ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

3921–3940 of 6,209 studies

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Using Single-Cell Raman Microspectroscopy to Profile Human Peripheral Blood Mononuclear Cells.

Gan, Elizabeth, Stoker, Megan, Guo, Edie et al.·Methods in molecular biology (Clifton, N.J.)·2025

This study describes a new laboratory technique called Raman microspectroscopy that can examine individual immune cells from blood samples in detail. The technique uses light and computer analysis to identify chemical differences inside cells that might help doctors distinguish between people with chronic illnesses and healthy people, potentially leading to better diagnosis and treatment.

Immune System

E3 PreliminaryCommentaryPEM unclear

Letter: Time to correct the record on the global burden of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Vardaman, Maya, Gilmour, Stuart·Journal of translational medicine·2025

This editorial letter addresses the need to correct how the global health burden of ME/CFS is measured and reported. The authors argue that current statistics may not fully capture how severely this illness affects patients worldwide. They emphasize that getting accurate numbers is important for raising awareness and securing resources for research and patient care.

E3 PreliminaryCohortPEM unclearCross-Sectional

Patient-Generated Data as Interventions in Doctor-Patient Relationships? Negotiating (Un)Invited Participation in Medical Consultations.

Augst, Ann Kristin, Lämmerhirt, Danny, Schubert, Cornelius·Sociology of health & illness·2025

This study looked at how doctors and patients with chronic illnesses (including ME/CFS) use health data from popular apps and devices like smartwatches. Researchers interviewed doctors and patients in Germany to understand when doctors accept, ignore, or use this patient-collected data in medical visits. The study found that doctors have very different attitudes—some welcome the data, some reject it, and some are unsure whether to trust it.

E3 PreliminaryCohortPEM not requiredCase-Control

A novel frameshift mutation in ADCK1 identified in a case of chronic fatigue syndrome successfully treated with oral 5-ALA/SFC.

Koga, Tomohiro, Kita, Kiyoshi, Okumura, Junko et al.·Immunological medicine·2025

This study reports a single patient with ME/CFS who carried a rare genetic mutation affecting how cells produce energy. When treated with a supplement called 5-ALA/SFC along with other nutrients, the patient's fatigue and daily functioning significantly improved. This case suggests that some people with ME/CFS may have mitochondrial (cellular energy) problems related to this genetic change, and that certain supplements might help.

Energy Metabolism

E3 PreliminaryPEM unclear

Inspiratory muscle training improves autonomic function in myalgic encephalomyelitis/chronic fatigue syndrome and post-acute sequelae of SARS-CoV-2: A pilot study.

Edgell, Heather, Pereira, Tania J, Kerr, Kathleen et al.·Respiratory physiology & neurobiology·2025

This study tested whether a simple breathing exercise program could help people with ME/CFS and Long COVID feel better. For 8 weeks, participants practiced strengthening their breathing muscles. People in all groups—including those with ME/CFS and Long COVID—showed improvements in how far they could walk, their heart rate, sleep quality, and how their nervous system functioned. Those with ME/CFS also noticed less pain and better blood vessel function.

SleepAutonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Hesperidin in Chronic Fatigue Syndrome: An Integrated Analysis of Traditional Pharmacology and Machine Learning-Based Therapeutic Predictions.

El-Shiekh, Riham A, Mohamed, Ahmed F, Mandour, Asmaa A et al.·Chemistry & biodiversity·2025

This review examines hesperidin, a natural compound found in citrus fruits like oranges and lemons, and explores whether it might help people with ME/CFS. The authors describe hesperidin's known anti-inflammatory and antioxidant properties, then use computer algorithms to predict how well it might work for chronic fatigue. They suggest hesperidin could be a promising natural supplement worth studying further.

E3 PreliminaryMechanismPEM requiredPreprintPreprint

Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis.

Zhang, Sai, Jahanbani, Fereshteh, Chander, Varuna et al.·medRxiv : the preprint server for health sciences·2025

Researchers used advanced artificial intelligence to analyze the genes of ME/CFS patients and discovered 115 genes that may contribute to the disease. They found that people with ME/CFS have lower levels of these risk genes active in their immune cells and nervous system. This genetic analysis could eventually help doctors diagnose ME/CFS more accurately and identify new treatment targets.

BiomarkersImmune SystemCognitive ImpairmentPost-Exertional Malaise

E3 PreliminaryCohortPEM unclearCross-Sectional

'She thought the same way I that I thought:' a qualitative study of patient-provider concordance among Gulf War Veterans with Gulf War Illness.

Lesnewich, Laura M, Hyde, Justeen K, McFarlin, Mikhaela L et al.·Psychology & health·2025

This study talked to 31 Gulf War Veterans with Gulf War Illness to understand what makes them feel heard and supported by their doctors. The researchers found that patients feel better about their care when doctors believe their symptoms are real, show they understand the condition, and build trust with them. When doctors dismissed patients' experiences or didn't know much about Gulf War Illness, it damaged the relationship and made treatment harder.

