ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

201–206 of 206 studies

E3 PreliminaryCohortPEM unclearCase-Control

Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome.

Zhang, C, Baumer, A, Mackay, I R et al.·Human molecular genetics·1995

This 1995 study examined muscle tissue from one adult patient with ME/CFS and found an unusual pattern of damaged mitochondrial DNA (the energy-producing structures in our cells). The researchers compared this patient's muscle cells to control samples and discovered deletions—missing pieces—in the mitochondrial DNA that weren't typically seen in healthy people. This finding suggested that energy production problems in muscle cells might contribute to the fatigue experienced by ME/CFS patients.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredCase-Control

Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome.

Plioplys, A V, Plioplys, S·Neuropsychobiology·1995

This study examined muscle tissue from CFS patients under a powerful microscope to look for damage to mitochondria (the energy-producing structures in cells). Researchers compared 15 CFS patients with 15 healthy people and found no visible structural differences in the mitochondria between the two groups, even though CFS causes severe fatigue and weakness.

Energy Metabolism

E3 PreliminaryCommentaryPEM not requiredEditorial

Eicosanoids and essential fatty acid modulation in chronic disease and the chronic fatigue syndrome.

Gray, J B, Martinovic, A M·Medical hypotheses·1994

This study proposes that ME/CFS may involve problems with how the body processes essential fatty acids—nutrients found in foods like fish and seeds. When stress is constant or too intense, the body's ability to use these fatty acids becomes sluggish, which can trigger ongoing immune system problems and exhaustion. The researchers suggest that changing your diet to better balance these fatty acids might help restore normal immune function and improve symptoms.

Energy MetabolismImmune System

E3 PreliminaryCommentaryPEM unclearEditorial

The grey area of effort syndrome and hyperventilation: from Thomas Lewis to today.

Nixon, P G·Journal of the Royal College of Physicians of London·1993

This article reviews the historical concept of 'effort syndrome'—a condition where the body loses its ability to handle physical exertion due to chemical imbalances, particularly in how the body buffers acids produced during exercise. The author argues that this old diagnosis remains relevant today and should be considered when evaluating chronic fatigue and other unexplained illnesses, especially when emotional stress and overbreathing (hyperventilation) are present.

Energy MetabolismPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Postviral fatigue syndrome.

Behan, P O, Behan, W M·Critical reviews in neurobiology·1988

This review examines ME/CFS, a condition that causes severe exhaustion, muscle pain, and cognitive difficulties, sometimes appearing in outbreaks and sometimes in individual cases. Researchers note that patients often experience emotional changes, memory problems, and depression alongside the physical symptoms. The authors suggest that a lingering viral infection may trigger a metabolic problem in the body, which could explain why people feel so severely fatigued.

Energy Metabolism

E3 PreliminaryCohortPEM unclearCase-Control

Chronic relapsing myalgia (? Post viral): clinical, histological, and biochemical studies.

Byrne, E, Trounce, I, Dennett, X·Australian and New Zealand journal of medicine·1985

This study examined two patients with ongoing muscle pain that started after a viral-like illness and came and went unpredictably. Doctors found the patients had weak muscle fibers and signs that their muscles weren't producing energy as efficiently as they should. The findings suggest these patients may have a mild form of ME/CFS, and importantly, their muscle problems were real biological issues rather than caused by psychological factors.

Energy Metabolism

← Previous

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome.

Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome.

Eicosanoids and essential fatty acid modulation in chronic disease and the chronic fatigue syndrome.

The grey area of effort syndrome and hyperventilation: from Thomas Lewis to today.

Postviral fatigue syndrome.

Chronic relapsing myalgia (? Post viral): clinical, histological, and biochemical studies.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research