypofunction or with hyperfunction of the biological clock.

Durlach, J, Pagès, N, Bac, P et al.·Magnesium research·2002

This paper suggests that low magnesium levels may disrupt the body's internal clock (circadian rhythm) in two opposite ways. In one pattern, the clock runs too fast, causing depression, nighttime headaches, and fatigue—similar to symptoms in ME/CFS and fibromyalgia. In the other pattern, the clock runs too slow, causing anxiety, migraines, and sleep problems. The authors propose that measuring melatonin levels could help distinguish between these two patterns and guide treatment.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

Distinguishing Mars from Venus: emergence of gender biology differences in oral health and systemic disease.

Slavkin, Harold C·Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)·2002

This article examines how men and women differ in their health, including oral health and overall diseases. The authors note that women and men have different genetics, body chemistry, and hormones, which leads to different rates of certain illnesses like autoimmune diseases, osteoporosis, and chronic fatigue syndrome. Understanding these gender differences can help doctors provide better, more personalized care for women.

E3 PreliminaryMechanismPEM not requiredMechanistic

Role of antioxidants in chronic fatigue syndrome in mice.

Singh, Amanpreet, Garg, Vivek, Gupta, Saraswati et al.·Indian journal of experimental biology·2002

This mouse study tested whether antioxidants—substances that protect cells from damage—might help with fatigue and despair-like behaviors. Researchers gave mice different treatments including antioxidant drugs (carvedilol and melatonin) and herbal products (St. John's Wort and GS-02), and found that these treatments reduced despair-like behavior and restored protective chemicals in the brain that were depleted by stress.

E3 PreliminaryPEM unclear

Intravenous nutrient therapy: the "Myers' cocktail".

Gaby, Alan R·Alternative medicine review : a journal of clinical therapeutic·2002

This study describes a intravenous nutrient mixture called the "Myers' cocktail," containing magnesium, calcium, B vitamins, and vitamin C, used to treat various conditions including chronic fatigue syndrome. The author reports clinical experiences suggesting this treatment may help reduce fatigue and other symptoms. The paper reviews why these nutrients might be helpful and discusses safety considerations.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Alternative tests in the diagnosis of food allergies].

Senna, Gianenrico, Gani, Federica, Leo, Gualtiero et al.·Recenti progressi in medicina·2002

This review examined whether alternative medical tests can reliably diagnose food allergies and intolerances. The researchers found that popular tests like cytotoxic testing, hair analysis, applied kinesiology, and food IgG testing are not scientifically supported for diagnosing food problems. The authors warn patients and doctors to be cautious about these tests because following unnecessary restricted diets based on their results can be harmful, especially for children.

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Cytokines in parvovirus B19 infection as an aid to understanding chronic fatigue syndrome.

Case reports and review of Postural Orthostatic Tachycardia syndrome (POTS).

The effect of granisetron, a 5-HT3 receptor antagonist, in the treatment of chronic fatigue syndrome patients--a pilot study.

Chronic fatigue syndrome or myalgic encephalomyelitis in children and adolescents.

An approach to persons with chronic fatigue syndrome based on the model of human occupation: part one, impact on occupational performance and participation.

Identification of masqueraders of autoimmune disease in the office.

Small adrenal glands in cats with feline interstitial cystitis.

Deficit in motor performance correlates with changed corticospinal excitability in patients with chronic fatigue syndrome.

[Chronic fatigue syndrome: the point of view of the internist].

The case definition of chronic fatigue syndrome.

Using an interleukin-6 challenge to evaluate neuropsychological performance in chronic fatigue syndrome.

Peripheral vestibular dysfunction in chronic fatigue syndrome.

[Role of pathological delayed-type hypersensitivity in chronic fatigue syndrome: importance of the evaluation of lymphocyte activation by flow cytometry and the measurement of urinary neopterin].

A computational analysis of Canale-Smith syndrome: chronic lymphadenopathy simulating malignant lymphoma.

Psychiatric management of severe somatoform disorders in childhood and adolescence.

Chronopathological forms of magnesium depletion with hypofunction or with hyperfunction of the biological clock.

Distinguishing Mars from Venus: emergence of gender biology differences in oral health and systemic disease.

Role of antioxidants in chronic fatigue syndrome in mice.

Intravenous nutrient therapy: the "Myers' cocktail".

[Alternative tests in the diagnosis of food allergies].

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