ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

401–420 of 2,422 studies

E3 PreliminaryCohortPEM unclearCase-Control

A Case Study of Successful Application of the Principles of ME/CFS Care to an Individual with Long COVID.

Petracek, Lindsay S, Broussard, Camille A, Swope, Renee L et al.·Healthcare (Basel, Switzerland)·2023

A 19-year-old developed severe ME/CFS-like symptoms after COVID-19 infection. Doctors used ME/CFS treatment approaches—including physical therapy, heart rate monitoring, and medications for heart and immune problems—and the patient improved significantly over 2.5 years. This case suggests that treatments developed for ME/CFS may also help some long COVID patients.

Autonomic Nervous System

E3 PreliminaryCohortPEM unclearCross-Sectional

Increased SARS-CoV-2 reactive low avidity T cells producing inflammatory cytokines in pediatric post-acute COVID-19 sequelae (PASC).

Paniskaki, Krystallenia, Goretzki, Sarah, Anft, Moritz et al.·Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2023

This study looked at children who had COVID-19 and developed long-lasting symptoms like breathing problems, fatigue, and brain fog—a condition called pediatric long COVID. Researchers found that these children had more immune cells fighting the virus that were less effective than usual, and these cells released inflammatory chemicals that may have been causing their symptoms. The findings suggest that ongoing immune system activation after COVID-19 might explain why some children develop persistent health problems similar to ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Whole-body cryotherapy as a treatment for chronic medical conditions?

Tabisz, Hanna, Modlinska, Aleksandra, Kujawski, Sławomir et al.·British medical bulletin·2023

This review article examines whole-body cryotherapy (WBC)—exposing your entire body to very cold temperatures—as a possible treatment for various chronic conditions, including ME/CFS. The authors suggest that because WBC appears to reduce inflammation in the body, it might help conditions involving persistent inflammation. However, they emphasize that current research quality is low and that proper clinical trials are needed before we can know if WBC actually works.

NeuroinflammationImmune System

E3 PreliminaryMechanismPEM requiredMechanistic

Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles.

Aschman, Tom, Wyler, Emanuel, Baum, Oliver et al.·Acta neuropathologica communications·2023

Researchers examined muscle tissue from people with long COVID who experience fatigue and worsening symptoms after activity. They found that these patients had fewer blood vessels in their muscles, thicker vessel walls, and signs of immune cells that might have been triggered by the initial infection. These physical changes in the muscle's blood supply could explain why exercise makes their symptoms worse.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM requiredObservational

Exercise-induced changes in gene expression do not mediate post exertional malaise in Gulf War illness.

Boruch, Alexander E, Lindheimer, Jacob B, Ninneman, Jacob V et al.·Brain, behavior, & immunity - health·2023

This study looked at whether post-exertional malaise (PEM)—the worsening of symptoms after physical activity—is caused by changes in gene activity in Gulf War illness patients. Veterans with Gulf War illness and healthy controls exercised on stationary bikes, and researchers measured gene expression in blood samples before and after exercise. While the study found that certain genes did change after exercise in Gulf War illness patients, these gene changes did not explain why their symptoms got worse.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM requiredPreprintPreprint

A Mixed Methods System for the Assessment of Post Exertional Malaise in Encephalomyelitis/Chronic Fatigue Syndrome.

Stussman, Barbara, Calco, Brice, Norato, Gina et al.·medRxiv : the preprint server for health sciences·2023

This study looked at how to better measure post-exertional malaise (PEM)—the symptom flare-up that happens after activity in ME/CFS patients. Researchers asked 10 ME/CFS patients and 9 healthy people to do an exercise test, then tracked their symptoms over 72 hours using both rating scales and detailed interviews. They found that combining interviews with rating scales captured PEM patterns much better than rating scales alone, especially because rating scales sometimes hit their limits and couldn't show the full picture of symptom changes.

Post-Exertional Malaise

E3 PreliminaryReviewPEM requiredReview-Narrative

[Myalgic Encephalitis/Chronic Fatigue Syndrome: Diagnostic and Therapeutic Approach and Biological Research].

Sato, Wakiro·Brain and nerve = Shinkei kenkyu no shinpo·2023

This article reviews what we currently know about ME/CFS, a serious illness marked by extreme tiredness, sleep problems, difficulty thinking clearly, and difficulty standing up without symptoms getting worse. A key feature is post-exertional malaise—when patients feel much worse after physical or mental activity—which means people with ME/CFS need to carefully manage their activity levels. The article summarizes current approaches to diagnosis and treatment, as well as recent scientific discoveries about what happens in the body during this disease.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

[Myalgic encephalomyelitis/chronic fatigue syndrome: an overview of current evidence].

