ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1841–1860 of 2,420 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome: the point of view of the internist].

Cogan, E·Revue medicale de Bruxelles·2002

This review examines how doctors approach patients with chronic fatigue. The authors note that most chronic fatigue cases stem from psychiatric conditions like depression and anxiety. A small group of patients have ME/CFS, which involves fatigue, mood and thinking problems, and various other physical symptoms—but doctors still don't know what causes it. Current treatments with limited evidence include antidepressants, talk therapy, and graded exercise programs.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Theoretical accounts of Gulf War Syndrome: from environmental toxins to psychoneuroimmunology and neurodegeneration.

Ferguson, E, Cassaday, H J·Behavioural neurology·2002

This paper suggests that the confusing mix of symptoms seen in Gulf War Syndrome and chronic fatigue syndrome may actually be one condition caused by inflammation in the body rather than separate diseases. The authors propose that inflammatory molecules called cytokines trigger a 'sickness response' similar to what happens when you have the flu, and that smells or other reminders from the environment can keep this sickness response going long after it should have stopped.

Immune System

E3 PreliminaryBehavioralPEM not requiredLongitudinal

An interdisciplinary therapeutic approach for dealing with patients attributing chronic fatigue and functional memory disorders to environmental poisoning--a pilot study.

Lacour, Michael, Zunder, Thomas, Dettenkofer, Markus et al.·International journal of hygiene and environmental health·2002

This study looked at whether a combination treatment approach—including self-help programs, acupuncture, and group counseling—could help 8 patients with ME/CFS or memory problems who believed their illness was caused by environmental exposure. Though patients were initially reluctant about psychological support, most became willing to try it during the study. After 8 months of treatment, patients reported improvements in quality of life, particularly in mental health, social function, and energy levels.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulation.

Gaab, Jens, Hüster, Dominik, Peisen, Renate et al.·Psychosomatic medicine·2002

This study looked at how the stress-response system (a hormone system in the brain called the HPA axis) works in ME/CFS patients compared to healthy people. Researchers exposed both groups to different types of stress—mental stress, exercise, and a hormone test—and measured how their bodies responded. ME/CFS patients showed lower levels of a stress hormone called ACTH at baseline and during stress tests, but their cortisol levels were mostly normal, suggesting their stress system works differently rather than being broken.

Post-Exertional Malaise

E3 PreliminaryCommentaryPEM unclearEditorial

Chronopathological forms of magnesium depletion with hypofunction or with hyperfunction of the biological clock.

Durlach, J, Pagès, N, Bac, P et al.·Magnesium research·2002

This paper suggests that low magnesium levels may disrupt the body's internal clock (circadian rhythm) in two opposite ways. In one pattern, the clock runs too fast, causing depression, nighttime headaches, and fatigue—similar to symptoms in ME/CFS and fibromyalgia. In the other pattern, the clock runs too slow, causing anxiety, migraines, and sleep problems. The authors propose that measuring melatonin levels could help distinguish between these two patterns and guide treatment.

Sleep

E3 PreliminaryBehavioralPEM not requiredObservational

From a lived body to a medicalized body: diagnostic transformation and chronic fatigue syndrome.

Sachs, L·Medical anthropology·2001

This study explored how receiving a CFS diagnosis affects people's lives and sense of self. Researchers interviewed 21 people with CFS to understand how they experience being diagnosed with an illness that doesn't show up on standard medical tests. The study found that a diagnosis can be both helpful and complicated—it validates that suffering is real, but it can also change how people see themselves and their future.

E3 PreliminaryMechanismPEM unclearCross-Sectional

Delayed-type hypersensitivity and chronic fatigue syndrome: the usefulness of assessing T-cell activation by flow cytometry--preliminary study.

Brunet, J L, Liaudet, A P, Later, R et al.·Allergie et immunologie·2001

This small study looked at whether people with ME/CFS have exaggerated immune reactions to common substances like yeast (Candida). Researchers tested this by applying yeast extract under the skin and watching for delayed reactions, then measuring immune cell activity in blood samples. About half of the ME/CFS patients showed these exaggerated reactions, suggesting the immune system may be responding unusually to everyday germs.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Chiari I malformation as a cause of orthostatic intolerance symptoms: a media myth?

