ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2861–2880 of 6,160 studies

E2 ModerateCohortPEM not requiredCross-Sectional

The prevalence of chronic fatigue syndrome in Nigeria.

Njoku, Mary Gloriac C, Jason, Leonard A, Torres-Harding, Susan R·Journal of health psychology·2007

This study measured how common ME/CFS is in Nigeria and found it occurs more often there than in similar studies done in the United States. The researchers suggest that illnesses like malaria and typhoid, combined with limited access to healthcare and poverty, may make people more likely to develop chronic fatigue. This highlights that ME/CFS may affect different populations around the world in different ways.

E2 ModerateCohortPEM not requiredCross-Sectional

Can submaximal exercise variables predict peak exercise performance in women with chronic fatigue syndrome?

Nijs, Jo, Demol, Seppe, Wallman, Karen·Archives of medical research·2007

Researchers tested whether measurements taken during moderate-intensity exercise could predict how much energy a person with ME/CFS could produce during their maximum effort. In 222 women with ME/CFS, oxygen use at moderate intensity correlated well with peak oxygen use, but the prediction had too much variation to be reliable for individual patients.

Post-Exertional Malaise

E2 ModerateBehavioralPEM unclearCross-Sectional

Alexithymia in chronic fatigue syndrome: associations with momentary, recall, and retrospective measures of somatic complaints and emotions.

Friedberg, Fred, Quick, Joyce·Psychosomatic medicine·2007

This study looked at whether difficulty identifying and expressing emotions (a trait called alexithymia) is linked to fatigue and pain in ME/CFS patients. Researchers asked 111 people with ME/CFS to report their symptoms three ways: in real-time through daily diaries, in weekly recall, and in overall retrospective ratings over 6 months. The results showed that day-to-day emotional difficulty was not connected to how patients experienced symptoms moment-to-moment, but there was a weak connection to how they remembered pain over longer periods.

E2 ModerateCohortPEM not requiredCase-Control

Hematologic and urinary excretion anomalies in patients with chronic fatigue syndrome.

Niblett, Suzanne H, King, Katrina E, Dunstan, R Hugh et al.·Experimental biology and medicine (Maywood, N.J.)·2007

Researchers compared blood and urine samples from 100 people with ME/CFS and 82 healthy controls to look for abnormalities. While standard blood tests appeared normal, closer examination found subtle differences in blood cell counts and patterns in how patients' bodies were processing and excreting amino acids (building blocks of protein) and other compounds in their urine.

Energy MetabolismImmune System

E2 ModerateBehavioralPEM not requiredObservational

Chronic fatigue syndrome treated by acupuncture and moxibustion in combination with psychological approaches in 310 cases.

Guo, Junhua·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2007

This study examined whether a combination of acupuncture, moxibustion (a traditional Chinese medicine technique using heat), and psychological support could help people with chronic fatigue syndrome. Researchers treated 310 patients with this combined approach and found that most patients reported significant improvement in their symptoms. The results suggest this traditional medicine approach may be helpful for managing ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

Exercise testing in children and adolescents with chronic fatigue syndrome.

Takken, T, Henneken, T, van de Putte, E et al.·International journal of sports medicine·2007

This study tested how well 20 young people with ME/CFS could exercise on a stationary bike and measured their oxygen use. The researchers found that most of these young people had similar exercise capacity to healthy peers their age, though a smaller group showed reduced fitness. The amount of fatigue they experienced was related to how active they were in daily life.

E2 ModerateBehavioralPEM unclearCross-Sectional

Alexithymia in adolescents with chronic fatigue syndrome.

van de Putte, Elise M, Engelbert, Raoul H H, Kuis, Wietse et al.·Journal of psychosomatic research·2007

This study looked at whether adolescents with ME/CFS have difficulty identifying and describing their emotions (a trait called alexithymia) more often than healthy teenagers. Researchers found that while some teens with ME/CFS did have this trait, it wasn't significantly different from healthy controls, and it didn't predict who would recover. The study suggests that difficulty with emotions is not a unique feature of ME/CFS in young people.

E2 ModerateCohortPEM not requiredCase-Control

Low-resolution electromagnetic brain tomography (LORETA) of monozygotic twins discordant for chronic fatigue syndrome.

Sherlin, Leslie, Budzynski, Thomas, Kogan Budzynski, Helen et al.·NeuroImage·2007

Researchers used a special brain scanning technique called LORETA to measure electrical activity in the brains of identical twins—one with ME/CFS and one without. They found that twins with ME/CFS had different patterns of brain activity in specific regions, particularly in areas related to mood, energy management, and the nervous system's stress response. This suggests that ME/CFS may involve measurable differences in how certain parts of the brain function.