Ludwig, Birgit, Olbert, Elisabeth, Trimmel, Karin et al.·Der Nervenarzt·2023

This review examines what we currently know about ME/CFS, including how it is diagnosed and what treatments have been studied. The authors note that after many years of research, we still don't have clear answers about what causes ME/CFS or proven treatments that work for everyone. They suggest that the high rates of depression and anxiety seen in ME/CFS patients should make us consider whether psychological factors play a role in the condition.

E3 PreliminaryCohortPEM not requiredCase-Control

Hypertension and Severe Hypokalemia Associated With Oral Ingestion of Topical Hydrocortisone Cream.

Saha, Arunava, Balakrishnan, Suryanarayanan, Trivedi, Nitin et al.·AACE clinical case reports·2023

This case report describes a woman with chronic fatigue syndrome who accidentally poisoned herself by swallowing topical hydrocortisone cream as a replacement for prescription prednisone. She developed dangerously high blood pressure and a severe drop in potassium levels, which can cause life-threatening heart problems. The key lesson is that over-the-counter medications can cause serious harm if used incorrectly, even when applied to skin.

E3 PreliminaryBehavioralPEM not requiredObservational

SingStrong-A singing and breathing retraining intervention for respiratory and other common symptoms of long COVID: A pilot study.

Cahalan, Roisin M, Meade, Ciara, Mockler, Sarah·Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR·2022

Researchers tested a 10-week online program called SingStrong that combines breathing exercises, singing, and mindfulness to help people with long COVID. The 21 participants who completed the program reported significant improvements in breathlessness, fatigue, pain, voice quality, and ability to do daily activities. Qualitative feedback was overwhelmingly positive, with participants reporting better breathing and overall wellbeing.

E3 PreliminaryMechanismPEM unclearMechanistic

Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic Epipharyngitis.

Nishi, Kensuke, Yoshimoto, Shohei, Nishi, Soichiro et al.·International journal of molecular sciences·2022

This study looked at a Japanese treatment called Epipharyngeal Abrasive Therapy (EAT) that targets chronic inflammation in the epipharynx (the area behind your nasal cavity). The researchers found that patients who received EAT had significantly lower levels of IL-6, a key inflammatory molecule linked to ME/CFS symptoms, compared to those who didn't receive the treatment. This suggests that reducing inflammation in this specific area might help improve systemic symptoms in ME/CFS and similar conditions.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

Serum of Post-COVID-19 Syndrome Patients with or without ME/CFS Differentially Affects Endothelial Cell Function In Vitro.

Flaskamp, Lavinia, Roubal, Constanze, Uddin, Steven et al.·Cells·2022

This study examined blood samples from people with long COVID and those who developed ME/CFS after COVID-19, comparing them to healthy controls. Researchers tested whether certain proteins in these blood samples could harm the cells that line blood vessels. They found that the blood of ME/CFS patients contained more of these harmful proteins, and the blood samples from both patient groups affected blood vessel cells in different ways that could contribute to the fatigue and other symptoms these patients experience.

E3 PreliminaryMechanismPEM unclearMechanistic

Decreased NO production in endothelial cells exposed to plasma from ME/CFS patients.

Bertinat, Romina, Villalobos-Labra, Roberto, Hofmann, Lidija et al.·Vascular pharmacology·2022

This study looked at how blood from ME/CFS patients affects the inner lining of blood vessels in a laboratory setting. Researchers found that blood vessels exposed to ME/CFS patient blood produced less of a substance called nitric oxide, which is important for healthy blood vessel function. This suggests that problems with blood vessel health in ME/CFS patients may involve reduced nitric oxide production.

E3 PreliminaryMechanismPEM unclearMechanistic

Transient receptor potential melastatin 3 dysfunction in post COVID-19 condition and myalgic encephalomyelitis/chronic fatigue syndrome patients.

Sasso, Etianne Martini, Muraki, Katsuhiko, Eaton-Fitch, Natalie et al.·Molecular medicine (Cambridge, Mass.)·2022

This study examined a specific ion channel called TRPM3 in immune cells from patients with ME/CFS and long COVID, comparing them to healthy people. Researchers found that both ME/CFS and long COVID patients had similar problems with how this ion channel functions. The findings suggest that broken ion channels might be part of why these conditions cause long-lasting fatigue and other symptoms.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

EBV/HHV-6A dUTPases contribute to myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology by enhancing TFH cell differentiation and extrafollicular activities.

Cox, Brandon S, Alharshawi, Khaled, Mena-Palomo, Irene et al.·JCI insight·2022

This study found that some people with ME/CFS have abnormal immune responses linked to past infections with Epstein-Barr virus (EBV) and human herpesvirus 6A (HHV-6A). The researchers discovered that proteins from these viruses may trigger the immune system to produce excess amounts of certain signaling molecules, leading to confused immune cell behavior. This suggests a possible biological mechanism for how these common viruses might contribute to ME/CFS symptoms in some patients.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Long COVID: nosographic aspects and clinical epidemiology].

