ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

381–400 of 729 studies

E2 ModerateCohortPEM requiredObservational

Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta.

Nijs, J, Van Oosterwijck, J, Meeus, M et al.·Journal of internal medicine·2010

This study looked at what happens in the blood after people with ME/CFS exercise. Researchers compared 22 women with ME/CFS to 22 healthy women and measured specific immune markers (elastase, IL-1beta, and complement C4a) before and after two different types of exercise. Both types of exercise triggered postexertional malaise (a worsening of symptoms after activity) in the ME/CFS group, but surprisingly, the immune markers they measured didn't show significant changes in either group.

Immune SystemPost-Exertional Malaise

E2 ModerateCohortPEM not requiredCase-Control

Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome.

Jones, D E J, Hollingsworth, K G, Taylor, R et al.·Journal of internal medicine·2010

This study looked at how muscles clear acid buildup after exercise in people with ME/CFS compared to healthy people. Researchers used a special MRI technique to measure this process and also checked the nervous system's ability to regulate heart rate. People with ME/CFS had much slower acid clearance from their muscles after exercise, and this slowness was linked to problems with their autonomic nervous system (the part that controls automatic body functions).

Evidence Atlas

Evidence browser

Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta.

Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome.

Severe versus Moderate criteria for the new pediatric case definition for ME/CFS.

Physiological cost of walking in those with chronic fatigue syndrome (CFS): a case-control study.

Chronic fatigue syndrome combines increased exercise-induced oxidative stress and reduced cytokine and Hsp responses.

The Energy Envelope Theory and myalgic encephalomyelitis/chronic fatigue syndrome.

Prefrontal cortex oxygenation during incremental exercise in chronic fatigue syndrome.

A real-time assessment of the effect of exercise in chronic fatigue syndrome.

Can submaximal exercise variables predict peak exercise performance in women with chronic fatigue syndrome?

Differential diagnosis of chronic fatigue syndrome and major depressive disorder.

Evaluation of maximal exercise performance, fatigue, and depression in athletes with acquired chronic training intolerance.

Time course of exercise induced alterations in daily activity in chronic fatigue syndrome.

Increased daily physical activity and fatigue symptoms in chronic fatigue syndrome.

Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise.

Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms.

Impact of a maximal exercise test on symptoms and activity in chronic fatigue syndrome.

Exercise responsive genes measured in peripheral blood of women with chronic fatigue syndrome and matched control subjects.

Sociodemographic and symptom correlates of fatigue in an adolescent primary care sample.

Physiological responses during a submaximal cycle test in chronic fatigue syndrome.

Chronic fatigue syndrome: matching exercise to symptom fluctuations.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research