ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5061–5080 of 6,164 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Resveratrol improves hippocampal atrophy in chronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cells.

Moriya, Junji, Chen, Rui, Yamakawa, Jun-ichi et al.·Biological & pharmaceutical bulletin·2011

Researchers created mice with chronic fatigue by repeatedly exposing them to a bacterial antigen, which caused them to move less and their brains to shrink in a region called the hippocampus. When they gave these mice resveratrol (a compound found in red grapes), the mice became more active and their hippocampus enlarged. The treatment appeared to work by reducing brain cell death and promoting the growth of new brain cells.

Neuroinflammation

E3 PreliminaryCommentaryPEM unclearEditorial

Diagnosis and management of fibromyalgia: how and why.

Hayhoe, Simon·Pain management·2011

Fibromyalgia is a condition causing widespread muscle pain, tiredness, and sleep problems that doctors still debate about. It shares some features with ME/CFS and may involve both physical changes in how the nervous system processes pain and psychological factors. Treatment typically includes certain antidepressants, anti-seizure medications, and talking therapy with gentle exercise, though most patients only get partial improvement.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Evidence and controversies on the role of XMRV in prostate cancer and chronic fatigue syndrome.

Menéndez-Arias, Luis·Reviews in medical virology·2011

Researchers discovered a virus called XMRV in some people with prostate cancer and ME/CFS, which generated significant interest. However, other studies have not been able to confirm this finding, leaving uncertainty about whether XMRV actually causes disease in humans. This review examines what we know and don't know about XMRV's role in these conditions.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fatigue and chronic fatigue in the elderly: definitions, diagnoses, and treatments.

Morelli, Vincent·Clinics in geriatric medicine·2011

This review article helps doctors understand fatigue in older adults by explaining three types: fatigue that comes on recently, fatigue that lasts a long time, and chronic fatigue syndrome. The article discusses how doctors can evaluate fatigue and offers both medication and non-medication treatments like exercise, vitamins, diet changes, and behavioral strategies.

Diagnostics

E3 PreliminaryCohortPEM not required

Decades of delayed diagnosis in 4 levodopa-responsive young-onset monogenetic parkinsonism patients.

Ling, Helen, Braschinsky, Mark, Taba, Pille et al.·Movement disorders : official journal of the Movement Disorder Society·2011

This study describes four young patients who were initially misdiagnosed with psychological movement disorders or chronic fatigue syndrome, but actually had a genetic form of Parkinson's disease. Their misdiagnosis lasted 10 to 23 years before the correct diagnosis was made. Once they received the correct treatment with levodopa medication, they all improved significantly, showing that the right diagnosis and treatment can make a major difference.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Endogenous retroviruses as potential hazards for vaccines.

Miyazawa, Takayuki·Biologicals : journal of the International Association of Biological Standardization·2010

This article reviews the concern that certain viruses called endogenous retroviruses (ERVs) may be present in animal cell lines used to make some vaccines. Scientists discovered a virus called XMRV in some patients with ME/CFS and prostate cancer. Because some vaccines are made using animal cells that naturally contain ERVs, there is a theoretical risk that these viruses could contaminate vaccines, though this has not been well studied.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The chronic asthenia syndrome: a clinical approach].

Young, Pablo, Finn, Bárbara C, Bruetman, Julio et al.·Medicina·2010

Fatigue is one of the most common reasons people visit doctors, affecting about 30% of patients. This article explains how doctors should think about different types of fatigue—including chronic fatigue syndrome (ME/CFS), which affects 0.2–0.7% of people. The authors emphasize that finding and treating the underlying cause is the best approach, though about 20% of patients never get a clear diagnosis.

Diagnostics

E3 PreliminaryCommentaryPEM unclearEditorial

Of Mice and Men: On the Origin of XMRV.

van der Kuyl, Antoinette Cornelia, Cornelissen, Marion, Berkhout, Ben·Frontiers in microbiology·2010

This study examines XMRV, a virus that was found in some ME/CFS patients but whose existence remains hotly debated in the scientific community. The authors suggest that XMRV may have entered humans through contamination in medical products like vaccines that were made using mouse cells. They explore how this virus, which is very similar to viruses naturally found in mice, could have crossed into humans.

