ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1781–1800 of 2,420 studies

E3 PreliminaryCommentaryPEM not requiredEditorial

Identification of masqueraders of autoimmune disease in the office.

Frieri, Marianne·Allergy and asthma proceedings·2003

This article discusses how several autoimmune and rheumatologic diseases can look like allergies or other conditions, making them easy to miss in a doctor's office. The author reviews nine conditions—including ME/CFS and fibromyalgia—that are often confused with other illnesses and explains how doctors can use blood tests and other tools to correctly identify them.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Fibromyalgia syndrome].

Siegmeth, Walter·Wiener medizinische Wochenschrift (1946)·2003

Fibromyalgia syndrome (FMS) is a real medical condition that causes widespread pain and should be diagnosed using clear, established criteria. Research suggests it may involve problems with the nervous system, hormonal systems, and pain control pathways in the brain. Treatment works best when it combines information and education, physical therapy, and sometimes medication, rather than relying on drugs alone.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

Dental amalgam and human health.

Yip, H K, Li, D K C, Yau, D C Y·International dental journal·2003

This review examines whether dental fillings containing mercury cause chronic fatigue syndrome and other neurological diseases. After 30 years of research, scientists have found that while small amounts of mercury do leak from these fillings, there is no clear evidence that they cause widespread health problems in patients. Most international health organizations agree these fillings are safe for patients, though protecting dental workers from mercury exposure remains important.

E3 PreliminaryGuidelinePEM not requiredEditorial

An approach to chronic fatigue syndrome in adults.

Sabin, Thomas D·The neurologist·2003

This paper helps doctors, especially neurologists, understand how to properly evaluate patients who are experiencing severe fatigue. The author emphasizes that while ME/CFS is a real condition, it's important to rule out other medical problems that can cause similar symptoms before confirming an ME/CFS diagnosis. Since there is no blood test or scan that can definitively diagnose ME/CFS, careful evaluation and questioning of patients is essential.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Single-photon emission computerized tomography and neurocognitive function in patients with chronic fatigue syndrome.

Schmaling, Karen B, Lewis, David H, Fiedelak, Jessica I et al.·Psychosomatic medicine·2003

Researchers used brain imaging scans to compare how the brains of people with ME/CFS and healthy people work during a challenging listening and memory task. People with ME/CFS performed just as well on the task as healthy people, but reported feeling like they had to work much harder mentally. The brain scans showed that people with ME/CFS had a different pattern of brain activity—more spread out rather than focused in specific areas—suggesting their brains may be working less efficiently.

Cognitive Impairment

E3 PreliminaryMechanismPEM unclearObservational

[Role of pathological delayed-type hypersensitivity in chronic fatigue syndrome: importance of the evaluation of lymphocyte activation by flow cytometry and the measurement of urinary neopterin].

Brunet, J L, Fatoohi, F, Liaudet, A Perret et al.·Allergie et immunologie·2002

This study investigated whether ME/CFS patients have exaggerated immune reactions to common fungi and bacteria that normally live on or around our bodies. Researchers tested this by placing small amounts of Candida (a common yeast) under the skin and watching for delayed reactions. They found that about half of ME/CFS patients showed these heightened reactions, and they developed methods to measure immune cell activation in the lab that matched what they saw on the skin.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Ribonuclease L proteolysis in peripheral blood mononuclear cells of chronic fatigue syndrome patients.

Demettre, Edith, Bastide, Lionel, D'Haese, Anne et al.·The Journal of biological chemistry·2002

Researchers found that immune cells from ME/CFS patients show abnormally high breakdown of a protein called RNase L, which normally helps fight viral infections. Instead of remaining whole, this protein is being cut into smaller pieces (37 kDa and 30 kDa fragments), yet these fragments can still work together to fight infections. This abnormal protein breakdown pattern could potentially be used as a marker to help diagnose ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The symptoms and management of myalgic encephalomyelitis.

