ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

821–840 of 2,422 studies

E3 PreliminaryMechanismPEM unclearMechanistic

High-fidelity discrete modeling of the HPA axis: a study of regulatory plasticity in biology.

Sedghamiz, Hooman, Morris, Matthew, Craddock, Travis J A et al.·BMC systems biology·2018

This study created a simple computer model to understand how the body's stress-response system (the HPA axis) works and how it can get stuck in unhealthy patterns in conditions like ME/CFS. The researchers found that stress may push this system into a low-cortisol state and keep it there, and that certain treatments might help restore normal daily rhythms. The model worked better and required less data than previous complex models.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease.

Petrescu, Anca D, Kain, Jessica, Liere, Victoria et al.·Frontiers in endocrinology·2018

This review examines how the stress hormone system (HPA axis) works and what happens when it breaks down in people with liver disease. The HPA axis is like your body's control center that manages stress responses and many other important functions. The authors explain how inflammation in the liver can disrupt this system, potentially leading to the fatigue and other symptoms seen in both liver disease and chronic fatigue syndrome.

Immune System

E3 PreliminaryMechanismPEM unclearObservational

The expression signature of very long non-coding RNA in myalgic encephalomyelitis/chronic fatigue syndrome.

Yang, Chin-An, Bauer, Sandra, Ho, Yu-Chen et al.·Journal of translational medicine·2018

Researchers looked at special molecules called very long non-coding RNAs in the blood of ME/CFS patients to see if they might be disease markers. They found that three of these RNA molecules (NTT, MIAT, and EmX2OS) were present at higher levels in ME/CFS patients compared to healthy people, and two of them (NTT and EmX2OS) increased with disease severity. When they tested these findings in lab cells exposed to oxidative stress and viral signals, the RNA levels increased, suggesting these molecules respond to the kinds of biological stresses that may occur in ME/CFS.

BiomarkersImmune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Causality on longitudinal data: Stable specification search in constrained structural equation modeling.

Rahmadi, Ridho, Groot, Perry, van Rijn, Marieke Hc et al.·Statistical methods in medical research·2018

This study developed a new statistical method for finding cause-and-effect relationships in long-term health data, even when sample sizes are small. The researchers tested their method on data from people with chronic fatigue syndrome, Alzheimer's disease, and chronic kidney disease, and found it could identify stable patterns of how different health factors influence each other over time.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Immunopathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)].

Yamamura, Takashi, Ono, Hirohiko, Sato, Wakiro·Brain and nerve = Shinkei kenkyu no shinpo·2018

This study found that people with ME/CFS have unusual patterns of immune system chemicals (cytokines) in their blood and spinal fluid, and some patients have antibodies that attack their own bodies. When researchers treated some ME/CFS patients with a medication that removes certain immune cells called B cells, patients improved. This suggests that ME/CFS may be caused by the immune system mistakenly attacking the body.

NeuroinflammationImmune System

E3 PreliminaryGuidelinePEM not requiredGuideline

Therapeutic patient education in adrenal insufficiency.

Guignat, Laurence·Annales d'endocrinologie·2018

This study describes educational programs that help patients with adrenal insufficiency (a condition where the adrenal glands don't make enough hormones) manage their condition safely. The programs teach patients to recognize warning signs of a dangerous crisis, carry emergency medication, adjust their doses for different situations like exercise or travel, and know when to seek medical help. The study notes that similar programs could help people with chronic fatigue syndrome avoid taking too much of their medication.

E3 PreliminaryMechanismPEM not requiredMechanistic

[Electroacupuncture of "Zusanli" (ST 36) Raises Muscular Force by Adjusting AMPK/PGC-1 α Signaling in Rats with Chronic Fatigue Syndrome].

Dong, Jia-Zi, Wei, Yun-Tao, Xu, Huan-Yu et al.·Zhen ci yan jiu = Acupuncture research·2018

This study tested whether acupuncture at a specific point (ST 36) could improve muscle weakness in rats with a chronic fatigue condition. Researchers found that the treatment increased muscle strength and improved how the rats' muscles produce energy by activating protective cellular pathways. The results suggest acupuncture may help muscle cells work more efficiently and reduce damage from fatigue.

Energy Metabolism

E3 PreliminaryMechanismPEM unclearMechanistic

CD24 Expression and B Cell Maturation Shows a Novel Link With Energy Metabolism: Potential Implications for Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Mensah, Fane F K, Armstrong, Christopher W, Reddy, Venkat et al.·Frontiers in immunology·2018

This study looked at a specific type of immune cell marker called CD24 found on B cells (infection-fighting cells) in ME/CFS patients. Researchers found that ME/CFS patients have more CD24+ B cells than healthy people, and these cells behave differently when it comes to energy use and cell survival. The findings suggest that ME/CFS may involve problems with how B cells handle energy metabolism.

