ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1981–2000 of 2,422 studies

E3 PreliminaryCohortPEM not requiredCase-Control

Recognition of chronic carbon monoxide poisoning.

Knobeloch, L, Jackson, R·WMJ : official publication of the State Medical Society of Wisconsin·1999

This study describes three families in Wisconsin whose members were diagnosed with chronic fatigue syndrome, depression, and other illnesses that turned out to be caused by carbon monoxide leaks from faulty home heating systems. The families' symptoms—including fatigue, headaches, dizziness, and confusion—went undiagnosed until heating contractors found the problem. The authors remind doctors to consider carbon monoxide poisoning when patients have vague, ongoing symptoms, especially during winter.

Diagnostics

E3 PreliminaryCohortPEM unclearCase-Control

Managing chronic fatigue syndrome: overview and case study.

Jason, L A, Melrose, H, Lerman, A et al.·AAOHN journal : official journal of the American Association of Occupational Health Nurses·1999

This study explains 'envelope theory,' a practical approach where people with ME/CFS stay within their energy limits to avoid crashes and gradually build tolerance. By tracking energy levels over time, patients and doctors can better understand each person's unique patterns and what activities trigger setbacks.

Post-Exertional Malaise

E3 PreliminaryGuidelinePEM not requiredGuideline

Social Security Ruling, SSR 99-2p.; titles II and XVI; evaluating cases involving chronic fatigue syndrome (CFS). Social Security Administration. Notice of Social Security ruling.

Federal register·1999

The Social Security Administration issued an official ruling in 1999 to help people with ME/CFS get disability benefits. The ruling states that ME/CFS is a real medical condition that can prevent someone from working, but only when doctors find specific signs or lab results that support the diagnosis. This ruling was meant to make sure all disability examiners across the country evaluate ME/CFS cases using the same fair standards.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

The effects on siblings in families with a child with chronic fatigue syndrome.

Jackson, E L·Journal of child health care : for professionals working with children in the hospital and community·1999

When a child has ME/CFS, it affects the entire family, not just the sick child. This review looked at how brothers and sisters of children with ME/CFS are impacted and how they cope with the situation. The authors found that healthy siblings often don't get enough attention and support because the focus is on caring for the ill child.

E3 PreliminaryMechanismPEM not requiredCase-Control

Interferon-induced proteins are elevated in blood samples of patients with chemically or virally induced chronic fatigue syndrome.

Vojdani, A, Lapp, C W·Immunopharmacology and immunotoxicology·1999

This study found that certain immune proteins called 2-5A and PKR are elevated in the blood of ME/CFS patients, whether their illness was triggered by a viral infection or chemical exposure. The researchers discovered that these two triggers activate these proteins through different biological pathways—viruses primarily use an immune signaling molecule called interferon-beta, while chemicals activate them mainly through heat shock proteins.

BiomarkersImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Is fibromyalgia a distinct clinical entity? Historical and epidemiological evidence.

Wessely, S, Hotopf, M·Bailliere's best practice & research. Clinical rheumatology·1999

This research article examines whether fibromyalgia is truly a separate disease or whether it's actually similar to other conditions like ME/CFS, irritable bowel syndrome, and chronic chest pain. The authors reviewed historical records, clinical observations, and population-level data and concluded that fibromyalgia shares many features with other unexplained illnesses rather than being completely distinct.

E3 PreliminaryPEM not required

Fatigue that doesn't go away.

Propsner, N M·New Jersey medicine : the journal of the Medical Society of New Jersey·1999

This article describes chronic fatigue syndrome (ME/CFS), a condition where people experience extreme tiredness that doesn't improve with rest. The fatigue often begins after a viral infection and is more commonly seen in middle-aged women. While current treatments can help manage symptoms, researchers are working to better understand the condition and develop more effective approaches.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: current concepts of pathogenesis and treatment.

