ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1841–1860 of 2,422 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

A computational analysis of Canale-Smith syndrome: chronic lymphadenopathy simulating malignant lymphoma.

Krueger, Gerhard R F, Brandt, Michael E, Wang, Guanyu et al.·Anticancer research·2002

Researchers used a computer model to simulate how the immune system changes when infected with a virus called HHV-6. They found that a chronic (long-lasting) simulated infection produced immune cell patterns similar to what is seen in ME/CFS patients, suggesting that persistent viral infection might be connected to the disease.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome: psychiatric perspectives].

Youssefi, M, Linkowski, P·Revue medicale de Bruxelles·2002

This review examines ME/CFS from a psychiatric perspective, looking at how mental health symptoms often occur alongside the physical illness. Many people with ME/CFS also experience depression, anxiety, or other mood problems, though it's unclear whether these conditions cause ME/CFS or develop because of living with a serious chronic illness. The authors discuss treatments that have shown promise, including talking therapy, exercise programs, and antidepressants when appropriate, while emphasizing that a supportive doctor-patient relationship is essential.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chiari type I malformation: overview of diagnosis and treatment.

Nash, John, Cheng, Joseph S, Meyer, Glenn A et al.·WMJ : official publication of the State Medical Society of Wisconsin·2002

Chiari Type I malformation is a condition where brain tissue extends into the spinal canal, potentially causing compression and various neurological symptoms. This review explains how doctors diagnose it using MRI imaging and discusses treatment options. The authors note that Chiari I symptoms can overlap significantly with ME/CFS and fibromyalgia, making diagnosis challenging, and they highlight controversy around whether surgery is appropriate for patients with these overlapping conditions.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome.

Singh, Amanpreet, Naidu, Pattipati S, Gupta, Saraswati et al.·Journal of medicinal food·2002

This study tested whether antioxidants—substances that reduce cellular damage—could help with fatigue in mice. Researchers used a mouse model of ME/CFS by making mice swim repeatedly, which increased their fatigue-like behavior. Both natural antioxidants (like melatonin and herbal supplements) and synthetic ones reduced this fatigue behavior and restored protective chemicals in the brain.

E3 PreliminaryMechanismPEM not requiredCase-Control

Using an interleukin-6 challenge to evaluate neuropsychological performance in chronic fatigue syndrome.

Arnold, M C, Papanicolaou, D A, O'Grady, J A et al.·Psychological medicine·2002

Researchers gave ME/CFS patients and healthy people a substance called interleukin-6 to temporarily trigger flu-like symptoms. They then tested how well both groups could think and remember during this induced illness. ME/CFS patients reported more overall sickness symptoms, but surprisingly, both groups performed equally well on memory and thinking tests, suggesting that the temporary immune activation didn't impair cognitive abilities in either group.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Update on chronic fatigue syndrome and Epstein-Barr virus.

Katz, Ben Z·Pediatric annals·2002

This editorial discusses the relationship between Epstein-Barr virus (EBV) and chronic fatigue syndrome (ME/CFS), particularly in children and teenagers. The author reviews what is known about EBV's role in ME/CFS and updates the medical community on current understanding of this connection.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Theoretical accounts of Gulf War Syndrome: from environmental toxins to psychoneuroimmunology and neurodegeneration.

Ferguson, E, Cassaday, H J·Behavioural neurology·2002

This paper suggests that the confusing mix of symptoms seen in Gulf War Syndrome and chronic fatigue syndrome may actually be one condition caused by inflammation in the body rather than separate diseases. The authors propose that inflammatory molecules called cytokines trigger a 'sickness response' similar to what happens when you have the flu, and that smells or other reminders from the environment can keep this sickness response going long after it should have stopped.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Potential mechanisms in chemical intolerance and related conditions.

Clauw, D J·Annals of the New York Academy of Sciences·2001

Many people with ME/CFS, fibromyalgia, and related conditions experience chemical intolerance alongside other symptoms like pain and fatigue. This study reviews research suggesting that these conditions share common biological problems, particularly in how the nervous system processes sensory information—making everyday smells, sounds, or lights feel unusually unpleasant or overwhelming. While stress and worry can sometimes make symptoms worse, the evidence shows that physical changes in the body's sensory processing are doing much of the heavy lifting in causing symptoms.

Autonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Cytokine and other immunologic markers in chronic fatigue syndrome and their relation to neuropsychological factors.

Patarca-Montero, R, Antoni, M, Fletcher, M A et al.·Applied neuropsychology·2001

This study looked at immune system markers in ME/CFS patients and found that their immune cells show signs of being overactive, with abnormal patterns of immune signaling molecules called cytokines. The researchers propose that when stress and difficult emotions interact with this immune dysfunction, they can perpetuate the cycle of fatigue, cognitive problems, and other symptoms seen in ME/CFS.

Immune System

E3 PreliminaryCohortPEM unclearObservational

Doing things with illness. The micro politics of the CFS clinic.

Banks, J, Prior, L·Social science & medicine (1982)·2001

This study observed conversations between ME/CFS patients and doctors in a UK clinic to understand how they think about the condition differently. Patients and doctors often disagreed about whether ME/CFS is a disease of the body or the mind, and these disagreements shaped how treatment was discussed. The researchers found that these conversations were really about who gets to decide what ME/CFS actually is.

Diagnostics

E3 PreliminaryCommentaryPEM not requiredEditorial

[Fatigue].

Reinhart, W H, Fleisch, F·Praxis·2001

Fatigue is a very common symptom that doctors see in many patients. This editorial discusses how doctors should evaluate someone with fatigue by taking a careful history, doing a physical exam, and ordering appropriate tests. When other diseases are ruled out, chronic fatigue syndrome may be diagnosed, though its causes remain unknown. The most proven treatments are graded exercise, cognitive behavioral therapy, and antidepressants if depression or anxiety are present.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Problems of chronic fatigue].

Kovaleva, A I, Pyshnov, G Iu·Meditsina truda i promyshlennaia ekologiia·2001

This review examines chronic fatigue syndrome and related conditions like burnout and caroshi (a Japanese term for work-related exhaustion), looking at them as forms of extreme tiredness. The authors suggest these conditions may be linked to workplace stress and occupational demands. The paper considers what these different conditions have in common and how they develop.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Evaluation of a recombinant line blot for diagnosis of Epstein-Barr Virus compared with ELISA, using immunofluorescence as reference method.

Gärtner, B C, Fischinger, J M, Roemer, K et al.·Journal of virological methods·2001

This study compared three different blood tests for detecting Epstein-Barr virus (EBV) infection: a newer line blot test, a standard ELISA test, and an older reference test called immunofluorescence. The researchers found that all three tests worked well at identifying new infections and past infections, but the line blot and ELISA were less reliable at detecting EBV reactivation (when the virus becomes active again in people with weakened immune systems).

E3 PreliminaryReviewPEM unclearReview-Narrative

Cognitive and mood disturbance as causes and symptoms of fatigue in cancer patients.

Valentine, A D, Meyers, C A·Cancer·2001

This review discusses how fatigue, brain fog, and depression are connected in cancer patients and how they may cause or worsen each other. The authors suggest that understanding these connections might help doctors develop better, more personalized treatments that address the specific needs of each patient.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredMechanistic

Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension.

Torpy, D J, Bachmann, A W, Grice, J E et al.·The Journal of clinical endocrinology and metabolism·2001

This study examined a family with a genetic mutation affecting a protein called corticosteroid-binding globulin (CBG), which helps transport the stress hormone cortisol in the blood. People with this mutation had unusually low blood pressure and chronic fatigue—in fact, 86% of affected adults met criteria for chronic fatigue syndrome. The findings suggest that problems with how the body handles cortisol may contribute to fatigue disorders.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredMechanistic

Decreased tryptophan availability but normal post-synaptic 5-HT2c receptor sensitivity in chronic fatigue syndrome.

