ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

2321–2340 of 2,420 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Analysis of clinical, epidemiologic, and laboratory data on chronic fatigue syndrome.

Redmond, C K·Reviews of infectious diseases·1991

This paper reviews how ME/CFS research has been studied and analyzed over time. The authors found that many ME/CFS studies don't use the best statistical methods available. They recommend that future ME/CFS research should include expert statisticians who can use more advanced analytical techniques to better understand patterns in patient data and find clues about what causes this illness.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The chronic fatigue syndrome: a reappraisal and unifying hypothesis.

Byrne, E·Clinical and experimental neurology·1991

This 1991 review examined ME/CFS from multiple scientific angles—including viral infection, immune system problems, metabolism, and mental health—to understand why this condition develops. The authors proposed that ME/CFS typically results from a combination of factors: personal characteristics before illness (like psychological traits or immune vulnerabilities), a trigger (such as a virus), and how someone's emotions respond to being sick. Rather than having one single cause, ME/CFS appears to exist on a spectrum of different presentations.

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic encephalomyelitis (chronic fatigue syndrome): an historic perspective.

Hyde, B M·Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada·1991

This article provides a historical overview of myalgic encephalomyelitis (ME/CFS), tracing how the condition has been understood and documented over time. It examines the disease's recognition in medical literature and explores how ME/CFS has been characterized throughout history. This historical perspective helps patients and the public understand how medical understanding of this illness has evolved.

E3 PreliminaryBehavioralPEM not requiredObservational

Cognitive behaviour therapy in chronic fatigue syndrome.

Butler, S, Chalder, T, Ron, M et al.·Journal of neurology, neurosurgery, and psychiatry·1991

This study tested whether cognitive behaviour therapy (CBT)—a type of talk therapy focusing on thoughts and behaviors—could help 50 ME/CFS patients who had been sick for an average of five years. Patients received therapy aimed at identifying unhelpful beliefs about their symptoms and gradually returning to activities. The therapy led to meaningful improvements in fatigue, overall functioning, and mood, though some patients refused treatment.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

Nervous system-immune system communication.

Arnason, B G·Reviews of infectious diseases·1991

Some people's bodies may be genetically or biologically wired to respond to infections in a way that leads to ME/CFS. This review examines how the immune system and nervous system communicate with each other through chemical messengers like interleukin-1 and hormones. The author suggests that measuring these chemicals in patients with ME/CFS compared to healthy people could help us understand why some people develop this disease after an infection.

Immune System

E3 PreliminaryMechanismPEM unclearObservational

Anti-neuronal antibody levels in chronic fatigue syndrome patients with neurologic abnormalities.

Buchwald, D, Wener, M H, Komaroff, A L·Arthritis and rheumatism·1991

This study looked at whether people with ME/CFS who have neurological symptoms (like problems with thinking or nerve function) have unusual antibodies in their blood that attack nerve cells. Researchers tested blood samples from ME/CFS patients and compared antibody levels between those with and without neurological problems. The goal was to understand whether immune system misdirection might be causing some of the neurological symptoms patients experience.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Pain syndromes, disability, and chronic disease in childhood.

Malleson, P N·Current opinion in rheumatology·1991

This editorial discusses how chronic pain and long-term illnesses affect children, and suggests that conditions like fibromyalgia and chronic fatigue syndrome (ME/CFS) may be related to each other. The author notes that doctors need better training to understand these complex conditions and that psychological factors may play a role in how these illnesses develop and affect children's lives.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue: myth or reality?].

Comtois, R·L'union medicale du Canada·1991

This 1991 review article addresses a fundamental question: Is chronic fatigue a real medical condition or just a perception? The authors acknowledge that while fatigue is one of the most common health complaints doctors hear, it can be difficult to diagnose and treat because we don't have simple blood tests like we do for cholesterol. The paper discusses how new diagnostic criteria for chronic fatigue syndrome were beginning to help doctors identify and manage this condition more effectively.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Clinical spectrum of postviral fatigue syndrome.

Behan, P O, Bakheit, A M·British medical bulletin·1991

This review article examines postviral fatigue syndrome (also called ME/CFS), a condition that develops after viral infections and causes severe tiredness and other symptoms. The authors describe how this syndrome appears both in individual cases and in epidemic clusters worldwide, and explain why doctors historically had difficulty recognizing it until outbreaks occurred.

E3 PreliminaryCommentaryPEM unclearEditorial

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Goldenberg, D L·Current opinion in rheumatology·1991

This review examines three related conditions—fibromyalgia, chronic fatigue syndrome, and myofascial pain—that often occur together and cause pain, tiredness, and sleep problems. Researchers are discovering that these conditions may share common biological causes involving how the body senses pain, hormone imbalances, and problems with muscle function. Unfortunately, the new treatments being tested at that time were not particularly effective.

Pain and SensitizationSleepDiagnostics

E3 PreliminaryCommentaryPEM not requiredEditorial

Chronic fatigue syndrome: issues in the diagnosis and estimation of incidence.

Armon, C, Kurland, L T·Reviews of infectious diseases·1991

This article examines how ME/CFS is diagnosed and points out problems with the current definition used by doctors. The authors identified several issues: the definition doesn't clearly address what happens when patients do too much activity, it doesn't specify how much rest is needed, and it may miss cases in poorer communities. They suggest a new flowchart that could help identify different types of ME/CFS and potentially help some patients avoid developing the condition.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Human herpesvirus-6 (HHV-6) (short review).

