ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

121–140 of 266 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Non-REM sleep EEG power distribution in fatigue and sleepiness.

Neu, Daniel, Mairesse, Olivier, Verbanck, Paul et al.·Journal of psychosomatic research·2014

This study compared brain wave patterns during sleep between people with ME/CFS, people with sleep apnea, and healthy controls. Researchers found that ME/CFS patients show a different pattern of brain activity during sleep compared to those with sleep apnea, which may help explain why ME/CFS fatigue doesn't improve with rest like normal sleepiness does.

Sleep

E2 ModerateCohortPEM not requiredLongitudinal

The role of hypocortisolism in chronic fatigue syndrome.

Nijhof, Sanne L, Rutten, Juliette M T M, Uiterwaal, Cuno S P M et al.·Psychoneuroendocrinology·2014

This study looked at stress hormone levels (cortisol) in adolescents with ME/CFS by measuring saliva samples. Teenagers with ME/CFS had lower cortisol levels than healthy peers, and those who improved with treatment showed their cortisol levels normalize, while those who didn't recover showed little change. The findings suggest that restoration of normal cortisol production during treatment may be linked to better outcomes.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

[Impact of the fibromyalgia in the chronic fatigue syndrome].

Faro, Mónica, Sáez-Francàs, Naia, Castro-Marrero, Jesús et al.·Medicina clinica·2014

This study looked at nearly 1,000 ME/CFS patients to see how many also had fibromyalgia (a condition causing widespread pain and fatigue), and whether having both conditions made symptoms worse. They found that about half of the ME/CFS patients also had fibromyalgia, and those patients experienced higher levels of fatigue, pain, sleep problems, and cognitive difficulties. People with both conditions reported a much greater impact on their quality of life compared to those with ME/CFS alone.

SleepCognitive ImpairmentAutonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Predictors and consequences of fatigue in prevalent kidney transplant recipients.

Chan, Winnie, Bosch, Jos A, Jones, David et al.·Transplantation·2013

This study looked at tiredness in people who have received kidney transplants and are doing well medically. Researchers found that nearly 6 out of 10 kidney transplant patients experience significant fatigue that affects their daily life and quality of life, yet most doctors weren't documenting this problem in their medical records. The fatigue levels were similar to those seen in chronic fatigue syndrome, and it was linked to factors like inflammation, kidney function decline, poor sleep, anxiety, and depression.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Temporal organization of rest defined by actigraphy data in healthy and childhood chronic fatigue syndrome children.

Kawabata, Minako, Ueno, Taro, Tomita, Jun et al.·BMC psychiatry·2013

This study looked at sleep and rest patterns in healthy children and children with chronic fatigue syndrome (CFS) using wristband activity trackers. The researchers found that when they looked at the patterns of rest and sleep separately—distinguishing between time spent out of bed versus in bed—children with CFS had different patterns compared to healthy children. This suggests that how the body organizes rest and activity may be disrupted in CFS.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Heart rate variability during sleep and subsequent sleepiness in patients with chronic fatigue syndrome.

Togo, Fumiharu, Natelson, Benjamin H·Autonomic neuroscience : basic & clinical·2013

This study looked at how the heart's rhythm changes during sleep in ME/CFS patients compared to healthy people, and whether these changes relate to feeling more or less tired after sleep. Researchers found that some ME/CFS patients who woke up feeling sleepier had different heart rhythm patterns during deep sleep than healthy controls, even though standard sleep measurements looked normal. This suggests the nervous system's control of the heart during sleep might be disrupted in ME/CFS, which could contribute to unrefreshing sleep.

SleepAutonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Are there sleep-specific phenotypes in patients with chronic fatigue syndrome? A cross-sectional polysomnography analysis.

Gotts, Zoe M, Deary, Vincent, Newton, Julia et al.·BMJ open·2013

This study looked at sleep patterns in 343 people with chronic fatigue syndrome using overnight sleep monitoring machines. Researchers found that about 30% of patients had a separate sleep disorder, and the remaining patients fell into four different groups based on their sleep problems—some had trouble falling asleep, some had frequent sleep interruptions, some slept longer than average, and some had very short sleep with lots of waking. The findings suggest that people with ME/CFS have different types of sleep problems and may benefit from different sleep treatments based on their specific pattern.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Subjective sleep quality and daytime sleepiness in a large sample of patients with chronic fatigue syndrome (CFS).

