ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

821–840 of 2,420 studies

E3 PreliminaryGuidelinePEM not requiredGuideline

Therapeutic patient education in adrenal insufficiency.

Guignat, Laurence·Annales d'endocrinologie·2018

This study describes educational programs that help patients with adrenal insufficiency (a condition where the adrenal glands don't make enough hormones) manage their condition safely. The programs teach patients to recognize warning signs of a dangerous crisis, carry emergency medication, adjust their doses for different situations like exercise or travel, and know when to seek medical help. The study notes that similar programs could help people with chronic fatigue syndrome avoid taking too much of their medication.

E3 PreliminaryMechanismPEM unclearMechanistic

High-fidelity discrete modeling of the HPA axis: a study of regulatory plasticity in biology.

Sedghamiz, Hooman, Morris, Matthew, Craddock, Travis J A et al.·BMC systems biology·2018

This study created a simple computer model to understand how the body's stress-response system (the HPA axis) works and how it can get stuck in unhealthy patterns in conditions like ME/CFS. The researchers found that stress may push this system into a low-cortisol state and keep it there, and that certain treatments might help restore normal daily rhythms. The model worked better and required less data than previous complex models.

Endocrine Disruption

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Causality on longitudinal data: Stable specification search in constrained structural equation modeling.

Rahmadi, Ridho, Groot, Perry, van Rijn, Marieke Hc et al.·Statistical methods in medical research·2018

This study developed a new statistical method for finding cause-and-effect relationships in long-term health data, even when sample sizes are small. The researchers tested their method on data from people with chronic fatigue syndrome, Alzheimer's disease, and chronic kidney disease, and found it could identify stable patterns of how different health factors influence each other over time.

E3 PreliminaryGuidelinePEM requiredGuideline

[Diagnosis and Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Kuratsune, Hirohiko·Brain and nerve = Shinkei kenkyu no shinpo·2018

This document presents official diagnostic criteria for ME/CFS developed by Japanese health authorities in 2016. These criteria were designed to help doctors in primary care clinics recognize and diagnose ME/CFS more consistently. The document also summarizes current treatment approaches and expected outcomes based on practices at major medical centers in Japan.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[Immunopathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)].

Yamamura, Takashi, Ono, Hirohiko, Sato, Wakiro·Brain and nerve = Shinkei kenkyu no shinpo·2018

This study found that people with ME/CFS have unusual patterns of immune system chemicals (cytokines) in their blood and spinal fluid, and some patients have antibodies that attack their own bodies. When researchers treated some ME/CFS patients with a medication that removes certain immune cells called B cells, patients improved. This suggests that ME/CFS may be caused by the immune system mistakenly attacking the body.

NeuroinflammationImmune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease.

Petrescu, Anca D, Kain, Jessica, Liere, Victoria et al.·Frontiers in endocrinology·2018

This review examines how the stress hormone system (HPA axis) works and what happens when it breaks down in people with liver disease. The HPA axis is like your body's control center that manages stress responses and many other important functions. The authors explain how inflammation in the liver can disrupt this system, potentially leading to the fatigue and other symptoms seen in both liver disease and chronic fatigue syndrome.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis.

Morris, Gerwyn, Stubbs, Brendon, Köhler, Cristiano A et al.·Sleep medicine reviews·2018

This review explores why people with ME/CFS, bipolar disorder, and multiple sclerosis often have severe sleep problems. The authors suggest that inflammation and stress in the body's cells may damage the brain's ability to control sleep and daily rhythms. They propose that when the immune system stays activated, it can trigger harmful processes that disrupt sleep, which then makes inflammation worse—creating a harmful cycle.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

CD24 Expression and B Cell Maturation Shows a Novel Link With Energy Metabolism: Potential Implications for Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Mensah, Fane F K, Armstrong, Christopher W, Reddy, Venkat et al.·Frontiers in immunology·2018

This study looked at a specific type of immune cell marker called CD24 found on B cells (infection-fighting cells) in ME/CFS patients. Researchers found that ME/CFS patients have more CD24+ B cells than healthy people, and these cells behave differently when it comes to energy use and cell survival. The findings suggest that ME/CFS may involve problems with how B cells handle energy metabolism.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Glial Activation and Expression of the Serotonin Transporter in Chronic Fatigue Syndrome.

