ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1881–1900 of 2,420 studies

E3 PreliminaryMechanismPEM not requiredCase-Control

Corticospinal inhibition appears normal in patients with chronic fatigue syndrome.

Zaman, R, Puri, B K, Main, J et al.·Experimental physiology·2001

This study used a brain stimulation technique called TMS to test whether the motor control systems in ME/CFS patients work differently than in healthy people. Researchers found that the brain's ability to inhibit (turn off) muscle activity was normal in ME/CFS patients, even though these patients moved more slowly and took longer to react to simple tasks. This suggests that the fatigue and slowness experienced in ME/CFS may not be caused by problems in how the brain controls muscles.

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Buskila, D·Current opinion in rheumatology·2001

This review examined fibromyalgia (FM), chronic fatigue syndrome (CFS), and related pain conditions across different countries. Researchers found that pain sensitivity involves brain chemistry (including a system called NMDA), hormone imbalances, and nervous system problems. CFS was found in about 0.4% of a large community sample, with many children recovering well, though the study notes that no major new treatments were tested during this period.

Pain and SensitizationAutonomic Nervous System

E3 PreliminaryCohortPEM not requiredCase-Control

Ciguatera poisoning: a global issue with common management problems.

Ting, J Y, Brown, A F·European journal of emergency medicine : official journal of the European Society for Emergency Medicine·2001

Ciguatera poisoning is a food-borne illness caused by eating contaminated tropical fish that causes stomach problems, nerve symptoms, and fatigue that can last months or years. This study describes four tourists who recovered well after receiving a specific treatment (intravenous mannitol), but highlights that the condition is often misdiagnosed as chronic fatigue syndrome or other illnesses, delaying proper treatment.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Cytokine and other immunologic markers in chronic fatigue syndrome and their relation to neuropsychological factors.

Patarca-Montero, R, Antoni, M, Fletcher, M A et al.·Applied neuropsychology·2001

This study looked at immune system markers in ME/CFS patients and found that their immune cells show signs of being overactive, with abnormal patterns of immune signaling molecules called cytokines. The researchers propose that when stress and difficult emotions interact with this immune dysfunction, they can perpetuate the cycle of fatigue, cognitive problems, and other symptoms seen in ME/CFS.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Decreased tryptophan availability but normal post-synaptic 5-HT2c receptor sensitivity in chronic fatigue syndrome.

Vassallo, C M, Feldman, E, Peto, T et al.·Psychological medicine·2001

This study examined whether people with ME/CFS have oversensitive serotonin receptors in the brain, which could explain some of their symptoms. Researchers gave patients and healthy people a drug that directly activates serotonin receptors and measured the response. They found that both groups responded similarly, suggesting the problem in ME/CFS is not overly sensitive receptors but rather increased serotonin activity from nerve cells themselves. Interestingly, people with ME/CFS had lower levels of tryptophan (a building block for serotonin) in their blood.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions.

Mullington, J M, Hinze-Selch, D, Pollmächer, T·Annals of the New York Academy of Sciences·2001

This study explores how the body's immune system and sleep are connected, and how this connection might explain the severe fatigue in ME/CFS. Researchers found that when the immune system is activated, it releases chemical messengers called cytokines that can affect sleep quality and cause fatigue. The study suggests that abnormal levels of these immune chemicals in ME/CFS patients could be responsible for the debilitating tiredness that characterizes the condition.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Can fibromyalgia and chronic fatigue syndrome be cured by surgery?

Wilke, W S·Cleveland Clinic journal of medicine·2001

This review article examines whether surgery can cure fibromyalgia and chronic fatigue syndrome (ME/CFS). The author concludes that surgery is not an effective treatment for these conditions. This is important because some patients and providers have explored surgical approaches, but the evidence does not support this as a cure.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Anti-nuclear envelope antibodies: Clinical associations.

Nesher, G, Margalit, R, Ashkenazi, Y J·Seminars in arthritis and rheumatism·2001

This study looked at antibodies (immune proteins) that attack the nuclear envelope, the protective membrane around cell nuclei. Researchers found that different types of these antibodies are associated with different diseases, and preliminary findings suggest they may help diagnose ME/CFS. The study suggests that testing for these antibodies could help doctors identify certain autoimmune conditions.

Immune System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Treatment of chronic fatigue with neurofeedback and self-hypnosis.

Hammond, D C·NeuroRehabilitation·2001

This study describes one young woman with ME/CFS whose main problem was brain fog and difficulty thinking clearly. Doctors found an abnormal brain wave pattern on her EEG scan and treated her with two techniques: neurofeedback (training to change brain wave patterns) and self-hypnosis. She felt significantly better, with improvements in fatigue and mental clarity that lasted for at least 9 months.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fatigue in primary care.

Morrison, R E, Keating, H J·Obstetrics and gynecology clinics of North America·2001

Fatigue is very common and can have many different causes. Doctors can usually figure out what's causing someone's tiredness through a careful conversation, physical exam, and a few blood tests. In rare cases, people have extreme fatigue lasting 6 months or longer that doesn't have an obvious cause—this may be chronic fatigue syndrome (ME/CFS).

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder.

Pall, M L, Satterlee, J D·Annals of the New York Academy of Sciences·2001

This theory paper proposes that ME/CFS, multiple chemical sensitivity (MCS), and post-traumatic stress disorder may share a common cause: abnormally high levels of nitric oxide and related harmful molecules in the body. The authors suggest that feedback loops—where one problem triggers another, which makes the first worse—could explain why these conditions become chronic and persist over time.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

DHEA. Monograph.

