ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1861–1880 of 2,420 studies

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Evaluation of a recombinant line blot for diagnosis of Epstein-Barr Virus compared with ELISA, using immunofluorescence as reference method.

Gärtner, B C, Fischinger, J M, Roemer, K et al.·Journal of virological methods·2001

This study compared three different blood tests for detecting Epstein-Barr virus (EBV) infection: a newer line blot test, a standard ELISA test, and an older reference test called immunofluorescence. The researchers found that all three tests worked well at identifying new infections and past infections, but the line blot and ELISA were less reliable at detecting EBV reactivation (when the virus becomes active again in people with weakened immune systems).

E3 PreliminaryMechanismPEM not requiredMechanistic

Detection of immunologically significant factors for chronic fatigue syndrome using neural-network classifiers.

Hanson, S J, Gause, W, Natelson, B·Clinical and diagnostic laboratory immunology·2001

Researchers used advanced computer analysis to find immune system differences in ME/CFS patients that traditional statistical methods had missed. They discovered that ME/CFS patients have lower levels of certain immune cells and higher levels of a chemical messenger called interleukin-4, suggesting their immune system may be stuck in a particular type of response pattern.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic Fatigue Syndrome (CFS) in 15 dogs and cats with specific biochemical and microbiological anomalies.

Tarello, W·Comparative immunology, microbiology and infectious diseases·2001

This study looked at 15 dogs and cats that had fatigue symptoms similar to ME/CFS and tested their blood for bacterial infections. Nine out of 15 animals had a type of bacteria called Staphylococcus in their blood. When these animals were treated with an antibiotic drug, all of them got completely better and the bacteria disappeared from their blood.

Biomarkers

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fatigue in primary care.

Morrison, R E, Keating, H J·Obstetrics and gynecology clinics of North America·2001

Fatigue is very common and can have many different causes. Doctors can usually figure out what's causing someone's tiredness through a careful conversation, physical exam, and a few blood tests. In rare cases, people have extreme fatigue lasting 6 months or longer that doesn't have an obvious cause—this may be chronic fatigue syndrome (ME/CFS).

Diagnostics

E3 PreliminaryBehavioralPEM not requiredCase-Control

Treatment of chronic fatigue with neurofeedback and self-hypnosis.

Hammond, D C·NeuroRehabilitation·2001

This study describes one young woman with ME/CFS whose main problem was brain fog and difficulty thinking clearly. Doctors found an abnormal brain wave pattern on her EEG scan and treated her with two techniques: neurofeedback (training to change brain wave patterns) and self-hypnosis. She felt significantly better, with improvements in fatigue and mental clarity that lasted for at least 9 months.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

The role of gender in fibromyalgia syndrome.

Yunus, M B·Current rheumatology reports·2001

This review examined why fibromyalgia syndrome (FMS) affects far more women than men—about 9 women for every 1 man. Researchers found that women with FMS tend to experience more fatigue, more tender points throughout their body, and more associated symptoms like irritable bowel syndrome compared to men. Interestingly, the severity of pain and depression levels were similar between men and women, suggesting gender differences involve complex interactions between biology, psychology, and social factors.

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Chronic illness -- a disruption in life: identity-transformation among women with chronic fatigue syndrome and fibromyalgia.

Asbring, P·Journal of advanced nursing·2001

This study looked at how women with ME/CFS and fibromyalgia experience major changes to their sense of self and identity after becoming ill. Researchers interviewed 25 Swedish women about how they adjusted to these illnesses, and found that while the conditions caused significant disruption to their work and social lives, many women also discovered unexpected positive aspects of their new identity as they adapted.

E3 PreliminaryCohortPEM not requiredLongitudinal

Dynamics of chronic active herpesvirus-6 infection in patients with chronic fatigue syndrome: data acquisition for computer modeling.

