ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

601–620 of 2,423 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Imaging and Manipulation of Stem and Progenitor Cells for Revealing the Novel Mechanism of Local Tissue Maintenance in the Brain].

Kataoka, Yosky·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2021

This study examined special cells in the brain called glial progenitor cells that help maintain healthy brain tissue and manage inflammation. Researchers used imaging technology to track these cells and discovered that when these cells are removed, the brain develops harmful inflammation and immune activation. The findings suggest these cells may play a protective role and could be targeted to treat conditions associated with brain inflammation, including chronic fatigue syndrome.

Neuroinflammation

E3 PreliminaryCohortPEM unclearCase-Control

Life-Threatening Malnutrition in Very Severe ME/CFS.

Baxter, Helen, Speight, Nigel, Weir, William·Healthcare (Basel, Switzerland)·2021

This study describes five patients with very severe ME/CFS who developed life-threatening malnutrition because doctors delayed providing tube feeding support. Some severely affected patients cannot eat or drink normally due to swallowing difficulties, severe stomach problems, or being too ill to feed themselves. The research shows that doctors sometimes mistakenly blamed psychological factors instead of recognizing nutrition problems as a direct result of the disease, leading to dangerous delays in life-saving treatment.

Severe ME

E3 PreliminaryBehavioralPEM unclear

Is Cognitive Change Necessary to Alleviate Symptoms in Patients With Functional Somatic Syndrome?

Maroti, Daniel, Johansson, Robert·Frontiers in psychiatry·2021

This study examined whether changing how patients think about their symptoms (cognitive change) is necessary to improve symptoms in people with functional somatic syndromes like ME/CFS. The researchers explored the relationship between psychological thinking patterns and symptom improvement to understand better which approaches might help patients feel better.

Cognitive Impairment

E3 PreliminaryCohortPEM not requiredCase-Control

Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection.

Hohberger, Bettina, Harrer, Thomas, Mardin, Christian et al.·Frontiers in medicine·2021

This case report describes one patient with long COVID who had ongoing fatigue, loss of taste, and poor blood flow in the eyes after a mild COVID-19 infection. The patient was found to have unusual antibodies that attack certain receptors in the body. When treated with a drug called BC 007 that neutralizes these antibodies, the patient's fatigue, taste, and eye blood flow all improved within days and stayed better for at least 4 weeks.

E3 PreliminaryCohortPEM not requiredObservational

Experiences Among School Personnel and School Nurses on Educational Adaptations for Students With CFS/ME: A Qualitative Interview Study.

Similä, Wenche Ann, Rø, Torstein Baade, Nøst, Torunn Hatlen·Frontiers in pediatrics·2021

This study asked teachers, counselors, and school nurses about their experiences helping students with ME/CFS stay in school and continue their education. The researchers found that it was harder to help these students before they received an official diagnosis, but things improved when schools worked together as a team, communicated well with families, and used digital learning tools.

E3 PreliminaryCohortPEM unclearCase-Control

Angina Simultaneously Diagnosed with the Recurrence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Li, Koki, Otsuka, Yuki, Nakano, Yasuhiro et al.·Diagnostics (Basel, Switzerland)·2021

This case report describes a young woman who experienced chest pain and worsening ME/CFS symptoms at the same time. Doctors discovered she had angina (reduced blood flow to the heart), which was successfully treated with heart medication. This case highlights that ME/CFS patients experiencing chest pain should be evaluated for actual heart problems, not assume all chest symptoms are from ME/CFS alone.

E3 PreliminaryReviewPEM unclearReview-Narrative

Potential Implications of Mammalian Transient Receptor Potential Melastatin 7 in the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review.

Du Preez, Stanley, Cabanas, Helene, Staines, Donald et al.·International journal of environmental research and public health·2021

This review examines a protein called TRPM7 that may play a role in ME/CFS. TRPM7 is an ion channel—a type of gateway that controls how calcium and other minerals move in and out of cells—and it appears to affect the nervous system, immune system, heart, and metabolism. The authors suggest that problems with TRPM7 could help explain some of the complex symptoms seen in ME/CFS, though this is still a developing area of research.

E3 PreliminaryMechanismPEM unclearCross-Sectional

Chronic fatigue syndrome: Abnormally fast muscle fiber conduction in the membranes of motor units at low static force load.

