ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

2221–2240 of 2,423 studies

E3 PreliminaryCommentaryPEM not requiredEditorial

Chronic fatigue syndrome. A fresh look at an old problem.

McSherry, J·Canadian family physician Medecin de famille canadien·1993

This editorial discusses chronic fatigue syndrome (ME/CFS) as a real medical condition affecting about 3 in 100,000 people. Most patients experience symptoms for approximately 2.5 years before recovering to normal health. Since there is no single definitive test, doctors diagnose ME/CFS by ruling out other diseases, and currently no one treatment works for everyone.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Hypothesis: the nasal fatigue reflex.

Chester, A C·Integrative physiological and behavioral science : the official journal of the Pavlovian Society·1993

This paper proposes a new theory: that extreme fatigue in ME/CFS and related conditions might be the body's protective reflex triggered by nasal or sinus problems. The idea is that in our evolutionary past, when a good sense of smell was crucial for survival, fatigue would have kept sick animals resting safely at home while their nose healed. The author suggests this ancient reflex may still be active in humans today.

E3 PreliminaryMechanismPEM not requiredMechanistic

Central basis of muscle fatigue in chronic fatigue syndrome.

Kent-Braun, J A, Sharma, K R, Weiner, M W et al.·Neurology·1993

Researchers tested whether muscle fatigue in ME/CFS patients was caused by problems within the muscle itself or in the brain's ability to control muscles. They found that the muscles worked normally and used energy normally during exercise, but the patients' brains were unable to fully activate their muscles during hard, sustained work. This suggests the primary problem may be in how the nervous system controls muscles rather than in the muscles themselves.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue in historical perspective.

Shorter, E·Ciba Foundation symposium·1993

This historical review examines how chronic fatigue as an illness has been understood and named over the past 150 years. The author traces how doctors have called similar conditions by different names—from 'neurasthenia' in the 1800s to 'myalgic encephalomyelitis,' 'chronic Epstein-Barr virus infection,' and 'fibromyalgia'—and explains how these separate medical concepts have recently begun to converge into what we now call chronic fatigue syndrome. The study shows that chronic fatigue became increasingly common in Europe and North America by the early 1900s, though it was rarely documented before the mid-1800s.

E3 PreliminaryCommentaryPEM not requiredEditorial

Somatization, illness attribution and the sociocultural psychiatry of chronic fatigue syndrome.

Abbey, S E·Ciba Foundation symposium·1993

This paper explores how psychological factors, personal beliefs about illness, and social influences may play a role in ME/CFS. The author examines how things like perfectionism, how people cope with stress, and the way doctors and media talk about ME/CFS can affect whether someone develops the condition or how severe their symptoms become.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Pharmacological approaches to the therapy of chronic fatigue syndrome.

McCluskey, D R·Ciba Foundation symposium·1993

This study examined various medications used to treat ME/CFS and found that none completely resolved symptoms. The researchers suggest that ME/CFS may be caused by a sleep regulation problem in the brain, which leads to not only extreme tiredness but also pain sensitivity, temperature control issues, and mood problems. They propose that medications affecting brain chemicals, especially serotonin, might help and should be tested in larger clinical trials.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic Fatigue Syndrome: New hope from psychoneuroimmunology and community psychology.

Jason, L A·The journal of primary prevention·1993

This 1993 paper explores how the mind, nervous system, and immune system are connected in ME/CFS, and how community support might help with recovery. The authors use a real patient's story to show how understanding these connections and building supportive relationships could be helpful for people struggling with this illness.

E3 PreliminaryCohortPEM unclear

[A case from practice (279). 1. Chronic fatigue syndrome (CFS). 2. Psychosocial problems].

Kiener, S·Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis·1993

This is a case report from a Swiss medical practice describing a patient with chronic fatigue syndrome (CFS) and the psychological and social problems that came along with the condition. The doctor documented how CFS affected this patient's daily life, relationships, and mental health. This type of case study helps doctors recognize CFS in their own patients and understand the broader impact it has beyond just physical symptoms.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Infection of natural killer cells by human herpesvirus 6.

Lusso, P, Malnati, M S, Garzino-Demo, A et al.·Nature·1993

This study found that a virus called HHV-6 can directly infect and damage natural killer cells, which are important immune cells that normally fight viruses. When HHV-6 infects these cells, it kills them and also causes them to express a protein that makes them vulnerable to HIV infection. This suggests that HHV-6 might be a way the body's natural antiviral defenses get weakened.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Amma therapy: a holistic approach to chronic fatigue syndrome.

Young, A·Journal of holistic nursing : official journal of the American Holistic Nurses' Association·1993

This study looked at Amma Therapy, a hands-on healing practice, as a possible way to help people with ME/CFS who feel frustrated with traditional medical care. The researcher examined how this holistic approach might benefit patients with chronic fatigue. The study suggests that some people with ME/CFS may find relief through this alternative therapy.

Interventions

E3 PreliminaryCohortPEM not requiredObservational

Society, mind and body in chronic fatigue syndrome: an anthropological view.

Ware, N C·Ciba Foundation symposium·1993

This study interviewed 50 people with chronic fatigue to understand how their daily lives, families, and work environments shaped their experience of illness. The researchers found that people often traced their illness to stressful life events and busy lifestyles, and that having ME/CFS sometimes led them to make positive changes by slowing down. The study also explains why ME/CFS patients often feel dismissed—society tends to separate 'mind' from 'body,' making psychological factors seem less real than physical ones.

E3 PreliminaryCohortPEM unclearCase-Control

[The "anti-Ki" syndrome: major clinical features].

