ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

601–620 of 2,422 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Historical Insight into Infections and Disorders Associated with Neurological and Psychiatric Sequelae Similar to Long COVID.

Stefano, George B·Medical science monitor : international medical journal of experimental and clinical research·2021

This review examines how long COVID causes long-term symptoms similar to those seen after other viral infections throughout history, particularly focusing on 'brain fog' and difficulty thinking clearly. By looking at past pandemics like the 1918 flu and other viral illnesses, researchers found that many infections can cause similar cognitive problems and fatigue that persist long after the initial infection. The study suggests that viruses may damage the brain's energy-producing structures (mitochondria), leading to reduced oxygen in the brain and chronic symptoms like those seen in ME/CFS and long COVID.

Neuroinflammation

E3 PreliminaryCohortPEM not requiredCase-Control

Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection.

Hohberger, Bettina, Harrer, Thomas, Mardin, Christian et al.·Frontiers in medicine·2021

This case report describes one patient with long COVID who had ongoing fatigue, loss of taste, and poor blood flow in the eyes after a mild COVID-19 infection. The patient was found to have unusual antibodies that attack certain receptors in the body. When treated with a drug called BC 007 that neutralizes these antibodies, the patient's fatigue, taste, and eye blood flow all improved within days and stayed better for at least 4 weeks.

E3 PreliminaryCohortPEM unclearCase-Control

Life-Threatening Malnutrition in Very Severe ME/CFS.

Baxter, Helen, Speight, Nigel, Weir, William·Healthcare (Basel, Switzerland)·2021

This study describes five patients with very severe ME/CFS who developed life-threatening malnutrition because doctors delayed providing tube feeding support. Some severely affected patients cannot eat or drink normally due to swallowing difficulties, severe stomach problems, or being too ill to feed themselves. The research shows that doctors sometimes mistakenly blamed psychological factors instead of recognizing nutrition problems as a direct result of the disease, leading to dangerous delays in life-saving treatment.

Severe ME

E3 PreliminaryGuidelinePEM requiredGuideline

Caring for the Patient with Severe or Very Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Montoya, Jose G, Dowell, Theresa G, Mooney, Amy E et al.·Healthcare (Basel, Switzerland)·2021

This guide focuses on caring for people with severe ME/CFS who struggle to leave their homes or beds. The authors explain that these patients often can't visit doctors' offices and doctors frequently don't have good information about how to help them. The guide provides practical recommendations for diagnosis, assessment, and treatment options, including using telemedicine and working closely with patients and caregivers to provide better care.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Radiation exposure and mitochondrial insufficiency in chronic fatigue and immune dysfunction syndrome.

Rusin, Andrej, Li, Megan, Cocchetto, Alan et al.·Medical hypotheses·2021

This paper explores the idea that ME/CFS may be caused by damage to mitochondria—the energy-producing parts of cells—possibly triggered by radiation exposure or other environmental stressors like viruses or toxins. When mitochondria cannot produce enough energy, cells throughout the body struggle, and neighboring tissues try to compensate, which may explain why ME/CFS patients experience widespread symptoms like fatigue and immune problems.

Biomarkers

E3 PreliminaryCohortPEM not requiredObservational

Experiences Among School Personnel and School Nurses on Educational Adaptations for Students With CFS/ME: A Qualitative Interview Study.

Similä, Wenche Ann, Rø, Torstein Baade, Nøst, Torunn Hatlen·Frontiers in pediatrics·2021

This study asked teachers, counselors, and school nurses about their experiences helping students with ME/CFS stay in school and continue their education. The researchers found that it was harder to help these students before they received an official diagnosis, but things improved when schools worked together as a team, communicated well with families, and used digital learning tools.

E3 PreliminaryCohortPEM unclearCase-Control

Angina Simultaneously Diagnosed with the Recurrence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Li, Koki, Otsuka, Yuki, Nakano, Yasuhiro et al.·Diagnostics (Basel, Switzerland)·2021

This case report describes a young woman who experienced chest pain and worsening ME/CFS symptoms at the same time. Doctors discovered she had angina (reduced blood flow to the heart), which was successfully treated with heart medication. This case highlights that ME/CFS patients experiencing chest pain should be evaluated for actual heart problems, not assume all chest symptoms are from ME/CFS alone.

E3 PreliminaryReviewPEM requiredReview-Narrative

COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review.

Poenaru, Sonia, Abdallah, Sara J, Corrales-Medina, Vicente et al.·Therapeutic advances in infectious disease·2021

Some people who recover from COVID-19 continue experiencing prolonged symptoms like fatigue, difficulty breathing, and brain fog for months afterward. These lingering symptoms are remarkably similar to ME/CFS, a chronic illness characterized by severe fatigue that worsens with activity. While COVID-19 could potentially trigger ME/CFS in some people, researchers currently don't have enough evidence to confirm this connection.