Krueger, G R, Koch, B, Hoffmann, A et al.·In vivo (Athens, Greece)·2001

This study followed 10 ME/CFS patients for two years to understand how a virus called HHV-6 might be involved in their illness. Researchers measured virus levels and immune cell counts in the patients' blood over time. They found that ME/CFS patients had slightly elevated virus levels and abnormal immune responses, different from what happens during acute HHV-6 infection.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Anti-nuclear envelope antibodies: Clinical associations.

Nesher, G, Margalit, R, Ashkenazi, Y J·Seminars in arthritis and rheumatism·2001

This study looked at antibodies (immune proteins) that attack the nuclear envelope, the protective membrane around cell nuclei. Researchers found that different types of these antibodies are associated with different diseases, and preliminary findings suggest they may help diagnose ME/CFS. The study suggests that testing for these antibodies could help doctors identify certain autoimmune conditions.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

Attitudes regarding chronic fatigue syndrome: the importance of a name.

Jason, L A, Taylor, R R, Stepanek, Z et al.·Journal of health psychology·2001

This study found that what doctors and students call ME/CFS affects how they think about the condition. When it was called "myalgic encephalopathy," people were more likely to believe it had a physical cause in the body. The name used also influenced whether healthcare workers thought patients were truly ill or just depressed. This suggests that even the language we use to describe ME/CFS can shape people's beliefs about how serious it is and how it should be treated.

E3 PreliminaryMechanismPEM not requiredMechanistic

Increased sensitivity to glucocorticoids in peripheral blood mononuclear cells of chronic fatigue syndrome patients, without evidence for altered density or affinity of glucocorticoid receptors.

Visser, J, Lentjes, E, Haspels, I et al.·Journal of investigative medicine : the official publication of the American Federation for Clinical Research·2001

Researchers found that immune cells from ME/CFS patients react more strongly to a stress hormone called dexamethasone (a type of glucocorticoid) than cells from healthy people. However, the cells have the same number of receptors for this hormone and bind it with the same strength, suggesting the heightened sensitivity comes from something happening inside the cells after the hormone attaches, rather than from problems with the receptors themselves.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

[Fatigue].

Reinhart, W H, Fleisch, F·Praxis·2001

Fatigue is a very common symptom that doctors see in many patients. This editorial discusses how doctors should evaluate someone with fatigue by taking a careful history, doing a physical exam, and ordering appropriate tests. When other diseases are ruled out, chronic fatigue syndrome may be diagnosed, though its causes remain unknown. The most proven treatments are graded exercise, cognitive behavioral therapy, and antidepressants if depression or anxiety are present.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

DHEA. Monograph.

Alternative medicine review : a journal of clinical therapeutic·2001

This article reviews DHEA, a hormone naturally produced by your body that decreases as you age. Research suggests that lower DHEA levels may be connected to several conditions, including ME/CFS, heart disease, diabetes, and autoimmune diseases like lupus and rheumatoid arthritis. DHEA acts as a 'buffer hormone' that can be converted into other important hormones like estrogen and testosterone.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: oxidative stress and dietary modifications.

Logan, A C, Wong, C·Alternative medicine review : a journal of clinical therapeutic·2001

This review examines how oxidative stress—damage caused by harmful molecules in the body—may contribute to ME/CFS symptoms. The authors suggest that certain dietary supplements with antioxidant properties, such as glutathione and alpha-lipoic acid, might help reduce this damage. They also discuss how food intolerances and undiagnosed celiac disease could play a role in ME/CFS, even when digestive symptoms are absent.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neural control of force output during maximal and submaximal exercise.

St Clair Gibson, A, Lambert, M L, Noakes, T D·Sports medicine (Auckland, N.Z.)·2001

This review challenges the common belief that muscle fatigue during exercise comes only from chemical changes in muscles themselves. Instead, the authors propose that the brain and nervous system actively control and limit how hard we can exercise to protect our bodies from damage. Interestingly, they note that people with ME/CFS experience fatigue even at rest, suggesting fatigue may be a protective signal from the nervous system rather than a simple muscle problem.

Post-Exertional Malaise

E3 PreliminaryCohortPEM unclearObservational

Doing things with illness. The micro politics of the CFS clinic.

