ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1861–1880 of 2,423 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: oxidative stress and dietary modifications.

Logan, A C, Wong, C·Alternative medicine review : a journal of clinical therapeutic·2001

This review examines how oxidative stress—damage caused by harmful molecules in the body—may contribute to ME/CFS symptoms. The authors suggest that certain dietary supplements with antioxidant properties, such as glutathione and alpha-lipoic acid, might help reduce this damage. They also discuss how food intolerances and undiagnosed celiac disease could play a role in ME/CFS, even when digestive symptoms are absent.

E3 PreliminaryCohortPEM unclearCase-Control

Chronic fatigue syndrome following a toxic exposure.

Racciatti, D, Vecchiet, J, Ceccomancini, A et al.·The Science of the total environment·2001

This study looked at five people who developed ME/CFS symptoms after being exposed to toxic substances—either through seafood poisoning or chemical fumes. Researchers compared them to people with ME/CFS that started after viral infections or depression to see if the cause mattered. They found that people whose ME/CFS followed toxic exposure had more significant problems with immune system function than the comparison groups.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Abnormalities in response to vasopressin infusion in chronic fatigue syndrome.

Altemus, M, Dale, J K, Michelson, D et al.·Psychoneuroendocrinology·2001

This study tested how the bodies of ME/CFS patients respond to a hormone called vasopressin. Researchers compared 19 patients with ME/CFS to 19 healthy volunteers by giving them vasopressin infusions and measuring hormone levels in their blood. ME/CFS patients showed a weaker response in a key stress hormone called ACTH, suggesting their brain may not be producing enough of another hormone called CRH that helps control stress responses.

Endocrine Disruption

E3 PreliminaryMechanismPEM unclearMechanistic

Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite.

Pall, M L·Medical hypotheses·2001

This study proposes that ME/CFS, fibromyalgia, multiple chemical sensitivity, and PTSD may all share the same root cause: a buildup of harmful molecules called nitric oxide and peroxynitrite in the body. These molecules can create a self-perpetuating cycle that keeps the illness going once it starts, often triggered by a period of stress. The same biochemical problem appearing in different tissues might explain why these conditions overlap and share similar symptoms.

E3 PreliminaryReviewPEM unclearReview-Narrative

Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder.

Pall, M L, Satterlee, J D·Annals of the New York Academy of Sciences·2001

This theory paper proposes that ME/CFS, multiple chemical sensitivity (MCS), and post-traumatic stress disorder may share a common cause: abnormally high levels of nitric oxide and related harmful molecules in the body. The authors suggest that feedback loops—where one problem triggers another, which makes the first worse—could explain why these conditions become chronic and persist over time.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Voluntary motor function in patients with chronic fatigue syndrome.

Davey, N J, Puri, B K, Nowicky, A V et al.·Journal of psychosomatic research·2001

This study tested whether ME/CFS patients have problems with the brain signals that control voluntary movement. Researchers used magnetic stimulation on the scalp to measure how well nerve signals traveled to hand muscles, and they also tested how quickly patients could react and move their hands. The main finding was that while patients moved more slowly than healthy people, the nerve pathways themselves worked normally, suggesting the slowness comes from somewhere else in the body or brain.

E3 PreliminaryMechanismPEM not requiredObservational

Role of impaired lower-limb venous innervation in the pathogenesis of the chronic fatigue syndrome.

Streeten, D H·The American journal of the medical sciences·2001

This study found that people with ME/CFS have problems with how blood vessels in their feet respond to stress. When standing up, their blood pressure drops abnormally after a delay, and their foot veins don't tighten properly in response to a hormone (norepinephrine) that normally helps maintain blood pressure. This suggests that the nerves controlling blood vessels in the legs may not be working correctly in ME/CFS.

Autonomic Nervous System

E3 PreliminaryCohortPEM not requiredCase-Control

Ciguatera poisoning: a global issue with common management problems.

Ting, J Y, Brown, A F·European journal of emergency medicine : official journal of the European Society for Emergency Medicine·2001

Ciguatera poisoning is a food-borne illness caused by eating contaminated tropical fish that causes stomach problems, nerve symptoms, and fatigue that can last months or years. This study describes four tourists who recovered well after receiving a specific treatment (intravenous mannitol), but highlights that the condition is often misdiagnosed as chronic fatigue syndrome or other illnesses, delaying proper treatment.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Attitudes regarding chronic fatigue syndrome: the importance of a name.

Jason, L A, Taylor, R R, Stepanek, Z et al.·Journal of health psychology·2001

This study found that what doctors and students call ME/CFS affects how they think about the condition. When it was called "myalgic encephalopathy," people were more likely to believe it had a physical cause in the body. The name used also influenced whether healthcare workers thought patients were truly ill or just depressed. This suggests that even the language we use to describe ME/CFS can shape people's beliefs about how serious it is and how it should be treated.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Cytokine and other immunologic markers in chronic fatigue syndrome and their relation to neuropsychological factors.

Patarca-Montero, R, Antoni, M, Fletcher, M A et al.·Applied neuropsychology·2001

This study looked at immune system markers in ME/CFS patients and found that their immune cells show signs of being overactive, with abnormal patterns of immune signaling molecules called cytokines. The researchers propose that when stress and difficult emotions interact with this immune dysfunction, they can perpetuate the cycle of fatigue, cognitive problems, and other symptoms seen in ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Can fibromyalgia and chronic fatigue syndrome be cured by surgery?