Severe MEPost-Exertional Malaise

E3 PreliminaryMechanismPEM unclearCross-Sectional

Chronic fatigue syndrome: Abnormally fast muscle fiber conduction in the membranes of motor units at low static force load.

Klaver-Krol, E G, Hermens, H J, Vermeulen, R C et al.·Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2021

Researchers used muscle sensors to measure how electrical signals travel through muscle fibers in people with ME/CFS, fibromyalgia, and healthy people during light strength exercises. They found that in ME/CFS patients, these electrical signals traveled unusually fast through muscle fibers as force increased, which didn't happen in the other groups. This suggests that muscle cells in ME/CFS may have a problem with how they work at the membrane level.

E3 PreliminaryMechanismPEM not requiredMechanistic

Antioxidant and antifatigue effect of a standardized fraction (HemoHIM) from Angelica gigas, Cnidium officinale, and Paeonia lactiflora.

Kwon, Da-Ae, Kim, Yong Sang, Kim, Seul-Ki et al.·Pharmaceutical biology·2021

Researchers tested an herbal supplement called HemoHIM, made from three plants used in traditional medicine, to see if it could help reduce fatigue and improve antioxidant protection in the body. In laboratory and animal studies, HemoHIM appeared to restore protective enzymes that fight cellular damage and helped mice perform better on physical tests, suggesting it may have antifatigue properties.

E3 PreliminaryBehavioralPEM unclear

Is Cognitive Change Necessary to Alleviate Symptoms in Patients With Functional Somatic Syndrome?

Maroti, Daniel, Johansson, Robert·Frontiers in psychiatry·2021

This study examined whether changing how patients think about their symptoms (cognitive change) is necessary to improve symptoms in people with functional somatic syndromes like ME/CFS. The researchers explored the relationship between psychological thinking patterns and symptom improvement to understand better which approaches might help patients feel better.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredMechanistic

[Electroacupuncture improves cognitive function by inhibiting NF-κB activity in rats with chronic fatigue syndrome].

Feng, Chu-Wen, Qu, Yuan-Yuan, Sun, Zhong-Ren et al.·Zhen ci yan jiu = Acupuncture research·2021

This study tested whether electroacupuncture (a form of acupuncture with electrical stimulation) could help rats with chronic fatigue syndrome recover cognitive abilities like memory and learning. The researchers found that electroacupuncture reduced inflammation in the brain's memory center (hippocampus) and improved the rats' ability to learn and remember, likely by blocking a inflammatory protein called NF-κB.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

Ross River Virus Immune Evasion Strategies and the Relevance to Post-viral Fatigue, and Myalgic Encephalomyelitis Onset.

Lidbury, Brett A·Frontiers in medicine·2021

This study examines how Ross River virus, a mosquito-borne virus common in Australia, might trigger long-lasting fatigue and ME/CFS symptoms. The virus uses several tricks to hide from the immune system, and researchers propose these tricks may disrupt the body's energy-producing systems and cause the persistent exhaustion seen in ME/CFS. The findings suggest that understanding how this virus evades immunity could help explain why some viral infections lead to chronic fatigue.

Immune System

E3 PreliminaryPEM unclear

How do women suffering from multiple chemical sensitivity experience the medical encounter? a qualitative study in Spain.

Briones-Vozmediano, Erica, Espinar-Ruiz, Eva·Disability and rehabilitation·2021

This study interviewed 22 Spanish women with Multiple Chemical Sensitivity (MCS) to understand their experiences with doctors and the healthcare system. The women reported two major problems: they cannot avoid exposure to chemicals in their environment, and they struggle to find effective treatment. Many also felt that healthcare providers didn't believe their illness was real or took their symptoms seriously.

Diagnostics

E3 PreliminaryMechanismPEM not required

Deconditioning does not explain orthostatic intolerance in ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome).

van Campen, C Linda M C, Rowe, Peter C, Visser, Frans C·Journal of translational medicine·2021

This study examined whether being physically deconditioned (out of shape) causes the dizziness and fainting symptoms that many ME/CFS patients experience when standing up. Researchers tested 199 ME/CFS patients and 22 healthy people using exercise tests and a tilt table test that measures blood flow to the brain. The results showed that ME/CFS patients had significant problems with blood flow to their brain when tilted upright, but this problem occurred regardless of how deconditioned they were.

Autonomic Nervous System

E3 PreliminaryReviewPEM requiredReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview.

