ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1981–2000 of 2,423 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Acute phase responses and cytokine secretion in chronic fatigue syndrome.

Cannon, J G, Angel, J B, Ball, R W et al.·Journal of clinical immunology·1999

This study tested whether people with ME/CFS have abnormal levels of immune signaling molecules called cytokines, which could explain their symptoms. Researchers compared 10 ME/CFS patients with 11 healthy controls at rest and after 15 minutes of stepping exercise, measuring immune markers in their blood. They found that ME/CFS patients had higher baseline levels of certain inflammatory markers, but exercise responses were similar between groups.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Report of a workshop on the epidemiology, natural history, and pathogenesis of chronic fatigue syndrome in adolescents.

Marshall, G S·The Journal of pediatrics·1999

This 1999 workshop report brought together experts to discuss what was known about ME/CFS in teenagers. The report summarized information about how common the illness is, how it develops over time, and what might cause it in young people. It served as an important step in recognizing that ME/CFS affects adolescents and that they needed specialized attention.

Diagnostics

E3 PreliminaryMechanismPEM unclearObservational

Demonstration of delayed recovery from fatiguing exercise in chronic fatigue syndrome.

Paul, L, Wood, L, Behan, W M et al.·European journal of neurology·1999

This study tested whether people with ME/CFS recover more slowly from exercise than healthy people. Researchers had both patients and control subjects perform intense leg muscle contractions, then measured how quickly their muscle strength returned to normal. The results confirmed that while both groups got tired similarly during exercise, people with ME/CFS took much longer to recover their muscle strength afterward—even 24 hours later.

Post-Exertional Malaise

E3 PreliminaryCohortPEM unclearObservational

Chronic Chlamydia pneumoniae infection: a treatable cause of chronic fatigue syndrome.

Chia, J K, Chia, L Y·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1999

This study examined whether a common bacterial infection called Chlamydia pneumoniae might be a treatable cause of ME/CFS. Researchers looked at patients with ME/CFS and tested whether treating this infection with antibiotics could improve their symptoms. The authors suggest that some cases of ME/CFS might be linked to this persistent bacterial infection.

E3 PreliminaryCohortPEM not requiredCase-Control

Monitoring and assessing symptoms of chronic fatigue syndrome: use of time series regression.

Jason, L A, Tryon, W W, Taylor, R R et al.·Psychological reports·1999

This study asked one person with ME/CFS to track their symptoms hourly and daily to understand what makes fatigue better or worse. Researchers found that energy levels, physical activity, and mental effort were closely connected to how tired the person felt. This detailed tracking method could help doctors and researchers better understand ME/CFS patterns.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The development of the Chronic Fatigue Syndrome Attitudes Test. A psychometric analysis.

Shlaes, J L, Jason, L A, Ferrari, J R·Evaluation & the health professions·1999

This study created a new tool called the Chronic Fatigue Syndrome Attitudes Test (CAT) to measure how people feel about ME/CFS and those who have it. Researchers designed a 13-question survey based on common negative attitudes people hold toward the illness. The tool was tested to make sure it works reliably and accurately captures these attitudes.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fungal spores: hazardous to health?

Sorenson, W G·Environmental health perspectives·1999

This review discusses how fungal spores in the air can affect human health. Fungal spores are tiny particles that can enter the lungs when inhaled, and some contain harmful substances called mycotoxins. The article notes that breathing in fungal spores has been linked to various health problems, including chronic fatigue syndrome, along with lung disease and other serious conditions.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Understanding chronic fatigue syndrome: an empirical guide to assessment and treatment.

Johnson, S K·Journal of health psychology·1999

This 1999 guide provides healthcare providers and patients with practical methods for evaluating and treating chronic fatigue syndrome (ME/CFS). The authors reviewed existing evidence to create a framework for assessment—including tests and questionnaires—and outlined treatment approaches. This work aims to help clinicians better recognize and manage ME/CFS in their patients.

