ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1801–1820 of 2,422 studies

E3 PreliminaryCohortPEM unclearCase-Control

Peripheral blood mononuclear cell beta-endorphin concentration is decreased in chronic fatigue syndrome and fibromyalgia but not in depression: preliminary report.

Panerai, Alberto E, Vecchiet, Jacopo, Panzeri, Paolo et al.·The Clinical journal of pain·2002

This study measured a natural pain-relieving substance called beta-endorphin in immune cells from people with ME/CFS, fibromyalgia, depression, and healthy controls. The researchers found that people with ME/CFS and fibromyalgia had significantly lower levels of beta-endorphin than healthy people and those with depression. This suggests the immune systems of people with ME/CFS and fibromyalgia may be working differently than in other conditions.

Immune System

E3 PreliminaryMechanismPEM requiredMechanistic

Activity rhythm degrades after strenuous exercise in chronic fatigue syndrome.

Ohashi, Kyoko, Yamamoto, Yoshiharu, Natelson, Benjamin H·Physiology & behavior·2002

This study looked at whether exhausting exercise disrupts the body's internal daily rhythm in people with ME/CFS. Researchers measured activity patterns in ME/CFS patients and healthy controls before and after a strenuous treadmill test. They found that ME/CFS patients' activity rhythms became abnormally lengthened (longer than 24 hours) after exercise, while healthy people's rhythms stayed normal—suggesting the body loses its ability to keep time after strenuous activity in ME/CFS.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue: introduction].

Ducobu, J·Revue medicale de Bruxelles·2002

This review article explains that chronic fatigue is very common in general medical practice. Doctors need to first rule out other medical conditions that cause tiredness, then look for psychological factors and chronic fatigue syndrome (CFS). The key message is that careful clinical evaluation by a doctor is more important than ordering many laboratory tests to figure out what's causing someone's fatigue.

Diagnostics

E3 PreliminaryCommentaryPEM not requiredEditorial

Somatization, sensitization, and functional dyspepsia.

Wilhelmsen, Ingvard·Scandinavian journal of psychology·2002

This study explores why people with conditions like ME/CFS, fibromyalgia, and functional dyspepsia experience overlapping symptoms such as fatigue, headaches, muscle pain, and sleep problems. The researchers suggest these different conditions may share a common underlying process where the nervous system becomes overly sensitive to pain and discomfort signals, leading the body to experience and report multiple symptoms across different areas.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

The symptoms and management of myalgic encephalomyelitis.

Richardson, Amanda·Nursing times·2002

ME/CFS is a long-lasting illness that affects people differently, and doctors still don't fully understand what causes it or how to cure it. However, there are helpful ways to manage the symptoms, and the best treatment plans are created together with each individual patient. While no medicine has been specifically designed for ME/CFS, doctors can adapt treatments used for similar symptoms in other conditions to help reduce suffering.

Interventions

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Characteristics of patients with persistent severe disability and medically unexplained neurological symptoms: a pilot study.

Allanson, J, Bass, C, Wade, D T·Journal of neurology, neurosurgery, and psychiatry·2002

This study looked at 25 patients with severe disability and neurological symptoms that doctors couldn't explain with standard tests. Most patients were in wheelchairs and very limited in daily activities, though they had been given different diagnoses—some psychiatric, some neurological. The researchers found that many of these patients had experienced trauma, had received psychiatric treatment, or had switched from self-harm to physical disability around the same time.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Gender differences in fibromyalgia and other related syndromes.

Yunus, Muhammad B·The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia·2002

This review looked at why fibromyalgia and similar conditions like chronic fatigue syndrome affect many more women than men. Women with fibromyalgia tend to report more fatigue, worse sleep, more widespread pain, and more tender points than men. The reasons for these differences likely involve a mix of biological factors, psychological factors, and social factors.

Pain and Sensitization

E3 PreliminaryCohortPEM not requiredCase-Control

Peripheral vestibular dysfunction in chronic fatigue syndrome.