Wilke, W S·Cleveland Clinic journal of medicine·2001

This review article examines whether surgery can cure fibromyalgia and chronic fatigue syndrome (ME/CFS). The author concludes that surgery is not an effective treatment for these conditions. This is important because some patients and providers have explored surgical approaches, but the evidence does not support this as a cure.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Buskila, D·Current opinion in rheumatology·2001

This review examined fibromyalgia (FM), chronic fatigue syndrome (CFS), and related pain conditions across different countries. Researchers found that pain sensitivity involves brain chemistry (including a system called NMDA), hormone imbalances, and nervous system problems. CFS was found in about 0.4% of a large community sample, with many children recovering well, though the study notes that no major new treatments were tested during this period.

Pain and SensitizationAutonomic Nervous System

E3 PreliminaryCommentaryPEM not requiredEditorial

[Fatigue].

Reinhart, W H, Fleisch, F·Praxis·2001

Fatigue is a very common symptom that doctors see in many patients. This editorial discusses how doctors should evaluate someone with fatigue by taking a careful history, doing a physical exam, and ordering appropriate tests. When other diseases are ruled out, chronic fatigue syndrome may be diagnosed, though its causes remain unknown. The most proven treatments are graded exercise, cognitive behavioral therapy, and antidepressants if depression or anxiety are present.

Diagnostics

E3 PreliminaryCommentaryPEM unclearEditorial

[Syndromes in environmental medicine: variants of somatoform disorders].

Wiesmüller, G A, Ebel, H, Hornberg, C·Fortschritte der Neurologie-Psychiatrie·2001

This editorial discusses several conditions related to environmental sensitivities and stress, including ME/CFS, that doctors often struggle to diagnose or treat. The authors note that these conditions may result from a mix of environmental exposures, personal traits, stress, and how the mind interprets these experiences. They emphasize that while doctors don't yet have solid scientific ways to diagnose or treat these conditions, patients' symptoms deserve to be taken seriously.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Problems of chronic fatigue].

Kovaleva, A I, Pyshnov, G Iu·Meditsina truda i promyshlennaia ekologiia·2001

This review examines chronic fatigue syndrome and related conditions like burnout and caroshi (a Japanese term for work-related exhaustion), looking at them as forms of extreme tiredness. The authors suggest these conditions may be linked to workplace stress and occupational demands. The paper considers what these different conditions have in common and how they develop.

E3 PreliminaryCohortPEM unclearObservational

Doing things with illness. The micro politics of the CFS clinic.

Banks, J, Prior, L·Social science & medicine (1982)·2001

This study observed conversations between ME/CFS patients and doctors in a UK clinic to understand how they think about the condition differently. Patients and doctors often disagreed about whether ME/CFS is a disease of the body or the mind, and these disagreements shaped how treatment was discussed. The researchers found that these conversations were really about who gets to decide what ME/CFS actually is.

Diagnostics

E3 PreliminaryCommentaryPEM unclearEditorial

Chiari I malformation as a cause of orthostatic intolerance symptoms: a media myth?

Garland, E M, Robertson, D·The American journal of medicine·2001

Some people with ME/CFS and fibromyalgia have heard that a brain condition called Chiari I malformation might be causing their symptoms, especially dizziness and fainting when standing up. This editorial reviews whether that claim is actually supported by scientific research and concludes that there is very little reliable evidence backing up this connection, despite media coverage and patient discussions online.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Cognitive and mood disturbance as causes and symptoms of fatigue in cancer patients.

Valentine, A D, Meyers, C A·Cancer·2001

This review discusses how fatigue, brain fog, and depression are connected in cancer patients and how they may cause or worsen each other. The authors suggest that understanding these connections might help doctors develop better, more personalized treatments that address the specific needs of each patient.

Cognitive Impairment

E3 PreliminaryCohortPEM not requiredCross-Sectional

Assessing attitudes toward new names for chronic fatigue syndrome.

Jason, L A, Eisele, H, Taylor, R R·Evaluation & the health professions·2001

Researchers asked 432 people with ME/CFS and medical professionals what they thought about changing the disease's name from 'chronic fatigue syndrome.' Most people surveyed (86%) agreed a name change was needed, with patients being more supportive than doctors. However, people disagreed about what the new name should be—some preferred 'myalgic encephalopathy' while others favored 'neuro-endocrine immune disorder,' and very few people liked both options equally.

E3 PreliminaryMechanismPEM not requiredMechanistic

Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension.

Torpy, D J, Bachmann, A W, Grice, J E et al.·The Journal of clinical endocrinology and metabolism·2001

This study examined a family with a genetic mutation affecting a protein called corticosteroid-binding globulin (CBG), which helps transport the stress hormone cortisol in the blood. People with this mutation had unusually low blood pressure and chronic fatigue—in fact, 86% of affected adults met criteria for chronic fatigue syndrome. The findings suggest that problems with how the body handles cortisol may contribute to fatigue disorders.

Autonomic Nervous System

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Chronic fatigue syndrome: oxidative stress and dietary modifications.

Chronic fatigue syndrome following a toxic exposure.

Abnormalities in response to vasopressin infusion in chronic fatigue syndrome.

Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite.

Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder.

Voluntary motor function in patients with chronic fatigue syndrome.

Role of impaired lower-limb venous innervation in the pathogenesis of the chronic fatigue syndrome.

Ciguatera poisoning: a global issue with common management problems.

Attitudes regarding chronic fatigue syndrome: the importance of a name.

Cytokine and other immunologic markers in chronic fatigue syndrome and their relation to neuropsychological factors.

Can fibromyalgia and chronic fatigue syndrome be cured by surgery?

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

[Fatigue].

[Syndromes in environmental medicine: variants of somatoform disorders].

[Problems of chronic fatigue].

Doing things with illness. The micro politics of the CFS clinic.

Chiari I malformation as a cause of orthostatic intolerance symptoms: a media myth?

Cognitive and mood disturbance as causes and symptoms of fatigue in cancer patients.

Assessing attitudes toward new names for chronic fatigue syndrome.

Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research