Lloyd, A R, Hickie, I, Peterson, P K·Current clinical topics in infectious diseases·1999

This review article examines what scientists understood in 1999 about how ME/CFS develops and what treatments might help. The authors synthesize existing knowledge about the condition's causes, which involve the immune system, infections, and other body system changes. They discuss various approaches to managing symptoms and improving function for people living with ME/CFS.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

[Immunological aspects of pathophysiology of chronic fatigue syndrome].

Matsumoto, Y·Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology·1999

This study examined how the immune system functions differently in people with ME/CFS compared to healthy individuals. The researchers looked at various immune markers to understand what might be going wrong in the body during this illness. This type of research helps scientists figure out whether ME/CFS is caused by immune system problems.

Immune System

E3 PreliminaryPEM unclear

Case of chronic fatigue syndrome after Crimean war and Indian mutiny.

Jones, E, Wessely, S·BMJ (Clinical research ed.)·1999

This historical research paper examines cases of chronic fatigue syndrome (then called different names) that occurred in soldiers during the Crimean War and Indian Mutiny in the 1800s. The authors looked back at medical records from these time periods to document how fatigue illnesses affected military personnel. This work shows that ME/CFS-like conditions are not new to modern times but have been documented for well over a century.

E3 PreliminaryReviewPEM unclearReview-Narrative

The neuroendocrinology of chronic fatigue syndrome: focus on the hypothalamic-pituitary-adrenal axis.

Scott, L V, Dinan, T G·Functional neurology·1999

This study examined how the stress-response system in the brain works differently in people with ME/CFS. The researchers focused on the hypothalamic-pituitary-adrenal (HPA) axis, which is the body's main system for managing stress and producing cortisol. The study reviewed evidence suggesting this system may not function normally in ME/CFS patients, potentially contributing to their symptoms.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredMechanistic

Mouse running activity is lowered by Brucella abortus treatment: a potential model to study chronic fatigue.

Ottenweller, J E, Natelson, B H, Gause, W C et al.·Physiology & behavior·1998

Researchers infected mice with a killed bacterium to see if it would create a model similar to ME/CFS. The mice immediately stopped running and grooming after infection, then slowly recovered over 2-4 weeks—though some mice recovered faster than others. Interestingly, during recovery, the mice could only run for short periods at first before becoming exhausted, gradually building up their endurance over time.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

The hypothalamic-pituitary-adrenal stress axis in fibromyalgia and chronic fatigue syndrome.

Crofford, L J·Zeitschrift fur Rheumatologie·1998

This review examines the stress response system (HPA axis) in fibromyalgia and chronic fatigue syndrome. The authors suggest that problems with this stress system may be connected to common symptoms like pain, exhaustion, sleep problems, and mood changes. Several treatments that help patients—including exercise and certain antidepressants—appear to work partly by affecting this stress response system.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredMechanistic

CD4 T lymphocytes from patients with chronic fatigue syndrome have decreased interferon-gamma production and increased sensitivity to dexamethasone.

Visser, J, Blauw, B, Hinloopen, B et al.·The Journal of infectious diseases·1998

This study looked at immune cells called CD4 T cells from ME/CFS patients and found they produced less of a protective immune protein called interferon-gamma compared to healthy people. Interestingly, these cells were also much more sensitive to dexamethasone, a steroid medication—it took 10-20 times less of the drug to suppress certain immune functions in ME/CFS patients than in controls. This suggests that the stress hormone system and immune system may be working abnormally together in ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, chronic fatigue syndrome, and myofascial pain.

Bennett, R·Current opinion in rheumatology·1998

This review examines how fibromyalgia, chronic fatigue syndrome, and widespread pain are related conditions that share similar features. Researchers found that these conditions run in families, involve abnormal pain processing in the nervous system, and may share some underlying biological problems like growth hormone imbalances and low blood pressure. Several medications and treatments showed promise in reducing symptoms.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Decreased immunoreactive beta-endorphin in mononuclear leucocytes from patients with chronic fatigue syndrome.

