ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

501–520 of 2,420 studies

E3 PreliminaryCohortPEM not requiredCase-Control

[Fatigue Doesn't Always have to be caused by SARS-CoV-2: Case Report].

Howanietz, Helmuth, Graf, Ulrike, Kainz, Theresa·Padiatrie und Padologie·2022

This case report describes a 17-year-old girl who experienced severe fatigue caused by Epstein-Barr virus (EBV) infection, commonly known as infectious mononucleosis. The authors highlight that fatigue in young people can come from many different causes, not just COVID-19, and that it's important to identify the correct cause. Notably, about 13.5% of people who have EBV infection go on to develop ME/CFS, making proper diagnosis essential.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Can l-carnitine reduce post-COVID-19 fatigue?

Vaziri-Harami, Roya, Delkash, Parisa·Annals of medicine and surgery (2012)·2022

Some people develop long-lasting fatigue after COVID-19 infection, similar to ME/CFS, and this fatigue can last for months. This article suggests that L-carnitine, a natural substance that helps cells produce energy, might help reduce this type of fatigue based on its success in treating fatigue caused by other diseases like cancer and multiple sclerosis. The authors recommend testing L-carnitine in clinical trials to see if it actually works and is safe for people with post-COVID fatigue.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

The Role of Neuro-Immune Interaction in Chronic Pain Conditions; Functional Somatic Syndrome, Neurogenic Inflammation, and Peripheral Neuropathy.

Meade, Elaine, Garvey, Mary·International journal of molecular sciences·2022

This review article examines how the nervous and immune systems interact to cause chronic pain and fatigue in conditions like ME/CFS, fibromyalgia, and IBS. The authors explain that childhood trauma and ongoing stress can permanently change how the body's stress response system works, leading to long-term symptoms. They discuss how these systems become dysregulated and contribute to the wide range of symptoms people with these conditions experience.

NeuroinflammationImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Possible Application of Melatonin in Long COVID.

Cardinali, Daniel P, Brown, Gregory M, Pandi-Perumal, Seithikurippu R·Biomolecules·2022

This review examines whether melatonin, a natural hormone that regulates sleep, might help people with long COVID who experience symptoms similar to ME/CFS—such as brain fog, fatigue, and muscle pain. Melatonin has several properties that could potentially help: it reduces inflammation, fights harmful molecules in the body, supports immune function, and protects nerve cells. The authors suggest melatonin might be worth studying further as a treatment for the lingering cognitive and pain symptoms some long COVID patients experience.

Pain and SensitizationSleepCognitive Impairment

E3 PreliminaryMechanismPEM unclearLongitudinal

Dynamic Epigenetic Changes during a Relapse and Recovery Cycle in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Helliwell, Amber M, Stockwell, Peter A, Edgar, Christina D et al.·International journal of molecular sciences·2022

This study looked at how a person's DNA changes during ME/CFS relapses by examining two patients' genetic material multiple times over several months as they experienced a relapse and recovery. The researchers found that during relapses, the patients' DNA showed much larger changes in a process called methylation (a chemical marking system that controls which genes are active) compared to healthy people. These changes affected genes involved in metabolism, immune function, and inflammation—processes that are important in ME/CFS.

E3 PreliminaryMechanismPEM unclearMechanistic

Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients.

Eaton-Fitch, Natalie, Du Preez, Stanley, Cabanas, Hélène et al.·Journal of translational medicine·2022

This study found that immune cells called natural killer cells in ME/CFS patients have a broken calcium channel (TRPM3) that prevents them from working properly. When researchers treated these cells overnight with a drug called naltrexone, the calcium channel started working better and the immune cells functioned more like those from healthy people. This suggests that ME/CFS may involve faulty ion channels and that naltrexone could potentially help restore immune cell function.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Estimating total morbidity burden of COVID-19: relative importance of death and disability.

Smith, Maia P·Journal of clinical epidemiology·2022

This study looked at the total health impact of COVID-19 by measuring not just deaths, but also the years of healthy life lost due to long-COVID symptoms. The researchers found that most of the burden from COVID-19 actually comes from people who survive but live with ongoing disability—not from deaths alone. The study suggests that resources should focus on preventing and treating long-COVID, especially in younger people and women who appear to bear a larger share of this burden.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM requiredMechanistic

Differential Effects of Exercise on fMRI of the Midbrain Ascending Arousal Network Nuclei in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI) in a Model of Postexertional Malaise (PEM).

Baraniuk, James N, Amar, Alison, Pepermitwala, Haris et al.·Brain sciences·2022

This study used brain imaging to examine how exercise affects people with ME/CFS and Gulf War Illness. Researchers found that after exercise, the brains of ME/CFS patients showed increased activity in areas that control alertness, mood, pain, and sleep, while Gulf War Illness patients showed the opposite pattern (decreased activity). These findings suggest that ME/CFS and Gulf War Illness affect the brain differently, which may explain why exercise can make symptoms worse in ME/CFS patients.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Circadian rhythm disruption in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for the post-acute sequelae of COVID-19.

