ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

3841–3860 of 6,162 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Anti-central fatigue effects of myelophil in 5-HTergic hyperactivity mice model.

Kang, Ji-Yun, Baek, Dong-Cheol, Lee, Jin-Seok et al.·BMC complementary medicine and therapies·2025

This study tested a herbal supplement called Myelophil (made from two traditional Korean medicinal plants) in mice that had high serotonin levels—a condition researchers believe may contribute to ME/CFS fatigue. Mice given Myelophil showed improvements in fatigue-related behaviors and pain sensitivity compared to untreated mice. The results suggest this supplement may help by adjusting how the brain handles serotonin.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Histone phosphorylation analysis of two main TCM syndromes of chronic fatigue syndrome.

Xu, Tingting, Gao, Shuo, Cheng, Xinxin et al.·Journal of translational medicine·2025

Researchers studied blood cells from 20 ME/CFS patients (divided into two Traditional Chinese Medicine symptom patterns) and 10 healthy controls. They found differences in how proteins were modified in the blood cells of ME/CFS patients compared to healthy people. These differences involved processes that affect how cells communicate with each other and organize their internal structures.

BiomarkersImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Jingfang Granule promotes the tricarboxylic acid cycle to improve chronic fatigue syndrome by increasing the expression of Idh1 and Idh2.

Wang, Kun, Shen, Mengmeng, Tang, Hongguang et al.·Journal of ethnopharmacology·2025

Researchers tested a traditional Chinese medicine called Jingfang Granule (JFG) in mice with chronic fatigue syndrome. The treatment improved fatigue symptoms, helped mice recover weight and exercise capacity, and reduced harmful inflammation and oxidative stress in their bodies. The medicine appeared to work by boosting how efficiently cells produce energy through a key metabolic pathway.

Post-Exertional Malaise

E3 PreliminaryCommentaryPEM unclear

Letter: Time to correct the record on the global burden of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Vardaman, Maya, Gilmour, Stuart·Journal of translational medicine·2025

This editorial letter addresses the need to correct how the global health burden of ME/CFS is measured and reported. The authors argue that current statistics may not fully capture how severely this illness affects patients worldwide. They emphasize that getting accurate numbers is important for raising awareness and securing resources for research and patient care.

E3 PreliminaryReviewPEM unclearReview-Narrative

Assessment of the therapeutic potential of salubrinal for ME/CFS and long-COVID.

Warrayat, Aseel, Ali, Ayah, Waked, Joulin et al.·Trends in molecular medicine·2025

This review article examines whether a drug called salubrinal might help people with ME/CFS and long-COVID. The researchers explain that both conditions involve stress inside cells that may contribute to symptoms. Salubrinal works by reducing this cellular stress, which could potentially help patients feel better. The authors call for more research and clinical trials to test whether this approach actually works in people.

E3 PreliminaryReviewPEM unclearReview-Narrative

Considerations for Long COVID Rehabilitation in Women.

Verduzco-Gutierrez, Monica, Fleming, Talya K, Azola, Alba M·Physical medicine and rehabilitation clinics of North America·2025

Long COVID is a condition where people experience ongoing symptoms weeks or months after a COVID-19 infection. This review examines how rehabilitation can help long COVID patients, with special attention to how women are affected differently. The authors emphasize that personalized treatment plans involving multiple types of therapy and healthcare teamwork are important for recovery.

Long COVID Overlap

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

How a Clinician Makes a Diagnosis for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Vallings, Rosamund·Methods in molecular biology (Clifton, N.J.)·2025

This guide explains how experienced doctors diagnose ME/CFS when standard blood tests or scans cannot detect the illness. Since there is no single definitive test for ME/CFS, doctors must carefully evaluate a patient's symptoms, medical history, and how the illness affects their daily functioning. This chapter walks through the practical steps clinicians use to identify ME/CFS and distinguish it from other conditions.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Rasch analysis of the hospital anxiety and depression scale in patients with chronic fatigue syndrome.

Bartholomew, Emerson J, Medvedev, Oleg N, Petrie, Keith J et al.·Journal of psychosomatic research·2025

This study tested whether a common questionnaire called the Hospital Anxiety and Depression Scale (HADS) accurately measures anxiety and depression in people with ME/CFS. Researchers analyzed responses from 286 ME/CFS patients and found that the questionnaire works reasonably well, but they discovered that converting the scores into a different format makes the results more precise and reliable for clinical use.

E3 PreliminaryBehavioralPEM not requiredCase-Control

Crohn's disease, irritable bowel syndrome, and chronic fatigue: the importance of communication and symptom management-a case report.

