ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4341–4360 of 6,188 studies

Comorbidity of chronic fatigue syndrome, postural tachycardia syndrome, and narcolepsy with 5,10-methylenetetrahydrofolate reductase (MTHFR) mutation in an adolescent: a case report.

Liao, Ying, Qi, Jian-Guang, Yan, Hui et al.·Chinese medical journal·2021

This case report describes one adolescent patient who had three conditions at the same time: ME/CFS (chronic fatigue syndrome), postural tachycardia syndrome (a condition where heart rate increases abnormally when standing), and narcolepsy (excessive daytime sleepiness). The doctors discovered this patient had a genetic variation in the MTHFR gene, which is involved in processing folate and other important molecules in the body. The authors suggest this genetic variation might help explain why this patient developed all three conditions together.

E3 PreliminaryDiagnosticPEM requiredMethods-Paper

The development of an instrument to assess post-exertional malaise in patients with myalgic encephalomyelitis and chronic fatigue syndrome.

Jason, Leonard A, Holtzman, Carly S, Sunnquist, Madison et al.·Journal of health psychology·2021

This study created a new questionnaire called the DePaul Post-Exertional Malaise Questionnaire to measure post-exertional malaise (PEM)—the worsening of symptoms that happens after physical or mental activity in ME/CFS patients. Researchers worked with hundreds of patients to develop questions that accurately capture what PEM feels like. Early testing showed the questionnaire works well and connects meaningfully with how much physical activity patients can do.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

[Intestinal flora and neurological disorders].

Tang, Qianqian, Cao, Lihua·Sheng wu gong cheng xue bao = Chinese journal of biotechnology·2021

Your gut bacteria (microbiome) communicate with your brain through multiple pathways, including immune signals and nerve connections. When this gut-brain communication goes wrong, it may contribute to various neurological conditions, including chronic fatigue syndrome. This review summarizes what scientists know about how imbalanced gut bacteria might affect the nervous system and cause disease.

Neuroinflammation

E3 PreliminaryMechanismPEM unclearObservational

Insights From Invasive Cardiopulmonary Exercise Testing of Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Joseph, Phillip, Arevalo, Carlo, Oliveira, Rudolf K F et al.·Chest·2021

This study used specialized heart and lung testing during exercise to understand why people with ME/CFS struggle with physical activity. Researchers found that ME/CFS patients had two different problems during exercise: some had reduced blood flow returning to the heart, while others couldn't efficiently extract oxygen from their blood. About 31% of patients also showed evidence of small nerve fiber damage in their skin biopsies.

Post-Exertional Malaise

E3 PreliminaryGuidelinePEM requiredGuideline

Caring for the Patient with Severe or Very Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Montoya, Jose G, Dowell, Theresa G, Mooney, Amy E et al.·Healthcare (Basel, Switzerland)·2021

This guide focuses on caring for people with severe ME/CFS who struggle to leave their homes or beds. The authors explain that these patients often can't visit doctors' offices and doctors frequently don't have good information about how to help them. The guide provides practical recommendations for diagnosis, assessment, and treatment options, including using telemedicine and working closely with patients and caregivers to provide better care.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Stanculescu, Dominic, Sepúlveda, Nuno, Lim, Chin Leong et al.·Frontiers in neurology·2021

This study compares how the body breaks down during heat stroke with what happens in ME/CFS. Both conditions involve similar problems: inflammation, damage to the gut lining that allows harmful substances into the bloodstream, blood clotting issues, and problems with how cells produce energy. By understanding heat stroke better, researchers hope to find new ways to treat ME/CFS.

Immune System

E3 PreliminaryReviewPEM requiredReview-Narrative

COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review.

Poenaru, Sonia, Abdallah, Sara J, Corrales-Medina, Vicente et al.·Therapeutic advances in infectious disease·2021

Some people who recover from COVID-19 continue experiencing prolonged symptoms like fatigue, difficulty breathing, and brain fog for months afterward. These lingering symptoms are remarkably similar to ME/CFS, a chronic illness characterized by severe fatigue that worsens with activity. While COVID-19 could potentially trigger ME/CFS in some people, researchers currently don't have enough evidence to confirm this connection.

Severe MEPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Current state about researches on selection of experimental indexs mechanisms of acupuncture underlying improvement of chronic fatigue syndrome].