McCarthy, Michael J·Brain, behavior, & immunity - health·2022

This review examines whether disrupted body clocks (circadian rhythms) contribute to ME/CFS symptoms like fatigue, sleep problems, and cognitive difficulties. The authors focus on a specific immune molecule called TGFB that may interfere with the body's natural daily rhythms. They suggest that COVID-19 infections may cause similar circadian disruptions, potentially explaining why some people develop long COVID symptoms that resemble ME/CFS.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM requiredReview-Narrative

Review of the Midbrain Ascending Arousal Network Nuclei and Implications for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Gulf War Illness (GWI) and Postexertional Malaise (PEM).

Baraniuk, James N·Brain sciences·2022

This review examines a brain region called the midbrain and how it might contribute to post-exertional malaise (PEM)—the worsening of symptoms after activity that happens in ME/CFS. When ME/CFS patients did exercise in a study, their midbrain showed increased activity during mental tasks, while Gulf War Illness patients showed the opposite pattern. The authors suggest that problems in this brain region could explain why ME/CFS patients have trouble with energy, sleep, mood, pain, and temperature control, especially after exertion.

Cognitive ImpairmentPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Commonalities in the Features of Cancer and Chronic Fatigue Syndrome (CFS): Evidence for Stress-Induced Phenotype Instability?

Rusin, Andrej, Seymour, Colin, Cocchetto, Alan et al.·International journal of molecular sciences·2022

This review compares ME/CFS with cancer-related fatigue, two conditions that share similar exhaustion symptoms. The authors examined research showing that both conditions may involve problems with stress hormones, immune system inflammation, energy production in cells, and genetic factors. They suggest these two different diseases might actually represent different points on a spectrum of how the body responds to stress, rather than being completely separate conditions.

Energy Metabolism

E3 PreliminaryCohortPEM not requiredCase-Control

Characterising DSCATT: A case series of Australian patients with debilitating symptom complexes attributed to ticks.

Schnall, Jesse, Oliver, Georgina, Braat, Sabine et al.·The Australian and New Zealand journal of psychiatry·2022

Researchers studied 29 Australian patients who believed their symptoms were caused by tick bites. Most had severe tiredness, headaches, and joint pain, and many had previously been diagnosed with conditions like ME/CFS or fibromyalgia. When doctors tested these patients, they found no evidence of Lyme disease or other common infections from ticks. The study suggests that tick-attributed illness in Australia remains unexplained and may overlap with other medically unexplained conditions.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[Human placenta hydrolysates: from V.P. Filatov to the present day: Review].

Gromova, O A, Torshin, I Y, Chuchalin, A G et al.·Terapevticheskii arkhiv·2022

This review examines human placenta hydrolysates (HPH)—processed extracts from human placental tissue—and their potential therapeutic effects on various conditions including chronic fatigue syndrome. The authors summarize over 5,000 published studies showing that HPH may work by stimulating the body's natural healing and regenerative abilities. The review discusses HPH's reported benefits for liver disease, skin conditions, viral infections, and fatigue-related disorders.

E3 PreliminaryCohortPEM not requiredCase-Control

New Clinical Phenotype of the Post-Covid Syndrome: Fibromyalgia and Joint Hypermobility Condition.

Gavrilova, Natalia, Soprun, Lidiia, Lukashenko, Maria et al.·Pathophysiology : the official journal of the International Society for Pathophysiology·2022

This study describes a pattern found in some people who developed fibromyalgia (widespread pain) after COVID-19 infection. The researchers noticed that young women with loose, flexible joints who had COVID-19 and a specific tendon injury were more likely to develop fibromyalgia along with signs of inflammation. The study presents three patient cases that fit this pattern, suggesting COVID-19 may trigger fibromyalgia in people whose connective tissues are already prone to damage.

Immune SystemLong COVID Overlap

E3 PreliminaryMechanismPEM not requiredMechanistic

Study on the active components and mechanism of Suanzaoren decoction in improving cognitive impairment caused by sleep deprivation.

Cheng, Li, Wang, Fei, Li, Zi-Heng et al.·Journal of ethnopharmacology·2022

This study examined how an ancient Chinese herbal remedy called Suanzaoren Decoction (SZRD) might help improve thinking and memory problems caused by poor sleep. Researchers used computer analysis and laboratory experiments to identify the active ingredients in the herbs and understand how they work in the body, finding that the remedy may work through pathways related to estrogen in the brain.

SleepCognitive Impairment

E3 PreliminaryMechanismPEM requiredCross-Sectional

Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome With Partial Least Squares Discriminant Analysis: Relevance of Blood Extracellular Vesicles.

