Low-dose hydrocortisone for treatment of chronic fatigue syndrome: a randomized controlled trial.
McKenzie, R, O'Fallon, A, Dale, J et al.·JAMA·1998
Researchers tested whether low-dose hydrocortisone (a steroid hormone) could help ME/CFS patients by addressing a potential hormone imbalance in the body. Over 12 weeks, patients taking hydrocortisone showed somewhat more improvement in overall wellness compared to those taking placebo, but the difference was small and not quite statistically significant. However, the treatment caused the body's ability to produce its own cortisol to be suppressed in 12 patients, which made doctors decide the risks were too high to recommend this treatment.