E3 PreliminaryCommentaryPEM unclearEditorial

Reframing Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Biological Basis of Disease and Recommendations for Supporting Patients.

Agarwal, Priya, Friedman, Kenneth J·Healthcare (Basel, Switzerland)·2025

This article is a special essay about ME/CFS that was written by a medical student and selected as the best submission in a scholarship competition. It explains what we currently know about how ME/CFS affects the body and offers practical advice for doctors on how to better care for ME/CFS patients. The essay highlights that ME/CFS is a serious, worldwide health problem affecting millions of people, many of whom haven't been properly diagnosed.

E3 PreliminaryMechanismPEM requiredMechanistic

Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS.

Che, Xiaoyu, Ranjan, Amit, Guo, Cheng et al.·npj metabolic health and disease·2025

This study examined blood samples and immune responses in ME/CFS patients to understand why they experience extreme fatigue and feeling worse after activity. Researchers found that patients' immune systems overreact to germs, their bodies have trouble producing energy efficiently, and they have several chemical imbalances in their blood. These problems got worse after exercise and matched how sick patients felt.

Energy MetabolismImmune SystemPost-Exertional Malaise

E3 PreliminaryCohortPEM unclearCase-Control

HERV Dysregulation in a Case of Myalgic Encephalomyelitis and Multiple Sclerosis Responsive to Rituximab.

Martín-Martínez, Eva, Gil-Perotin, Sara, Giménez-Orenga, Karen et al.·International journal of molecular sciences·2025

This study describes one patient who had ME/CFS and was later diagnosed with multiple sclerosis (MS). Doctors discovered that his blood had unusual patterns of human endogenous retroviruses (HERVs)—ancient viral-like sequences in our DNA that can sometimes affect immune function. Importantly, this patient improved significantly after receiving rituximab, a treatment that modifies the immune system, even though standard treatments had not worked for him.

Immune System

E3 PreliminaryMechanismPEM unclearObservational

Effects of recumbent isometric yoga on the orthostatic cardiovascular response of patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Oka, Takakazu, Lkhagvasuren, Battuvshin·BioPsychoSocial medicine·2025

This small study looked at whether a gentle yoga practice done while lying down could help ME/CFS patients who experience dizziness or fast heartbeats when standing up (a condition called POTS). Ten women with ME/CFS practiced this special yoga for 12 weeks, and the researchers measured their blood pressure and heart rate before and after standing. The two patients who had POTS at the start showed improvement and had normal responses after the yoga practice.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM unclear

Analysis of Transient Receptor Potential Ion Channels in ME/CFS.

Eaton-Fitch, Natalie, Muraki, Katsuhiko, Sasso, Etianne Martini et al.·Methods in molecular biology (Clifton, N.J.)·2025

This study describes the scientific methods used to examine special proteins called ion channels (specifically TRPM3) in the cells of ME/CFS patients. Researchers took blood samples, isolated specific immune cells, and used advanced techniques like imaging and electrical measurements to see how these ion channels work. This work provides a detailed handbook for scientists studying how ion channel problems might contribute to ME/CFS.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Histone phosphorylation analysis of two main TCM syndromes of chronic fatigue syndrome.

Xu, Tingting, Gao, Shuo, Cheng, Xinxin et al.·Journal of translational medicine·2025

Researchers studied blood cells from 20 ME/CFS patients (divided into two Traditional Chinese Medicine symptom patterns) and 10 healthy controls. They found differences in how proteins were modified in the blood cells of ME/CFS patients compared to healthy people. These differences involved processes that affect how cells communicate with each other and organize their internal structures.

BiomarkersImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Causal Relationship Between Diet, Lipids, Immune Cells, and Chronic Fatigue Syndrome: A Two-Mediation Mendelian Randomization Study.

Li, Jixu, Qin, Qi, Zhu, Yiran et al.·Food science & nutrition·2025

This study explored whether diet, cholesterol levels, and immune cell changes might contribute to ME/CFS development. Researchers found that eating cheese and pork, and avoiding alcohol and spicy food, may protect against ME/CFS, possibly by improving cholesterol profiles. The study suggests that certain types of cholesterol and immune cell changes may influence ME/CFS risk, creating a potential chain linking food choices to immune health to fatigue development.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Post-COVID-19 Vaccination (or Long Vax) Syndrome: Putative Manifestation, Pathophysiology, and Therapeutic Options.

Yong, Shin Jie, Kenny, Tiff-Annie, Halim, Alice et al.·Reviews in medical virology·2025

This review describes a condition called post-COVID-19 vaccination syndrome (PCVS), where some people develop long-lasting symptoms similar to long COVID after receiving a vaccine. Symptoms typically start within days to weeks after vaccination and can last for months or years, including fatigue, brain fog, and nerve tingling. The study examines what might cause PCVS and discusses possible treatments, though researchers emphasize that much remains unknown about this condition.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCohortPEM unclearCross-Sectional

Patient experiences of remote consulting with chronic fatigue syndrome/myalgic encephalomyelitis and fibromyalgia: a qualitative study.