Palaniappan, Rudrapathy, Sirimanna, Tony·International journal of pediatric otorhinolaryngology·2002

This study describes a 12-year-old boy with ME/CFS who experienced dizziness caused by a problem with the balance system in his inner ear (his left vestibular system). The doctors found that specific tests could identify this balance problem, and that exercises designed to help retrain the balance system were an effective treatment. This case suggests that some people with ME/CFS who have dizziness might benefit from checking their balance system and doing targeted exercises.

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

The role of fear of physical movement and activity in chronic fatigue syndrome.

Silver, A, Haeney, M, Vijayadurai, P et al.·Journal of psychosomatic research·2002

This study looked at whether fear of movement and activity contributes to people with ME/CFS avoiding exercise. Researchers created a questionnaire to measure this fear and asked patients to ride an exercise bike as long as they could. They found that people's beliefs about whether activity was dangerous predicted how much they exercised, even when other factors like tiredness and heart rate did not.

E3 PreliminaryReviewPEM unclearReview-Narrative

Quality of life issues in patients with essential thrombocythemia and polycythemia vera.

Hoffman, Ronald·Seminars in oncology·2002

This article discusses how doctors should measure quality of life in patients with two rare blood disorders (essential thrombocythemia and polycythemia vera). The author explains that while treatments can control blood cell production and prevent some serious complications, they often cause side effects. The article suggests that doctors should use quality-of-life questionnaires to better understand whether treatments are truly helping patients feel better overall.

E3 PreliminaryMechanismPEM unclearObservational

[Role of pathological delayed-type hypersensitivity in chronic fatigue syndrome: importance of the evaluation of lymphocyte activation by flow cytometry and the measurement of urinary neopterin].

Brunet, J L, Fatoohi, F, Liaudet, A Perret et al.·Allergie et immunologie·2002

This study investigated whether ME/CFS patients have exaggerated immune reactions to common fungi and bacteria that normally live on or around our bodies. Researchers tested this by placing small amounts of Candida (a common yeast) under the skin and watching for delayed reactions. They found that about half of ME/CFS patients showed these heightened reactions, and they developed methods to measure immune cell activation in the lab that matched what they saw on the skin.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome: psychiatric perspectives].

Youssefi, M, Linkowski, P·Revue medicale de Bruxelles·2002

This review examines ME/CFS from a psychiatric perspective, looking at how mental health symptoms often occur alongside the physical illness. Many people with ME/CFS also experience depression, anxiety, or other mood problems, though it's unclear whether these conditions cause ME/CFS or develop because of living with a serious chronic illness. The authors discuss treatments that have shown promise, including talking therapy, exercise programs, and antidepressants when appropriate, while emphasizing that a supportive doctor-patient relationship is essential.

E3 PreliminaryMechanismPEM not requiredCase-Control

Using an interleukin-6 challenge to evaluate neuropsychological performance in chronic fatigue syndrome.

Arnold, M C, Papanicolaou, D A, O'Grady, J A et al.·Psychological medicine·2002

Researchers gave ME/CFS patients and healthy people a substance called interleukin-6 to temporarily trigger flu-like symptoms. They then tested how well both groups could think and remember during this induced illness. ME/CFS patients reported more overall sickness symptoms, but surprisingly, both groups performed equally well on memory and thinking tests, suggesting that the temporary immune activation didn't impair cognitive abilities in either group.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Environmental factors in medically unexplained symptoms and related syndromes: the evidence and the challenge.

Kipen, Howard M, Fiedler, Nancy·Environmental health perspectives·2002

This paper discusses how many patients experience symptoms that doctors cannot easily explain, and how these symptoms sometimes get organized into syndrome names like chronic fatigue syndrome. The authors note that these syndromes are defined only by how patients feel, not by medical tests, and that arguments continue about whether environmental factors cause them. They call for better research and clearer definitions to help both doctors and patients understand these conditions.

Diagnostics

E3 PreliminaryBehavioralPEM not requiredLongitudinal

An interdisciplinary therapeutic approach for dealing with patients attributing chronic fatigue and functional memory disorders to environmental poisoning--a pilot study.

Lacour, Michael, Zunder, Thomas, Dettenkofer, Markus et al.·International journal of hygiene and environmental health·2002

This study looked at whether a combination treatment approach—including self-help programs, acupuncture, and group counseling—could help 8 patients with ME/CFS or memory problems who believed their illness was caused by environmental exposure. Though patients were initially reluctant about psychological support, most became willing to try it during the study. After 8 months of treatment, patients reported improvements in quality of life, particularly in mental health, social function, and energy levels.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Use of IVIG in secondary immunodeficiencies].