Li, Yan-Hui, Ma, Qiao-Lin, Hu, Bin et al.·Zhen ci yan jiu = Acupuncture research·2021

This review examined research from the past 10 years on how acupuncture may help chronic fatigue syndrome by looking at four main body systems: immune function, stress hormones and brain chemistry, the body's ability to handle cellular damage, and cell signaling pathways. The researchers found evidence that acupuncture appears to work through multiple mechanisms rather than just one, potentially helping the body recover from CFS through different pathways.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Potential Implications of Mammalian Transient Receptor Potential Melastatin 7 in the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review.

Du Preez, Stanley, Cabanas, Helene, Staines, Donald et al.·International journal of environmental research and public health·2021

This review examines a protein called TRPM7 that may play a role in ME/CFS. TRPM7 is an ion channel—a type of gateway that controls how calcium and other minerals move in and out of cells—and it appears to affect the nervous system, immune system, heart, and metabolism. The authors suggest that problems with TRPM7 could help explain some of the complex symptoms seen in ME/CFS, though this is still a developing area of research.

E3 PreliminaryReviewPEM requiredReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview.

Deumer, Undine-Sophie, Varesi, Angelica, Floris, Valentina et al.·Journal of clinical medicine·2021

ME/CFS is a long-term illness that causes extreme tiredness, worsening of symptoms after activity, and difficulty thinking clearly. Patients experience these symptoms very differently from one another, and currently there are no blood tests or physical exams that can definitively diagnose the condition. This review examines several potential causes, including past infections, genetic factors, hormone imbalances, and changes in gut bacteria, while exploring whether a simple blood test might someday help diagnose ME/CFS.

BiomarkersPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Wirth, Klaus J, Scheibenbogen, Carmen, Paul, Friedemann·Journal of translational medicine·2021

This paper proposes an explanation for why ME/CFS patients experience brain fog, cognitive problems, headaches, and other neurological symptoms. The authors suggest that blood vessels in the brain may not be working properly, reducing blood flow to the brain and increasing pressure inside the skull. They argue this could also cause an overactive stress response in the nervous system, leading to the wide range of symptoms patients experience.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Split-Second Unlearning: Developing a Theory of Psychophysiological Dis-ease.

Hudson, Matt, Johnson, Mark I·Frontiers in psychology·2021

This study proposes that early emotional experiences—both traumatic and everyday—can create lasting patterns in how our bodies respond to stress. When we encounter triggers related to those memories, our body automatically activates a stress response even if the threat is no longer present. The researchers describe a new therapy approach where patients learn to observe their own automatic responses in the moment and gradually 'unlearn' the connection between the memory and the physical stress reaction.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Post-Acute COVID-19 Syndrome and the cardiovascular system: What is known?

Dixit, Neal M, Churchill, Austin, Nsair, Ali et al.·American heart journal plus : cardiology research and practice·2021

Some people who have had COVID-19 develop long-lasting symptoms weeks or months later, including chest pain and heart palpitations (feeling your heart racing). This review examines what we know about how COVID-19 affects the heart during this long-COVID period. While the virus itself rarely causes direct heart damage, it can trigger several heart-related conditions that may explain why patients experience these symptoms.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Photobiomodulation and Sports: Results of a Narrative Review.

Ailioaie, Laura Marinela, Litscher, Gerhard·Life (Basel, Switzerland)·2021

This review looked at studies on photobiomodulation (PBM)—a treatment using light to help cells work better—and how it might help athletes recover faster and perform better. The researchers found that in about 25 human studies, PBM appeared helpful for reducing fatigue and supporting recovery, though some studies didn't show clear benefits. The authors suggest that with better devices and clearer protocols, PBM could potentially help people dealing with exhaustion and physical stress.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Global survey-based assessment of lifestyle changes during the COVID-19 pandemic.

Agarwal, Poonam, Kaushik, Abhinav, Sarkar, Sutapa et al.·PloS one·2021

This study surveyed people during the COVID-19 lockdowns to understand how the pandemic affected their daily lives, work, mental health, and social connections. Most people found ways to cope by using technology to stay connected with others, staying physically active, and spending time on hobbies. The study found that while many people faced mental health challenges from isolation and pandemic stress, most kept their jobs and lived with family or roommates, which may have provided support.

E3 PreliminaryMechanismPEM not requiredMechanistic

Inflammation plays a causal role in fatigue-like behavior induced by pelvic irradiation in mice.

