ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

2321–2340 of 2,423 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Molecular approaches to epidemiologic evaluation of viruses as risk factors for patients who have chronic fatigue syndrome.

Miller, G·Reviews of infectious diseases·1991

This paper proposes that studying how viral infections like flu, hepatitis, and mono can trigger long-term fatigue might help us understand ME/CFS. The researchers suggest examining not just whether someone had a virus, but how much virus was present, which type of virus it was, where it spread in the body, and whether the virus was active or dormant. They also recommend looking carefully at how individual patients' immune systems respond to specific parts of viruses.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Human herpesvirus-6 (HHV-6) (short review).

Ablashi, D V, Salahuddin, S Z, Josephs, S F et al.·In vivo (Athens, Greece)·1991

This review examines Human Herpesvirus-6 (HHV-6), a common virus that most people carry. The virus can reactivate in people with certain illnesses, including ME/CFS. The study found that people with ME/CFS sometimes have higher levels of antibodies to HHV-6, suggesting the virus may be active in their bodies.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Psychiatric perspectives: an overview.

Woods, T O, Goldberg, D P·British medical bulletin·1991

This review examines how psychological and social factors may play a role in ME/CFS. The authors suggest that while a viral illness may trigger the condition in people with certain personality traits, over time the disorder becomes maintained by how people and doctors respond to the illness rather than the original virus itself. They discuss how doctor-patient interactions and how people cope with their illness may contribute to keeping ME/CFS going.

E3 PreliminaryReviewPEM unclearReview-Narrative

Human herpesvirus 6 (HHV6) and chronic fatigue syndrome (CFS).

Ablashi, D V, Zompetta, C, Lease, C et al.·Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada·1991

This review article examines whether human herpesvirus 6 (HHV6), a common virus that infects most people in childhood, might be connected to ME/CFS. The authors gathered available evidence about HHV6 and its potential role in causing or contributing to chronic fatigue syndrome symptoms.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

alpha-Interferon and 5-fluorouracil: possible mechanisms of antitumor action.

Meadows, L M, Walther, P, Ozer, H·Seminars in oncology·1991

This study tested a cancer treatment combining two drugs (5-fluorouracil and interferon alfa-2b) in 17 patients. One side effect observed was chronic fatigue syndrome, which forced doctors to reduce the interferon dose in some patients. The study found the drug combination showed promise against certain cancers, but it also caused significant side effects including fatigue, mouth sores, and other complications.

E3 PreliminaryCommentaryPEM not requiredEditorial

Assessment of depression in patients with chronic fatigue syndrome.

Thase, M E·Reviews of infectious diseases·1991

This paper examines how depression and ME/CFS are connected and how to tell them apart. The authors warn that depression is sometimes mistakenly diagnosed as ME/CFS, while in other cases ME/CFS itself may cause depression-like symptoms. They recommend that doctors use multiple assessment tools and be careful to distinguish between these conditions rather than assuming one is the cause of the other.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Nervous system-immune system communication.

Arnason, B G·Reviews of infectious diseases·1991

Some people's bodies may be genetically or biologically wired to respond to infections in a way that leads to ME/CFS. This review examines how the immune system and nervous system communicate with each other through chemical messengers like interleukin-1 and hormones. The author suggests that measuring these chemicals in patients with ME/CFS compared to healthy people could help us understand why some people develop this disease after an infection.

Immune System

E3 PreliminaryTrialPEM not requiredRCT

A randomized comparison of two doses of human lymphoblastoid interferon-alpha in hairy cell leukemia. Wellcome HCL Study Group.

Smalley, R V, Anderson, S A, Tuttle, R L et al.·Blood·1991

This study tested two different doses of interferon-alpha (a type of immune protein) in patients with hairy cell leukemia, a blood cancer. Researchers found that the lower dose worked almost as well as the higher dose for improving blood cell counts but caused fewer side effects, including less chronic fatigue. Based on these results, doctors were advised to start patients on the lower dose.

E3 PreliminaryBehavioralPEM unclearCase-Control

Nortriptyline in chronic fatigue syndrome: a double blind, placebo-controlled single case study.

Gracious, B, Wisner, K L·Biological psychiatry·1991

This study tested whether a medication called nortriptyline (an older type of antidepressant) could help one person with ME/CFS. The researchers gave the patient either the medication or a placebo (inactive pill) without telling them which was which, and tracked how they felt. This type of single-patient study can provide useful information, but it only shows what happened with one individual and cannot prove the treatment works for everyone with ME/CFS.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

Detection of Epstein-Barr virus with molecular hybridization techniques.

Pagano, J S·Reviews of infectious diseases·1991

This paper reviews different laboratory techniques for detecting Epstein-Barr virus (EBV), a common virus that some researchers suspect might play a role in ME/CFS. The authors explain that newer methods like genetic testing and blood analysis are much faster and more accurate than older traditional tests, and could help scientists understand whether EBV actually causes chronic fatigue syndrome.

Immune System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Seasonal affective disorder presenting as chronic fatigue syndrome.

Lam, R W·Canadian journal of psychiatry. Revue canadienne de psychiatrie·1991

This study describes two patients who were diagnosed with chronic fatigue syndrome (CFS) but actually had seasonal affective disorder (SAD)—a type of depression that occurs during certain seasons. Both patients improved significantly when treated with light therapy rather than typical CFS treatments. The study highlights that depression, including seasonal depression, can look very similar to CFS and needs to be carefully ruled out before diagnosing CFS.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Definition and measurement of fatigue.