Zeman, Krzysztof, Lewandowicz-Uszyńska, Aleksandra·Postepy higieny i medycyny doswiadczalnej·2002

This review article examines whether intravenous immunoglobulin (IVIG)—a blood product containing antibodies—might help patients with weakened immune systems, including those with HIV and chronic fatigue syndrome. The authors looked at published research to understand when and how IVIG might be useful, particularly for people recovering from serious injuries, burns, or major surgery.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulation.

Gaab, Jens, Hüster, Dominik, Peisen, Renate et al.·Psychosomatic medicine·2002

This study looked at how the stress-response system (a hormone system in the brain called the HPA axis) works in ME/CFS patients compared to healthy people. Researchers exposed both groups to different types of stress—mental stress, exercise, and a hormone test—and measured how their bodies responded. ME/CFS patients showed lower levels of a stress hormone called ACTH at baseline and during stress tests, but their cortisol levels were mostly normal, suggesting their stress system works differently rather than being broken.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: probable pathogenesis and possible treatments.

Evengård, Birgitta, Klimas, Nancy·Drugs·2002

ME/CFS is a serious illness affecting about 1 in 200 people in Western countries, causing extreme tiredness that lasts at least 6 months along with problems thinking clearly, poor sleep, and pain. While doctors don't yet know exactly what causes it, research shows the immune system is overactive and certain brain functions are disrupted. Currently, talking therapy (cognitive behavioural therapy) can help improve quality of life, but scientists are still searching for more effective treatments.

Immune SystemPost-Exertional Malaise

E3 PreliminaryBehavioralPEM not requiredCase-Control

[Symptom or illness? The exhausting life of an adolescent with chronic fatigue syndrome].

Di Gallo, A·Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie·2002

This study describes the medical experience of a teenage boy diagnosed with chronic fatigue syndrome (CFS). The doctors examined questions about what causes CFS, how it develops, how to diagnose it, and what treatments might help. The case provides a detailed look at one patient's journey with this complex illness.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Update on chronic fatigue syndrome and Epstein-Barr virus.

Katz, Ben Z·Pediatric annals·2002

This editorial discusses the relationship between Epstein-Barr virus (EBV) and chronic fatigue syndrome (ME/CFS), particularly in children and teenagers. The author reviews what is known about EBV's role in ME/CFS and updates the medical community on current understanding of this connection.

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Peripheral blood mononuclear cell beta-endorphin concentration is decreased in chronic fatigue syndrome and fibromyalgia but not in depression: preliminary report.

Activity rhythm degrades after strenuous exercise in chronic fatigue syndrome.

[Chronic fatigue: introduction].

Somatization, sensitization, and functional dyspepsia.

The symptoms and management of myalgic encephalomyelitis.

Characteristics of patients with persistent severe disability and medically unexplained neurological symptoms: a pilot study.

Gender differences in fibromyalgia and other related syndromes.

Peripheral vestibular dysfunction in chronic fatigue syndrome.

The role of fear of physical movement and activity in chronic fatigue syndrome.

Quality of life issues in patients with essential thrombocythemia and polycythemia vera.

[Role of pathological delayed-type hypersensitivity in chronic fatigue syndrome: importance of the evaluation of lymphocyte activation by flow cytometry and the measurement of urinary neopterin].

[Chronic fatigue syndrome: psychiatric perspectives].

Using an interleukin-6 challenge to evaluate neuropsychological performance in chronic fatigue syndrome.

Environmental factors in medically unexplained symptoms and related syndromes: the evidence and the challenge.

An interdisciplinary therapeutic approach for dealing with patients attributing chronic fatigue and functional memory disorders to environmental poisoning--a pilot study.

[Use of IVIG in secondary immunodeficiencies].

Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulation.

Chronic fatigue syndrome: probable pathogenesis and possible treatments.

[Symptom or illness? The exhausting life of an adolescent with chronic fatigue syndrome].

Update on chronic fatigue syndrome and Epstein-Barr virus.

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