Diagnostics

E3 PreliminaryMechanismPEM unclearMechanistic

Chronic fatigue syndrome and/or fibromyalgia as a variation of antiphospholipid antibody syndrome: an explanatory model and approach to laboratory diagnosis.

Berg, D, Berg, L H, Couvaras, J et al.·Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·1999

This study proposes that ME/CFS and fibromyalgia may be caused by low-level blood clotting activation triggered by certain antibodies in the immune system. Researchers used five specific blood tests to detect signs of abnormal clotting in patients with these conditions. If confirmed, this finding could help doctors diagnose these diseases and monitor treatment with blood-thinning medications.

Immune System

E3 PreliminaryMechanismPEM unclearCase-Control

Immunological response in chronic fatigue syndrome following a graded exercise test to exhaustion.

LaManca, J J, Sisto, S A, Zhou, X D et al.·Journal of clinical immunology·1999

Researchers tested whether people with ME/CFS have an unusual immune system response to hard exercise compared to healthy people who don't exercise regularly. They had 20 women with ME/CFS and 14 healthy women do an exhausting treadmill test, then checked their blood for immune cells and immune chemicals at several time points. While people with ME/CFS reported much worse fatigue 24 hours later, their immune systems actually responded to the exercise in the same way as the healthy controls.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

The importance of orthostatic intolerance in the chronic fatigue syndrome.

Schondorf, R, Freeman, R·The American journal of the medical sciences·1999

This review examines how problems with standing up (orthostatic intolerance) are connected to ME/CFS. Many people with ME/CFS experience symptoms like dizziness, fatigue, trouble concentrating, shaking, and nausea when standing or sitting upright. The authors review what we know about this connection, including how to diagnose it, what tests can help, what might cause it, and how it might be treated.

Autonomic Nervous SystemDiagnostics

E3 PreliminaryCommentaryPEM not requiredEditorial

Chronic fatigue syndrome: new insights and old ignorance.

Evengård, B, Schacterle, R S, Komaroff, A L·Journal of internal medicine·1999

ME/CFS is a complex condition that affects thinking, sleep quality, and causes physical symptoms like sore throats, muscle pain, and exhaustion after activity. While many patients report that their illness began with an infection, scientists still don't fully understand how infections connect to ME/CFS. Research shows the immune system is overactive and certain brain systems aren't working normally, suggesting ME/CFS involves multiple body systems.

Immune SystemPost-Exertional Malaise

E3 PreliminaryBehavioralPEM unclear

A 56-year-old woman with chronic fatigue syndrome, 1 year later.

Delbanco, T L, Daley, J, Hartman, E E·JAMA·1998

This study describes the medical journey of one woman with ME/CFS over the course of a year, documenting how her symptoms changed and how different treatments affected her condition. The researchers tracked her experiences to provide insight into what living with ME/CFS is like over time and what approaches doctors tried to help her.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Pathogenesis of chronic fatigue syndrome and fibromyalgia.

Klimas, N·Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society·1998

This 1998 review article explores how ME/CFS and fibromyalgia may develop, focusing on potential biological mechanisms in the body. The researchers, led by Dr. Nancy Klimas, examined connections between growth hormone, immune system dysfunction, and the symptoms patients experience. Understanding these underlying causes is an important step toward better treatments.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Dysfunction of natural killer activity in a family with chronic fatigue syndrome.

Levine, P H, Whiteside, T L, Friberg, D et al.·Clinical immunology and immunopathology·1998

Researchers studied a family where 8 members had ME/CFS and found that their natural killer (NK) cells—immune cells that help fight infections and cancer—were not working as well as they should. Some unaffected family members also had lower NK activity, suggesting this might be an inherited trait. The findings raise the possibility that a genetic weakness in immune function could increase risk for both ME/CFS and cancer in this family.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Evaluation of central serotonergic function in affective and related disorders by the fenfluramine challenge test: a critical review.

