ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1821–1840 of 2,420 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Distinguishing Mars from Venus: emergence of gender biology differences in oral health and systemic disease.

Slavkin, Harold C·Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)·2002

This article examines how men and women differ in their health, including oral health and overall diseases. The authors note that women and men have different genetics, body chemistry, and hormones, which leads to different rates of certain illnesses like autoimmune diseases, osteoporosis, and chronic fatigue syndrome. Understanding these gender differences can help doctors provide better, more personalized care for women.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The case definition of chronic fatigue syndrome.

Tan, Eng M, Sugiura, Kazumitsu, Gupta, Sudhir·Journal of clinical immunology·2002

This review discusses how ME/CFS is currently diagnosed using symptom-based criteria from 1994, which doesn't account for the fact that different patients have very different experiences. The authors suggest that ME/CFS might actually be four distinct subtypes based on which body system is most affected: nervous system (memory problems, headaches), endocrine system (poor sleep, post-exertion crashes), musculoskeletal system (muscle and joint pain), or immune/infection-related (sore throat, swollen lymph nodes). If researchers studied more similar groups of patients separately instead of mixing everyone together, they might get clearer and more consistent results.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome.

Singh, Amanpreet, Naidu, Pattipati S, Gupta, Saraswati et al.·Journal of medicinal food·2002

This study tested whether antioxidants—substances that reduce cellular damage—could help with fatigue in mice. Researchers used a mouse model of ME/CFS by making mice swim repeatedly, which increased their fatigue-like behavior. Both natural antioxidants (like melatonin and herbal supplements) and synthetic ones reduced this fatigue behavior and restored protective chemicals in the brain.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome. Symptom relief is primary goal.

Hoffman, Diane B·Advance for nurse practitioners·2002

This article discusses chronic fatigue syndrome (ME/CFS) and emphasizes that helping patients feel better is the main goal of treatment. The author, writing for nurse practitioners, focuses on practical approaches to managing symptoms and improving patients' quality of life.

Interventions

E3 PreliminaryMechanismPEM not requiredMechanistic

Brain regions involved in fatigue sensation: reduced acetylcarnitine uptake into the brain.

Kuratsune, Hirohiko, Yamaguti, Kouzi, Lindh, Gudrun et al.·NeuroImage·2002

This study looked at how the brain uses a molecule called acetylcarnitine, which helps cells produce energy. Researchers found that people with ME/CFS have lower levels of acetylcarnitine in their blood, and their brains take up less of this molecule than healthy people do. The reduced uptake happened in several brain areas involved in thinking, emotion, and movement coordination, suggesting this may be connected to why people with ME/CFS experience severe fatigue.

E3 PreliminaryPEM unclear

Intravenous nutrient therapy: the "Myers' cocktail".

Gaby, Alan R·Alternative medicine review : a journal of clinical therapeutic·2002

This study describes a intravenous nutrient mixture called the "Myers' cocktail," containing magnesium, calcium, B vitamins, and vitamin C, used to treat various conditions including chronic fatigue syndrome. The author reports clinical experiences suggesting this treatment may help reduce fatigue and other symptoms. The paper reviews why these nutrients might be helpful and discusses safety considerations.

E3 PreliminaryBehavioralPEM not requiredLongitudinal

An interdisciplinary therapeutic approach for dealing with patients attributing chronic fatigue and functional memory disorders to environmental poisoning--a pilot study.

Lacour, Michael, Zunder, Thomas, Dettenkofer, Markus et al.·International journal of hygiene and environmental health·2002

This study looked at whether a combination treatment approach—including self-help programs, acupuncture, and group counseling—could help 8 patients with ME/CFS or memory problems who believed their illness was caused by environmental exposure. Though patients were initially reluctant about psychological support, most became willing to try it during the study. After 8 months of treatment, patients reported improvements in quality of life, particularly in mental health, social function, and energy levels.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Psychiatric management of severe somatoform disorders in childhood and adolescence.