Haedrich, Johannes, Huber, Roman·Journal of medical case reports·2025

This case study describes a 64-year-old man with Crohn's disease (an inflammatory bowel condition) who developed persistent diarrhea, abdominal pain, fatigue, and other symptoms that resembled both irritable bowel syndrome and chronic fatigue syndrome. When doctors provided him with a clear explanation of how his symptoms were connected to his gut condition, stress, and nervous system function, along with appropriate treatment, his symptoms improved significantly over 2.5 years. The case highlights how physical diseases and functional conditions (like ME/CFS) are often interconnected and may improve when both are recognized and treated together.

E3 PreliminaryCommentaryPEM not requiredEditorial

Post infectious fatigue and circadian rhythm disruption in long-COVID and other infections: a need for further research.

Livieratos, Achilleas, Lockley, Steven W, Tsiodras, Sotirios·EClinicalMedicine·2025

This article discusses how infections like COVID-19 can disrupt the body's internal 24-hour clock, leading to persistent fatigue and sleep problems. The authors explain that viral infections may damage the genes and cellular machinery that control our daily rhythms, trigger inflammation in the brain, and harm energy-producing structures in our cells. Understanding these mechanisms could help doctors develop better treatments for Long COVID and chronic fatigue syndrome.

Neuroinflammation

E3 PreliminaryCohortPEM unclearCase-Control

Novel Oronasal Drainage for Long COVID: Proposed Mechanisms-Case Report.

Lorenz, Claudia, Frankenberger, Roland·Viruses·2025

Researchers tested a new treatment called oronasal drainage (OND) for Long COVID, which involves a gentle abrasive therapy targeting the drainage areas in the nose and mouth. In one patient case, this treatment appeared to reduce various Long COVID symptoms and improve blood circulation to the hands. While these results are promising, the study was very small and more research is needed to confirm whether this treatment actually works.

E3 PreliminaryCommentaryPEM requiredEditorial

Complex chronic adverse events following immunization: a systemic critique and reform proposal for vaccine pharmacovigilance.

Kenny, Tiff-Annie·Therapeutic advances in drug safety·2025

This paper describes complex, long-lasting health problems that some people develop after vaccination, which resemble ME/CFS and Long COVID symptoms like fatigue, pain, brain fog, and heart rhythm issues. The author argues that current vaccine safety systems are not well-designed to detect or investigate these kinds of slow-developing, multisystem conditions because they work best for identifying immediate reactions like fever or allergies. The paper proposes changes to how we monitor vaccine safety—including better training for doctors, longer-term tracking of patients, and including patients' own descriptions of their symptoms—to catch these problems more effectively.

Post-Exertional Malaise

E3 PreliminaryCohortPEM unclearCross-Sectional

["Ultimately, you are on your own." A qualitative analysis of barriers to health care from the perspective of patients with long COVID].

Hammer, Sabine, Monaca, Clara, Hoelz, Annika et al.·Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen·2025

This study asked 264 long COVID patients about their experiences with doctors and healthcare services. Most patients reported that healthcare providers don't understand their condition, often dismiss it as psychological, and sometimes recommend treatments that make them sicker. Patients felt stigmatized and unsupported, with some waiting up to two years just to see a specialist.

Diagnostics

E3 PreliminaryMechanismPEM requiredMechanistic

Inactivation of ATG13 stimulates chronic demyelinating pathologies in muscle-serving nerves and spinal cord.

Drosen, Molly E, Bulbule, Sarojini, Gottschalk, Gunnar et al.·Immunologic research·2025

Researchers gave mice a drug that overactivates a protein called mTOR and found it triggered muscle weakness, nerve damage, and worsening fatigue after exercise—similar to post-exertional malaise (PEM) in ME/CFS. The drug blocked a cellular cleanup system called autophagy, which led to inflammation and damage to the nerves controlling muscles. Mice engineered to have impaired autophagy showed similar problems, suggesting that broken autophagy may be involved in ME/CFS fatigue and exercise intolerance.

NeuroinflammationPost-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

A Decade With Sheehan's Syndrome: A Case Report and Personal Experience.

D, Kayalvizhi, Moradeyo, Adedeji Yusuf, G, Bhuvaneswari·Case reports in endocrinology·2025

This case report describes a woman who developed Sheehan's syndrome, a rare condition where the pituitary gland (a hormone-producing gland in the brain) is damaged after severe bleeding during childbirth. Her symptoms—including extreme tiredness, hair loss, irregular periods, and mood swings—were mistakenly attributed to postpartum depression for years before the correct diagnosis was made. She required lifelong hormone replacement therapy, though her symptoms persisted despite treatment adjustments.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Using Single-Cell Raman Microspectroscopy to Profile Human Peripheral Blood Mononuclear Cells.

