ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1841–1860 of 2,423 studies

E3 PreliminaryMechanismPEM not requiredCase-Control

Using an interleukin-6 challenge to evaluate neuropsychological performance in chronic fatigue syndrome.

Arnold, M C, Papanicolaou, D A, O'Grady, J A et al.·Psychological medicine·2002

Researchers gave ME/CFS patients and healthy people a substance called interleukin-6 to temporarily trigger flu-like symptoms. They then tested how well both groups could think and remember during this induced illness. ME/CFS patients reported more overall sickness symptoms, but surprisingly, both groups performed equally well on memory and thinking tests, suggesting that the temporary immune activation didn't impair cognitive abilities in either group.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue: introduction].

Ducobu, J·Revue medicale de Bruxelles·2002

This review article explains that chronic fatigue is very common in general medical practice. Doctors need to first rule out other medical conditions that cause tiredness, then look for psychological factors and chronic fatigue syndrome (CFS). The key message is that careful clinical evaluation by a doctor is more important than ordering many laboratory tests to figure out what's causing someone's fatigue.

Diagnostics

E3 PreliminaryBehavioralPEM not requiredCase-Control

Homeopathic treatment of Chronic Fatigue Syndrome: three case studies using Jan Scholten's methodology.

Geraghty, J·Homeopathy : the journal of the Faculty of Homeopathy·2002

This study looked at three young people with ME/CFS that developed after a viral infection, and tried treating them with homeopathic remedies based on a specific system of selecting remedies. The researchers describe how they chose three different phosphate-based homeopathic medicines and claim that patients experienced improvement, though the study is very small and doesn't use a comparison group.

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

The role of fear of physical movement and activity in chronic fatigue syndrome.

Silver, A, Haeney, M, Vijayadurai, P et al.·Journal of psychosomatic research·2002

This study looked at whether fear of movement and activity contributes to people with ME/CFS avoiding exercise. Researchers created a questionnaire to measure this fear and asked patients to ride an exercise bike as long as they could. They found that people's beliefs about whether activity was dangerous predicted how much they exercised, even when other factors like tiredness and heart rate did not.

E3 PreliminaryReviewPEM unclearReview-Narrative

Quality of life issues in patients with essential thrombocythemia and polycythemia vera.

Hoffman, Ronald·Seminars in oncology·2002

This article discusses how doctors should measure quality of life in patients with two rare blood disorders (essential thrombocythemia and polycythemia vera). The author explains that while treatments can control blood cell production and prevent some serious complications, they often cause side effects. The article suggests that doctors should use quality-of-life questionnaires to better understand whether treatments are truly helping patients feel better overall.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Gender differences in fibromyalgia and other related syndromes.

Yunus, Muhammad B·The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia·2002

This review looked at why fibromyalgia and similar conditions like chronic fatigue syndrome affect many more women than men. Women with fibromyalgia tend to report more fatigue, worse sleep, more widespread pain, and more tender points than men. The reasons for these differences likely involve a mix of biological factors, psychological factors, and social factors.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredMechanistic

Role of antioxidants in chronic fatigue syndrome in mice.

Singh, Amanpreet, Garg, Vivek, Gupta, Saraswati et al.·Indian journal of experimental biology·2002

This mouse study tested whether antioxidants—substances that protect cells from damage—might help with fatigue and despair-like behaviors. Researchers gave mice different treatments including antioxidant drugs (carvedilol and melatonin) and herbal products (St. John's Wort and GS-02), and found that these treatments reduced despair-like behavior and restored protective chemicals in the brain that were depleted by stress.

E3 PreliminaryMechanismPEM not requiredMechanistic

Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome.

Singh, Amanpreet, Naidu, Pattipati S, Gupta, Saraswati et al.·Journal of medicinal food·2002

This study tested whether antioxidants—substances that reduce cellular damage—could help with fatigue in mice. Researchers used a mouse model of ME/CFS by making mice swim repeatedly, which increased their fatigue-like behavior. Both natural antioxidants (like melatonin and herbal supplements) and synthetic ones reduced this fatigue behavior and restored protective chemicals in the brain.