Richardson, Amanda·Nursing times·2002

ME/CFS is a long-lasting illness that affects people differently, and doctors still don't fully understand what causes it or how to cure it. However, there are helpful ways to manage the symptoms, and the best treatment plans are created together with each individual patient. While no medicine has been specifically designed for ME/CFS, doctors can adapt treatments used for similar symptoms in other conditions to help reduce suffering.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

The chronic fatigue syndrome is a disease of the autonomic nervous system. Sometimes.

Freeman, Roy·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2002

This review article examines whether ME/CFS might be caused by problems with the autonomic nervous system—the part of your body that controls automatic functions like heart rate and blood pressure. The author, Dr. Roy Freeman, discusses evidence suggesting that some ME/CFS patients do show signs of autonomic dysfunction, but emphasizes that this is not true for all patients with the condition.

Autonomic Nervous System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Homeopathic treatment of Chronic Fatigue Syndrome: three case studies using Jan Scholten's methodology.

Geraghty, J·Homeopathy : the journal of the Faculty of Homeopathy·2002

This study looked at three young people with ME/CFS that developed after a viral infection, and tried treating them with homeopathic remedies based on a specific system of selecting remedies. The researchers describe how they chose three different phosphate-based homeopathic medicines and claim that patients experienced improvement, though the study is very small and doesn't use a comparison group.

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

The role of fear of physical movement and activity in chronic fatigue syndrome.

Silver, A, Haeney, M, Vijayadurai, P et al.·Journal of psychosomatic research·2002

This study looked at whether fear of movement and activity contributes to people with ME/CFS avoiding exercise. Researchers created a questionnaire to measure this fear and asked patients to ride an exercise bike as long as they could. They found that people's beliefs about whether activity was dangerous predicted how much they exercised, even when other factors like tiredness and heart rate did not.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Evaluating attributions for an illness based upon the name: chronic fatigue syndrome, myalgic encephalopathy and Florence Nightingale disease.

Jason, Leonard A, Taylor, Renee R, Plioplys, Sigita et al.·American journal of community psychology·2002

This study asked medical trainees to read about a patient with ME/CFS symptoms, but gave different groups different names for the illness: "chronic fatigue syndrome," "myalgic encephalopathy," or "Florence Nightingale disease." Researchers found that the name used affected how seriously the trainees thought about the illness—specifically, "myalgic encephalopathy" sounded more serious than "chronic fatigue syndrome." This suggests that what doctors call a disease can influence how much they respect and understand it.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Cytokine responses to physical activity, with particular reference to IL-6: sources, actions, and clinical implications.

Shephard, Roy J·Critical reviews in immunology·2002

When people exercise, their muscles release a protein called IL-6 that helps control inflammation and manage energy. This review examines how the body produces different types of inflammatory signals during and after exercise, with IL-6 playing a central role. The authors note that people with ME/CFS have higher levels of these inflammatory proteins, though it's unclear whether these proteins actually cause the fatigue experienced by patients.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Distinguishing Mars from Venus: emergence of gender biology differences in oral health and systemic disease.

Slavkin, Harold C·Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)·2002

This article examines how men and women differ in their health, including oral health and overall diseases. The authors note that women and men have different genetics, body chemistry, and hormones, which leads to different rates of certain illnesses like autoimmune diseases, osteoporosis, and chronic fatigue syndrome. Understanding these gender differences can help doctors provide better, more personalized care for women.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Alternative tests in the diagnosis of food allergies].

Senna, Gianenrico, Gani, Federica, Leo, Gualtiero et al.·Recenti progressi in medicina·2002

This review examined whether alternative medical tests can reliably diagnose food allergies and intolerances. The researchers found that popular tests like cytotoxic testing, hair analysis, applied kinesiology, and food IgG testing are not scientifically supported for diagnosing food problems. The authors warn patients and doctors to be cautious about these tests because following unnecessary restricted diets based on their results can be harmful, especially for children.

E3 PreliminaryCohortPEM not requiredCase-Control

Peripheral vestibular dysfunction in chronic fatigue syndrome.

