ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4801–4820 of 6,163 studies

E3 PreliminaryCohortPEM not requiredCase-Control

A case of femoral arteriovenous fistula causing high-output cardiac failure, originally misdiagnosed as chronic fatigue syndrome.

Porter, J, Al-Jarrah, Q, Richardson, S·Case reports in vascular medicine·2014

This case study describes a 34-year-old marathon runner who was initially diagnosed with chronic fatigue syndrome but actually had a rare blood vessel problem called a femoral arteriovenous fistula. This condition, caused by a small injury during a heart catheterization procedure years earlier, created an abnormal connection between an artery and vein in the leg that forced the heart to work much harder than normal. Surgery to repair this fistula completely resolved the patient's fatigue and heart problems, showing that careful medical evaluation is important when fatigue symptoms don't improve with standard treatment.

E3 PreliminaryReviewPEM unclearReview-Narrative

Prolonged school non-attendance in adolescence: a practical approach.

Hawkrigg, S, Payne, D N·Archives of disease in childhood·2014

This article discusses why some teenagers stop attending school and how doctors can help them return. The authors explain that missing school can lead to serious problems like depression and difficulties with relationships and jobs later in life. They suggest a practical framework for understanding why a student is absent and developing a plan to help them go back to school.

E3 PreliminaryReviewPEM unclearReview-Narrative

Review: Vitamin D3 deficiency results in dysfunctions of immunity with severe fatigue and depression in a variety of diseases.

Höck, Anna Dorothea·In vivo (Athens, Greece)·2014

This review explains how vitamin D3 deficiency may contribute to severe fatigue and depression in conditions like ME/CFS. Vitamin D3 helps regulate the immune system, and without enough of it, the body's natural defenses become unbalanced, allowing infections and inflammation to persist. The authors suggest that vitamin D3 supplements might help prevent or improve these chronic conditions.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome, fibromyalgia, and myalgic encephalomyelitis: a clinical perspective.

Teitelbaum, Jacob·Alternative therapies in health and medicine·2014

This article reviews how chronic fatigue syndrome (ME/CFS), fibromyalgia, and related conditions present in clinical practice. Dr. Teitelbaum, an experienced clinician, discusses the symptoms and practical aspects of these overlapping illnesses that affect energy, pain, and sleep. The piece offers a clinical perspective on recognizing and understanding these conditions from a doctor's viewpoint.

E3 PreliminaryReviewPEM unclearReview-Narrative

The gut microbiome and the brain.

Galland, Leo·Journal of medicinal food·2014

Your gut bacteria can communicate with your brain in several ways: they produce substances that trigger your immune system, create chemicals that affect your mood and sleep, and send signals directly to your brain through a major nerve called the vagus nerve. When the balance of gut bacteria is disrupted, this communication can go wrong and may contribute to problems like chronic fatigue, brain fog, and mood changes.

NeuroinflammationGut MicrobiomeImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The glutathione system: a new drug target in neuroimmune disorders.

Morris, Gerwyn, Anderson, George, Dean, Olivia et al.·Molecular neurobiology·2014

This review examines glutathione (GSH), a naturally occurring substance in our cells that protects against damage and helps our immune system work properly. When glutathione levels drop, cells become more stressed and inflamed, which may contribute to ME/CFS and other conditions affecting the brain and immune system. The authors suggest several potential treatments—including supplements like N-acetyl cysteine and natural compounds like curcumin—that might help restore glutathione levels.

NeuroinflammationImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Isoflavones inhibit poly(I:C)-induced serum, brain, and skin inflammatory mediators - relevance to chronic fatigue syndrome.

Vasiadi, Magdalini, Newman, Jennifer, Theoharides, Theoharis C·Journal of neuroinflammation·2014

This study tested whether isoflavones (plant compounds found in soy) could reduce inflammation and fatigue-like symptoms in mice exposed to immune triggers and stress. Mice given a high-isoflavone diet showed less activity loss and lower inflammation markers in their blood, brain, and skin compared to mice on regular diet. The findings suggest isoflavones might help reduce some ME/CFS symptoms by calming the body's immune response.

Immune System

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

Assessment of fatigue using the Multidimensional Fatigue Inventory in patients with major depressive disorder.

