ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

561–580 of 2,422 studies

E3 PreliminaryCohortPEM unclearObservational

Tolerability and Efficacy of s.c. IgG Self-Treatment in ME/CFS Patients with IgG/IgG Subclass Deficiency: A Proof-of-Concept Study.

Scheibenbogen, Carmen, Sotzny, Franziska, Hartwig, Jelka et al.·Journal of clinical medicine·2021

This study tested whether injecting immunoglobulin G (IgG), a type of protective protein from the immune system, could help ME/CFS patients who have low levels of this protein and get frequent infections. Seventeen patients received monthly injections under the skin for 12 months. About half the patients who completed the treatment felt noticeably better, with less fatigue and improved ability to function in daily life, though some patients had to stop due to side effects.

Immune System

E3 PreliminaryPEM unclear

My experience of chronic fatigue syndrome.

BMJ paediatrics open·2021

This article is a personal account of one person's experience living with ME/CFS, published in a medical journal. It describes the journey of managing this condition and how it has affected daily life. While personal stories are valuable for understanding what patients go through, they are not the same as research that tests treatments or identifies causes.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrom: modern aspects of diagnosis and treatment].

Vorobyova, Yu D, Danilov, A B·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2021

This article reviews how ME/CFS develops by looking at both genes and environmental factors that trigger the illness. The authors explain known genetic problems found in ME/CFS patients, what can start the disease, and how these factors combine to cause the symptoms people experience. They also describe a systematic approach to diagnosing and treating ME/CFS.

Diagnostics

E3 PreliminaryCommentaryPEM unclearEditorial

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: When Suffering Is Multiplied.

Komaroff, Anthony L·Healthcare (Basel, Switzerland)·2021

ME/CFS is a real illness with measurable biological problems in the body, even though standard blood tests often appear normal. Over the past 20 years, advanced research tools have found objective abnormalities in people with ME/CFS. Unfortunately, many doctors aren't aware of this evidence, which can lead them to dismiss patients' symptoms and wrongly suggest there's nothing physically wrong—adding emotional harm on top of the already serious illness.

Biomarkers

E3 PreliminaryReviewPEM unclearReview-Narrative

Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 'long-haulers'?

Wood, Emily, Hall, Katherine H, Tate, Warren·Chronic diseases and translational medicine·2021

This study reviews research on how mitochondria (the energy-producing centers in our cells) and oxidative stress (cellular damage from harmful molecules) may contribute to ME/CFS and long COVID symptoms. The authors examine whether antioxidant treatments could help restore energy production and reduce fatigue in these conditions. They highlight that many COVID-19 long-haulers develop symptoms that look very similar to ME/CFS, suggesting they may share underlying biological causes.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Stanculescu, Dominic, Sepúlveda, Nuno, Lim, Chin Leong et al.·Frontiers in neurology·2021

This study compares how the body breaks down during heat stroke with what happens in ME/CFS. Both conditions involve similar problems: inflammation, damage to the gut lining that allows harmful substances into the bloodstream, blood clotting issues, and problems with how cells produce energy. By understanding heat stroke better, researchers hope to find new ways to treat ME/CFS.

Immune System

E3 PreliminaryCohortPEM unclear

Comorbidity of chronic fatigue syndrome, postural tachycardia syndrome, and narcolepsy with 5,10-methylenetetrahydrofolate reductase (MTHFR) mutation in an adolescent: a case report.

Liao, Ying, Qi, Jian-Guang, Yan, Hui et al.·Chinese medical journal·2021

This case report describes one adolescent patient who had three conditions at the same time: ME/CFS (chronic fatigue syndrome), postural tachycardia syndrome (a condition where heart rate increases abnormally when standing), and narcolepsy (excessive daytime sleepiness). The doctors discovered this patient had a genetic variation in the MTHFR gene, which is involved in processing folate and other important molecules in the body. The authors suggest this genetic variation might help explain why this patient developed all three conditions together.

E3 PreliminaryGuidelinePEM requiredGuideline

Caring for the Patient with Severe or Very Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Montoya, Jose G, Dowell, Theresa G, Mooney, Amy E et al.·Healthcare (Basel, Switzerland)·2021

This guide focuses on caring for people with severe ME/CFS who struggle to leave their homes or beds. The authors explain that these patients often can't visit doctors' offices and doctors frequently don't have good information about how to help them. The guide provides practical recommendations for diagnosis, assessment, and treatment options, including using telemedicine and working closely with patients and caregivers to provide better care.

Post-Exertional Malaise

E3 PreliminaryCohortPEM unclearCase-Control

Young and exhausted.