Vassallo, C M, Feldman, E, Peto, T et al.·Psychological medicine·2001

This study examined whether people with ME/CFS have oversensitive serotonin receptors in the brain, which could explain some of their symptoms. Researchers gave patients and healthy people a drug that directly activates serotonin receptors and measured the response. They found that both groups responded similarly, suggesting the problem in ME/CFS is not overly sensitive receptors but rather increased serotonin activity from nerve cells themselves. Interestingly, people with ME/CFS had lower levels of tryptophan (a building block for serotonin) in their blood.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions.

Mullington, J M, Hinze-Selch, D, Pollmächer, T·Annals of the New York Academy of Sciences·2001

This study explores how the body's immune system and sleep are connected, and how this connection might explain the severe fatigue in ME/CFS. Researchers found that when the immune system is activated, it releases chemical messengers called cytokines that can affect sleep quality and cause fatigue. The study suggests that abnormal levels of these immune chemicals in ME/CFS patients could be responsible for the debilitating tiredness that characterizes the condition.

Immune System

E3 PreliminaryBehavioralPEM not requiredObservational

From a lived body to a medicalized body: diagnostic transformation and chronic fatigue syndrome.

Sachs, L·Medical anthropology·2001

This study explored how receiving a CFS diagnosis affects people's lives and sense of self. Researchers interviewed 21 people with CFS to understand how they experience being diagnosed with an illness that doesn't show up on standard medical tests. The study found that a diagnosis can be both helpful and complicated—it validates that suffering is real, but it can also change how people see themselves and their future.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Psychoneuroendocrinological contributions to the etiology of depression, posttraumatic stress disorder, and stress-related bodily disorders: the role of the hypothalamus-pituitary-adrenal axis.

Ehlert, U, Gaab, J, Heinrichs, M·Biological psychology·2001

This study examines how stress affects hormone levels in the body, particularly through a system called the HPA axis that controls the release of cortisol and other stress hormones. The researchers found that people with depression tend to have too much HPA activity, while people with chronic fatigue syndrome and post-traumatic stress disorder tend to have too little. Understanding these differences may help doctors better diagnose and treat these conditions.

Endocrine Disruption

E3 PreliminaryCohortPEM not requiredCross-Sectional

Assessing attitudes toward new names for chronic fatigue syndrome.

Jason, L A, Eisele, H, Taylor, R R·Evaluation & the health professions·2001

Researchers asked 432 people with ME/CFS and medical professionals what they thought about changing the disease's name from 'chronic fatigue syndrome.' Most people surveyed (86%) agreed a name change was needed, with patients being more supportive than doctors. However, people disagreed about what the new name should be—some preferred 'myalgic encephalopathy' while others favored 'neuro-endocrine immune disorder,' and very few people liked both options equally.

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A computational analysis of Canale-Smith syndrome: chronic lymphadenopathy simulating malignant lymphoma.

[Chronic fatigue syndrome: psychiatric perspectives].

Chiari type I malformation: overview of diagnosis and treatment.

Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome.

Using an interleukin-6 challenge to evaluate neuropsychological performance in chronic fatigue syndrome.

Update on chronic fatigue syndrome and Epstein-Barr virus.

Theoretical accounts of Gulf War Syndrome: from environmental toxins to psychoneuroimmunology and neurodegeneration.

Potential mechanisms in chemical intolerance and related conditions.

Cytokine and other immunologic markers in chronic fatigue syndrome and their relation to neuropsychological factors.

Doing things with illness. The micro politics of the CFS clinic.

[Fatigue].

[Problems of chronic fatigue].

Evaluation of a recombinant line blot for diagnosis of Epstein-Barr Virus compared with ELISA, using immunofluorescence as reference method.

Cognitive and mood disturbance as causes and symptoms of fatigue in cancer patients.

Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension.

Decreased tryptophan availability but normal post-synaptic 5-HT2c receptor sensitivity in chronic fatigue syndrome.

Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions.

From a lived body to a medicalized body: diagnostic transformation and chronic fatigue syndrome.

Psychoneuroendocrinological contributions to the etiology of depression, posttraumatic stress disorder, and stress-related bodily disorders: the role of the hypothalamus-pituitary-adrenal axis.

Assessing attitudes toward new names for chronic fatigue syndrome.

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