González-Cebrián, Alba, Almenar-Pérez, Eloy, Xu, Jiabao et al.·Frontiers in medicine·2022

Researchers tested whether tiny particles called extracellular vesicles in blood could help diagnose ME/CFS. They analyzed various substances in blood from patients and healthy controls using a computer analysis method. The study found that certain features of these blood particles, combined with other markers, could potentially identify ME/CFS, though more testing is needed to confirm this works reliably in larger groups.

Biomarkers

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Evaluation of natural killer cell assay performance on shipped blood specimens.

Querec, Troy D, Abrams, Joseph, Stewart, Jennifer J et al.·Journal of immunological methods·2021

This study tested different laboratory methods for measuring natural killer (NK) cell function—an immune system measurement that may be important for ME/CFS—using blood samples that were shipped overnight instead of tested immediately. Researchers compared three different testing approaches and found that two of them (CRCA and FCCA) gave similar results when blood samples were processed a day after collection, suggesting these tests could work for clinical settings where samples need to be shipped.

BiomarkersImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Ross River Virus Immune Evasion Strategies and the Relevance to Post-viral Fatigue, and Myalgic Encephalomyelitis Onset.

Lidbury, Brett A·Frontiers in medicine·2021

This study examines how Ross River virus, a mosquito-borne virus common in Australia, might trigger long-lasting fatigue and ME/CFS symptoms. The virus uses several tricks to hide from the immune system, and researchers propose these tricks may disrupt the body's energy-producing systems and cause the persistent exhaustion seen in ME/CFS. The findings suggest that understanding how this virus evades immunity could help explain why some viral infections lead to chronic fatigue.

Immune System

E3 PreliminaryMechanismPEM unclearCross-Sectional

Chronic fatigue syndrome: Abnormally fast muscle fiber conduction in the membranes of motor units at low static force load.

Klaver-Krol, E G, Hermens, H J, Vermeulen, R C et al.·Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2021

Researchers used muscle sensors to measure how electrical signals travel through muscle fibers in people with ME/CFS, fibromyalgia, and healthy people during light strength exercises. They found that in ME/CFS patients, these electrical signals traveled unusually fast through muscle fibers as force increased, which didn't happen in the other groups. This suggests that muscle cells in ME/CFS may have a problem with how they work at the membrane level.

E3 PreliminaryReviewPEM unclearReview-Narrative

The Impact of Severe ME/CFS on Student Learning and K-12 Educational Limitations.

Newton, Faith R·Healthcare (Basel, Switzerland)·2021

This article examines how severe ME/CFS affects children's ability to attend school and learn. Many severely ill children are confined to bed or home and cannot attend regular classes. The study suggests that schools are not providing adequate support for these students and proposes new educational approaches and resources that could help them continue learning despite their illness.

Severe ME

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Evidence Atlas

Evidence browser

[Fatigue Doesn't Always have to be caused by SARS-CoV-2: Case Report].

Can l-carnitine reduce post-COVID-19 fatigue?

The Role of Neuro-Immune Interaction in Chronic Pain Conditions; Functional Somatic Syndrome, Neurogenic Inflammation, and Peripheral Neuropathy.

Possible Application of Melatonin in Long COVID.

Dynamic Epigenetic Changes during a Relapse and Recovery Cycle in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients.

Estimating total morbidity burden of COVID-19: relative importance of death and disability.

Differential Effects of Exercise on fMRI of the Midbrain Ascending Arousal Network Nuclei in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI) in a Model of Postexertional Malaise (PEM).

Circadian rhythm disruption in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for the post-acute sequelae of COVID-19.

Review of the Midbrain Ascending Arousal Network Nuclei and Implications for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Gulf War Illness (GWI) and Postexertional Malaise (PEM).

Commonalities in the Features of Cancer and Chronic Fatigue Syndrome (CFS): Evidence for Stress-Induced Phenotype Instability?

Characterising DSCATT: A case series of Australian patients with debilitating symptom complexes attributed to ticks.

[Human placenta hydrolysates: from V.P. Filatov to the present day: Review].

New Clinical Phenotype of the Post-Covid Syndrome: Fibromyalgia and Joint Hypermobility Condition.

Study on the active components and mechanism of Suanzaoren decoction in improving cognitive impairment caused by sleep deprivation.

Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome With Partial Least Squares Discriminant Analysis: Relevance of Blood Extracellular Vesicles.

Evaluation of natural killer cell assay performance on shipped blood specimens.

Ross River Virus Immune Evasion Strategies and the Relevance to Post-viral Fatigue, and Myalgic Encephalomyelitis Onset.

Chronic fatigue syndrome: Abnormally fast muscle fiber conduction in the membranes of motor units at low static force load.

The Impact of Severe ME/CFS on Student Learning and K-12 Educational Limitations.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

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