Oleksak, Filip, Durdik, Peter, Jakusova, Lubica et al.·Advances in respiratory medicine·2021

This case report describes a young patient who was diagnosed with ME/CFS (extreme exhaustion lasting at least six months) but actually had a different, treatable heart and lung condition. The doctors used a special exercise test called cardiopulmonary exercise testing to discover the real cause. This story reminds us that it's important to carefully check for other medical conditions before diagnosing someone with ME/CFS, especially in children and young people.

Diagnostics

E3 PreliminaryMechanismPEM unclearCross-Sectional

Altered endothelial dysfunction-related miRs in plasma from ME/CFS patients.

Blauensteiner, J, Bertinat, R, León, L E et al.·Scientific reports·2021

This study looked at tiny molecules called microRNAs in the blood of ME/CFS patients to understand what might be going wrong with their blood vessels. The researchers found that five specific microRNAs were higher in ME/CFS patients compared to healthy people, and these molecules are known to affect how blood vessels function. This discovery suggests that blood vessel problems might be part of what causes ME/CFS symptoms.

BiomarkersImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Does muscular or mental fatigue have an influence on the nociceptive flexion reflex? A randomized cross-over study in healthy people.

Dhondt, Evy, Danneels, Lieven, Rijckaert, Johan et al.·European journal of pain (London, England)·2021

This study tested whether being physically or mentally tired changes how the body's spinal cord responds to pain signals. Researchers measured a reflex that happens in the spinal cord when stimulated with electrical pulses to a nerve in the leg, both before and after participants either rested, did tiring leg exercises, or completed a difficult mental task. They found that low-to-moderate levels of fatigue—whether physical or mental—did not change this spinal reflex, suggesting the body's pain-dampening systems stay stable even when tired.

Pain and Sensitization

E3 PreliminaryCohortPEM unclearCase-Control

Idiopathic combined adrenocorticotropin and growth hormone deficiency mimicking chronic fatigue syndrome.

Tokumasu, Kazuki, Ochi, Kanako, Otsuka, Fumio·BMJ case reports·2021

This case describes a 42-year-old man who was told he had chronic fatigue syndrome (CFS) and fibromyalgia, but was actually missing two important hormones: cortisol and growth hormone. When doctors tested his pituitary gland (which makes these hormones), they found deficiencies that weren't caught before. After starting treatment with these hormones, his severe tiredness, muscle pain, and depression all improved significantly.

Diagnostics

E3 PreliminaryMechanismPEM requiredObservational

Reduced Endothelial Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Results From Open-Label Cyclophosphamide Intervention Study.

Sørland, Kari, Sandvik, Miriam Kristine, Rekeland, Ingrid Gurvin et al.·Frontiers in medicine·2021

This study found that blood vessels in people with ME/CFS don't work as well as they do in healthy people. The researchers measured how blood vessels widen and respond to changes in blood flow, and found these responses were reduced in ME/CFS patients. Interestingly, when patients received a strong immune-suppressing drug called cyclophosphamide, improvements in symptoms didn't match up with improvements in blood vessel function.

Post-Exertional Malaise

E3 PreliminaryBehavioralPEM unclear

Is Cognitive Change Necessary to Alleviate Symptoms in Patients With Functional Somatic Syndrome?

Maroti, Daniel, Johansson, Robert·Frontiers in psychiatry·2021

This study examined whether changing how patients think about their symptoms (cognitive change) is necessary to improve symptoms in people with functional somatic syndromes like ME/CFS. The researchers explored the relationship between psychological thinking patterns and symptom improvement to understand better which approaches might help patients feel better.

Cognitive Impairment

E3 PreliminaryMechanismPEM unclearMechanistic

Acute Corticotropin-Releasing Factor Receptor Type 2 Agonism Results in Sustained Symptom Improvement in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Pereira, Gerard, Gillies, Hunter, Chanda, Sanjay et al.·Frontiers in systems neuroscience·2021

Researchers tested a new drug called CT38s that targets a receptor in the brain called CRFR2, which they believe may be overactive in ME/CFS. Fourteen ME/CFS patients received a single infusion of this drug, and most experienced symptom improvement that lasted at least 28 days. Side effects were mild and similar to typical ME/CFS symptoms, suggesting the drug was working on systems related to the disease.

Endocrine Disruption

E3 PreliminaryCohortPEM unclearCross-Sectional

In-Depth Analysis of the Plasma Proteome in ME/CFS Exposes Disrupted Ephrin-Eph and Immune System Signaling.

