ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4341–4360 of 6,163 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Inflammation plays a causal role in fatigue-like behavior induced by pelvic irradiation in mice.

Wolff, Brian S, Alshawi, Sarah A, Feng, Li Rebekah et al.·Brain, behavior, & immunity - health·2021

Researchers gave mice targeted radiation to the pelvis (similar to cancer treatment) and found that the mice became less active afterward—a fatigue-like behavior. They discovered that inflammation, particularly a protein called IL-6, plays a key role in causing this fatigue. When they reduced inflammation using a drug called minocycline or using mice genetically unable to trigger certain inflammatory pathways, the fatigue was reduced but not completely eliminated.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

The Health-Promoting Properties and Clinical Applications of Rice Bran Arabinoxylan Modified with Shiitake Mushroom Enzyme-A Narrative Review.

Ooi, Soo Liang, Pak, Sok Cheon, Micalos, Peter S et al.·Molecules (Basel, Switzerland)·2021

This review examines a supplement called RBAC, made from rice bran processed with shiitake mushroom enzyme, which may have immune-boosting and anti-inflammatory effects. The authors found evidence that RBAC might help with several conditions including cancer, HIV, diabetes, irritable bowel syndrome, liver disease, and possibly chronic fatigue syndrome and the common cold. The supplement appears safe at typical doses of 2-3 grams per day, but more research is needed to confirm its benefits.

Immune System

E3 PreliminaryMechanismPEM unclearCross-Sectional

Chronic fatigue syndrome: Abnormally fast muscle fiber conduction in the membranes of motor units at low static force load.

Klaver-Krol, E G, Hermens, H J, Vermeulen, R C et al.·Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2021

Researchers used muscle sensors to measure how electrical signals travel through muscle fibers in people with ME/CFS, fibromyalgia, and healthy people during light strength exercises. They found that in ME/CFS patients, these electrical signals traveled unusually fast through muscle fibers as force increased, which didn't happen in the other groups. This suggests that muscle cells in ME/CFS may have a problem with how they work at the membrane level.

E3 PreliminaryCohortPEM not requiredObservational

Experiences Among School Personnel and School Nurses on Educational Adaptations for Students With CFS/ME: A Qualitative Interview Study.

Similä, Wenche Ann, Rø, Torstein Baade, Nøst, Torunn Hatlen·Frontiers in pediatrics·2021

This study asked teachers, counselors, and school nurses about their experiences helping students with ME/CFS stay in school and continue their education. The researchers found that it was harder to help these students before they received an official diagnosis, but things improved when schools worked together as a team, communicated well with families, and used digital learning tools.

E3 PreliminaryReviewPEM unclearReview-Narrative

Ross River Virus Immune Evasion Strategies and the Relevance to Post-viral Fatigue, and Myalgic Encephalomyelitis Onset.

Lidbury, Brett A·Frontiers in medicine·2021

This study examines how Ross River virus, a mosquito-borne virus common in Australia, might trigger long-lasting fatigue and ME/CFS symptoms. The virus uses several tricks to hide from the immune system, and researchers propose these tricks may disrupt the body's energy-producing systems and cause the persistent exhaustion seen in ME/CFS. The findings suggest that understanding how this virus evades immunity could help explain why some viral infections lead to chronic fatigue.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Central sensitivity and fibromyalgia.

Mezhov, Veronica, Guymer, Emma, Littlejohn, Geoffrey·Internal medicine journal·2021

Fibromyalgia and ME/CFS are conditions where the nervous system becomes oversensitive, causing widespread pain, fatigue, sleep problems, and brain fog. These conditions often occur together and share similar underlying problems with how the brain and spinal cord process pain and other signals. This review explains what causes these conditions and how doctors can recognize and treat them using a combination of education, exercise, stress management, and medications.

SleepCognitive Impairment

E3 PreliminaryCohortPEM unclearCross-Sectional

"it's a medical condition … you need to support as much as possible": a qualitative analysis of teachers' experiences of chronic fatigue syndrome / myalgic encephalomyelitis (CFS/ME).

Brigden, Amberly, Shaw, Alison, Crawley, Esther·BMC pediatrics·2021

This study asked 11 primary school teachers about their experiences supporting children aged 5-11 with ME/CFS in the classroom. Teachers described seeing significant fatigue and thinking problems in their students, along with variable symptoms like pain, headaches, and sensitivity to light or sound. Most teachers wanted to help and used practical strategies like rest breaks and modified activities, but said they needed more training and resources to understand ME/CFS better.

E3 PreliminaryReviewPEM unclearReview-Narrative

Ehlers-Danlos Syndrome: Immunologic contrasts and connective tissue comparisons.