Newman, Michael E., Shapira, Baruch, Lerer, Bernard·The international journal of neuropsychopharmacology·1998

This review examines a test called the fenfluramine challenge test, which measures how well the brain's serotonin system is working by looking at prolactin levels after taking fenfluramine. The researchers found that people with depression typically had a blunted (reduced) prolactin response, and that some people with chronic fatigue syndrome might have had an enhanced response, though not many studies existed in this group.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Neurally mediated hypotension and autonomic dysfunction measured by heart rate variability during head-up tilt testing in children with chronic fatigue syndrome.

Stewart, J, Weldon, A, Arlievsky, N et al.·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·1998

This study looked at how the nervous system controls heart rate in children with ME/CFS during a tilt test (where patients lie flat then are gradually tilted upright). Researchers found that children with ME/CFS had much lower heart rate variability—a measure of how well the nervous system adjusts the heart—compared to children who faint from other causes and healthy controls. When tilted, children with ME/CFS did not show the normal nervous system adjustments that other groups showed, suggesting their autonomic nervous system (which controls involuntary functions) may not be working properly.

Autonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Natural killer cells and natural killer cell activity in chronic fatigue syndrome.

Whiteside, T L, Friberg, D·The American journal of medicine·1998

This study examines natural killer (NK) cells—white blood cells that help fight infections and abnormal cells—in people with ME/CFS. The researchers found that many ME/CFS patients have lower-than-normal NK cell activity. The study explores why this happens and how it might be related to the disease, while also noting that findings have been difficult to confirm across different studies.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Silicone breast implants and autoimmune disease.

Brown, S L, Langone, J J, Brinton, L A·Journal of the American Medical Women's Association (1972)·1998

In 1992, the FDA paused approval of silicone breast implants due to safety concerns, particularly worries about autoimmune diseases like scleroderma. This editorial reviews studies conducted since then and finds that while large increases in connective tissue disease overall were ruled out, studies were too small to detect rare diseases. The authors note that new methodologies for studying conditions like fibromyalgia and chronic fatigue syndrome might help answer whether implants cause a specific syndrome.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome.

Kuratsune, H, Yamaguti, K, Sawada, M et al.·International journal of molecular medicine·1998

This study found that most ME/CFS patients in Japan had lower-than-normal levels of a hormone called DHEA-S, which is made by the adrenal glands. DHEA-S helps regulate mood, memory, stress response, sleep, and anxiety. The researchers suggest that low DHEA-S levels might explain some of the brain-related symptoms ME/CFS patients experience, like depression and cognitive problems.

Endocrine Disruption

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Evidence browser

Acute phase responses and cytokine secretion in chronic fatigue syndrome.

Report of a workshop on the epidemiology, natural history, and pathogenesis of chronic fatigue syndrome in adolescents.

Demonstration of delayed recovery from fatiguing exercise in chronic fatigue syndrome.

Chronic Chlamydia pneumoniae infection: a treatable cause of chronic fatigue syndrome.

Monitoring and assessing symptoms of chronic fatigue syndrome: use of time series regression.

The development of the Chronic Fatigue Syndrome Attitudes Test. A psychometric analysis.

Fungal spores: hazardous to health?

Understanding chronic fatigue syndrome: an empirical guide to assessment and treatment.

Chronic fatigue syndrome and/or fibromyalgia as a variation of antiphospholipid antibody syndrome: an explanatory model and approach to laboratory diagnosis.

Immunological response in chronic fatigue syndrome following a graded exercise test to exhaustion.

The importance of orthostatic intolerance in the chronic fatigue syndrome.

Chronic fatigue syndrome: new insights and old ignorance.

A 56-year-old woman with chronic fatigue syndrome, 1 year later.

Pathogenesis of chronic fatigue syndrome and fibromyalgia.

Dysfunction of natural killer activity in a family with chronic fatigue syndrome.

Evaluation of central serotonergic function in affective and related disorders by the fenfluramine challenge test: a critical review.

Neurally mediated hypotension and autonomic dysfunction measured by heart rate variability during head-up tilt testing in children with chronic fatigue syndrome.

Natural killer cells and natural killer cell activity in chronic fatigue syndrome.

Silicone breast implants and autoimmune disease.

Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome.

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