E3 PreliminaryReviewPEM unclearReview-Narrative

Idiopathic environmental intolerances (IEI): from molecular epidemiology to molecular medicine.

De Luca, C, Scordo, G, Cesareo, E et al.·Indian journal of experimental biology·2010

Some people with ME/CFS and related conditions may have difficulty processing chemicals, metals, and other substances they encounter in the environment because of inherited or acquired differences in how their bodies handle these toxins. This review suggests that genetic variations affecting enzymes responsible for detoxifying chemicals, combined with problems in the body's antioxidant systems, might explain why some people react strongly to very small amounts of environmental exposures. Understanding these biological mechanisms could help develop personalized treatments.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredMechanistic

Apobec 3G efficiently reduces infectivity of the human exogenous gammaretrovirus XMRV.

Stieler, Kristin, Fischer, Nicole·PloS one·2010

This study examined how a virus called XMRV (which has been suspected in ME/CFS) interacts with human immune defense proteins called Apobec3 proteins. Researchers found that one specific immune protein, called A3G, is very effective at stopping XMRV from infecting cells and spreading. Interestingly, cancer cells that are easily infected by XMRV don't produce much of this protective A3G protein.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

EBV Chronic Infections.

Eligio, Pizzigallo, Delia, Racciatti, Valeria, Gorgoretti·Mediterranean journal of hematology and infectious diseases·2010

This review explores the connection between Epstein-Barr virus (EBV)—the virus that causes mononucleosis—and ME/CFS. While EBV can persist in the body and reactivate at times, it is not clear whether it directly causes chronic fatigue syndrome in most patients. The authors suggest that ME/CFS likely has multiple causes, including EBV in some people, other viruses in others, and non-infectious factors, but the underlying mechanism may involve inflammation and oxidative damage.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

An endogenous murine leukemia viral genome contaminant in a commercial RT-PCR kit is amplified using standard primers for XMRV.

Sato, Eiji, Furuta, Rika A, Miyazawa, Takayuki·Retrovirology·2010

Researchers testing for a virus called XMRV in ME/CFS patients discovered that one commercial laboratory test kit was contaminated with mouse virus DNA. This contamination meant that positive results from this kit could not be trusted, since the positive signal came from the kit itself rather than from patient samples. The researchers are warning other scientists to carefully check their test kits for this contamination before using them in studies.

E3 PreliminaryMechanismPEM unclearMechanistic

Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors.

Groom, Harriet C T, Yap, Melvyn W, Galão, Rui Pedro et al.·Proceedings of the National Academy of Sciences of the United States of America·2010

Scientists studied a virus called XMRV that had been linked to ME/CFS to understand how it survives in human cells. They discovered that the body's natural antiviral defense proteins can block this virus, but XMRV does not appear to have developed ways to escape these defenses like some other viruses do. This finding helps researchers understand which cells XMRV can infect and how to design better laboratory studies of this virus.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The Hebrew version of the FibroFatigue scale: validation of a questionnaire for assessment of fibromyalgia and chronic fatigue syndrome.

Ablin, Jacob N, Odes, Lisa, Neumann, Lily et al.·Rheumatology international·2010

This study tested whether a Hebrew-language questionnaire called the FibroFatigue Scale (FFS) accurately measures symptoms in fibromyalgia patients. Researchers gave 100 patients with fibromyalgia this questionnaire along with other standard symptom-measuring tools, and found that the FFS reliably detected and measured how severe their symptoms were.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Distribution of xenotropic murine leukemia virus-related virus (XMRV) infection in chronic fatigue syndrome and prostate cancer.

Mikovits, Judy A, Huang, Ying, Pfost, Max A et al.·AIDS reviews·2010

Researchers tested blood samples from ME/CFS patients for a virus called XMRV using different detection methods. They found that simple DNA tests alone missed infections that were caught by more sensitive techniques. This study explains why different research teams got different results—the testing method matters a lot.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome, fibromyalgia, and related illnesses: a clinical model of assessment and intervention.