Klaver-Krol, E G, Hermens, H J, Vermeulen, R C et al.·Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2021

Researchers used muscle sensors to measure how electrical signals travel through muscle fibers in people with ME/CFS, fibromyalgia, and healthy people during light strength exercises. They found that in ME/CFS patients, these electrical signals traveled unusually fast through muscle fibers as force increased, which didn't happen in the other groups. This suggests that muscle cells in ME/CFS may have a problem with how they work at the membrane level.

E3 PreliminaryReviewPEM unclearReview-Narrative

Radiation exposure and mitochondrial insufficiency in chronic fatigue and immune dysfunction syndrome.

Rusin, Andrej, Li, Megan, Cocchetto, Alan et al.·Medical hypotheses·2021

This paper explores the idea that ME/CFS may be caused by damage to mitochondria—the energy-producing parts of cells—possibly triggered by radiation exposure or other environmental stressors like viruses or toxins. When mitochondria cannot produce enough energy, cells throughout the body struggle, and neighboring tissues try to compensate, which may explain why ME/CFS patients experience widespread symptoms like fatigue and immune problems.

Biomarkers

E3 PreliminaryCommentaryPEM unclearEditorial

Dorsal root ganglia: fibromyalgia pain factory?

Martínez-Lavín, Manuel·Clinical rheumatology·2021

This article explores whether structures called dorsal root ganglia (DRG)—small nerve clusters along the spine—might be the main source of pain in fibromyalgia. These ganglia contain pain-sensing nerve cells and immune molecules that can become overactive. Recent evidence suggests that in some fibromyalgia patients, these nerve clusters show signs of damage and increased pain signaling.

Neuroinflammation

E3 PreliminaryBehavioralPEM unclearCross-Sectional

Qualitative study of the acceptability and feasibility of acceptance and commitment therapy for adolescents with chronic fatigue syndrome.

Clery, Philippa, Starbuck, Jennifer, Laffan, Amanda et al.·BMJ paediatrics open·2021

This study asked teenagers with ME/CFS who weren't getting better, along with their parents and doctors, what they thought about a therapy called Acceptance and Commitment Therapy (ACT). Everyone interviewed thought ACT sounded like a good option because it helps people focus on what matters to them while accepting difficult thoughts and feelings, rather than trying to fight them. Most teenagers were willing to try ACT, though they worried about being randomly assigned to different treatment groups in a future study.

E3 PreliminaryReviewPEM not requiredReview-Narrative

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Wirth, Klaus J, Scheibenbogen, Carmen, Paul, Friedemann·Journal of translational medicine·2021

This paper proposes an explanation for why ME/CFS patients experience brain fog, cognitive problems, headaches, and other neurological symptoms. The authors suggest that blood vessels in the brain may not be working properly, reducing blood flow to the brain and increasing pressure inside the skull. They argue this could also cause an overactive stress response in the nervous system, leading to the wide range of symptoms patients experience.

Cognitive Impairment

E3 PreliminaryMechanismPEM unclearMechanistic

Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment.

Cabanas, Helene, Muraki, Katsuhiko, Eaton-Fitch, Natalie et al.·Frontiers in immunology·2021

This study investigated whether a low-dose medication called naltrexone (LDN) might help treat ME/CFS by examining how it affects immune cells called NK cells. Researchers found that NK cells from ME/CFS patients taking LDN showed restored activity in a specific ion channel (TRPM3) that had previously been impaired. This suggests LDN may help restore normal immune function in ME/CFS patients, though larger clinical trials are needed to confirm whether it actually improves symptoms.

Immune System

E3 PreliminaryReviewPEM requiredReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview.

Deumer, Undine-Sophie, Varesi, Angelica, Floris, Valentina et al.·Journal of clinical medicine·2021

ME/CFS is a long-term illness that causes extreme tiredness, worsening of symptoms after activity, and difficulty thinking clearly. Patients experience these symptoms very differently from one another, and currently there are no blood tests or physical exams that can definitively diagnose the condition. This review examines several potential causes, including past infections, genetic factors, hormone imbalances, and changes in gut bacteria, while exploring whether a simple blood test might someday help diagnose ME/CFS.

BiomarkersPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Ross River Virus Immune Evasion Strategies and the Relevance to Post-viral Fatigue, and Myalgic Encephalomyelitis Onset.

Lidbury, Brett A·Frontiers in medicine·2021

This study examines how Ross River virus, a mosquito-borne virus common in Australia, might trigger long-lasting fatigue and ME/CFS symptoms. The virus uses several tricks to hide from the immune system, and researchers propose these tricks may disrupt the body's energy-producing systems and cause the persistent exhaustion seen in ME/CFS. The findings suggest that understanding how this virus evades immunity could help explain why some viral infections lead to chronic fatigue.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

[Electroacupuncture improves cognitive function by inhibiting NF-κB activity in rats with chronic fatigue syndrome].