Banks, J, Prior, L·Social science & medicine (1982)·2001

This study observed conversations between ME/CFS patients and doctors in a UK clinic to understand how they think about the condition differently. Patients and doctors often disagreed about whether ME/CFS is a disease of the body or the mind, and these disagreements shaped how treatment was discussed. The researchers found that these conversations were really about who gets to decide what ME/CFS actually is.

Diagnostics

E3 PreliminaryCommentaryPEM unclearEditorial

Chiari I malformation as a cause of orthostatic intolerance symptoms: a media myth?

Garland, E M, Robertson, D·The American journal of medicine·2001

Some people with ME/CFS and fibromyalgia have heard that a brain condition called Chiari I malformation might be causing their symptoms, especially dizziness and fainting when standing up. This editorial reviews whether that claim is actually supported by scientific research and concludes that there is very little reliable evidence backing up this connection, despite media coverage and patient discussions online.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Cytokines and chronic fatigue syndrome.

Patarca, R·Annals of the New York Academy of Sciences·2001

This study found that people with ME/CFS show signs of immune system activation (more active immune cells and elevated immune signaling molecules), yet paradoxically have weak immune function (poor natural killer cell activity and weak responses to infections). The immune system appears to be stuck in an imbalanced state, favoring certain types of inflammatory responses, which may relate to symptom cycles of improvement and worsening.

Immune System

E3 PreliminaryMechanismPEM not requiredCase-Control

Corticospinal inhibition appears normal in patients with chronic fatigue syndrome.

Zaman, R, Puri, B K, Main, J et al.·Experimental physiology·2001

This study used a brain stimulation technique called TMS to test whether the motor control systems in ME/CFS patients work differently than in healthy people. Researchers found that the brain's ability to inhibit (turn off) muscle activity was normal in ME/CFS patients, even though these patients moved more slowly and took longer to react to simple tasks. This suggests that the fatigue and slowness experienced in ME/CFS may not be caused by problems in how the brain controls muscles.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Brainstem conundrum: the Chiari I malformation.

Mueller, D·Journal of the American Academy of Nurse Practitioners·2001

Chiari I Malformation is a condition where brain tissue extends into the spinal canal, causing various symptoms. This study reviews cases and explains why patients with this condition are often misdiagnosed with ME/CFS, fibromyalgia, or other illnesses, sometimes delaying proper diagnosis by months or years.

Diagnostics

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Evaluation of a recombinant line blot for diagnosis of Epstein-Barr Virus compared with ELISA, using immunofluorescence as reference method.

Detection of immunologically significant factors for chronic fatigue syndrome using neural-network classifiers.

Chronic Fatigue Syndrome (CFS) in 15 dogs and cats with specific biochemical and microbiological anomalies.

Fatigue in primary care.

Treatment of chronic fatigue with neurofeedback and self-hypnosis.

The role of gender in fibromyalgia syndrome.

Chronic illness -- a disruption in life: identity-transformation among women with chronic fatigue syndrome and fibromyalgia.

Dynamics of chronic active herpesvirus-6 infection in patients with chronic fatigue syndrome: data acquisition for computer modeling.

Anti-nuclear envelope antibodies: Clinical associations.

Attitudes regarding chronic fatigue syndrome: the importance of a name.

Increased sensitivity to glucocorticoids in peripheral blood mononuclear cells of chronic fatigue syndrome patients, without evidence for altered density or affinity of glucocorticoid receptors.

[Fatigue].

DHEA. Monograph.

Chronic fatigue syndrome: oxidative stress and dietary modifications.

Neural control of force output during maximal and submaximal exercise.

Doing things with illness. The micro politics of the CFS clinic.

Chiari I malformation as a cause of orthostatic intolerance symptoms: a media myth?

Cytokines and chronic fatigue syndrome.

Corticospinal inhibition appears normal in patients with chronic fatigue syndrome.

Brainstem conundrum: the Chiari I malformation.

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