ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

2121–2140 of 2,422 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome.

Vecchiet, L, Montanari, G, Pizzigallo, E et al.·Neuroscience letters·1996

This study tested whether people with ME/CFS have increased pain sensitivity in their muscles compared to their skin. Researchers found that muscles were significantly more sensitive to pain in ME/CFS patients, while skin sensitivity was normal. They also discovered abnormal structures and damage in muscle cells from ME/CFS patients, including problems with mitochondria (the energy-producing parts of cells) and signs of degeneration.

Pain and Sensitization

E3 PreliminaryCohortPEM not required

The value of the dehydroepiandrosterone-annexed vitamin C infusion treatment in the clinical control of chronic fatigue syndrome (CFS). I. A Pilot study of the new vitamin C infusion treatment with a volunteer CFS patient.

Kodama, M, Kodama, T, Murakami, M·In vivo (Athens, Greece)·1996

This pilot study tested whether high-dose vitamin C infusions, combined with a hormone called DHEA, could help one male ME/CFS patient who also had pneumonia-like symptoms. The patient received different types of infusions over 10 months, and his pneumonia-related symptoms improved when the new DHEA-enhanced vitamin C treatment was used alongside antibiotics. The researchers measured increased levels of certain hormones in his urine after treatment.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Fibromyalgia syndrome and chronic fatigue syndrome. Similarities and differences].

Hoffmann, A, Linder, R, Kröger, B et al.·Deutsche medizinische Wochenschrift (1946)·1996

This study compared fibromyalgia syndrome and chronic fatigue syndrome (ME/CFS) to understand how they are similar and how they differ. Researchers examined patients with both conditions to identify shared symptoms and unique characteristics that could help doctors better recognize and distinguish between them.

E3 PreliminaryCohortPEM not requiredCross-Sectional

["Prolonged" decay test and auditory brainstem responses in the clinical diagnosis of the chronic fatigue syndrome].

Neri, G, Bianchedi, M, Croce, A et al.·Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·1996

This study tested whether two hearing-related tests could help diagnose ME/CFS. Researchers examined 21 people with suspected ME/CFS using specialized hearing tests that measure how the brainstem processes sound and how the ear muscles respond to loud noises. When both tests were combined, they correctly identified about 82% of people with ME/CFS, suggesting these tests might be useful diagnostic tools.

Biomarkers

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--psychiatric aspects].

Lemke, M R·Fortschritte der Neurologie-Psychiatrie·1996

This editorial discusses how ME/CFS involves both physical symptoms and mental health aspects that need to be understood together. The authors explain that while doctors have focused heavily on physical symptoms, psychiatric factors—such as stress, sleep problems, and how the body's stress system works—play an important role in the syndrome. An effective approach to ME/CFS requires doctors from different specialties to work together.

SleepImmune System

E3 PreliminaryCohortPEM not requiredCase-Control

N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.

Wiebe, E·Canadian family physician Medecin de famille canadien·1996

This study looked at two individual ME/CFS patients to see which treatments might help them personally. One patient tried high-dose vitamin B12 injections but they didn't help. Another patient tried a medication called nimodipine and found it worked very well for them. The doctors used a special testing method called N of 1 trials, where treatments are tested in one person at a time to see what actually helps that specific individual.

Interventions

E3 PreliminaryCohortPEM not requiredCase-Control

Epstein-Barr virus-related primary cutaneous amyloidosis. Successful treatment with acyclovir and interferon-alpha.

Drago, F, Ranieri, E, Pastorino, A et al.·The British journal of dermatology·1996

This case report describes a woman with ME/CFS who developed unusual skin lesions (brownish patches and bumps) on her chest and back for 10 years. Doctors found that the Epstein-Barr virus (EBV)—the virus that causes mononucleosis—was active in her skin and other body areas, and abnormal protein deposits were building up in her skin. When she was treated with antiviral medication (acyclovir) and a type of immune-boosting therapy (interferon-alpha), both her skin lesions and other symptoms improved significantly.

Immune System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Chronic fatigue syndrome and dieting disorders: diagnosis and management problems.