E2 ModerateCohortPEM not requiredCross-Sectional

Sympathetic predominance of cardiovascular regulation during mild orthostatic stress in adolescents with chronic fatigue.

Wyller, Vegard B, Saul, J P, Amlie, Jan P et al.·Clinical physiology and functional imaging·2007

This study looked at how the nervous system controls the heart and blood vessels in teenagers with ME/CFS when their bodies experience mild stress (tilting on a bed). Researchers found that adolescents with ME/CFS showed an exaggerated sympathetic nervous system response—meaning their "fight or flight" system kicked in too strongly compared to healthy teenagers. This suggests the body's automatic control of heart rate and blood pressure may not work normally in ME/CFS.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

beta-Alanine and gamma-aminobutyric acid in chronic fatigue syndrome.

Hannestad, Ulf, Theodorsson, Elvar, Evengård, Birgitta·Clinica chimica acta; international journal of clinical chemistry·2007

Researchers measured two brain chemicals (GABA and beta-alanine) in the urine of ME/CFS patients and healthy people to see if abnormal levels might explain fatigue and sleep problems. They found no overall difference between patients and controls, but a small subgroup of ME/CFS patients (4 out of 33) had unusually high beta-alanine levels, suggesting this chemical imbalance might affect some—but not all—people with ME/CFS.

E2 ModerateCohortPEM not required

Characteristics of the formation of chronic fatigue syndrome and approaches to its treatment in young patients with focal brain damage.

Boiko, A N, Batysheva, T T, Matvievskaya, O V et al.·Neuroscience and behavioral physiology·2007

This study looked at why people with brain injuries (from multiple sclerosis, stroke, infection, or trauma) develop severe fatigue. Researchers tested 50 patients and gave half of them a medication called Fezam to see if it would help. The medication reduced fatigue symptoms, especially in MS patients, with few side effects.

Interventions

E2 ModerateCohortPEM unclearCross-Sectional

The experience of cancer-related fatigue and chronic fatigue syndrome: a qualitative and comparative study.

Bennett, Barbara, Goldstein, David, Friedlander, Michael et al.·Journal of pain and symptom management·2007

This study compared how fatigue affects women with cancer-related fatigue (after breast cancer treatment) versus women with ME/CFS. Both groups described very similar experiences: exhaustion, problems with thinking and memory, and mood changes. Women with ME/CFS also reported muscle pain and flu-like symptoms more often. The researchers found that these two conditions share a common set of disabling symptoms, suggesting they may involve similar underlying causes despite different triggers.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

The relative impact of 13 chronic conditions across three different outcomes.

Perruccio, Anthony V, Power, J Denise, Badley, Elizabeth M·Journal of epidemiology and community health·2007

This study looked at how 13 common long-term health conditions—including ME/CFS and fibromyalgia—affect people's daily activities, overall health, and doctor visits. Researchers used information from over 130,000 Canadians and found that ME/CFS and fibromyalgia had the strongest individual impact on activity limitations and poor health ratings, while conditions like arthritis and heart disease affected the most people overall in the population.

E2 ModerateCohortPEM unclearCase-Control

Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome.

Maes, Michael, Mihaylova, Ivana, Kubera, Marta et al.·Neuro endocrinology letters·2007

This study found that people with ME/CFS have higher levels of two inflammatory molecules (COX-2 and iNOS) in their white blood cells compared to healthy people. The levels of these inflammatory markers were directly linked to how severe their symptoms were, including fatigue, pain, brain fog, and feeling like they have an infection. This suggests ME/CFS involves real inflammation in the body, not just psychological factors.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Cold pressor pain sensitivity in monozygotic twins discordant for chronic fatigue syndrome.

Ullrich, Philip M, Afari, Niloofar, Jacobsen, Clemma et al.·Pain medicine (Malden, Mass.)·2007

This study compared identical twins where one had ME/CFS and one did not to understand pain sensitivity. Researchers tested how twins responded to cold pain and found that while people with ME/CFS reported significantly higher levels of pain and fatigue during the test, their actual physical pain thresholds were not substantially different from their unaffected twins. This suggests that the pain experience in ME/CFS may be more about how the brain perceives and processes pain rather than a difference in the body's basic pain detection system.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Decreased expression of CD69 in chronic fatigue syndrome in relation to inflammatory markers: evidence for a severe disorder in the early activation of T lymphocytes and natural killer cells.