Garland, E M, Robertson, D·The American journal of medicine·2001

Some people with ME/CFS and fibromyalgia have heard that a brain condition called Chiari I malformation might be causing their symptoms, especially dizziness and fainting when standing up. This editorial reviews whether that claim is actually supported by scientific research and concludes that there is very little reliable evidence backing up this connection, despite media coverage and patient discussions online.

Autonomic Nervous System

E3 PreliminaryCohortPEM unclear

Recovery from chronic fatigue syndrome associated with changes in neuroendocrine function.

Sharma, A, Oyebode, F, Kendall, M J et al.·Journal of the Royal Society of Medicine·2001

This study looked at whether people who recovered from ME/CFS showed changes in their body's hormone and nervous system function compared to those still sick and healthy controls. The researchers examined whether normalizing these biological systems was connected to getting better from the illness.

Endocrine Disruption

E3 PreliminaryTrialPEM not requiredRCT

Impact of cortisol on buspirone stimulated prolactin release: a double-blind placebo-controlled study.

Dinan, T G, Scott, L V, Thakore, J et al.·Psychoneuroendocrinology·2001

This study tested whether a drug called buspirone can trigger the release of a hormone called prolactin, and whether a person's baseline stress hormone (cortisol) level affects this response. Fifty healthy volunteers received either buspirone or placebo in a blinded trial. The researchers found that buspirone did increase prolactin levels, and importantly, people with higher baseline cortisol levels showed a stronger prolactin response.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Problems of chronic fatigue].

Kovaleva, A I, Pyshnov, G Iu·Meditsina truda i promyshlennaia ekologiia·2001

This review examines chronic fatigue syndrome and related conditions like burnout and caroshi (a Japanese term for work-related exhaustion), looking at them as forms of extreme tiredness. The authors suggest these conditions may be linked to workplace stress and occupational demands. The paper considers what these different conditions have in common and how they develop.

E3 PreliminaryCohortPEM unclearObservational

Doing things with illness. The micro politics of the CFS clinic.

Banks, J, Prior, L·Social science & medicine (1982)·2001

This study observed conversations between ME/CFS patients and doctors in a UK clinic to understand how they think about the condition differently. Patients and doctors often disagreed about whether ME/CFS is a disease of the body or the mind, and these disagreements shaped how treatment was discussed. The researchers found that these conversations were really about who gets to decide what ME/CFS actually is.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[Stress-related syndromes--contemporary illnesses].

Anderberg, U M·Lakartidningen·2001

This review article examines stress-related conditions including chronic fatigue syndrome (CFS), burnout, and fibromyalgia, suggesting they may be different ways the body reacts to extreme stress. The authors note that family problems and work stress are major risk factors for developing these illnesses, and that these conditions may sometimes be early warning signs of more serious diseases like heart problems.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: neurological findings may be related to blood--brain barrier permeability.

Bested, A C, Saunders, P R, Logan, A C·Medical hypotheses·2001

This study proposes that ME/CFS symptoms may be caused by a breakdown in the blood-brain barrier (BBB), a protective layer that normally keeps harmful substances out of the brain. The researchers reviewed scientific literature to identify factors that could damage this barrier in ME/CFS patients, including viral infections, stress, and certain chemical imbalances. They suggest that if this protective barrier becomes leaky, it could allow harmful substances into the brain and disrupt normal nerve function, potentially explaining many ME/CFS symptoms.

Neuroinflammation

E3 PreliminaryReviewPEM not requiredReview-Narrative

The role of gender in fibromyalgia syndrome.

Yunus, M B·Current rheumatology reports·2001

This review examined why fibromyalgia syndrome (FMS) affects far more women than men—about 9 women for every 1 man. Researchers found that women with FMS tend to experience more fatigue, more tender points throughout their body, and more associated symptoms like irritable bowel syndrome compared to men. Interestingly, the severity of pain and depression levels were similar between men and women, suggesting gender differences involve complex interactions between biology, psychology, and social factors.