Chung, Ka-Fai, Yu, Branda Yee-Man, Yung, Kam-Ping et al.·Comprehensive psychiatry·2014

This study tested whether a fatigue measurement tool called the MFI-20 works well for people with depression. Researchers gave the test to 137 people with depression and found it reliably measured different types of tiredness—physical and mental exhaustion, reduced energy, and loss of motivation. The tool successfully tracked changes in fatigue over time and correlated with other health measures.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Stress triggers coronary mast cells leading to cardiac events.

Alevizos, Michail, Karagkouni, Anna, Panagiotidou, Smaro et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2014

When we experience stress, our body releases chemicals that can activate immune cells in the heart called mast cells. These activated mast cells release inflammatory substances that can trigger heart problems or make existing heart disease worse. This review found that stress-related activation of heart mast cells may be a key pathway connecting emotional stress to heart attacks and coronary artery disease.

Immune System

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Orthostatic responses in adolescent chronic fatigue syndrome: contributions from expectancies as well as gravity.

Wyller, Vegard Bruun, Fagermoen, Even, Sulheim, Dag et al.·BioPsychoSocial medicine·2014

When people with ME/CFS stand up or imagine standing, their body's nervous system responds differently than in healthy people. This study found that teenagers with ME/CFS have higher resting heart rate and blood pressure, and their nervous system shows stronger stress responses when they think about standing upright, even though their actual physical response to tilting was similar to healthy peers. This suggests that both the physical challenge of gravity and a person's expectations or anxiety about standing may contribute to the symptoms they experience.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Competences required for the delivery of high and low-intensity cognitive behavioural interventions for chronic fatigue, chronic fatigue syndrome/ME and irritable bowel syndrome.

Rimes, Katharine A, Wingrove, Janet, Moss-Morris, Rona et al.·Behavioural and cognitive psychotherapy·2014

This study developed clear guidelines describing what skills therapists need to deliver cognitive behavioural therapy (CBT) for ME/CFS and related conditions. Researchers gathered input from experienced therapists to create competence frameworks for both brief interventions and longer, more intensive treatments. These guidelines can help train new therapists and identify what skills they need to learn.

E3 PreliminaryBehavioralPEM unclearCross-Sectional

Couples' experiences of interacting with outside others in chronic fatigue syndrome: a qualitative study.

Brooks, Joanna, King, Nigel, Wearden, Alison·Chronic illness·2014

This study looked at how ME/CFS affects not just patients, but also their spouses or partners who live with them. Researchers interviewed two couples to understand their experiences, focusing on how they interact with doctors and people outside their home. The key finding was that both patients and their partners struggle with how others—whether healthcare providers or friends—understand and respond to ME/CFS, and these outside interactions significantly affect how couples cope together.

E3 PreliminaryReviewPEM unclearReview-Narrative

Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports.

Tarakji, B, Ashok, N, Alakeel, R et al.·Annals of medical and health sciences research·2014

This review looked at reported side effects from the Hepatitis B vaccine given to children and adults. While the vaccine is generally considered safe, researchers found reports of various health complications that occurred after vaccination, including some that affect the mouth and jaw. The authors note that most side effects go away on their own, but a few can be serious and need hospital care.

E3 PreliminaryMechanismPEM unclearObservational

High-throughput sequencing of plasma microRNA in chronic fatigue syndrome/myalgic encephalomyelitis.

Brenu, Ekua W, Ashton, Kevin J, Batovska, Jana et al.·PloS one·2014

This study looked for tiny molecular messages called microRNAs in the blood of ME/CFS patients to see if they might work as a diagnostic tool. Researchers compared blood samples from ME/CFS patients and healthy people, and found three microRNAs that were higher in ME/CFS patients. This is an early-stage discovery that could eventually help doctors identify ME/CFS more easily through a simple blood test.

Biomarkers

E3 PreliminaryReviewPEM unclearReview-Narrative

Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS).

Morris, Gerwyn, Maes, Michael·Current neuropharmacology·2014

This study proposes that ME/CFS involves a harmful cycle where the body's immune system becomes overactive and produces damaging molecules called oxidative stress. These problems can be triggered by infections, gut bacteria leaking into the bloodstream, or problems with the energy-producing parts of cells called mitochondria. Once started, this cycle feeds on itself, causing brain inflammation, reduced blood flow to the brain, and damage to cells throughout the body.

NeuroinflammationImmune System

E3 PreliminaryCohortPEM not requiredObservational

Multiple Sclerosis/Chronic Fatigue Syndrome overlap: When two common disorders collide.