Barofsky, I, Legro, M W·Reviews of infectious diseases·1991

This paper examines how fatigue is defined and measured in ME/CFS, highlighting that these definitions have not been well-developed in medical research. The authors reviewed different tools available to measure fatigue—ranging from simple single-item questions to more complex multi-part assessments—and discussed how fatigue in ME/CFS differs from fatigue studied in healthy people in laboratory settings. They emphasize the need to study fatigue as it actually occurs in patients with ME/CFS and to use consistent measurement methods across research.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Physiologic measurement of exercise and fatigue with special reference to chronic fatigue syndrome.

Lewis, S F, Haller, R G·Reviews of infectious diseases·1991

This review article explains how scientists measure exercise capacity and fatigue in the body. It describes three key concepts: aerobic fitness (how efficiently your heart and muscles use oxygen), muscle strength (your muscles' ability to produce force), and fatigue (the loss of strength that happens during activity). The authors discuss how these measurements might help us better understand what happens in ME/CFS when patients experience excessive fatigue.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Treatment of chronic fatigue syndrome.

McBride, S J, McCluskey, D R·British medical bulletin·1991

This review examines different treatments that doctors have tried for ME/CFS, a condition marked by severe tiredness and other ongoing symptoms. Because the exact cause of ME/CFS isn't yet known, it's challenging to design treatments that target the underlying problem. The authors discuss various treatment approaches and the difficulties involved in managing this complicated illness.

E3 PreliminaryMechanismPEM not requiredMechanistic

Altered cytokine release in peripheral blood mononuclear cell cultures from patients with the chronic fatigue syndrome.

Chao, C C, Janoff, E N, Hu, S X et al.·Cytokine·1991

This study found that immune cells from people with ME/CFS respond differently to stimulation than cells from healthy people. Specifically, when researchers activated these immune cells in the lab, they released higher levels of inflammatory molecules (IL-1 beta, IL-6, and TNF-alpha), suggesting that ME/CFS patients' immune cells may be in a heightened state of readiness. The study also found unusual patterns in a molecule called TGF-beta, which normally helps regulate immune responses.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Goldenberg, D L·Current opinion in rheumatology·1991

This review examines three related conditions—fibromyalgia, chronic fatigue syndrome, and myofascial pain—that often occur together and cause pain, tiredness, and sleep problems. Researchers are discovering that these conditions may share common biological causes involving how the body senses pain, hormone imbalances, and problems with muscle function. Unfortunately, the new treatments being tested at that time were not particularly effective.

Pain and SensitizationSleepDiagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Evaluation and management of patients with chronic fatigue.

Matthews, D A, Manu, P, Lane, T J·The American journal of the medical sciences·1991

This review article examines how doctors diagnose and treat patients who experience chronic fatigue in everyday medical practice. The authors note that chronic fatigue has many possible causes, including medical illnesses, psychiatric conditions like depression and anxiety, lifestyle factors, and medications. They emphasize that building trust with patients and using a combination of psychiatric evaluation, functional assessment, and both medication and behavioral therapy approaches are important for effective care.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Post-viral fatigue syndrome. Epidemiology: lessons from the past.

Jenkins, R·British medical bulletin·1991

This review examines the history of post-viral fatigue syndrome (PVFS), including early outbreaks of what we now call ME/CFS, and how doctors have understood and tracked this illness over time. The author notes that cases are not officially recorded by health authorities, making it hard to spot when the condition becomes more common in communities. The review explores important questions about how the illness is defined, why some people develop it after infections, and how psychological factors relate to the physical symptoms.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome.

Demitrack, M A, Dale, J K, Straus, S E et al.·The Journal of clinical endocrinology and metabolism·1991

This study examined whether ME/CFS patients have a problem with their body's stress hormone system, specifically the network that controls cortisol production. Researchers found that ME/CFS patients had lower cortisol levels than healthy people, but their bodies were responding unusually to stimulation—suggesting the problem lies in the brain's control center rather than the adrenal glands themselves.

Endocrine Disruption

E3 PreliminaryCommentaryPEM not requiredEditorial

Chronic fatigue syndrome: issues in the diagnosis and estimation of incidence.

Armon, C, Kurland, L T·Reviews of infectious diseases·1991

This article examines how ME/CFS is diagnosed and points out problems with the current definition used by doctors. The authors identified several issues: the definition doesn't clearly address what happens when patients do too much activity, it doesn't specify how much rest is needed, and it may miss cases in poorer communities. They suggest a new flowchart that could help identify different types of ME/CFS and potentially help some patients avoid developing the condition.

Post-Exertional Malaise

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Molecular approaches to epidemiologic evaluation of viruses as risk factors for patients who have chronic fatigue syndrome.

Human herpesvirus-6 (HHV-6) (short review).

Psychiatric perspectives: an overview.

Human herpesvirus 6 (HHV6) and chronic fatigue syndrome (CFS).

alpha-Interferon and 5-fluorouracil: possible mechanisms of antitumor action.

Assessment of depression in patients with chronic fatigue syndrome.

Nervous system-immune system communication.

A randomized comparison of two doses of human lymphoblastoid interferon-alpha in hairy cell leukemia. Wellcome HCL Study Group.

Nortriptyline in chronic fatigue syndrome: a double blind, placebo-controlled single case study.

Detection of Epstein-Barr virus with molecular hybridization techniques.

Seasonal affective disorder presenting as chronic fatigue syndrome.

Definition and measurement of fatigue.

Physiologic measurement of exercise and fatigue with special reference to chronic fatigue syndrome.

Treatment of chronic fatigue syndrome.

Altered cytokine release in peripheral blood mononuclear cell cultures from patients with the chronic fatigue syndrome.

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Evaluation and management of patients with chronic fatigue.

Post-viral fatigue syndrome. Epidemiology: lessons from the past.

Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome.

Chronic fatigue syndrome: issues in the diagnosis and estimation of incidence.

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