Palaniappan, Rudrapathy, Sirimanna, Tony·International journal of pediatric otorhinolaryngology·2002

This study describes a 12-year-old boy with ME/CFS who experienced dizziness caused by a problem with the balance system in his inner ear (his left vestibular system). The doctors found that specific tests could identify this balance problem, and that exercises designed to help retrain the balance system were an effective treatment. This case suggests that some people with ME/CFS who have dizziness might benefit from checking their balance system and doing targeted exercises.

E3 PreliminaryCohortPEM unclearCase-Control

Finding Amy Peterson. An olympic speed skater battles with chronic fatigue syndrome.

Gaines, Susan·Minnesota medicine·2002

This article tells the story of Amy Peterson, an Olympic speed skater who developed chronic fatigue syndrome (ME/CFS). The case describes her experience with the illness and how it affected her athletic career and daily life. Through her personal journey, the article highlights the real-world impact of ME/CFS on people who were previously very active and healthy.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Theoretical accounts of Gulf War Syndrome: from environmental toxins to psychoneuroimmunology and neurodegeneration.

Ferguson, E, Cassaday, H J·Behavioural neurology·2002

This paper suggests that the confusing mix of symptoms seen in Gulf War Syndrome and chronic fatigue syndrome may actually be one condition caused by inflammation in the body rather than separate diseases. The authors propose that inflammatory molecules called cytokines trigger a 'sickness response' similar to what happens when you have the flu, and that smells or other reminders from the environment can keep this sickness response going long after it should have stopped.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Evidence for the presence of immune dysfunction in chronic fatigue syndrome.

Natelson, Benjamin H, Haghighi, Mohammad H, Ponzio, Nicholas M·Clinical and diagnostic laboratory immunology·2002

This review article examines whether people with ME/CFS have problems with their immune system. The researchers looked at evidence from multiple studies and found signs that the immune system may not be working normally in people with this condition. This helps explain why ME/CFS causes such severe fatigue and other symptoms.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome.

Singh, Amanpreet, Naidu, Pattipati S, Gupta, Saraswati et al.·Journal of medicinal food·2002

This study tested whether antioxidants—substances that reduce cellular damage—could help with fatigue in mice. Researchers used a mouse model of ME/CFS by making mice swim repeatedly, which increased their fatigue-like behavior. Both natural antioxidants (like melatonin and herbal supplements) and synthetic ones reduced this fatigue behavior and restored protective chemicals in the brain.

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Identification of masqueraders of autoimmune disease in the office.

[Fibromyalgia syndrome].

Dental amalgam and human health.

An approach to chronic fatigue syndrome in adults.

Single-photon emission computerized tomography and neurocognitive function in patients with chronic fatigue syndrome.

[Role of pathological delayed-type hypersensitivity in chronic fatigue syndrome: importance of the evaluation of lymphocyte activation by flow cytometry and the measurement of urinary neopterin].

Ribonuclease L proteolysis in peripheral blood mononuclear cells of chronic fatigue syndrome patients.

The symptoms and management of myalgic encephalomyelitis.

The chronic fatigue syndrome is a disease of the autonomic nervous system. Sometimes.

Homeopathic treatment of Chronic Fatigue Syndrome: three case studies using Jan Scholten's methodology.

The role of fear of physical movement and activity in chronic fatigue syndrome.

Evaluating attributions for an illness based upon the name: chronic fatigue syndrome, myalgic encephalopathy and Florence Nightingale disease.

Cytokine responses to physical activity, with particular reference to IL-6: sources, actions, and clinical implications.

Distinguishing Mars from Venus: emergence of gender biology differences in oral health and systemic disease.

[Alternative tests in the diagnosis of food allergies].

Peripheral vestibular dysfunction in chronic fatigue syndrome.

Finding Amy Peterson. An olympic speed skater battles with chronic fatigue syndrome.

Theoretical accounts of Gulf War Syndrome: from environmental toxins to psychoneuroimmunology and neurodegeneration.

Evidence for the presence of immune dysfunction in chronic fatigue syndrome.

Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome.

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