Gaber, Tarek A-Z K, Oo, Wah Wah, Ringrose, Hollie·NeuroRehabilitation·2014

This study looked at whether people with Multiple Sclerosis (MS) might also have ME/CFS at the same time. Researchers examined 64 MS patients and found that 14% of them—all women—also met the diagnostic criteria for ME/CFS. Their fatigue and other symptoms like pain and headaches couldn't be fully explained by their MS alone, suggesting the two conditions can occur together in the same person.

E3 PreliminaryReviewPEM unclearReview-Narrative

What is called symptom?

Eriksen, Thor Eirik, Risør, Mette Bech·Medicine, health care, and philosophy·2014

This paper explores what we actually mean by the word 'symptom' in medicine. The authors argue that when doctors can't find a clear medical cause for illness—like ME/CFS—our usual way of thinking about symptoms breaks down. They suggest we need to understand symptoms in broader ways, including how patients' social lives, personal experiences, and individual circumstances shape how they experience illness.

Diagnostics

E3 PreliminaryCohortPEM unclearObservational

A qualitative natural history study of ME/CFS in the community.

Anderson, Valerie R, Jason, Leonard A, Hlavaty, Laura E·Health care for women international·2014

This study interviewed 19 people with ME/CFS who were living in their communities (rather than patients seen at specialty clinics) to understand their experiences with the illness over time. The researchers found that ME/CFS affects people in multiple ways—physically, emotionally, and socially—and that how communities and healthcare providers respond to patients can significantly impact their illness progression and quality of life.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Biopersistence and systemic distribution of intramuscularly injected particles: what impact on long-term tolerability of alum adjuvants?].

Gherardi, Romain K, Cadusseau, Josette, Authier, François-jérôme·Bulletin de l'Academie nationale de medecine·2014

This review examines how aluminum-based vaccine adjuvants (immune-boosting ingredients) may rarely cause long-term health problems in susceptible people, including muscle pain, exhaustion, and brain fog that can last years. The researchers found that aluminum particles can travel from the injection site through the body to distant organs and the brain, and that a specific immune protein called MCP-1 may control how much this happens. For most people, aluminum adjuvants are safe, but genetic and environmental differences may make some individuals more vulnerable to prolonged effects.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredObservational

Deficient EBV-specific B- and T-cell response in patients with chronic fatigue syndrome.

Loebel, Madlen, Strohschein, Kristin, Giannini, Carolin et al.·PloS one·2014

This study looked at how the immune system responds to Epstein-Barr virus (EBV), a common virus that causes mono, in people with ME/CFS compared to healthy controls. Researchers found that ME/CFS patients have a weaker immune response to EBV, particularly in their B cells and T cells—the immune cells that normally fight off this virus. The findings suggest that ME/CFS patients may have difficulty controlling EBV reactivation in their bodies.

Immune System

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A case of femoral arteriovenous fistula causing high-output cardiac failure, originally misdiagnosed as chronic fatigue syndrome.

Prolonged school non-attendance in adolescence: a practical approach.

Review: Vitamin D3 deficiency results in dysfunctions of immunity with severe fatigue and depression in a variety of diseases.

Chronic fatigue syndrome, fibromyalgia, and myalgic encephalomyelitis: a clinical perspective.

The gut microbiome and the brain.

The glutathione system: a new drug target in neuroimmune disorders.

Isoflavones inhibit poly(I:C)-induced serum, brain, and skin inflammatory mediators - relevance to chronic fatigue syndrome.

Assessment of fatigue using the Multidimensional Fatigue Inventory in patients with major depressive disorder.

Stress triggers coronary mast cells leading to cardiac events.

Orthostatic responses in adolescent chronic fatigue syndrome: contributions from expectancies as well as gravity.

Competences required for the delivery of high and low-intensity cognitive behavioural interventions for chronic fatigue, chronic fatigue syndrome/ME and irritable bowel syndrome.

Couples' experiences of interacting with outside others in chronic fatigue syndrome: a qualitative study.

Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports.

High-throughput sequencing of plasma microRNA in chronic fatigue syndrome/myalgic encephalomyelitis.

Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS).

Multiple Sclerosis/Chronic Fatigue Syndrome overlap: When two common disorders collide.

What is called symptom?

A qualitative natural history study of ME/CFS in the community.

[Biopersistence and systemic distribution of intramuscularly injected particles: what impact on long-term tolerability of alum adjuvants?].

Deficient EBV-specific B- and T-cell response in patients with chronic fatigue syndrome.

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