Gan, Elizabeth, Stoker, Megan, Guo, Edie et al.·Methods in molecular biology (Clifton, N.J.)·2025

This study describes a new laboratory technique called Raman microspectroscopy that can examine individual immune cells from blood samples in detail. The technique uses light and computer analysis to identify chemical differences inside cells that might help doctors distinguish between people with chronic illnesses and healthy people, potentially leading to better diagnosis and treatment.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

User-Driven Development of a Digital Behavioral Intervention for Chronic Pain: Multimethod Multiphase Study.

Taygar, Afra Selma, Bartels, Sara Laureen, de la Vega, Rocío et al.·JMIR formative research·2025

This study asked patients with chronic pain and therapists what they wanted in a digital app to help manage their pain. Researchers created fictional patient profiles, held focus groups to understand needs, and then tested a prototype app with real patients. The final 6-week app included flexible features like short sessions, easy navigation, and different ways to contact a therapist. Patients found it helpful and easy to use.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The emerging role of exosomal LncRNAs in chronic fatigue syndrome: from intercellular communication to disease biomarkers.

Wang, Lei, Xu, Yujia, Zhong, Xiang et al.·Frontiers in molecular biosciences·2025

This review examines tiny packages called exosomes that cells release into the body, which contain special molecules called long noncoding RNAs (lncRNAs). These molecules may help cells communicate with each other and could be involved in ME/CFS. The researchers explored whether these lncRNAs could potentially be used as biological markers to help doctors identify and diagnose ME/CFS earlier.

E3 PreliminaryMechanismPEM not requiredMechanistic

Causal Relationship Between Diet, Lipids, Immune Cells, and Chronic Fatigue Syndrome: A Two-Mediation Mendelian Randomization Study.

Li, Jixu, Qin, Qi, Zhu, Yiran et al.·Food science & nutrition·2025

This study explored whether diet, cholesterol levels, and immune cell changes might contribute to ME/CFS development. Researchers found that eating cheese and pork, and avoiding alcohol and spicy food, may protect against ME/CFS, possibly by improving cholesterol profiles. The study suggests that certain types of cholesterol and immune cell changes may influence ME/CFS risk, creating a potential chain linking food choices to immune health to fatigue development.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

Patient-Generated Data as Interventions in Doctor-Patient Relationships? Negotiating (Un)Invited Participation in Medical Consultations.

Augst, Ann Kristin, Lämmerhirt, Danny, Schubert, Cornelius·Sociology of health & illness·2025

This study looked at how doctors and patients with chronic illnesses (including ME/CFS) use health data from popular apps and devices like smartwatches. Researchers interviewed doctors and patients in Germany to understand when doctors accept, ignore, or use this patient-collected data in medical visits. The study found that doctors have very different attitudes—some welcome the data, some reject it, and some are unsure whether to trust it.

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Evidence browser

Anti-central fatigue effects of myelophil in 5-HTergic hyperactivity mice model.

Histone phosphorylation analysis of two main TCM syndromes of chronic fatigue syndrome.

Jingfang Granule promotes the tricarboxylic acid cycle to improve chronic fatigue syndrome by increasing the expression of Idh1 and Idh2.

Letter: Time to correct the record on the global burden of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Assessment of the therapeutic potential of salubrinal for ME/CFS and long-COVID.

Considerations for Long COVID Rehabilitation in Women.

How a Clinician Makes a Diagnosis for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Rasch analysis of the hospital anxiety and depression scale in patients with chronic fatigue syndrome.

Crohn's disease, irritable bowel syndrome, and chronic fatigue: the importance of communication and symptom management-a case report.

Post infectious fatigue and circadian rhythm disruption in long-COVID and other infections: a need for further research.

Novel Oronasal Drainage for Long COVID: Proposed Mechanisms-Case Report.

Complex chronic adverse events following immunization: a systemic critique and reform proposal for vaccine pharmacovigilance.

["Ultimately, you are on your own." A qualitative analysis of barriers to health care from the perspective of patients with long COVID].

Inactivation of ATG13 stimulates chronic demyelinating pathologies in muscle-serving nerves and spinal cord.

A Decade With Sheehan's Syndrome: A Case Report and Personal Experience.

Using Single-Cell Raman Microspectroscopy to Profile Human Peripheral Blood Mononuclear Cells.

User-Driven Development of a Digital Behavioral Intervention for Chronic Pain: Multimethod Multiphase Study.

The emerging role of exosomal LncRNAs in chronic fatigue syndrome: from intercellular communication to disease biomarkers.

Causal Relationship Between Diet, Lipids, Immune Cells, and Chronic Fatigue Syndrome: A Two-Mediation Mendelian Randomization Study.

Patient-Generated Data as Interventions in Doctor-Patient Relationships? Negotiating (Un)Invited Participation in Medical Consultations.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research