Garralda, M Elena·Acta neuropsychiatrica·2002

This review examined how doctors can help children with unexplained medical symptoms, including chronic fatigue syndrome. The authors looked at different treatment approaches, particularly psychological and behavioral therapies, and found that many children improved with these methods. However, they note that more rigorous research is needed to confirm which treatments work best.

E3 PreliminaryCommentaryPEM unclearEditorial

Chronic fatigue syndrome in the psychiatric practice.

Van Duyse, A, Mariman, A, Poppe, C et al.·Acta neuropsychiatrica·2002

This review examines how psychiatric symptoms interact with ME/CFS. Many people with ME/CFS also experience depression, anxiety, or sleep problems, and doctors often miss these conditions. The study found that while antidepressant medications help with mood and social functioning, they don't improve fatigue itself. Cognitive behavioral therapy and graded exercise were the only treatments shown to actually improve fatigue and other ME/CFS symptoms.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredMechanistic

Role of antioxidants in chronic fatigue syndrome in mice.

Singh, Amanpreet, Garg, Vivek, Gupta, Saraswati et al.·Indian journal of experimental biology·2002

This mouse study tested whether antioxidants—substances that protect cells from damage—might help with fatigue and despair-like behaviors. Researchers gave mice different treatments including antioxidant drugs (carvedilol and melatonin) and herbal products (St. John's Wort and GS-02), and found that these treatments reduced despair-like behavior and restored protective chemicals in the brain that were depleted by stress.

E3 PreliminaryCommentaryPEM not requiredEditorial

Somatization, sensitization, and functional dyspepsia.

Wilhelmsen, Ingvard·Scandinavian journal of psychology·2002

This study explores why people with conditions like ME/CFS, fibromyalgia, and functional dyspepsia experience overlapping symptoms such as fatigue, headaches, muscle pain, and sleep problems. The researchers suggest these different conditions may share a common underlying process where the nervous system becomes overly sensitive to pain and discomfort signals, leading the body to experience and report multiple symptoms across different areas.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

Theoretical accounts of Gulf War Syndrome: from environmental toxins to psychoneuroimmunology and neurodegeneration.

Ferguson, E, Cassaday, H J·Behavioural neurology·2002

This paper suggests that the confusing mix of symptoms seen in Gulf War Syndrome and chronic fatigue syndrome may actually be one condition caused by inflammation in the body rather than separate diseases. The authors propose that inflammatory molecules called cytokines trigger a 'sickness response' similar to what happens when you have the flu, and that smells or other reminders from the environment can keep this sickness response going long after it should have stopped.

Immune System

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Characteristics of patients with persistent severe disability and medically unexplained neurological symptoms: a pilot study.

Allanson, J, Bass, C, Wade, D T·Journal of neurology, neurosurgery, and psychiatry·2002

This study looked at 25 patients with severe disability and neurological symptoms that doctors couldn't explain with standard tests. Most patients were in wheelchairs and very limited in daily activities, though they had been given different diagnoses—some psychiatric, some neurological. The researchers found that many of these patients had experienced trauma, had received psychiatric treatment, or had switched from self-harm to physical disability around the same time.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The intelligent body and its discontents.

Hyland, Michael E·Journal of health psychology·2002

This paper proposes that the whole body—not just the brain—can learn and process information like a complex computer system. When this body-wide system malfunctions, it can create widespread health problems distributed throughout the body rather than in one location. The authors suggest ME/CFS is an example of this type of whole-body dysfunction and may require different treatment approaches than traditional medicine typically offers.

E3 PreliminaryCommentaryPEM unclearEditorial

Environmental factors in medically unexplained symptoms and related syndromes: the evidence and the challenge.

Kipen, Howard M, Fiedler, Nancy·Environmental health perspectives·2002

This paper discusses how many patients experience symptoms that doctors cannot easily explain, and how these symptoms sometimes get organized into syndrome names like chronic fatigue syndrome. The authors note that these syndromes are defined only by how patients feel, not by medical tests, and that arguments continue about whether environmental factors cause them. They call for better research and clearer definitions to help both doctors and patients understand these conditions.

Diagnostics

E3 PreliminaryCohortPEM unclearCross-Sectional

Women's experiences of stigma in relation to chronic fatigue syndrome and fibromyalgia.