Ablashi, D V, Salahuddin, S Z, Josephs, S F et al.·In vivo (Athens, Greece)·1991

This review examines Human Herpesvirus-6 (HHV-6), a common virus that most people carry. The virus can reactivate in people with certain illnesses, including ME/CFS. The study found that people with ME/CFS sometimes have higher levels of antibodies to HHV-6, suggesting the virus may be active in their bodies.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Dual infections of the immune system in patients with chronic active Epstein-Barr virus infection mimicking chronic fatigue syndrome.

Purtilo, D T·Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada·1991

This article discusses the importance of distinguishing patients with ME/CFS (the commonly recognized illness) from those who have dual infections or weakened immune systems that only look like ME/CFS. The authors argue that some patients appearing to have ME/CFS may actually have other treatable conditions involving multiple infections, and recommend long-term studies tracking people who develop ME/CFS-like symptoms after documented viral infections.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Testing of vestibular function: an adjunct in the assessment of chronic fatigue syndrome.

Furman, J M·Reviews of infectious diseases·1991

Many people with ME/CFS experience dizziness and balance problems, but doctors don't fully understand why. This study looked at whether problems with the inner ear (the system that helps control balance) might explain these symptoms. The researchers tested the vestibular system—which controls balance and eye movement—using specialized equipment to see if people with ME/CFS had measurable abnormalities in how this system works.

Autonomic Nervous System

E3 PreliminaryCohortPEM unclearCase-Control

Fibromyalgia and parvovirus infection.

Leventhal, L J, Naides, S J, Freundlich, B·Arthritis and rheumatism·1991

This study describes three patients who developed fibromyalgia (a condition causing widespread pain and fatigue) shortly after having parvovirus B19 infections. Blood tests confirmed the virus was present, and sleep studies showed abnormal sleep patterns in two patients. The researchers suggest that doctors should look more carefully for viral infections in fibromyalgia patients whose symptoms started with flu-like illness.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Validation of biologic markers for use in research on chronic fatigue syndrome.

Schulte, P A·Reviews of infectious diseases·1991

This paper explains how scientists should evaluate biological markers—measurable signs in blood, tissue, or other body samples—before using them in ME/CFS research. The authors provide a practical checklist that researchers should follow to make sure these markers are reliable, meaningful, and won't be affected by other factors. This helps ensure that future ME/CFS studies measure things accurately and produce trustworthy results.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Treatment of chronic fatigue syndrome.

McBride, S J, McCluskey, D R·British medical bulletin·1991

This review examines different treatments that doctors have tried for ME/CFS, a condition marked by severe tiredness and other ongoing symptoms. Because the exact cause of ME/CFS isn't yet known, it's challenging to design treatments that target the underlying problem. The authors discuss various treatment approaches and the difficulties involved in managing this complicated illness.

E3 PreliminaryCohortPEM not requiredCase-Control

Infectious mononucleosis, Epstein-Barr virus, and chronic fatigue syndrome: a prospective case series.

Fark, A R·The Journal of family practice·1991

This study looked at whether Epstein-Barr virus (EBV), the virus that causes infectious mononucleosis (mono), might be the cause of ME/CFS. Researchers found that some people with chronic fatigue had high levels of antibodies (immune markers) against EBV, and some of them had never fully recovered from a previous mono infection. The study suggests a possible link between EBV infection and the development of chronic fatigue, though it doesn't prove the virus directly causes ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome; psychiatric aspects].

Hawton, K E, Hengeveld, M W·Nederlands tijdschrift voor geneeskunde·1991

This 1991 review article examines the psychiatric aspects of chronic fatigue syndrome (ME/CFS), exploring how mental health factors relate to the condition. The authors discuss the connection between psychiatric symptoms and fatigue, helping to clarify whether psychological issues cause ME/CFS or occur alongside it. This work contributed to early medical understanding of how ME/CFS affects both the body and mind.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Clinical indications and diagnostic techniques of human herpesvirus-6 (HHV-6) infection.

Krueger, G R, Ablashi, D V, Josephs, S F et al.·In vivo (Athens, Greece)·1991

This review examines how doctors can diagnose human herpesvirus-6 (HHV-6) infection and its connection to various illnesses, including a condition called postinfectious chronic fatigue syndrome. HHV-6 is a common virus that most people catch in childhood and then carry dormant in their bodies for life. The authors explain which tests doctors should use to accurately identify active HHV-6 infection and discuss why proper diagnosis matters for treatment.

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Analysis of clinical, epidemiologic, and laboratory data on chronic fatigue syndrome.

The chronic fatigue syndrome: a reappraisal and unifying hypothesis.

Myalgic encephalomyelitis (chronic fatigue syndrome): an historic perspective.

Cognitive behaviour therapy in chronic fatigue syndrome.

Nervous system-immune system communication.

Anti-neuronal antibody levels in chronic fatigue syndrome patients with neurologic abnormalities.

Pain syndromes, disability, and chronic disease in childhood.

[Chronic fatigue: myth or reality?].

Clinical spectrum of postviral fatigue syndrome.

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Chronic fatigue syndrome: issues in the diagnosis and estimation of incidence.

Human herpesvirus-6 (HHV-6) (short review).

Dual infections of the immune system in patients with chronic active Epstein-Barr virus infection mimicking chronic fatigue syndrome.

Testing of vestibular function: an adjunct in the assessment of chronic fatigue syndrome.

Fibromyalgia and parvovirus infection.

Validation of biologic markers for use in research on chronic fatigue syndrome.

Treatment of chronic fatigue syndrome.

Infectious mononucleosis, Epstein-Barr virus, and chronic fatigue syndrome: a prospective case series.

[Chronic fatigue syndrome; psychiatric aspects].

Clinical indications and diagnostic techniques of human herpesvirus-6 (HHV-6) infection.

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