Matsunaga, K·Rinsho byori. The Japanese journal of clinical pathology·1993

Researchers found that four patients with autoimmune diseases had high levels of anti-Ki antibodies, a type of immune marker. These patients shared several symptoms including hair loss, severe fatigue, muscle weakness, joint inflammation, dry mouth, and blood sugar problems. The study suggests that this antibody pattern may be related to conditions like chronic fatigue syndrome and fibromyalgia.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Is chronic fatigue syndrome an infectious disease?

Mawle, A C, Reyes, M, Schmid, D S·Infectious agents and disease·1993

This 1993 paper examines whether chronic fatigue syndrome (ME/CFS) might be caused by an infection. The authors reviewed evidence about infectious agents and their possible role in ME/CFS development. While the study explores this connection, it does not provide definitive answers about whether an infection causes the illness.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The role of viral infection in polymyositis, dermatomyositis and chronic fatigue syndrome.

Behan, W M, Behan, P O·Bailliere's clinical neurology·1993

This review examines whether viral infections might be responsible for causing three conditions: polymyositis, dermatomyositis, and ME/CFS. The authors looked at evidence connecting viruses to these diseases, which cause muscle weakness and persistent fatigue. Understanding these potential links could help explain why some people develop ME/CFS after infections.

Immune System

E3 PreliminaryCohortPEM unclearCase-Control

[The chronic fatigue syndrome associated with Epstein-Barr virus infection].

Bojić, I, Mijusković, P, Lilić, D et al.·Vojnosanitetski pregled·1993

This 1993 study examined whether Epstein-Barr virus (EBV)—a common virus that causes mononucleosis—might be connected to chronic fatigue syndrome (ME/CFS). Researchers compared a group of people with ME/CFS to a control group to see if EBV infection patterns differed between them. The study aimed to explore whether EBV could play a role in developing or maintaining ME/CFS symptoms.

E3 PreliminaryCohortPEM unclearCross-Sectional

Experience at a referral center for patients with suspected Lyme disease in an area of nonendemicity: first 65 patients.

Burdge, D R, O'Hanlon, D P·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1993

Doctors at a hospital created a special clinic to evaluate patients who thought they had Lyme disease, even though Lyme disease is not common in that region. Out of 65 patients referred to the clinic, only 2 actually had Lyme disease. However, the clinic successfully identified other real medical conditions in most patients, including rheumatologic diseases, infections, and chronic fatigue syndrome.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCase-Control

Exercise performance and fatiguability in patients with chronic fatigue syndrome.

Gibson, H, Carroll, N, Clague, J E et al.·Journal of neurology, neurosurgery, and psychiatry·1993

This study compared how muscles work in people with ME/CFS and healthy controls during and after exercise. Researchers found that the muscles themselves functioned normally, but people with ME/CFS reported feeling much more tired and exhausted during exercise relative to their heart rate compared to controls. This suggests that the fatigue comes from how the brain perceives effort rather than from actual muscle damage or weakness.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Service delivery for people with chronic fatigue syndrome: a pilot action research study.

Denz-Penhey, H, Murdoch, J C·Family practice·1993

This study looked at how general practices (family doctors' offices) could better serve patients with ME/CFS. Researchers worked with doctors and patients over time to find ways of talking about the condition and organizing services that felt acceptable and helpful to both. The goal was to develop self-management approaches that encouraged the body's natural healing abilities while fitting within what doctors' offices could realistically offer.

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, sleep disorder and chronic fatigue syndrome.

Moldofsky, H·Ciba Foundation symposium·1993

This study examined how sleep problems, tiredness, and muscle pain are connected in ME/CFS and fibromyalgia. Both conditions share similar unusual brain wave patterns during sleep that make sleep feel unrefreshing even though people sleep. The research suggests that problems with the immune system and sleep-wake cycle are linked, and interfering with either one can trigger the other and cause ME/CFS symptoms.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Treatment of the chronic fatigue syndrome. A review and practical guide.

Blondel-Hill, E, Shafran, S D·Drugs·1993

This 1993 guide explains that ME/CFS is a real illness defined by severe, disabling fatigue along with other physical and mental symptoms, though its exact cause remains unknown. The main treatment is getting a proper diagnosis, learning about the condition, and working with a caring doctor who understands it. Some patients may benefit from antidepressant medications even without depression, though no single treatment has been proven to work reliably for everyone.

Diagnostics

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Evidence browser

Chronic fatigue syndrome. A fresh look at an old problem.

Hypothesis: the nasal fatigue reflex.

Central basis of muscle fatigue in chronic fatigue syndrome.

Chronic fatigue in historical perspective.

Somatization, illness attribution and the sociocultural psychiatry of chronic fatigue syndrome.

Pharmacological approaches to the therapy of chronic fatigue syndrome.

Chronic Fatigue Syndrome: New hope from psychoneuroimmunology and community psychology.

[A case from practice (279). 1. Chronic fatigue syndrome (CFS). 2. Psychosocial problems].

Infection of natural killer cells by human herpesvirus 6.

Amma therapy: a holistic approach to chronic fatigue syndrome.

Society, mind and body in chronic fatigue syndrome: an anthropological view.

[The "anti-Ki" syndrome: major clinical features].

Is chronic fatigue syndrome an infectious disease?

The role of viral infection in polymyositis, dermatomyositis and chronic fatigue syndrome.

[The chronic fatigue syndrome associated with Epstein-Barr virus infection].

Experience at a referral center for patients with suspected Lyme disease in an area of nonendemicity: first 65 patients.

Exercise performance and fatiguability in patients with chronic fatigue syndrome.

Service delivery for people with chronic fatigue syndrome: a pilot action research study.

Fibromyalgia, sleep disorder and chronic fatigue syndrome.

Treatment of the chronic fatigue syndrome. A review and practical guide.

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