Immune System

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Perception of induced dyspnea in fibromyalgia and chronic fatigue syndrome.

Van Den Houte, Maaike, Bogaerts, Katleen, Van Diest, Ilse et al.·Journal of psychosomatic research·2018

This study tested how people with ME/CFS and fibromyalgia perceive breathlessness compared to healthy people. Participants breathed into a machine that gradually increased CO2 levels while researchers measured both their physical responses and what they reported feeling. The main finding was that ME/CFS and fibromyalgia patients reported more breathlessness during the recovery phase (after the test ended) than healthy controls, even though their actual physical responses were similar.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Glial Activation and Expression of the Serotonin Transporter in Chronic Fatigue Syndrome.

Noda, Mami, Ifuku, Masataka, Hossain, Md Shamim et al.·Frontiers in psychiatry·2018

This review examines how brain inflammation might cause ME/CFS symptoms. When the body fights off a viral infection, special immune cells in the brain called microglia and astrocytes can become overactive and trigger a chain of events that reduces serotonin levels—a chemical important for mood and energy. Understanding this pathway could help researchers develop new treatments for ME/CFS.

Neuroinflammation

E3 PreliminaryCohortPEM not requiredCross-Sectional

Tiredness, Fatigue, and Exhaustion as Perceived by Recreational Marathon Runners.

Olson, Karin, Zimka, Oksana, Pasiorowski, Ashley et al.·Qualitative health research·2018

Researchers interviewed 13 recreational marathon runners to understand how they experience and describe tiredness and fatigue. The runners shared strategies that help them manage exhaustion, including taking planned recovery breaks after intense exercise, using mental distraction techniques, and relying on support from others. The researchers suggest these coping strategies might also be helpful for people with medical conditions that cause severe fatigue.

E3 PreliminaryReviewPEM unclearReview-Narrative

Dehydroepiandrosterone Research: Past, Current, and Future.

Klinge, Carolyn M, Clark, Barbara J, Prough, Russell A·Vitamins and hormones·2018

This is a historical review of dehydroepiandrosterone (DHEA), a hormone that naturally decreases with age. Scientists have studied whether DHEA might help with various health conditions including chronic fatigue syndrome, but the evidence in humans is limited. While some benefits have been found in postmenopausal women and certain autoimmune disorders, most human studies show only weak connections between DHEA levels and disease outcomes.

Energy MetabolismImmune System

E3 PreliminaryPEM unclearBiobank-Resource

Using a participatory approach to develop and implement the UK ME/CFS Biobank.

Lacerda, Eliana M, Kingdon, Caroline C, Bowman, Erinna W et al.·Fatigue : biomedicine, health & behavior·2018

This study describes how researchers in the UK created a biobank—a collection of biological samples and health information from ME/CFS patients—using input from patients themselves. By involving patients in the planning and running of the biobank, the researchers were able to build a resource that better meets the needs of both patients and scientists studying the disease.

E3 PreliminaryReviewPEM requiredReview-Narrative

Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model.

Blomberg, Jonas, Gottfries, Carl-Gerhard, Elfaitouri, Amal et al.·Frontiers in immunology·2018

This study proposes that ME/CFS may develop when a person's immune system mistakenly attacks their own body after an infection, particularly affecting energy production in muscles and the brain. The researchers suggest that some people may have a genetic tendency to develop these harmful immune responses, especially when their gut bacteria are out of balance. When exposed to a triggering infection, the immune system can begin attacking proteins involved in energy metabolism and nerve function, leading to the exhaustion and post-exertion symptoms that characterize ME/CFS.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis.

Morris, Gerwyn, Stubbs, Brendon, Köhler, Cristiano A et al.·Sleep medicine reviews·2018

This review explores why people with ME/CFS, bipolar disorder, and multiple sclerosis often have severe sleep problems. The authors suggest that inflammation and stress in the body's cells may damage the brain's ability to control sleep and daily rhythms. They propose that when the immune system stays activated, it can trigger harmful processes that disrupt sleep, which then makes inflammation worse—creating a harmful cycle.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Clinical Criteria of Central Sensitization in Chronic Pelvic and Perineal Pain (Convergences PP Criteria): Elaboration of a Clinical Evaluation Tool Based on Formal Expert Consensus.