Mihaylova, Ivana, DeRuyter, Marcel, Rummens, Jean-Luc et al.·Neuro endocrinology letters·2007

This study looked at immune cell activation in people with ME/CFS by measuring a protein called CD69 on the surface of immune cells. Researchers found that ME/CFS patients had significantly lower levels of this activation marker on their T cells and natural killer cells compared to healthy people, even though the total number of immune cells was normal. This suggests that immune cells in ME/CFS may have trouble becoming activated properly in response to challenges.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Assessment of vulvodynia symptoms in a sample of US women: a prevalence survey with a nested case control study.

Arnold, Lauren D, Bachmann, Gloria A, Rosen, Raymond et al.·American journal of obstetrics and gynecology·2007

This study looked at how common vulvodynia (chronic pain in the vulva) is among American women and found that about 4% currently experience it. Women with vulvodynia were more likely to also have other conditions like chronic fatigue syndrome, fibromyalgia, depression, and irritable bowel syndrome. Many women reported that the pain significantly affected their sexual life and daily activities.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Usefulness of an abnormal cardiovascular response during low-grade head-up tilt-test for discriminating adolescents with chronic fatigue from healthy controls.

Wyller, Vegard Bruun, Due, Reidar, Saul, J Philip et al.·The American journal of cardiology·2007

This study tested how the hearts of adolescents with ME/CFS respond to mild physical stress (tilting the body slightly upright for 15 minutes) compared to healthy teenagers. Researchers found that young people with ME/CFS had abnormal heart and blood vessel responses during this test—their hearts beat faster, their blood pressure increased more, and their stroke volume (amount of blood pumped per heartbeat) decreased more than in healthy controls. These differences suggest that ME/CFS involves problems with how the body regulates blood flow and heart function during even mild stress.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredObservational

Actuarial analysis of private payer administrative claims data for women with endometriosis.

Mirkin, David, Murphy-Barron, Carrieann, Iwasaki, Kosuke·Journal of managed care pharmacy : JMCP·2007

This study looked at insurance claims from nearly 4 million people to understand how common endometriosis is and how much it costs to treat. Researchers found that women with endometriosis spend significantly more on medical care than other women, have frequent hospital stays and surgeries, and often have other health conditions at the same time—including chronic fatigue syndrome. The study shows endometriosis is a serious, expensive condition that affects many aspects of a woman's health.

E2 ModerateCohortPEM not requiredCross-Sectional

Symptoms of autonomic dysfunction in chronic fatigue syndrome.

Newton, J L, Okonkwo, O, Sutcliffe, K et al.·QJM : monthly journal of the Association of Physicians·2007

This study looked at whether people with ME/CFS have problems with their autonomic nervous system (the part that controls automatic body functions like heart rate and blood pressure). Researchers used a questionnaire called COMPASS to measure autonomic symptoms in ME/CFS patients and healthy controls. They found that autonomic dysfunction symptoms were significantly more common in ME/CFS patients and were linked to how severe their fatigue was.

Autonomic Nervous System

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The prevalence of chronic fatigue syndrome in Nigeria.

Can submaximal exercise variables predict peak exercise performance in women with chronic fatigue syndrome?

Alexithymia in chronic fatigue syndrome: associations with momentary, recall, and retrospective measures of somatic complaints and emotions.

Hematologic and urinary excretion anomalies in patients with chronic fatigue syndrome.

Chronic fatigue syndrome treated by acupuncture and moxibustion in combination with psychological approaches in 310 cases.

Exercise testing in children and adolescents with chronic fatigue syndrome.

Alexithymia in adolescents with chronic fatigue syndrome.

Low-resolution electromagnetic brain tomography (LORETA) of monozygotic twins discordant for chronic fatigue syndrome.

Sympathetic predominance of cardiovascular regulation during mild orthostatic stress in adolescents with chronic fatigue.

beta-Alanine and gamma-aminobutyric acid in chronic fatigue syndrome.

Characteristics of the formation of chronic fatigue syndrome and approaches to its treatment in young patients with focal brain damage.

The experience of cancer-related fatigue and chronic fatigue syndrome: a qualitative and comparative study.

The relative impact of 13 chronic conditions across three different outcomes.

Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome.

Cold pressor pain sensitivity in monozygotic twins discordant for chronic fatigue syndrome.

Decreased expression of CD69 in chronic fatigue syndrome in relation to inflammatory markers: evidence for a severe disorder in the early activation of T lymphocytes and natural killer cells.

Assessment of vulvodynia symptoms in a sample of US women: a prevalence survey with a nested case control study.

Usefulness of an abnormal cardiovascular response during low-grade head-up tilt-test for discriminating adolescents with chronic fatigue from healthy controls.

Actuarial analysis of private payer administrative claims data for women with endometriosis.

Symptoms of autonomic dysfunction in chronic fatigue syndrome.

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