Leach, Helen, Eccles, Abi, Chew-Graham, Carolyn A et al.·BJGP open·2025

This study asked 13 people with ME/CFS and fibromyalgia about their experiences using phone and video appointments with their doctors during and after 2020. Patients said the most important thing was feeling believed and listened to by their doctor. While remote appointments had some benefits (like being easier when symptoms were bad), many people found it harder to communicate without face-to-face visits, though having a trusted, familiar doctor made a big difference.

E3 PreliminaryReviewPEM requiredReview-Narrative

Advocating the role of trained immunity in the pathogenesis of ME/CFS: a mini review.

Humer, Bart, Dik, Willem A, Versnel, Marjan A·Frontiers in immunology·2025

This review explores how a single severe infection might trigger long-term changes in the immune system that could lead to ME/CFS. After infection, immune cells can become 'trained' to overreact to future triggers, potentially causing the chronic symptoms patients experience. The researchers suggest this overactive immune response might explain why about 60% of ME/CFS patients remember getting sick before their symptoms started.

Immune SystemPost-Exertional Malaise

E3 PreliminaryPEM unclear

Static and Kinetic Disequilibrium are Central Neural Signs in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Therapeutic Effect of Repetitive Transcranial Magnetic Stimulation.

Miwa, Kunihisa·Journal of integrative neuroscience·2025

This study found that nearly half of ME/CFS patients experience balance problems—either when standing still (static disequilibrium) or when walking (kinetic disequilibrium). These balance issues were linked to difficulty standing upright and limitations in daily activities. When researchers used a brain stimulation treatment called repetitive transcranial magnetic stimulation (rTMS) on specific brain regions, most patients' balance problems improved, suggesting the root cause is in the central nervous system rather than the inner ear alone.

Autonomic Nervous System

E3 PreliminaryPEM unclear

Wearable Devices Enable Long COVID Patients to Decrease Symptom Severity: A Case Series From Pilot User Testing.

Goosen, Andrea, Foster-Bonds, Romina, Vogel, Julia Moore·Cardiopulmonary physical therapy journal·2025

This small study looked at whether fitness trackers (Garmin watches) could help Long COVID patients manage their symptoms through pacing—carefully controlling activity levels to avoid overexertion. Eleven patients received a tracker, educational materials about pacing, and were asked about their experience. Most participants found the information helpful for managing their symptoms, and none had difficulty using the device, even those who had never used a wearable before.

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Using Single-Cell Raman Microspectroscopy to Profile Human Peripheral Blood Mononuclear Cells.

Letter: Time to correct the record on the global burden of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Patient-Generated Data as Interventions in Doctor-Patient Relationships? Negotiating (Un)Invited Participation in Medical Consultations.

A novel frameshift mutation in ADCK1 identified in a case of chronic fatigue syndrome successfully treated with oral 5-ALA/SFC.

Inspiratory muscle training improves autonomic function in myalgic encephalomyelitis/chronic fatigue syndrome and post-acute sequelae of SARS-CoV-2: A pilot study.

Hesperidin in Chronic Fatigue Syndrome: An Integrated Analysis of Traditional Pharmacology and Machine Learning-Based Therapeutic Predictions.

Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis.

'She thought the same way I that I thought:' a qualitative study of patient-provider concordance among Gulf War Veterans with Gulf War Illness.

Reframing Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Biological Basis of Disease and Recommendations for Supporting Patients.

Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS.

HERV Dysregulation in a Case of Myalgic Encephalomyelitis and Multiple Sclerosis Responsive to Rituximab.

Effects of recumbent isometric yoga on the orthostatic cardiovascular response of patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Analysis of Transient Receptor Potential Ion Channels in ME/CFS.

Histone phosphorylation analysis of two main TCM syndromes of chronic fatigue syndrome.

Causal Relationship Between Diet, Lipids, Immune Cells, and Chronic Fatigue Syndrome: A Two-Mediation Mendelian Randomization Study.

Post-COVID-19 Vaccination (or Long Vax) Syndrome: Putative Manifestation, Pathophysiology, and Therapeutic Options.

Patient experiences of remote consulting with chronic fatigue syndrome/myalgic encephalomyelitis and fibromyalgia: a qualitative study.

Advocating the role of trained immunity in the pathogenesis of ME/CFS: a mini review.

Static and Kinetic Disequilibrium are Central Neural Signs in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Therapeutic Effect of Repetitive Transcranial Magnetic Stimulation.

Wearable Devices Enable Long COVID Patients to Decrease Symptom Severity: A Case Series From Pilot User Testing.

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