Griffiths, R A, Beumont, P J, Moore, G M et al.·The Australian and New Zealand journal of psychiatry·1996

This study looked at three patients who were diagnosed with ME/CFS but also had eating disorders (anorexia nervosa or bulimia nervosa). The doctors found that proper screening for eating disorders is important because patients and families may focus on the ME/CFS diagnosis and miss the eating disorder, which delays appropriate treatment. Early identification of both conditions together can help reduce serious health problems.

Diagnostics

E3 PreliminaryCohortPEM not requiredCase-Control

Possible relationship between chronic fatigue and postural tachycardia syndromes.

De Lorenzo, F, Hargreaves, J, Kakkar, V V·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·1996

This study looked at five people with ME/CFS who experienced symptoms like dizziness, blurred vision, and heart palpitations when standing up. When these patients were tested while lying on a tilting table that slowly moved them upright, researchers found that their blood pressure dropped and heart rate increased significantly. This suggests that some ME/CFS patients may have a condition called postural tachycardia syndrome, which affects how the body manages blood pressure during position changes.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Neuroimmune mechanisms in health and disease: 2. Disease.

Anisman, H, Baines, M G, Berczi, I et al.·CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·1996

When your body fights an infection, your immune system releases chemical messengers called cytokines that trigger fatigue, fever, loss of appetite, and inactivity—changes controlled partly by your brain and nervous system. This review explains how problems in the communication between your immune system and brain (particularly an area called the hypothalamus-pituitary-adrenal axis) may contribute to chronic conditions including ME/CFS, fibromyalgia, and autoimmune diseases. Understanding these connections could lead to new treatments using hormones and other brain-signaling molecules.

Immune System

E3 PreliminaryMechanismPEM unclearObservational

Influence of immediate hypersensitivity skin reactions on delayed reactions in patients with chronic fatigue syndrome.

Steinberg, P, Pheley, A, Peterson, P K·The Journal of allergy and clinical immunology·1996

This study looked at how immediate allergic skin reactions (like those that happen within minutes of allergen exposure) might affect delayed allergic reactions (which develop over hours or days) in people with ME/CFS. Researchers were investigating whether the immune system's early response to allergens could influence its later response in this patient population. Understanding these connections may help explain why some ME/CFS patients experience unusual or prolonged allergic reactions.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

The use of transfer factors in chronic fatigue syndrome: prospects and problems.

Levine, P H·Biotherapy (Dordrecht, Netherlands)·1996

ME/CFS often starts with a viral infection and some people have ongoing herpes virus activity. This article discusses transfer factors—a type of immune therapy—that might help fight these viruses and improve symptoms. The authors explain why we need better-designed studies to test if this treatment actually works.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Reversible and selective inhibitors of monoamine oxidase A in mental and other disorders.

Priest, R G, Gimbrett, R, Roberts, M et al.·Acta psychiatrica Scandinavica. Supplementum·1995

This review examines moclobemide and similar medications called RIMAs, which work by affecting brain chemicals involved in mood. The medication has proven effective for depression and is being tested in chronic fatigue syndrome (ME/CFS). Researchers note it may also help with anxiety, social phobia, and other conditions, with fewer side effects than older antidepressants.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Human herpesvirus-7 (HHV-7): current status.

Ablashi, D V, Berneman, Z N, Kramarsky, B et al.·Clinical and diagnostic virology·1995

This review article summarizes what scientists knew about human herpesvirus-7 (HHV-7) as of 1995, a newly discovered virus related to other common herpesviruses. HHV-7 was found in a chronic fatigue syndrome patient, along with healthy people, and is very common in the population (affecting over 85% of Americans). The virus has been linked to a few childhood rash illnesses and possibly some cases with liver involvement, but scientists had limited information about whether it causes ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The pathogenesis of chronic pain and fatigue syndromes, with special reference to fibromyalgia.

Clauw, D J·Medical hypotheses·1995

This paper reviews what doctors and researchers knew in 1995 about fibromyalgia and similar conditions that cause chronic pain and tiredness. The authors noticed that fibromyalgia overlaps significantly with chronic fatigue syndrome, migraines, irritable bowel syndrome, and mood disorders, suggesting these conditions may share common underlying causes rather than being completely separate diseases.

SleepAutonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

10 key questions answered on chronic fatigue syndrome.

Gantz, N M·Contemporary internal medicine·1995

This is an editorial article that addresses 10 frequently asked questions about chronic fatigue syndrome (ME/CFS). Rather than reporting new research data, the author discusses common questions patients and doctors have about the condition, its diagnosis, and management. The article aims to help clarify misconceptions and provide practical information about ME/CFS.

Diagnostics

E3 PreliminaryBehavioralPEM not requiredCase-Control

Chronic fatigue syndrome associated with a psychotic state resulting in multiple murders.

Ghahramani, M, Gooriah, V·The Bulletin of the American Academy of Psychiatry and the Law·1995

This case study describes a young man who developed severe fatigue and depression following infectious mononucleosis, and later experienced a serious mental health crisis involving psychosis and grandiose delusions. The case highlights how severe infections can sometimes lead to complex psychiatric symptoms that took considerable time to properly diagnose and treat with antipsychotic medications.

E3 PreliminaryMechanismPEM not requiredMechanistic

Phylogenetic analysis of short enteroviral sequences from patients with chronic fatigue syndrome.

Galbraith, D N, Nairn, C, Clements, G B·The Journal of general virology·1995

Researchers looked for enterovirus genetic material in ME/CFS patients and compared it to viruses found in people with acute infections. Using genetic analysis, they found that most of the virus sequences from ME/CFS patients were novel and distinct from known enteroviruses. This suggests that some ME/CFS patients may have persistent enterovirus infections that are different from typical acute infections.

E3 PreliminaryCommentaryPEM unclearEditorial

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Goldenberg, D L·Current opinion in rheumatology·1995

This review article examines fibromyalgia, chronic fatigue syndrome, and related muscle pain conditions. Research using specialized magnetic imaging showed that muscle damage is not the main problem in fibromyalgia. Scientists are now focusing on how the brain and nervous system may be involved in these conditions, using new technologies to better understand what causes them.

E3 PreliminaryMechanismPEM not requiredMechanistic

African green monkey origin of the atypical cytopathic 'stealth virus' isolated from a patient with chronic fatigue syndrome.

Martin, W J, Ahmed, K N, Zeng, L C et al.·Clinical and diagnostic virology·1995

Researchers found a virus in a chronic fatigue syndrome patient that resembled cytomegalovirus but had unusual characteristics. By comparing the virus's genetic code to known viruses in databases, they discovered it was most similar to a virus found in African green monkeys, suggesting this may be its original source.

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Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome.

The value of the dehydroepiandrosterone-annexed vitamin C infusion treatment in the clinical control of chronic fatigue syndrome (CFS). I. A Pilot study of the new vitamin C infusion treatment with a volunteer CFS patient.

[Fibromyalgia syndrome and chronic fatigue syndrome. Similarities and differences].

["Prolonged" decay test and auditory brainstem responses in the clinical diagnosis of the chronic fatigue syndrome].

[Chronic fatigue syndrome--psychiatric aspects].

N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.

Epstein-Barr virus-related primary cutaneous amyloidosis. Successful treatment with acyclovir and interferon-alpha.

Chronic fatigue syndrome and dieting disorders: diagnosis and management problems.

Possible relationship between chronic fatigue and postural tachycardia syndromes.

Neuroimmune mechanisms in health and disease: 2. Disease.

Influence of immediate hypersensitivity skin reactions on delayed reactions in patients with chronic fatigue syndrome.

The use of transfer factors in chronic fatigue syndrome: prospects and problems.

Reversible and selective inhibitors of monoamine oxidase A in mental and other disorders.

Human herpesvirus-7 (HHV-7): current status.

The pathogenesis of chronic pain and fatigue syndromes, with special reference to fibromyalgia.

10 key questions answered on chronic fatigue syndrome.

Chronic fatigue syndrome associated with a psychotic state resulting in multiple murders.

Phylogenetic analysis of short enteroviral sequences from patients with chronic fatigue syndrome.

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

African green monkey origin of the atypical cytopathic 'stealth virus' isolated from a patient with chronic fatigue syndrome.

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