Levesque, Amélie, Riant, Thibault, Ploteau, Stéphane et al.·Pain medicine (Malden, Mass.)·2018

This study created a simple checklist to help doctors identify when chronic pelvic pain is caused by the nervous system becoming overly sensitive, rather than from a structural injury or disease they can see on tests. Experts agreed on 10 key signs to look for, including pain that changes in intensity, pain triggered by normal activities, and having other conditions like fibromyalgia or chronic fatigue syndrome alongside pelvic pain.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue and immune deficiency syndrome (CFIDS), cellular metabolism, and ionizing radiation: a review of contemporary scientific literature and suggested directions for future research.

Rusin, Andrej, Seymour, Colin, Mothersill, Carmel·International journal of radiation biology·2018

This study looked at whether ME/CFS and radiation sickness might share similar problems in how cells produce energy. Researchers found evidence that both conditions may involve damage to mitochondria (the "power plants" of cells) and disrupted energy production. They suggest specific biological pathways worth studying to better understand ME/CFS and possibly develop new treatments.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Metabolic Disease or Disturbed Homeostasis due to Focal Inflammation in the Hypothalamus?

Hatziagelaki, Erifili, Adamaki, Maria, Tsilioni, Irene et al.·The Journal of pharmacology and experimental therapeutics·2018

This study proposes that ME/CFS may be caused by inflammation in a small brain region called the hypothalamus, triggered by problems with how cells produce energy. The researchers suggest that when mitochondria (the energy factories in cells) malfunction, they may release harmful substances that activate immune cells in the brain, creating a chain reaction that leads to ME/CFS symptoms. If this theory is correct, it could open new doors for treating the condition by targeting this brain inflammation.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

HPV vaccination syndrome: A clinical mirage, or a new tragic fibromyalgia model.

Martínez-Lavín, Manuel·Reumatologia clinica·2018

Some people have reported developing chronic pain and autonomic symptoms (problems with heart rate, blood pressure, and sweating) after receiving the HPV vaccine. This article reviews whether this connection is real and suggests that if it exists, these cases might share similarities with fibromyalgia—a condition involving widespread pain and nervous system dysfunction. The authors propose that understanding fibromyalgia's mechanisms could help diagnose and treat patients who develop symptoms after HPV vaccination.

Pain and SensitizationAutonomic Nervous System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Functional brain connectivity of remembered fatigue or happiness in healthy adults: Use of arterial spin labeling.

Boissoneault, Jeff, Sevel, Landrew, Robinson, Michael E et al.·Journal of clinical and experimental neuropsychology·2018

Researchers used brain scans to study what happens in the brain when healthy people remember feeling tired versus happy. They found that fatigue activated different brain regions than happiness did, particularly areas involved in vision and a structure called the globus pallidum. This helps scientists understand the brain basis of fatigue without the complications of studying people who have chronic fatigue syndrome with other medical conditions.

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High-fidelity discrete modeling of the HPA axis: a study of regulatory plasticity in biology.

Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease.

The expression signature of very long non-coding RNA in myalgic encephalomyelitis/chronic fatigue syndrome.

Causality on longitudinal data: Stable specification search in constrained structural equation modeling.

[Immunopathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)].

Therapeutic patient education in adrenal insufficiency.

[Electroacupuncture of "Zusanli" (ST 36) Raises Muscular Force by Adjusting AMPK/PGC-1 α Signaling in Rats with Chronic Fatigue Syndrome].

CD24 Expression and B Cell Maturation Shows a Novel Link With Energy Metabolism: Potential Implications for Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Perception of induced dyspnea in fibromyalgia and chronic fatigue syndrome.

Glial Activation and Expression of the Serotonin Transporter in Chronic Fatigue Syndrome.

Tiredness, Fatigue, and Exhaustion as Perceived by Recreational Marathon Runners.

Dehydroepiandrosterone Research: Past, Current, and Future.

Using a participatory approach to develop and implement the UK ME/CFS Biobank.

Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model.

The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis.

Clinical Criteria of Central Sensitization in Chronic Pelvic and Perineal Pain (Convergences PP Criteria): Elaboration of a Clinical Evaluation Tool Based on Formal Expert Consensus.

Chronic fatigue and immune deficiency syndrome (CFIDS), cellular metabolism, and ionizing radiation: a review of contemporary scientific literature and suggested directions for future research.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Metabolic Disease or Disturbed Homeostasis due to Focal Inflammation in the Hypothalamus?

HPV vaccination syndrome: A clinical mirage, or a new tragic fibromyalgia model.

Functional brain connectivity of remembered fatigue or happiness in healthy adults: Use of arterial spin labeling.

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