Wolff, Brian S, Alshawi, Sarah A, Feng, Li Rebekah et al.·Brain, behavior, & immunity - health·2021

Researchers gave mice targeted radiation to the pelvis (similar to cancer treatment) and found that the mice became less active afterward—a fatigue-like behavior. They discovered that inflammation, particularly a protein called IL-6, plays a key role in causing this fatigue. When they reduced inflammation using a drug called minocycline or using mice genetically unable to trigger certain inflammatory pathways, the fatigue was reduced but not completely eliminated.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

Chronic fatigue syndrome/myalgic encephalomyelitis in children aged 5 to 11 years: A qualitative study.

Brigden, Amberly, Shaw, Alison, Anderson, Emma et al.·Clinical child psychology and psychiatry·2021

This study looked at how ME/CFS affects younger children (ages 5-11) and what their families experience. Researchers interviewed children and parents to understand how the illness impacts daily life and what kind of support they need. The study found that children over 8 years old can better understand and manage their illness compared to younger children, and that parents of very young children need more support from healthcare providers.

E3 PreliminaryGuidelinePEM unclearGuideline

European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe.

Nacul, Luis, Authier, François Jérôme, Scheibenbogen, Carmen et al.·Medicina (Kaunas, Lithuania)·2021

This study brings together ME/CFS experts from 22 European countries to agree on how to diagnose the illness and provide better care for patients. The researchers and healthcare professionals worked together with people who have ME/CFS to create recommendations that can help doctors recognize and treat the condition more consistently across Europe. Their goal was to improve diagnosis and healthcare services for ME/CFS patients everywhere.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Imaging and Manipulation of Stem and Progenitor Cells for Revealing the Novel Mechanism of Local Tissue Maintenance in the Brain].

Kataoka, Yosky·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2021

This study examined special cells in the brain called glial progenitor cells that help maintain healthy brain tissue and manage inflammation. Researchers used imaging technology to track these cells and discovered that when these cells are removed, the brain develops harmful inflammation and immune activation. The findings suggest these cells may play a protective role and could be targeted to treat conditions associated with brain inflammation, including chronic fatigue syndrome.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia and Associated Disorders: From Pain to Chronic Suffering, From Subjective Hypersensitivity to Hypersensitivity Syndrome.

Maugars, Yves, Berthelot, Jean-Marie, Le Goff, Benoit et al.·Frontiers in medicine·2021

This article reviews what scientists know about fibromyalgia as of 2020, including how it's diagnosed and why it happens. The authors explain that fibromyalgia involves the brain processing pain signals too intensely, and that people with fibromyalgia often experience many other symptoms like fatigue, sleep problems, and sensitivity to sounds, lights, and touch. They also discuss how fibromyalgia shares common features with other conditions like ME/CFS, all involving a heightened sensitivity to stimuli controlled by the central nervous system.

Sleep

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Comorbidity of chronic fatigue syndrome, postural tachycardia syndrome, and narcolepsy with 5,10-methylenetetrahydrofolate reductase (MTHFR) mutation in an adolescent: a case report.

The development of an instrument to assess post-exertional malaise in patients with myalgic encephalomyelitis and chronic fatigue syndrome.

[Intestinal flora and neurological disorders].

Insights From Invasive Cardiopulmonary Exercise Testing of Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Caring for the Patient with Severe or Very Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review.

[Current state about researches on selection of experimental indexs mechanisms of acupuncture underlying improvement of chronic fatigue syndrome].

Potential Implications of Mammalian Transient Receptor Potential Melastatin 7 in the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview.

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Split-Second Unlearning: Developing a Theory of Psychophysiological Dis-ease.

Post-Acute COVID-19 Syndrome and the cardiovascular system: What is known?

Photobiomodulation and Sports: Results of a Narrative Review.

Global survey-based assessment of lifestyle changes during the COVID-19 pandemic.

Inflammation plays a causal role in fatigue-like behavior induced by pelvic irradiation in mice.

Chronic fatigue syndrome/myalgic encephalomyelitis in children aged 5 to 11 years: A qualitative study.

European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe.

[Imaging and Manipulation of Stem and Progenitor Cells for Revealing the Novel Mechanism of Local Tissue Maintenance in the Brain].

Fibromyalgia and Associated Disorders: From Pain to Chronic Suffering, From Subjective Hypersensitivity to Hypersensitivity Syndrome.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research