Alternative medicine review : a journal of clinical therapeutic·2001

This article reviews DHEA, a hormone naturally produced by your body that decreases as you age. Research suggests that lower DHEA levels may be connected to several conditions, including ME/CFS, heart disease, diabetes, and autoimmune diseases like lupus and rheumatoid arthritis. DHEA acts as a 'buffer hormone' that can be converted into other important hormones like estrogen and testosterone.

Immune System

E3 PreliminaryCohortPEM not requiredLongitudinal

Dynamics of chronic active herpesvirus-6 infection in patients with chronic fatigue syndrome: data acquisition for computer modeling.

Krueger, G R, Koch, B, Hoffmann, A et al.·In vivo (Athens, Greece)·2001

This study followed 10 ME/CFS patients for two years to understand how a virus called HHV-6 might be involved in their illness. Researchers measured virus levels and immune cell counts in the patients' blood over time. They found that ME/CFS patients had slightly elevated virus levels and abnormal immune responses, different from what happens during acute HHV-6 infection.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Problems of chronic fatigue].

Kovaleva, A I, Pyshnov, G Iu·Meditsina truda i promyshlennaia ekologiia·2001

This review examines chronic fatigue syndrome and related conditions like burnout and caroshi (a Japanese term for work-related exhaustion), looking at them as forms of extreme tiredness. The authors suggest these conditions may be linked to workplace stress and occupational demands. The paper considers what these different conditions have in common and how they develop.

E3 PreliminaryCohortPEM unclearObservational

Doing things with illness. The micro politics of the CFS clinic.

Banks, J, Prior, L·Social science & medicine (1982)·2001

This study observed conversations between ME/CFS patients and doctors in a UK clinic to understand how they think about the condition differently. Patients and doctors often disagreed about whether ME/CFS is a disease of the body or the mind, and these disagreements shaped how treatment was discussed. The researchers found that these conversations were really about who gets to decide what ME/CFS actually is.

Diagnostics

E3 PreliminaryCommentaryPEM not requiredEditorial

[Fatigue].

Reinhart, W H, Fleisch, F·Praxis·2001

Fatigue is a very common symptom that doctors see in many patients. This editorial discusses how doctors should evaluate someone with fatigue by taking a careful history, doing a physical exam, and ordering appropriate tests. When other diseases are ruled out, chronic fatigue syndrome may be diagnosed, though its causes remain unknown. The most proven treatments are graded exercise, cognitive behavioral therapy, and antidepressants if depression or anxiety are present.

Diagnostics

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Chronic illness -- a disruption in life: identity-transformation among women with chronic fatigue syndrome and fibromyalgia.

Asbring, P·Journal of advanced nursing·2001

This study looked at how women with ME/CFS and fibromyalgia experience major changes to their sense of self and identity after becoming ill. Researchers interviewed 25 Swedish women about how they adjusted to these illnesses, and found that while the conditions caused significant disruption to their work and social lives, many women also discovered unexpected positive aspects of their new identity as they adapted.

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic Fatigue Syndrome (CFS) in 15 dogs and cats with specific biochemical and microbiological anomalies.

Tarello, W·Comparative immunology, microbiology and infectious diseases·2001

This study looked at 15 dogs and cats that had fatigue symptoms similar to ME/CFS and tested their blood for bacterial infections. Nine out of 15 animals had a type of bacteria called Staphylococcus in their blood. When these animals were treated with an antibiotic drug, all of them got completely better and the bacteria disappeared from their blood.

Biomarkers

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Buskila, D·Current opinion in rheumatology·2000

This review article examines the connections between fibromyalgia, chronic fatigue syndrome (ME/CFS), and myofascial pain syndrome. Researchers found that people with these conditions often have tender points in their muscles, hormonal imbalances affecting stress response, and possible immune system involvement. The study suggests that talking therapies like cognitive behavioral therapy may help manage chronic pain in these conditions, and that children and adolescents with these illnesses often improve over time.

Pain and SensitizationAutonomic Nervous System

E3 PreliminaryCohortPEM not requiredObservational

Treatment of chronic fatigue syndrome with 5-HT3 receptor antagonists--preliminary results.

Späth, M, Welzel, D, Färber, L·Scandinavian journal of rheumatology. Supplement·2000

Researchers tested whether two medications that block serotonin receptors (tropisetron and ondansetron) might help ME/CFS patients feel less fatigued. About one third of the patients who took these medications reported meaningful improvement in fatigue and energy levels over 15 days, with no serious side effects reported.

Interventions

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Evidence browser

Corticospinal inhibition appears normal in patients with chronic fatigue syndrome.

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Ciguatera poisoning: a global issue with common management problems.

Cytokine and other immunologic markers in chronic fatigue syndrome and their relation to neuropsychological factors.

Decreased tryptophan availability but normal post-synaptic 5-HT2c receptor sensitivity in chronic fatigue syndrome.

Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions.

Can fibromyalgia and chronic fatigue syndrome be cured by surgery?

Anti-nuclear envelope antibodies: Clinical associations.

Treatment of chronic fatigue with neurofeedback and self-hypnosis.

Fatigue in primary care.

Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder.

DHEA. Monograph.

Dynamics of chronic active herpesvirus-6 infection in patients with chronic fatigue syndrome: data acquisition for computer modeling.

[Problems of chronic fatigue].

Doing things with illness. The micro politics of the CFS clinic.

[Fatigue].

Chronic illness -- a disruption in life: identity-transformation among women with chronic fatigue syndrome and fibromyalgia.

Chronic Fatigue Syndrome (CFS) in 15 dogs and cats with specific biochemical and microbiological anomalies.

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Treatment of chronic fatigue syndrome with 5-HT3 receptor antagonists--preliminary results.

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Biomarkers

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