Conti, F, Pittoni, V, Sacerdote, P et al.·Clinical and experimental rheumatology·1998

Researchers measured levels of beta-endorphin, a natural chemical in the body that helps reduce pain and promotes well-being, in immune cells from ME/CFS patients and healthy people. They found that ME/CFS patients had significantly lower levels of this chemical compared to healthy controls. The authors suggest this difference might help explain why ME/CFS causes fatigue and weakness.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

The psychotherapeutic effects of estrogens.

Panay, N, Studd, J W·Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·1998

This review examines how estrogen, a hormone in women's bodies, may affect mood, thinking ability, and symptoms of depression. The authors found that estrogen therapy can help treat depression and improve memory in some women, and that early research suggests it might also help with fatigue and mood in women with chronic fatigue syndrome (ME/CFS).

E3 PreliminaryMechanismPEM not requiredMechanistic

The in vitro immunomodulatory effects of glyconutrients on peripheral blood mononuclear cells of patients with chronic fatigue syndrome.

See, D M, Cimoch, P, Chou, S et al.·Integrative physiological and behavioral science : the official journal of the Pavlovian Society·1998

This study tested whether a supplement containing eight specific sugars (called glyconutrients) could help fix immune system problems in ME/CFS patients. Researchers added the supplement to immune cells from ME/CFS patients and healthy controls in a laboratory dish and measured whether it improved immune function. The supplement appeared to increase the activity of several types of immune cells and reduce cell death in ME/CFS patients' immune cells.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Reviewing the reviews: the example of chronic fatigue syndrome.

Joyce, J, Rabe-Hesketh, S, Wessely, S·JAMA·1998

This study examined how researchers write review articles about ME/CFS and found that what gets included depends heavily on the author's background and where they're from. Scientists with laboratory training tend to focus on lab-based research, while psychiatrists tend to focus on psychiatric research. Authors also tend to cite papers from their own country much more often than papers from other countries.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: a literature review from a physiatric perspective.

Jain, S S, DeLisa, J A·American journal of physical medicine & rehabilitation·1998

This review examined over 200 scientific studies about ME/CFS to understand what we know about the condition, particularly focusing on thinking problems and exercise. The authors found that while patients often report cognitive difficulties, actual measured problems are subtle and mainly affect how quickly the brain processes complex information. Brain imaging studies suggest changes may occur in the white matter of the brain rather than in the muscles themselves.

Post-Exertional Malaise

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Evidence browser

Recognition of chronic carbon monoxide poisoning.

Managing chronic fatigue syndrome: overview and case study.

Social Security Ruling, SSR 99-2p.; titles II and XVI; evaluating cases involving chronic fatigue syndrome (CFS). Social Security Administration. Notice of Social Security ruling.

The effects on siblings in families with a child with chronic fatigue syndrome.

Interferon-induced proteins are elevated in blood samples of patients with chemically or virally induced chronic fatigue syndrome.

Is fibromyalgia a distinct clinical entity? Historical and epidemiological evidence.

Fatigue that doesn't go away.

Chronic fatigue syndrome: current concepts of pathogenesis and treatment.

[Immunological aspects of pathophysiology of chronic fatigue syndrome].

Case of chronic fatigue syndrome after Crimean war and Indian mutiny.

The neuroendocrinology of chronic fatigue syndrome: focus on the hypothalamic-pituitary-adrenal axis.

Mouse running activity is lowered by Brucella abortus treatment: a potential model to study chronic fatigue.

The hypothalamic-pituitary-adrenal stress axis in fibromyalgia and chronic fatigue syndrome.

CD4 T lymphocytes from patients with chronic fatigue syndrome have decreased interferon-gamma production and increased sensitivity to dexamethasone.

Fibromyalgia, chronic fatigue syndrome, and myofascial pain.

Decreased immunoreactive beta-endorphin in mononuclear leucocytes from patients with chronic fatigue syndrome.

The psychotherapeutic effects of estrogens.

The in vitro immunomodulatory effects of glyconutrients on peripheral blood mononuclear cells of patients with chronic fatigue syndrome.

Reviewing the reviews: the example of chronic fatigue syndrome.

Chronic fatigue syndrome: a literature review from a physiatric perspective.

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