Asbring, Pia, Närvänen, Anna-Liisa·Qualitative health research·2002

This study interviewed 25 women with ME/CFS or fibromyalgia about their experiences with stigma—being doubted, judged, or not taken seriously. Women reported that stigma was most common before they received a diagnosis, and that having many different symptoms made it harder for others to believe they were truly ill. People sometimes questioned whether the illnesses were real or blamed them on emotional problems rather than physical causes.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: evaluation and treatment.

Craig, Timothy, Kakumanu, Sujani·American family physician·2002

ME/CFS is a serious condition marked by extreme tiredness that doesn't go away, along with muscle pain, swollen lymph nodes, and feeling worse after physical activity. Doctors diagnose it mainly by ruling out other illnesses, since there's no single blood test or physical sign that definitively confirms it. Treatment is personalized and may include exercise, sleep improvements, diet changes, and medications like antidepressants.

Post-Exertional Malaise

E3 PreliminaryBehavioralPEM not requiredCase-Control

Chronic fatigue syndrome and eating disorders: concurrence or coincidence?

Fisher, Martin, Krilov, Leonard R, Ovadia, Marc·International journal of adolescent medicine and health·2002

This study looked at four adolescent patients who had both an eating disorder and ME/CFS at the same time. In all four cases, the eating disorder appeared first, followed later by ME/CFS symptoms. The authors explored whether these two conditions might be related through common causes, whether an eating disorder could trigger ME/CFS, or whether they simply occurred together by chance.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Generation of classification criteria for chronic fatigue syndrome using an artificial neural network and traditional criteria set.

Linder, R, Dinser, R, Wagner, M et al.·In vivo (Athens, Greece)·2002

Researchers tested whether a computer program called an artificial neural network could help doctors better identify ME/CFS by looking at patient symptoms and comparing them to two other conditions that also cause fatigue: lupus and fibromyalgia. The computer program was very accurate—correctly identifying ME/CFS about 95% of the time—and worked better than traditional statistical methods for creating diagnostic rules.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Role of fatigue in limiting physical activities in humans with neuromuscular diseases.

Miller, Robert G·American journal of physical medicine & rehabilitation·2002

Fatigue in people with muscle and nerve diseases works differently than tiredness in healthy people, and scientists are now developing better tools to measure it. This paper reviews what we know about two types of fatigue: one that comes from the brain and nervous system (central fatigue) and one that comes from the muscles themselves (peripheral fatigue). The authors explain how these different types of fatigue affect people with conditions like ME/CFS, post-polio syndrome, and other neuromuscular diseases.

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Distinguishing Mars from Venus: emergence of gender biology differences in oral health and systemic disease.

The case definition of chronic fatigue syndrome.

Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome.

Chronic fatigue syndrome. Symptom relief is primary goal.

Brain regions involved in fatigue sensation: reduced acetylcarnitine uptake into the brain.

Intravenous nutrient therapy: the "Myers' cocktail".

An interdisciplinary therapeutic approach for dealing with patients attributing chronic fatigue and functional memory disorders to environmental poisoning--a pilot study.

Psychiatric management of severe somatoform disorders in childhood and adolescence.

Chronic fatigue syndrome in the psychiatric practice.

Role of antioxidants in chronic fatigue syndrome in mice.

Somatization, sensitization, and functional dyspepsia.

Theoretical accounts of Gulf War Syndrome: from environmental toxins to psychoneuroimmunology and neurodegeneration.

Characteristics of patients with persistent severe disability and medically unexplained neurological symptoms: a pilot study.

The intelligent body and its discontents.

Environmental factors in medically unexplained symptoms and related syndromes: the evidence and the challenge.

Women's experiences of stigma in relation to chronic fatigue syndrome and fibromyalgia.

Chronic fatigue syndrome: evaluation and treatment.

Chronic fatigue syndrome and eating disorders: concurrence or coincidence?

Generation of classification criteria for chronic fatigue syndrome using an artificial neural network and traditional criteria set.

Role of fatigue in limiting physical activities in humans with neuromuscular diseases.

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