Electrodermal dissociation of chronic fatigue and depression: evidence for distinct physiological mechanisms.
Pazderka-Robinson, Hannah, Morrison, James W, Flor-Henry, Pierre·International journal of psychophysiology : official journal of the International Organization of Psychophysiology·2004
This study looked at how the bodies of people with ME/CFS and people with depression respond differently to their surroundings. Researchers measured skin conductance (how easily electricity travels across the skin) and skin temperature while participants performed a task. They found that people with ME/CFS had notably lower skin conductance levels and higher skin temperature compared to people with depression and healthy controls, suggesting these are two different conditions with different underlying biology.