Friedberg, Fred·Journal of clinical psychology·2010

This article reviews how doctors and mental health professionals can better assess and help people with ME/CFS, fibromyalgia, and related conditions. The authors present a practical framework using cognitive-behavioral approaches—strategies that address both thoughts and behaviors—to improve care for patients who often feel dismissed by the medical system. The goal is to help clinicians understand why these patients experience unusual physical symptoms and provide more effective support.

E3 PreliminaryMechanismPEM unclearMechanistic

Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity.

Vermeulen, Ruud C W, Kurk, Ruud M, Visser, Frans C et al.·Journal of translational medicine·2010

This study compared how well people with ME/CFS and healthy controls performed during two exercise tests done 24 hours apart. Patients became exhausted at much lower exercise levels than controls, and performed even worse on the second test. Surprisingly, when researchers tested the energy-producing structures (mitochondria) in patients' blood cells, they appeared to work normally, suggesting the problem may lie elsewhere in the energy production process.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes.

Sperber, Ami D, Dekel, Roy·Journal of neurogastroenterology and motility·2010

Many people with irritable bowel syndrome (IBS) also experience other chronic conditions like fibromyalgia or chronic fatigue syndrome (ME/CFS). When patients have IBS plus another functional disorder, their symptoms tend to be worse, they report lower quality of life, and they miss more work. This suggests these conditions may share common underlying mechanisms rather than being completely separate diseases.

E3 PreliminaryMechanismPEM not requiredMechanistic

Host range and cellular tropism of the human exogenous gammaretrovirus XMRV.

Stieler, Kristin, Schulz, Claudia, Lavanya, Madakasira et al.·Virology·2010

This study examined how XMRV, a virus found in some ME/CFS patients' blood cells, infects different types of human cells. Researchers tested which cells the virus could enter and grow in, finding that it could infect various cell types including immune cells and prostate cells. The virus appeared to replicate most efficiently in prostate tissue, suggesting the virus may have preferred targets in the body.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neuroendocrine and immune contributors to fatigue.

Silverman, Marni N, Heim, Christine M, Nater, Urs M et al.·PM & R : the journal of injury, function, and rehabilitation·2010

This review explores how three body systems—the stress response system, the nervous system, and the immune system—may work together to cause the overwhelming tiredness experienced in ME/CFS. The researchers found that people with chronic fatigue often have an underactive stress-response system, an overactive fight-or-flight response, and immune system imbalances. Understanding how these systems interact may help explain why rest alone doesn't always resolve the fatigue.

Autonomic Nervous SystemImmune System

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Resveratrol improves hippocampal atrophy in chronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cells.

Diagnosis and management of fibromyalgia: how and why.

Evidence and controversies on the role of XMRV in prostate cancer and chronic fatigue syndrome.

Fatigue and chronic fatigue in the elderly: definitions, diagnoses, and treatments.

Decades of delayed diagnosis in 4 levodopa-responsive young-onset monogenetic parkinsonism patients.

Endogenous retroviruses as potential hazards for vaccines.

[The chronic asthenia syndrome: a clinical approach].

Of Mice and Men: On the Origin of XMRV.

Idiopathic environmental intolerances (IEI): from molecular epidemiology to molecular medicine.

Apobec 3G efficiently reduces infectivity of the human exogenous gammaretrovirus XMRV.

EBV Chronic Infections.

An endogenous murine leukemia viral genome contaminant in a commercial RT-PCR kit is amplified using standard primers for XMRV.

Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors.

The Hebrew version of the FibroFatigue scale: validation of a questionnaire for assessment of fibromyalgia and chronic fatigue syndrome.

Distribution of xenotropic murine leukemia virus-related virus (XMRV) infection in chronic fatigue syndrome and prostate cancer.

Chronic fatigue syndrome, fibromyalgia, and related illnesses: a clinical model of assessment and intervention.

Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity.

Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes.

Host range and cellular tropism of the human exogenous gammaretrovirus XMRV.

Neuroendocrine and immune contributors to fatigue.

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