E3 PreliminaryMechanismPEM not requiredMechanistic

Detection of immunologically significant factors for chronic fatigue syndrome using neural-network classifiers.

Hanson, S J, Gause, W, Natelson, B·Clinical and diagnostic laboratory immunology·2001

Researchers used advanced computer analysis to find immune system differences in ME/CFS patients that traditional statistical methods had missed. They discovered that ME/CFS patients have lower levels of certain immune cells and higher levels of a chemical messenger called interleukin-4, suggesting their immune system may be stuck in a particular type of response pattern.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Cytokines and chronic fatigue syndrome.

Patarca, R·Annals of the New York Academy of Sciences·2001

This study found that people with ME/CFS show signs of immune system activation (more active immune cells and elevated immune signaling molecules), yet paradoxically have weak immune function (poor natural killer cell activity and weak responses to infections). The immune system appears to be stuck in an imbalanced state, favoring certain types of inflammatory responses, which may relate to symptom cycles of improvement and worsening.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fatigue in primary care.

Morrison, R E, Keating, H J·Obstetrics and gynecology clinics of North America·2001

Fatigue is very common and can have many different causes. Doctors can usually figure out what's causing someone's tiredness through a careful conversation, physical exam, and a few blood tests. In rare cases, people have extreme fatigue lasting 6 months or longer that doesn't have an obvious cause—this may be chronic fatigue syndrome (ME/CFS).

Diagnostics

E3 PreliminaryBehavioralPEM not requiredCase-Control

Treatment of chronic fatigue with neurofeedback and self-hypnosis.

Hammond, D C·NeuroRehabilitation·2001

This study describes one young woman with ME/CFS whose main problem was brain fog and difficulty thinking clearly. Doctors found an abnormal brain wave pattern on her EEG scan and treated her with two techniques: neurofeedback (training to change brain wave patterns) and self-hypnosis. She felt significantly better, with improvements in fatigue and mental clarity that lasted for at least 9 months.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: oxidative stress and dietary modifications.

Logan, A C, Wong, C·Alternative medicine review : a journal of clinical therapeutic·2001

This review examines how oxidative stress—damage caused by harmful molecules in the body—may contribute to ME/CFS symptoms. The authors suggest that certain dietary supplements with antioxidant properties, such as glutathione and alpha-lipoic acid, might help reduce this damage. They also discuss how food intolerances and undiagnosed celiac disease could play a role in ME/CFS, even when digestive symptoms are absent.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Attitudes regarding chronic fatigue syndrome: the importance of a name.

Jason, L A, Taylor, R R, Stepanek, Z et al.·Journal of health psychology·2001

This study found that what doctors and students call ME/CFS affects how they think about the condition. When it was called "myalgic encephalopathy," people were more likely to believe it had a physical cause in the body. The name used also influenced whether healthcare workers thought patients were truly ill or just depressed. This suggests that even the language we use to describe ME/CFS can shape people's beliefs about how serious it is and how it should be treated.

E3 PreliminaryCommentaryPEM unclearEditorial

Potential mechanisms in chemical intolerance and related conditions.

Clauw, D J·Annals of the New York Academy of Sciences·2001

Many people with ME/CFS, fibromyalgia, and related conditions experience chemical intolerance alongside other symptoms like pain and fatigue. This study reviews research suggesting that these conditions share common biological problems, particularly in how the nervous system processes sensory information—making everyday smells, sounds, or lights feel unusually unpleasant or overwhelming. While stress and worry can sometimes make symptoms worse, the evidence shows that physical changes in the body's sensory processing are doing much of the heavy lifting in causing symptoms.

Autonomic Nervous System

E3 PreliminaryBehavioralPEM not requiredObservational

From a lived body to a medicalized body: diagnostic transformation and chronic fatigue syndrome.