Noda, Mami, Ifuku, Masataka, Hossain, Md Shamim et al.·Frontiers in psychiatry·2018

This review examines how brain inflammation might cause ME/CFS symptoms. When the body fights off a viral infection, special immune cells in the brain called microglia and astrocytes can become overactive and trigger a chain of events that reduces serotonin levels—a chemical important for mood and energy. Understanding this pathway could help researchers develop new treatments for ME/CFS.

Neuroinflammation

E3 PreliminaryCohortPEM not requiredCross-Sectional

Tiredness, Fatigue, and Exhaustion as Perceived by Recreational Marathon Runners.

Olson, Karin, Zimka, Oksana, Pasiorowski, Ashley et al.·Qualitative health research·2018

Researchers interviewed 13 recreational marathon runners to understand how they experience and describe tiredness and fatigue. The runners shared strategies that help them manage exhaustion, including taking planned recovery breaks after intense exercise, using mental distraction techniques, and relying on support from others. The researchers suggest these coping strategies might also be helpful for people with medical conditions that cause severe fatigue.

E3 PreliminaryMechanismPEM not requiredMechanistic

[Electroacupuncture of "Zusanli" (ST 36) Raises Muscular Force by Adjusting AMPK/PGC-1 α Signaling in Rats with Chronic Fatigue Syndrome].

Dong, Jia-Zi, Wei, Yun-Tao, Xu, Huan-Yu et al.·Zhen ci yan jiu = Acupuncture research·2018

This study tested whether acupuncture at a specific point (ST 36) could improve muscle weakness in rats with a chronic fatigue condition. Researchers found that the treatment increased muscle strength and improved how the rats' muscles produce energy by activating protective cellular pathways. The results suggest acupuncture may help muscle cells work more efficiently and reduce damage from fatigue.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Dehydroepiandrosterone Research: Past, Current, and Future.

Klinge, Carolyn M, Clark, Barbara J, Prough, Russell A·Vitamins and hormones·2018

This is a historical review of dehydroepiandrosterone (DHEA), a hormone that naturally decreases with age. Scientists have studied whether DHEA might help with various health conditions including chronic fatigue syndrome, but the evidence in humans is limited. While some benefits have been found in postmenopausal women and certain autoimmune disorders, most human studies show only weak connections between DHEA levels and disease outcomes.

Energy MetabolismImmune System

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Perception of induced dyspnea in fibromyalgia and chronic fatigue syndrome.

Van Den Houte, Maaike, Bogaerts, Katleen, Van Diest, Ilse et al.·Journal of psychosomatic research·2018

This study tested how people with ME/CFS and fibromyalgia perceive breathlessness compared to healthy people. Participants breathed into a machine that gradually increased CO2 levels while researchers measured both their physical responses and what they reported feeling. The main finding was that ME/CFS and fibromyalgia patients reported more breathlessness during the recovery phase (after the test ended) than healthy controls, even though their actual physical responses were similar.

E3 PreliminaryReviewPEM requiredReview-Narrative

Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model.

Blomberg, Jonas, Gottfries, Carl-Gerhard, Elfaitouri, Amal et al.·Frontiers in immunology·2018

This study proposes that ME/CFS may develop when a person's immune system mistakenly attacks their own body after an infection, particularly affecting energy production in muscles and the brain. The researchers suggest that some people may have a genetic tendency to develop these harmful immune responses, especially when their gut bacteria are out of balance. When exposed to a triggering infection, the immune system can begin attacking proteins involved in energy metabolism and nerve function, leading to the exhaustion and post-exertion symptoms that characterize ME/CFS.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM unclearMechanistic

Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Ziyang Green Tea on Chronic Fatigue Syndrome.

Shao, Changzhuan, Song, Jing, Zhao, Shanguang et al.·Polymers·2018

Researchers tested whether a compound called selenium-polysaccharide (Se-TP) from a Chinese green tea called Ziyang could help rats with fatigue similar to ME/CFS. They found that the treatment improved certain markers in the rats' blood and urine, suggesting it may work by affecting how the body makes and uses steroid hormones and processes amino acids.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Metabolic Disease or Disturbed Homeostasis due to Focal Inflammation in the Hypothalamus?