Feng, Chu-Wen, Qu, Yuan-Yuan, Sun, Zhong-Ren et al.·Zhen ci yan jiu = Acupuncture research·2021

This study tested whether electroacupuncture (a form of acupuncture with electrical stimulation) could help rats with chronic fatigue syndrome recover cognitive abilities like memory and learning. The researchers found that electroacupuncture reduced inflammation in the brain's memory center (hippocampus) and improved the rats' ability to learn and remember, likely by blocking a inflammatory protein called NF-κB.

Neuroinflammation

E3 PreliminaryMechanismPEM not requiredMechanistic

Homeostatic disturbance of thermoregulatory functions in rats with chronic fatigue.

Li, Danxi, Hu, Di, Shigeta, Mika et al.·Neuroscience research·2021

Many ME/CFS patients report feeling feverish or chilled even when their body temperature is normal. This study used rats with chronic fatigue to understand what goes wrong with the body's temperature control system. Researchers found that in early fatigue, the body tried to raise its temperature to cope, but over time this system broke down and stopped working properly, which may explain why fatigue becomes long-lasting.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Discernment of mediator and outcome measurement in the PACE trial.

Carr, Ewan, Vitoratou, Silia, Chalder, Trudie et al.·Journal of psychosomatic research·2021

Researchers wanted to check whether different questionnaires used in ME/CFS studies were actually measuring different things. They looked at data from 640 people in a large treatment trial and used statistical methods to see if the questions meant to measure thinking/behavior problems overlapped too much with questions measuring physical function and fatigue. They found that most of the questionnaires were measuring distinct concepts, which means the study design was solid.

E3 PreliminaryMechanismPEM not required

Deconditioning does not explain orthostatic intolerance in ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome).

van Campen, C Linda M C, Rowe, Peter C, Visser, Frans C·Journal of translational medicine·2021

This study examined whether being physically deconditioned (out of shape) causes the dizziness and fainting symptoms that many ME/CFS patients experience when standing up. Researchers tested 199 ME/CFS patients and 22 healthy people using exercise tests and a tilt table test that measures blood flow to the brain. The results showed that ME/CFS patients had significant problems with blood flow to their brain when tilted upright, but this problem occurred regardless of how deconditioned they were.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Ehlers-Danlos Syndrome: Immunologic contrasts and connective tissue comparisons.

Islam, Mareesa, Chang, Christopher, Gershwin, M Eric·Journal of translational autoimmunity·2021

This review article explains Ehlers-Danlos Syndrome (EDS), a group of inherited disorders that affect connective tissue in the body, causing symptoms like loose, stretchy skin and flexible joints. The authors describe the 13 different types of EDS, how doctors diagnose them, and how they're treated. While some forms of EDS involve inflammation, the exact mechanisms causing the disease are not fully understood.

Diagnostics

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[Imaging and Manipulation of Stem and Progenitor Cells for Revealing the Novel Mechanism of Local Tissue Maintenance in the Brain].

Life-Threatening Malnutrition in Very Severe ME/CFS.

Is Cognitive Change Necessary to Alleviate Symptoms in Patients With Functional Somatic Syndrome?

Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection.

Experiences Among School Personnel and School Nurses on Educational Adaptations for Students With CFS/ME: A Qualitative Interview Study.

Angina Simultaneously Diagnosed with the Recurrence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Potential Implications of Mammalian Transient Receptor Potential Melastatin 7 in the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review.

Chronic fatigue syndrome: Abnormally fast muscle fiber conduction in the membranes of motor units at low static force load.

Radiation exposure and mitochondrial insufficiency in chronic fatigue and immune dysfunction syndrome.

Dorsal root ganglia: fibromyalgia pain factory?

Qualitative study of the acceptability and feasibility of acceptance and commitment therapy for adolescents with chronic fatigue syndrome.

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview.

Ross River Virus Immune Evasion Strategies and the Relevance to Post-viral Fatigue, and Myalgic Encephalomyelitis Onset.

[Electroacupuncture improves cognitive function by inhibiting NF-κB activity in rats with chronic fatigue syndrome].

Homeostatic disturbance of thermoregulatory functions in rats with chronic fatigue.

Discernment of mediator and outcome measurement in the PACE trial.

Deconditioning does not explain orthostatic intolerance in ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome).

Ehlers-Danlos Syndrome: Immunologic contrasts and connective tissue comparisons.

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