Sachs, L·Medical anthropology·2001

This study explored how receiving a CFS diagnosis affects people's lives and sense of self. Researchers interviewed 21 people with CFS to understand how they experience being diagnosed with an illness that doesn't show up on standard medical tests. The study found that a diagnosis can be both helpful and complicated—it validates that suffering is real, but it can also change how people see themselves and their future.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neural control of force output during maximal and submaximal exercise.

St Clair Gibson, A, Lambert, M L, Noakes, T D·Sports medicine (Auckland, N.Z.)·2001

This review challenges the common belief that muscle fatigue during exercise comes only from chemical changes in muscles themselves. Instead, the authors propose that the brain and nervous system actively control and limit how hard we can exercise to protect our bodies from damage. Interestingly, they note that people with ME/CFS experience fatigue even at rest, suggesting fatigue may be a protective signal from the nervous system rather than a simple muscle problem.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Increased sensitivity to glucocorticoids in peripheral blood mononuclear cells of chronic fatigue syndrome patients, without evidence for altered density or affinity of glucocorticoid receptors.

Visser, J, Lentjes, E, Haspels, I et al.·Journal of investigative medicine : the official publication of the American Federation for Clinical Research·2001

Researchers found that immune cells from ME/CFS patients react more strongly to a stress hormone called dexamethasone (a type of glucocorticoid) than cells from healthy people. However, the cells have the same number of receptors for this hormone and bind it with the same strength, suggesting the heightened sensitivity comes from something happening inside the cells after the hormone attaches, rather than from problems with the receptors themselves.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Anti-nuclear envelope antibodies: Clinical associations.

Nesher, G, Margalit, R, Ashkenazi, Y J·Seminars in arthritis and rheumatism·2001

This study looked at antibodies (immune proteins) that attack the nuclear envelope, the protective membrane around cell nuclei. Researchers found that different types of these antibodies are associated with different diseases, and preliminary findings suggest they may help diagnose ME/CFS. The study suggests that testing for these antibodies could help doctors identify certain autoimmune conditions.

Immune System

E3 PreliminaryMechanismPEM not requiredCase-Control

Corticospinal inhibition appears normal in patients with chronic fatigue syndrome.

Zaman, R, Puri, B K, Main, J et al.·Experimental physiology·2001

This study used a brain stimulation technique called TMS to test whether the motor control systems in ME/CFS patients work differently than in healthy people. Researchers found that the brain's ability to inhibit (turn off) muscle activity was normal in ME/CFS patients, even though these patients moved more slowly and took longer to react to simple tasks. This suggests that the fatigue and slowness experienced in ME/CFS may not be caused by problems in how the brain controls muscles.

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Using an interleukin-6 challenge to evaluate neuropsychological performance in chronic fatigue syndrome.

[Chronic fatigue: introduction].

Homeopathic treatment of Chronic Fatigue Syndrome: three case studies using Jan Scholten's methodology.

The role of fear of physical movement and activity in chronic fatigue syndrome.

Quality of life issues in patients with essential thrombocythemia and polycythemia vera.

Gender differences in fibromyalgia and other related syndromes.

Role of antioxidants in chronic fatigue syndrome in mice.

Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome.

Detection of immunologically significant factors for chronic fatigue syndrome using neural-network classifiers.

Cytokines and chronic fatigue syndrome.

Fatigue in primary care.

Treatment of chronic fatigue with neurofeedback and self-hypnosis.

Chronic fatigue syndrome: oxidative stress and dietary modifications.

Attitudes regarding chronic fatigue syndrome: the importance of a name.

Potential mechanisms in chemical intolerance and related conditions.

From a lived body to a medicalized body: diagnostic transformation and chronic fatigue syndrome.

Neural control of force output during maximal and submaximal exercise.

Increased sensitivity to glucocorticoids in peripheral blood mononuclear cells of chronic fatigue syndrome patients, without evidence for altered density or affinity of glucocorticoid receptors.

Anti-nuclear envelope antibodies: Clinical associations.

Corticospinal inhibition appears normal in patients with chronic fatigue syndrome.

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