Islam, Mareesa, Chang, Christopher, Gershwin, M Eric·Journal of translational autoimmunity·2021

This review article explains Ehlers-Danlos Syndrome (EDS), a group of inherited disorders that affect connective tissue in the body, causing symptoms like loose, stretchy skin and flexible joints. The authors describe the 13 different types of EDS, how doctors diagnose them, and how they're treated. While some forms of EDS involve inflammation, the exact mechanisms causing the disease are not fully understood.

Diagnostics

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic Fatigue Syndrome and Bone Marrow Defects of the Jaw - A Case Report on Additional Dental X-Ray Diagnostics with Ultrasound.

Lechner, Johann, Schick, Fabian·International medical case reports journal·2021

This case report describes a young man with ME/CFS who had headaches and tinnitus but no visible bone problems on standard X-rays. When doctors used ultrasound imaging, they found a suspicious area in his lower jawbone. Surgery revealed a fungal infection (aspergillosis) and inflamed tissue that standard X-rays had missed. This suggests that ultrasound might be a better tool for detecting hidden bone and jaw problems in some ME/CFS patients.

E3 PreliminaryReviewPEM not required

Elements of Suffering in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Experience of Loss, Grief, Stigma, and Trauma in the Severely and Very Severely Affected.

Fennell, Patricia A, Dorr, Nancy, George, Shane S·Healthcare (Basel, Switzerland)·2021

This review article explores the deep suffering experienced by people with severe ME/CFS, looking at how losses, grief, stigma, and trauma from healthcare interactions affect their lives. The authors use a framework called the Fennell Four-Phase Model to help explain how chronic illness affects patients over time. The study emphasizes that healthcare providers need to understand and acknowledge the intense struggles that severely affected patients endure.

E3 PreliminaryCohortPEM unclearCase-Control

Chronic Fatigue Syndrome: A Case Report Highlighting Diagnosing and Treatment Challenges and the Possibility of Jarisch-Herxheimer Reactions If High Infectious Loads Are Present.

Straub, Rachel K, Powers, Christopher M·Healthcare (Basel, Switzerland)·2021

This study follows one patient's journey with severe ME/CFS, examining how past infections and health conditions may have contributed to her illness and how various treatments affected her recovery. The case highlights that some treatments can paradoxically make symptoms worse before improvement occurs, especially if someone has high levels of lingering infections. The patient eventually improved enough to return to graduate school, though her experience also shows how serious and disabling ME/CFS can be for some people.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrom: modern aspects of diagnosis and treatment].

Vorobyova, Yu D, Danilov, A B·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2021

This article reviews how ME/CFS develops by looking at both genes and environmental factors that trigger the illness. The authors explain known genetic problems found in ME/CFS patients, what can start the disease, and how these factors combine to cause the symptoms people experience. They also describe a systematic approach to diagnosing and treating ME/CFS.

Diagnostics

E3 PreliminaryPEM unclear

My experience of chronic fatigue syndrome.

BMJ paediatrics open·2021

This article is a personal account of one person's experience living with ME/CFS, published in a medical journal. It describes the journey of managing this condition and how it has affected daily life. While personal stories are valuable for understanding what patients go through, they are not the same as research that tests treatments or identifies causes.

E3 PreliminaryCohortPEM unclearCase-Control

Adolescent and Young Adult ME/CFS After Confirmed or Probable COVID-19.

Petracek, Lindsay S, Suskauer, Stacy J, Vickers, Rebecca F et al.·Frontiers in medicine·2021

This study describes three teenagers and young adults who developed ME/CFS after having COVID-19. All three patients experienced symptoms like dizziness when standing up early in their illness, and by 6 months, all met the clinical criteria for ME/CFS. The researchers noticed several patterns across these patients, including allergies, elevated histamine levels, reduced flexibility, and unusual nerve reflexes—findings that may help identify and treat ME/CFS after COVID-19.

Post-Exertional Malaise

E3 PreliminaryCohortPEM unclearCase-Control

Postdengue chronic fatigue syndrome in an adolescent boy.

Thadchanamoorthy, Vijayakumary, Dayasiri, Kavinda·BMJ case reports·2021

This case report describes an 11-year-old boy who developed ME/CFS symptoms after recovering from dengue hemorrhagic fever. Three weeks after initially feeling better, he experienced severe joint pain, muscle aches, and headaches that persisted for at least a year despite physiotherapy and nutrition support. This case adds to growing evidence that ME/CFS can develop following viral infections, even in young people.

E3 PreliminaryMechanismPEM unclearMechanistic

Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment.