Germain, Arnaud, Levine, Susan M, Hanson, Maureen R·Proteomes·2021

Researchers measured 4,790 different proteins in the blood of 20 ME/CFS patients and 20 healthy people to look for differences that might explain the disease. They found that 19 proteins were significantly different between the two groups, particularly involving pathways related to immune function and cell communication. Using these protein patterns, they were able to distinguish ME/CFS patients from healthy controls with high accuracy, suggesting proteins in blood could potentially help diagnose ME/CFS.

Immune System

E3 PreliminaryPEM unclear

How do women suffering from multiple chemical sensitivity experience the medical encounter? a qualitative study in Spain.

Briones-Vozmediano, Erica, Espinar-Ruiz, Eva·Disability and rehabilitation·2021

This study interviewed 22 Spanish women with Multiple Chemical Sensitivity (MCS) to understand their experiences with doctors and the healthcare system. The women reported two major problems: they cannot avoid exposure to chemicals in their environment, and they struggle to find effective treatment. Many also felt that healthcare providers didn't believe their illness was real or took their symptoms seriously.

Diagnostics

E3 PreliminaryCohortPEM unclearCase-Control

Postdengue chronic fatigue syndrome in an adolescent boy.

Thadchanamoorthy, Vijayakumary, Dayasiri, Kavinda·BMJ case reports·2021

This case report describes an 11-year-old boy who developed ME/CFS symptoms after recovering from dengue hemorrhagic fever. Three weeks after initially feeling better, he experienced severe joint pain, muscle aches, and headaches that persisted for at least a year despite physiotherapy and nutrition support. This case adds to growing evidence that ME/CFS can develop following viral infections, even in young people.

E3 PreliminaryCohortPEM unclearCross-Sectional

Chronic fatigue syndrome/myalgic encephalomyelitis in children aged 5 to 11 years: A qualitative study.

Brigden, Amberly, Shaw, Alison, Anderson, Emma et al.·Clinical child psychology and psychiatry·2021

This study looked at how ME/CFS affects younger children (ages 5-11) and what their families experience. Researchers interviewed children and parents to understand how the illness impacts daily life and what kind of support they need. The study found that children over 8 years old can better understand and manage their illness compared to younger children, and that parents of very young children need more support from healthcare providers.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

A comparison of approaches for combining predictive markers for personalised treatment recommendations.

Pierce, Matthias, Emsley, Richard·Trials·2021

This study compared three statistical methods for using blood test results (biomarkers) to predict which ME/CFS patients would benefit most from rehabilitation treatment. The researchers tested these methods using computer simulations and real data from a rehabilitation trial, to figure out the best way to combine multiple biomarkers to personalize treatment recommendations for individual patients.

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Evidence Atlas

Evidence browser

Tolerability and Efficacy of s.c. IgG Self-Treatment in ME/CFS Patients with IgG/IgG Subclass Deficiency: A Proof-of-Concept Study.

My experience of chronic fatigue syndrome.

[Chronic fatigue syndrom: modern aspects of diagnosis and treatment].

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: When Suffering Is Multiplied.

Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 'long-haulers'?

Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Comorbidity of chronic fatigue syndrome, postural tachycardia syndrome, and narcolepsy with 5,10-methylenetetrahydrofolate reductase (MTHFR) mutation in an adolescent: a case report.

Caring for the Patient with Severe or Very Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Young and exhausted.

Altered endothelial dysfunction-related miRs in plasma from ME/CFS patients.

Does muscular or mental fatigue have an influence on the nociceptive flexion reflex? A randomized cross-over study in healthy people.

Idiopathic combined adrenocorticotropin and growth hormone deficiency mimicking chronic fatigue syndrome.

Reduced Endothelial Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Results From Open-Label Cyclophosphamide Intervention Study.

Is Cognitive Change Necessary to Alleviate Symptoms in Patients With Functional Somatic Syndrome?

Acute Corticotropin-Releasing Factor Receptor Type 2 Agonism Results in Sustained Symptom Improvement in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

In-Depth Analysis of the Plasma Proteome in ME/CFS Exposes Disrupted Ephrin-Eph and Immune System Signaling.

How do women suffering from multiple chemical sensitivity experience the medical encounter? a qualitative study in Spain.

Postdengue chronic fatigue syndrome in an adolescent boy.

Chronic fatigue syndrome/myalgic encephalomyelitis in children aged 5 to 11 years: A qualitative study.

A comparison of approaches for combining predictive markers for personalised treatment recommendations.

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Neuroinflammation Evidence

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