Abrignani, Maurizio G, Maloberti, Alessandro, Temporelli, Pier Luigi et al.·Giornale italiano di cardiologia (2006)·2022

Long COVID is a condition where people experience ongoing symptoms weeks or months after recovering from COVID-19 infection. Symptoms can include fatigue, difficulty thinking clearly, shortness of breath, muscle pain, sleep problems, and reduced ability to do daily activities. This review looks at how common long COVID is, who is most likely to develop it, and what we currently know about the condition.

Post-Exertional Malaise

E3 PreliminaryGuidelinePEM requiredGuideline

[Recommendation for standardized medical care for children and adolescents with long COVID].

Töpfner, Nicole, Deutsche Gesellschaft für Pädiatrische Infektiologie e. V. (DGPI), Alberer, Martin et al.·Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde·2022

This guideline provides doctors with expert recommendations for recognizing and treating long COVID in children and teenagers. It includes screening questions and step-by-step evaluation tools to help identify long COVID cases, as well as guidance on how different medical specialists should work together to care for affected young people. The recommendations are based on the best available evidence, though more research is still needed.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fatigue in Cirrhosis.

Bhandari, Krishnagopal, Kapoor, Dharmesh·Journal of clinical and experimental hepatology·2022

This review examines fatigue in patients with liver disease, explaining that fatigue is common and significantly affects quality of life. The authors describe how the liver plays a central role in energy production and how fatigue in liver disease likely has multiple causes involving the gut, muscles, and brain. The article discusses various ways to measure fatigue and different treatment approaches, including lifestyle changes, medications, diet, and exercise.

E3 PreliminaryMechanismPEM requiredMechanistic

Exosome-associated mitochondrial DNA from patients with myalgic encephalomyelitis/chronic fatigue syndrome stimulates human microglia to release IL-1β.

Tsilioni, Irene, Natelson, Benjamin, Theoharides, Theoharis C·The European journal of neuroscience·2022

This study found that after exercise, patients with ME/CFS have more pieces of DNA from their mitochondria (the energy-producing parts of cells) floating in their blood inside tiny particles called exosomes. When researchers tested these exosomes on immune cells in the lab, they triggered the release of IL-1β, a chemical that causes inflammation in the brain. This suggests that exercise might trigger a chain reaction involving these DNA-carrying particles that could contribute to ME/CFS symptoms.

NeuroinflammationImmune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Mechanism of acupuncture and moxibustion in treatment of chronic fatigue syndrome from perspective of intestinal flora].

Li, Chao-Ran, Sun, Zhong-Ren, Wang, Yu-Lin et al.·Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2022

This study explores how gut bacteria may contribute to chronic fatigue syndrome and suggests that acupuncture and moxibustion (traditional Chinese medicine techniques) might help by restoring healthy gut bacteria. The researchers believe that an imbalance in gut bacteria can trigger inflammation and metabolism problems in ME/CFS patients, and that these traditional treatments could reduce fatigue by improving gut health and communication between the gut and brain.

Gut MicrobiomeImmune System

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A Case Study of Successful Application of the Principles of ME/CFS Care to an Individual with Long COVID.

Increased SARS-CoV-2 reactive low avidity T cells producing inflammatory cytokines in pediatric post-acute COVID-19 sequelae (PASC).

Whole-body cryotherapy as a treatment for chronic medical conditions?

Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles.

Exercise-induced changes in gene expression do not mediate post exertional malaise in Gulf War illness.

A Mixed Methods System for the Assessment of Post Exertional Malaise in Encephalomyelitis/Chronic Fatigue Syndrome.

[Myalgic Encephalitis/Chronic Fatigue Syndrome: Diagnostic and Therapeutic Approach and Biological Research].

[Myalgic encephalomyelitis/chronic fatigue syndrome: an overview of current evidence].

Hypertension and Severe Hypokalemia Associated With Oral Ingestion of Topical Hydrocortisone Cream.

SingStrong-A singing and breathing retraining intervention for respiratory and other common symptoms of long COVID: A pilot study.

Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic Epipharyngitis.

Serum of Post-COVID-19 Syndrome Patients with or without ME/CFS Differentially Affects Endothelial Cell Function In Vitro.

Decreased NO production in endothelial cells exposed to plasma from ME/CFS patients.

Transient receptor potential melastatin 3 dysfunction in post COVID-19 condition and myalgic encephalomyelitis/chronic fatigue syndrome patients.

EBV/HHV-6A dUTPases contribute to myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology by enhancing TFH cell differentiation and extrafollicular activities.

[Long COVID: nosographic aspects and clinical epidemiology].

[Recommendation for standardized medical care for children and adolescents with long COVID].

Fatigue in Cirrhosis.

Exosome-associated mitochondrial DNA from patients with myalgic encephalomyelitis/chronic fatigue syndrome stimulates human microglia to release IL-1β.

[Mechanism of acupuncture and moxibustion in treatment of chronic fatigue syndrome from perspective of intestinal flora].

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research