Hatziagelaki, Erifili, Adamaki, Maria, Tsilioni, Irene et al.·The Journal of pharmacology and experimental therapeutics·2018

This study proposes that ME/CFS may be caused by inflammation in a small brain region called the hypothalamus, triggered by problems with how cells produce energy. The researchers suggest that when mitochondria (the energy factories in cells) malfunction, they may release harmful substances that activate immune cells in the brain, creating a chain reaction that leads to ME/CFS symptoms. If this theory is correct, it could open new doors for treating the condition by targeting this brain inflammation.

Neuroinflammation

E3 PreliminaryMechanismPEM not requiredCross-Sectional

[New Diagnostic Biomarkers for Chronic Fatigue Syndrome].

Yamano, Emi, Kataoka, Yosky·Brain and nerve = Shinkei kenkyu no shinpo·2018

This study looked at the chemicals and compounds in the blood of people with ME/CFS compared to healthy people to find objective markers that could help doctors diagnose the condition. Researchers used advanced testing methods to examine how the body's metabolism, immune system, and hormones differ in people with ME/CFS. The goal was to develop a simple blood test that could definitively identify ME/CFS, since there is currently no reliable diagnostic test.

Biomarkers

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Psychometric Properties and Factor Structure of a Long and Shortened Version of the Cognitive and Behavioural Responses Questionnaire.

Ryan, Elizabeth G, Vitoratou, Silia, Goldsmith, Kimberley A et al.·Psychosomatic medicine·2018

This study tested a questionnaire designed to measure how people with ME/CFS think and behave in response to their illness—such as pushing through fatigue or avoiding activity. Researchers created a shorter, easier-to-use version of the original questionnaire by removing unnecessary questions while keeping the important ones. Both versions were found to be reliable and accurate tools for understanding these psychological responses.

Cognitive Impairment

E3 PreliminaryPEM unclearBiobank-Resource

Using a participatory approach to develop and implement the UK ME/CFS Biobank.

Lacerda, Eliana M, Kingdon, Caroline C, Bowman, Erinna W et al.·Fatigue : biomedicine, health & behavior·2018

This study describes how researchers in the UK created a biobank—a collection of biological samples and health information from ME/CFS patients—using input from patients themselves. By involving patients in the planning and running of the biobank, the researchers were able to build a resource that better meets the needs of both patients and scientists studying the disease.

E3 PreliminaryMechanismPEM not requiredMechanistic

Changes in fatigue, autonomic functions, and blood biomarkers due to sitting isometric yoga in patients with chronic fatigue syndrome.

Oka, Takakazu, Tanahashi, Tokusei, Sudo, Nobuyuki et al.·BioPsychoSocial medicine·2018

This study tested whether a gentle form of yoga practiced while sitting could help reduce fatigue in ME/CFS patients. Fifteen patients who had not improved with standard treatments did sitting isometric yoga twice a week with an instructor plus daily practice at home for eight weeks. After a single session, patients reported feeling less tired and more energetic, with their bodies showing signs of reduced stress and inflammation.

Immune System

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Therapeutic patient education in adrenal insufficiency.

High-fidelity discrete modeling of the HPA axis: a study of regulatory plasticity in biology.

Causality on longitudinal data: Stable specification search in constrained structural equation modeling.

[Diagnosis and Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

[Immunopathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)].

Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease.

The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis.

CD24 Expression and B Cell Maturation Shows a Novel Link With Energy Metabolism: Potential Implications for Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Glial Activation and Expression of the Serotonin Transporter in Chronic Fatigue Syndrome.

Tiredness, Fatigue, and Exhaustion as Perceived by Recreational Marathon Runners.

[Electroacupuncture of "Zusanli" (ST 36) Raises Muscular Force by Adjusting AMPK/PGC-1 α Signaling in Rats with Chronic Fatigue Syndrome].

Dehydroepiandrosterone Research: Past, Current, and Future.

Perception of induced dyspnea in fibromyalgia and chronic fatigue syndrome.

Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model.

Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Ziyang Green Tea on Chronic Fatigue Syndrome.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Metabolic Disease or Disturbed Homeostasis due to Focal Inflammation in the Hypothalamus?

[New Diagnostic Biomarkers for Chronic Fatigue Syndrome].

Psychometric Properties and Factor Structure of a Long and Shortened Version of the Cognitive and Behavioural Responses Questionnaire.

Using a participatory approach to develop and implement the UK ME/CFS Biobank.

Changes in fatigue, autonomic functions, and blood biomarkers due to sitting isometric yoga in patients with chronic fatigue syndrome.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research