Cabanas, Helene, Muraki, Katsuhiko, Eaton-Fitch, Natalie et al.·Frontiers in immunology·2021

This study investigated whether a low-dose medication called naltrexone (LDN) might help treat ME/CFS by examining how it affects immune cells called NK cells. Researchers found that NK cells from ME/CFS patients taking LDN showed restored activity in a specific ion channel (TRPM3) that had previously been impaired. This suggests LDN may help restore normal immune function in ME/CFS patients, though larger clinical trials are needed to confirm whether it actually improves symptoms.

Immune System

E3 PreliminaryCommentaryPEM unclear

ME/CFS: Past, Present and Future.

Weir, William, Speight, Nigel·Healthcare (Basel, Switzerland)·2021

This article reviews the history and current understanding of ME/CFS, arguing that the condition has a biological basis rather than being primarily psychological. The authors emphasize that scientific research, not psychological theories, is the path forward for properly understanding and treating ME/CFS. They highlight how patients have suffered from misunderstandings about their condition's cause.

Diagnostics

E3 PreliminaryCommentaryPEM unclear

Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome.

Komaroff, Anthony L, Lipkin, W Ian·Trends in molecular medicine·2021

This article compares myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) with long COVID to see if they might share similar causes. The authors suggest that some people who develop long COVID symptoms—like persistent fatigue, cognitive problems, and pain—may experience similar biological problems to those seen in ME/CFS. Understanding these shared mechanisms could help doctors better treat both conditions.

Energy MetabolismLong COVID Overlap

E3 PreliminaryCohortPEM unclearCase-Control

Young and exhausted.

Oleksak, Filip, Durdik, Peter, Jakusova, Lubica et al.·Advances in respiratory medicine·2021

This case report describes a young patient who was diagnosed with ME/CFS (extreme exhaustion lasting at least six months) but actually had a different, treatable heart and lung condition. The doctors used a special exercise test called cardiopulmonary exercise testing to discover the real cause. This story reminds us that it's important to carefully check for other medical conditions before diagnosing someone with ME/CFS, especially in children and young people.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Benefits of micronutrient supplementation on nutritional status, energy metabolism, and subjective wellbeing.

Maggini, Silvia, Óvári, Veronika, Ferreres Giménez, Inmaculada et al.·Nutricion hospitalaria·2021

Your body needs several vitamins and minerals—like vitamins A, D, E, folate, iron, zinc, and selenium—to make energy in your cells. Many people, even in wealthy countries, don't get enough of these nutrients. Studies show that taking a combination of these micronutrients, sometimes with coenzyme Q10, may help reduce fatigue, improve thinking, and make people feel better overall.

Energy Metabolism

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Evidence Atlas

Evidence browser

Inflammation plays a causal role in fatigue-like behavior induced by pelvic irradiation in mice.

The Health-Promoting Properties and Clinical Applications of Rice Bran Arabinoxylan Modified with Shiitake Mushroom Enzyme-A Narrative Review.

Chronic fatigue syndrome: Abnormally fast muscle fiber conduction in the membranes of motor units at low static force load.

Experiences Among School Personnel and School Nurses on Educational Adaptations for Students With CFS/ME: A Qualitative Interview Study.

Ross River Virus Immune Evasion Strategies and the Relevance to Post-viral Fatigue, and Myalgic Encephalomyelitis Onset.

Central sensitivity and fibromyalgia.

"it's a medical condition … you need to support as much as possible": a qualitative analysis of teachers' experiences of chronic fatigue syndrome / myalgic encephalomyelitis (CFS/ME).

Ehlers-Danlos Syndrome: Immunologic contrasts and connective tissue comparisons.

Chronic Fatigue Syndrome and Bone Marrow Defects of the Jaw - A Case Report on Additional Dental X-Ray Diagnostics with Ultrasound.

Elements of Suffering in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Experience of Loss, Grief, Stigma, and Trauma in the Severely and Very Severely Affected.

Chronic Fatigue Syndrome: A Case Report Highlighting Diagnosing and Treatment Challenges and the Possibility of Jarisch-Herxheimer Reactions If High Infectious Loads Are Present.

[Chronic fatigue syndrom: modern aspects of diagnosis and treatment].

My experience of chronic fatigue syndrome.

Adolescent and Young Adult ME/CFS After Confirmed or Probable COVID-19.

Postdengue chronic fatigue syndrome in an adolescent boy.

Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment.

ME/CFS: Past, Present and Future.

Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome.

Young and exhausted.

Benefits of micronutrient supplementation on nutritional status, energy metabolism, and subjective wellbeing.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research