Mariman, A, Vogelaers, D, Hanoulle, I et al.·Acta clinica Belgica·2012

This study looked at sleep problems in 415 ME/CFS patients by asking them to complete questionnaires about sleep quality and daytime sleepiness. The researchers found that ME/CFS patients reported both poor sleep quality and high daytime sleepiness, but these two problems didn't always occur together—some patients had poor sleep quality without feeling sleepy during the day, and a smaller group resembled people with insomnia. The findings suggest that sleep problems in ME/CFS are complex and may affect different patients in different ways.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

Sleep-stage dynamics in patients with chronic fatigue syndrome with or without fibromyalgia.

Kishi, Akifumi, Natelson, Benjamin H, Togo, Fumiharu et al.·Sleep·2011

This study looked at sleep patterns in women with ME/CFS, comparing those with ME/CFS alone to those who also have fibromyalgia (FM). Researchers found that people with ME/CFS alone had trouble staying asleep and waking up too often from REM sleep, while those with both conditions showed different sleep problems including difficulty maintaining deeper sleep stages. These findings suggest that ME/CFS and fibromyalgia may involve different types of sleep disturbances.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Characteristics of chronic fatigue syndrome in a Japanese community population : chronic fatigue syndrome in Japan.

Hamaguchi, Masahide, Kawahito, Yutaka, Takeda, Noriyuki et al.·Clinical rheumatology·2011

This Japanese study looked at how many people have ME/CFS in the general population and what their daily habits are like. Researchers found that about 1 in 100 people in Japan have ME/CFS, and people with the condition slept significantly less (about 5.5 hours per night) compared to people without it (about 6.3 hours). The symptom of unrefreshing sleep was particularly useful for identifying who has ME/CFS.

Sleep

E2 ModerateBehavioralPEM not requiredCross-Sectional

Long-term sickness absence among patients with chronic fatigue syndrome.

Knudsen, Ann Kristin, Henderson, Max, Harvey, Samuel B et al.·The British journal of psychiatry : the journal of mental science·2011

This study looked at ME/CFS patients who were on long-term sick leave from work and compared them to those still working. Patients taking sick leave had more severe physical fatigue and sleep problems than other patients. Interestingly, those on sick leave also tended to avoid situations they found embarrassing and rested more often as a coping strategy. The researchers suggest that helping patients manage embarrassment-related thoughts and avoidance behaviors might help them return to work.

Sleep

E2 ModerateCohortPEM not requiredCase-Control

Cognitive impairment in fatigue and sleepiness associated conditions.

Neu, Daniel, Kajosch, Hendrik, Peigneux, Philippe et al.·Psychiatry research·2011

This study compared how fatigue and sleepiness affect thinking and memory. Researchers tested 15 people with ME/CFS, 15 people with sleep apnea, and 16 healthy controls using memory tests, attention tasks, and brain wave measurements. Both patient groups showed cognitive problems, though people with sleep apnea had slightly more difficulty with certain thinking tasks and movement speed.

Cognitive ImpairmentSleep

E2 ModerateCohortPEM not requiredCase-Control

Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study.

Moldofsky, Harvey, Patcai, John·BMC neurology·2011

This study looked at people who had severe SARS infection and were unable to return to work for over a year afterward. These patients experienced long-lasting fatigue, widespread muscle pain, weakness, depression, and poor sleep quality. Researchers found that their sleep patterns and symptoms were very similar to those seen in fibromyalgia and chronic fatigue syndrome.

SleepPain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Interstitial cystitis/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome.

Nickel, J Curtis, Tripp, Dean A, Pontari, Michel et al.·The Journal of urology·2010

This study looked at how often bladder pain syndrome occurs alongside other conditions like irritable bowel syndrome, fibromyalgia, and ME/CFS. Researchers found that people with bladder pain syndrome were much more likely to have these other conditions compared to healthy controls. Importantly, people who had multiple overlapping conditions experienced worse pain, sleep problems, depression, and lower quality of life than those with just one condition.

Pain and SensitizationSleep

E2 ModerateCohortPEM not requiredCross-Sectional

Fatigue status in relation to lifestyle in healthy Japanese adolescents.

Zou, Ning, Kubota, Masaru, Kuruma, Eriko et al.·International journal of pediatrics·2010

This study looked at fatigue in over 1,200 healthy Japanese teenagers aged 11–16 to see how common different types of fatigue were and whether lifestyle habits made a difference. Researchers found that girls reported higher fatigue scores related to ME/CFS-type symptoms than boys, and fatigue increased as teenagers got older. Sleep, exercise, diet quality, and sugary drinks were all linked to how tired teenagers felt.

