ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

241–250 of 250 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome. Definition, diagnostic measures and therapeutic possibilities].

Lieb, K, Dammann, G, Berger, M et al.·Der Nervenarzt·1996

ME/CFS is a disorder that causes persistent tiredness, but doctors cannot diagnose it with a simple blood test or scan. Instead, doctors use specific clinical criteria to identify the condition, while carefully ruling out other illnesses like depression or sleep problems that can look similar. Currently, there is no cure for ME/CFS, so treatment focuses on managing individual symptoms like poor sleep, pain, and mood changes with a combination of medical care and psychological support.

Pain and SensitizationSleepDiagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fibromyalgia syndrome: a review.

Reiffenberger, D H, Amundson, L H·American family physician·1996

Fibromyalgia syndrome is a chronic condition characterized by widespread pain, stiffness, and tender points in muscles and soft tissues, often accompanied by fatigue and sleep problems. It affects women more than men, typically starting around age 49. Treatment combines medication (like certain antidepressants), education, reassurance, and exercise to help manage symptoms.

Pain and SensitizationSleep

E3 PreliminaryCohortPEM not requiredObservational

[Multiple chemical sensitivity disorder in patients with neurotoxic illnesses].

Lohmann, K, Pröhl, A, Schwarz, E·Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))·1996

This study looked at 466 people who had neurological symptoms from toxic chemical exposure and found that 136 of them also had Multiple Chemical Sensitivity (MCS)—a condition where people react strongly to low levels of chemicals. The researchers found that wood preservatives, solvents, and formaldehyde were common culprits, and people with MCS were more likely to have chronic fatigue symptoms and allergies than those without MCS.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredMechanistic

Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome.

Vecchiet, L, Montanari, G, Pizzigallo, E et al.·Neuroscience letters·1996

This study tested whether people with ME/CFS have increased pain sensitivity in their muscles compared to their skin. Researchers found that muscles were significantly more sensitive to pain in ME/CFS patients, while skin sensitivity was normal. They also discovered abnormal structures and damage in muscle cells from ME/CFS patients, including problems with mitochondria (the energy-producing parts of cells) and signs of degeneration.

Pain and Sensitization

E3 PreliminaryBehavioralPEM not required

'Repetitive strain injury': from Australia to the UK.

Reilly, P A·Journal of psychosomatic research·1995

In the 1980s, Australia experienced a widespread outbreak of upper limb pain that didn't fit standard medical diagnoses. The UK is now seeing a similar epidemic. This study examines whether the condition is truly caused by workplace activities or whether psychological and social factors play a larger role, similar to what happens in chronic fatigue syndrome.

Pain and Sensitization

E3 PreliminaryCohortPEM not requiredCross-Sectional

The ocular signs and symptoms of chronic fatigue syndrome.

Caffery, B E, Josephson, J E, Samek, M J·Journal of the American Optometric Association·1994

This study looked at eye problems in 25 people with ME/CFS and found that all of them experienced some eye-related symptoms. The most common issues were problems with tears and the eye's surface, as well as difficulty focusing on close objects. Eye doctors should be aware of these issues when examining ME/CFS patients.

Pain and Sensitization

E3 PreliminaryCohortPEM not requiredCase-Control

Development of multiple chemical sensitivity after an outbreak of sick-building syndrome.

Welch, L S, Sokas, R·Toxicology and industrial health·1992

When workers were exposed to problems in a building (sick-building syndrome), some developed multiple chemical sensitivity (MCS)—a condition where people react to low levels of chemicals. This study looked at 20 people affected by the outbreak and found that most had existing health conditions like allergies or asthma that got worse. Importantly, having ME/CFS did not predict who would develop MCS, and many people had ongoing problems beyond just MCS after leaving the building.

Pain and Sensitization

E3 PreliminaryCommentaryPEM unclearEditorial

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Goldenberg, D L·Current opinion in rheumatology·1991

This review examines three related conditions—fibromyalgia, chronic fatigue syndrome, and myofascial pain—that often occur together and cause pain, tiredness, and sleep problems. Researchers are discovering that these conditions may share common biological causes involving how the body senses pain, hormone imbalances, and problems with muscle function. Unfortunately, the new treatments being tested at that time were not particularly effective.

Pain and SensitizationSleepDiagnostics

E3 PreliminaryCommentaryPEM unclearEditorial

Pain syndromes, disability, and chronic disease in childhood.

Malleson, P N·Current opinion in rheumatology·1991

This editorial discusses how chronic pain and long-term illnesses affect children, and suggests that conditions like fibromyalgia and chronic fatigue syndrome (ME/CFS) may be related to each other. The author notes that doctors need better training to understand these complex conditions and that psychological factors may play a role in how these illnesses develop and affect children's lives.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

Depression and chronic fatigue in the patient with chronic pain.

Covington, E C·Primary care·1991

This study explores how chronic pain, fatigue, and depression often occur together in patients. The authors suggest that these three conditions share common causes and may influence each other. Treatment works best when doctors address each problem separately using a combination of physical rehabilitation, education, medications, and counseling.

Pain and Sensitization

← Previous

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

[Chronic fatigue syndrome. Definition, diagnostic measures and therapeutic possibilities].

Fibromyalgia syndrome: a review.

[Multiple chemical sensitivity disorder in patients with neurotoxic illnesses].

Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome.

'Repetitive strain injury': from Australia to the UK.

The ocular signs and symptoms of chronic fatigue syndrome.

Development of multiple chemical sensitivity after an outbreak of sick-building syndrome.

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Pain syndromes, disability, and chronic disease in childhood.

Depression and chronic fatigue in the patient with chronic pain.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research