E3 PreliminaryPEM unclear

Narrative Identities and the Management of Personal Accountability in Talk about ME: A Discursive Psychology Approach to Illness Narrative.

Horton-Salway, M·Journal of health psychology·2001

This study examined how people with ME/CFS talk about their illness and explain what caused it. Researchers found that patients often describe working too hard before getting sick, but in doing so, they unintentionally suggest they might have caused their own illness—even while trying to prove ME is a real physical disease. The study shows how the words people choose and stories they tell can have complicated effects on how others understand their condition.

E3 PreliminaryPEM not required

Chronic fatigue syndrome in horses: diagnosis and treatment of 4 cases.

Tarello, W·Comparative immunology, microbiology and infectious diseases·2001

This study describes four horses that had symptoms similar to chronic fatigue syndrome in humans—severe tiredness and other health problems that didn't improve with standard treatments. The veterinarian treated them with a low dose of an arsenic-based medication given intravenously, and all four horses showed complete improvement in their fatigue and symptoms. The horses also recovered from anemia and showed other positive blood changes after treatment.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome].

Miike, T·Nihon rinsho. Japanese journal of clinical medicine·2001

This is a review article that examines what is known about chronic fatigue syndrome (ME/CFS). Rather than presenting new research data, the authors summarize existing knowledge about the condition, including its characteristics, how it affects patients, and what is understood about its causes. This type of article helps bring together information from many different studies to provide a comprehensive overview of the disease.

E3 PreliminaryReviewPEM unclearReview-Narrative

Can fibromyalgia and chronic fatigue syndrome be cured by surgery?

Wilke, W S·Cleveland Clinic journal of medicine·2001

This review article examines whether surgery can cure fibromyalgia and chronic fatigue syndrome (ME/CFS). The author concludes that surgery is not an effective treatment for these conditions. This is important because some patients and providers have explored surgical approaches, but the evidence does not support this as a cure.

Diagnostics

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic Fatigue Syndrome (CFS) in 15 dogs and cats with specific biochemical and microbiological anomalies.

Tarello, W·Comparative immunology, microbiology and infectious diseases·2001

This study looked at 15 dogs and cats that had fatigue symptoms similar to ME/CFS and tested their blood for bacterial infections. Nine out of 15 animals had a type of bacteria called Staphylococcus in their blood. When these animals were treated with an antibiotic drug, all of them got completely better and the bacteria disappeared from their blood.

Biomarkers

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Evidence browser

[Chronic fatigue syndrome: the point of view of the internist].

Theoretical accounts of Gulf War Syndrome: from environmental toxins to psychoneuroimmunology and neurodegeneration.

An interdisciplinary therapeutic approach for dealing with patients attributing chronic fatigue and functional memory disorders to environmental poisoning--a pilot study.

Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulation.

Chronopathological forms of magnesium depletion with hypofunction or with hyperfunction of the biological clock.

From a lived body to a medicalized body: diagnostic transformation and chronic fatigue syndrome.

Delayed-type hypersensitivity and chronic fatigue syndrome: the usefulness of assessing T-cell activation by flow cytometry--preliminary study.

Chiari I malformation as a cause of orthostatic intolerance symptoms: a media myth?

Recovery from chronic fatigue syndrome associated with changes in neuroendocrine function.

Impact of cortisol on buspirone stimulated prolactin release: a double-blind placebo-controlled study.

[Problems of chronic fatigue].

Doing things with illness. The micro politics of the CFS clinic.

[Stress-related syndromes--contemporary illnesses].

Chronic fatigue syndrome: neurological findings may be related to blood--brain barrier permeability.

The role of gender in fibromyalgia syndrome.

Narrative Identities and the Management of Personal Accountability in Talk about ME: A Discursive Psychology Approach to Illness Narrative.

Chronic fatigue syndrome in horses: diagnosis and treatment of 4 cases.

[Chronic fatigue syndrome].

Can fibromyalgia and chronic fatigue syndrome be cured by surgery?

Chronic Fatigue Syndrome (CFS) in 15 dogs and cats with specific biochemical and microbiological anomalies.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

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