Sleep

E2 ModerateBehavioralPEM not requiredCross-Sectional

Physical and psychosocial correlates of severe fatigue in rheumatoid arthritis.

van Hoogmoed, Dewy, Fransen, Jaap, Bleijenberg, Gijs et al.·Rheumatology (Oxford, England)·2010

This study looked at severe fatigue in people with rheumatoid arthritis (RA), a condition that causes joint inflammation. Researchers found that 42% of RA patients experienced severe fatigue that felt frustrating and exhausting. Importantly, this severe fatigue was more closely linked to pain, mood, sleep quality, and how patients thought about their fatigue—rather than to inflammation markers alone.

Pain and SensitizationSleep

E2 ModerateCohortPEM unclearObservational

A retrospective review of the sleep characteristics in patients with chronic fatigue syndrome and fibromyalgia.

Spitzer, A Robert, Broadman, Melissa·Pain practice : the official journal of World Institute of Pain·2010

Researchers studied sleep patterns in 118 patients with ME/CFS and fibromyalgia using objective sleep tests. They found that most patients had abnormal sleep studies showing excessive daytime sleepiness, and some had sleep features similar to narcolepsy. A genetic marker (HLA DQB1*0602) associated with narcolepsy was found in 43% of patients, much higher than in the general population.

Sleep

E2 ModerateCohortPEM not requiredCase-Control

Adolescent offspring of mothers with chronic fatigue syndrome.

Smith, Mark S, Buchwald, Dedra S, Bogart, Andy et al.·The Journal of adolescent health : official publication of the Society for Adolescent Medicine·2010

This study looked at whether teenagers whose mothers have ME/CFS are more likely to develop ME/CFS themselves or experience fatigue and other related symptoms. Researchers compared 26 teenagers with mothers who had ME/CFS to 45 teenagers whose mothers were healthy. While teenagers with affected mothers showed higher rates of prolonged fatigue and ME/CFS diagnosis, the differences were small and not statistically proven.

SleepPain and Sensitization

E2 ModerateCohortPEM unclearObservational

Treatment of the narcoleptiform sleep disorder in chronic fatigue syndrome and fibromyalgia with sodium oxybate.

Spitzer, A Robert, Broadman, Melissa·Pain practice : the official journal of World Institute of Pain·2010

Researchers looked at 118 patients with ME/CFS or fibromyalgia who had sleep problems similar to narcolepsy. When these patients were treated with a medication called sodium oxybate, 75% reported significant improvement in fatigue and 60% reported significant improvement in pain. This suggests that fixing the underlying sleep disorder might help relieve both conditions.

Sleep

E2 ModerateBehavioralPEM not requiredCross-Sectional

Sleep apnea and psychological functioning in chronic fatigue syndrome.

Libman, Eva, Creti, Laura, Baltzan, Marcel et al.·Journal of health psychology·2009

This study looked at whether sleep apnea (a condition where breathing stops and starts during sleep) is common in people with ME/CFS and how it affects mood and psychological well-being. The researchers found that 68% of ME/CFS patients had sleep apnea, but those who did were not significantly more ill than those without it. Both the ME/CFS and sleep apnea groups showed more psychological difficulties than healthy controls, but the researchers suggest these emotional struggles are likely a natural response to living with a chronic illness rather than a separate psychiatric condition.

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Non-REM sleep EEG power distribution in fatigue and sleepiness.

The role of hypocortisolism in chronic fatigue syndrome.

[Impact of the fibromyalgia in the chronic fatigue syndrome].

Predictors and consequences of fatigue in prevalent kidney transplant recipients.

Temporal organization of rest defined by actigraphy data in healthy and childhood chronic fatigue syndrome children.

Heart rate variability during sleep and subsequent sleepiness in patients with chronic fatigue syndrome.

Are there sleep-specific phenotypes in patients with chronic fatigue syndrome? A cross-sectional polysomnography analysis.

Subjective sleep quality and daytime sleepiness in a large sample of patients with chronic fatigue syndrome (CFS).

Sleep-stage dynamics in patients with chronic fatigue syndrome with or without fibromyalgia.

Characteristics of chronic fatigue syndrome in a Japanese community population : chronic fatigue syndrome in Japan.

Long-term sickness absence among patients with chronic fatigue syndrome.

Cognitive impairment in fatigue and sleepiness associated conditions.

Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study.

Interstitial cystitis/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome.

Fatigue status in relation to lifestyle in healthy Japanese adolescents.

Physical and psychosocial correlates of severe fatigue in rheumatoid arthritis.

A retrospective review of the sleep characteristics in patients with chronic fatigue syndrome and fibromyalgia.

Adolescent offspring of mothers with chronic fatigue syndrome.

Treatment of the narcoleptiform sleep disorder in chronic fatigue syndrome and fibromyalgia with sodium oxybate.

Sleep apnea and psychological functioning in chronic fatigue syndrome.

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