Deumer, Undine-Sophie, Varesi, Angelica, Floris, Valentina et al.·Journal of clinical medicine·2021

ME/CFS is a long-term illness that causes extreme tiredness, worsening of symptoms after activity, and difficulty thinking clearly. Patients experience these symptoms very differently from one another, and currently there are no blood tests or physical exams that can definitively diagnose the condition. This review examines several potential causes, including past infections, genetic factors, hormone imbalances, and changes in gut bacteria, while exploring whether a simple blood test might someday help diagnose ME/CFS.

BiomarkersPost-Exertional Malaise

E3 PreliminaryMechanismPEM unclearCross-Sectional

Orthostatic stress testing in myalgic encephalomyelitis/chronic fatigue syndrome patients with or without concomitant fibromyalgia: effects on pressure pain thresholds and temporal summation.

van Campen, C Linda M C, Rowe, Peter C, Verheugt, Freek W A et al.·Clinical and experimental rheumatology·2021

This study tested how standing up quickly (which can trigger ME/CFS symptoms) affects pain sensitivity in ME/CFS patients. Researchers measured how much pressure patients could tolerate on their finger and shoulder before and after a tilt test. They found that ME/CFS patients became more pain-sensitive after the tilt test, meaning their bodies responded to pain more strongly than healthy people, and this effect was even more pronounced in those who also had fibromyalgia.

Pain and SensitizationAutonomic Nervous System

E3 PreliminaryCommentaryPEM unclear

ME/CFS: Past, Present and Future.

Weir, William, Speight, Nigel·Healthcare (Basel, Switzerland)·2021

This article reviews the history and current understanding of ME/CFS, arguing that the condition has a biological basis rather than being primarily psychological. The authors emphasize that scientific research, not psychological theories, is the path forward for properly understanding and treating ME/CFS. They highlight how patients have suffered from misunderstandings about their condition's cause.

Diagnostics

E3 PreliminaryCohortPEM not requiredCross-Sectional

Global survey-based assessment of lifestyle changes during the COVID-19 pandemic.

Agarwal, Poonam, Kaushik, Abhinav, Sarkar, Sutapa et al.·PloS one·2021

This study surveyed people during the COVID-19 lockdowns to understand how the pandemic affected their daily lives, work, mental health, and social connections. Most people found ways to cope by using technology to stay connected with others, staying physically active, and spending time on hobbies. The study found that while many people faced mental health challenges from isolation and pandemic stress, most kept their jobs and lived with family or roommates, which may have provided support.

E3 PreliminaryReviewPEM unclearReview-Narrative

Ehlers-Danlos Syndrome: Immunologic contrasts and connective tissue comparisons.

Islam, Mareesa, Chang, Christopher, Gershwin, M Eric·Journal of translational autoimmunity·2021

This review article explains Ehlers-Danlos Syndrome (EDS), a group of inherited disorders that affect connective tissue in the body, causing symptoms like loose, stretchy skin and flexible joints. The authors describe the 13 different types of EDS, how doctors diagnose them, and how they're treated. While some forms of EDS involve inflammation, the exact mechanisms causing the disease are not fully understood.

Diagnostics

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Evidence browser

Historical Insight into Infections and Disorders Associated with Neurological and Psychiatric Sequelae Similar to Long COVID.

Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection.

Life-Threatening Malnutrition in Very Severe ME/CFS.

Caring for the Patient with Severe or Very Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Radiation exposure and mitochondrial insufficiency in chronic fatigue and immune dysfunction syndrome.

Experiences Among School Personnel and School Nurses on Educational Adaptations for Students With CFS/ME: A Qualitative Interview Study.

Angina Simultaneously Diagnosed with the Recurrence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review.

Chronic fatigue syndrome: Abnormally fast muscle fiber conduction in the membranes of motor units at low static force load.

Antioxidant and antifatigue effect of a standardized fraction (HemoHIM) from Angelica gigas, Cnidium officinale, and Paeonia lactiflora.

Is Cognitive Change Necessary to Alleviate Symptoms in Patients With Functional Somatic Syndrome?

[Electroacupuncture improves cognitive function by inhibiting NF-κB activity in rats with chronic fatigue syndrome].

Ross River Virus Immune Evasion Strategies and the Relevance to Post-viral Fatigue, and Myalgic Encephalomyelitis Onset.

How do women suffering from multiple chemical sensitivity experience the medical encounter? a qualitative study in Spain.

Deconditioning does not explain orthostatic intolerance in ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome).

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview.

Orthostatic stress testing in myalgic encephalomyelitis/chronic fatigue syndrome patients with or without concomitant fibromyalgia: effects on pressure pain thresholds and temporal summation.

ME/CFS: Past, Present and Future.

Global survey-based assessment of lifestyle changes during the COVID-19 pandemic.

Ehlers-Danlos Syndrome: Immunologic contrasts and connective tissue comparisons.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research