ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5101–5120 of 6,188 studies

E3 PreliminaryCohortPEM not requiredCase-Control

Endometriosis-associated Lyme disease.

Matalliotakis, I M, Cakmak, H, Ziogos, M D E et al.·Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2010

This study looked at whether Lyme disease (an infection from tick bites) appears more often in women with endometriosis (a painful condition affecting the uterus). Researchers reviewed medical records from 605 women over 6 years and found that 3 women had both endometriosis and Lyme disease. The study suggests that women with endometriosis may be more likely to develop autoimmune and inflammatory conditions, including Lyme disease.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequences.

Oakes, Brendan, Tai, Albert K, Cingöz, Oya et al.·Retrovirology·2010

Researchers tested blood samples from ME/CFS patients and healthy people for a virus called XMRV. They discovered that when using very sensitive testing methods, they were getting false positive results because mouse DNA was contaminating the samples, not because patients actually had the virus. This study shows why careful testing procedures are essential when looking for viruses in patient samples.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Frequency and content analysis of chronic fatigue syndrome in medical text books.

Jason, Leonard A, Paavola, Erin, Porter, Nicole et al.·Australian journal of primary health·2010

This study looked at how much information about ME/CFS appears in medical textbooks that doctors and medical students use for training. Researchers found that while about 4 out of 10 textbooks mentioned ME/CFS at all, the information took up less than 0.1% of the total pages. Compared to other diseases like multiple sclerosis that are actually rarer, ME/CFS received much less coverage in these important educational materials.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The cerebralization of fatigue: an analysis of the cerebral hypothesis in the case of chronic fatigue syndrome].

Ortega, Francisco, Zorzanelli, Rafaela·Historia, ciencias, saude--Manguinhos·2010

This article examines how ME/CFS came to be understood as a brain-based illness rather than purely a physical one. The authors explore the history of how brain imaging and neuroscience research influenced medical thinking about ME/CFS, and how this shift reflected broader changes in how society views illness in general—increasingly looking to the brain as the primary source of disease.

E3 PreliminaryCohortPEM not requiredCross-Sectional

A qualitative exploration of adolescents' experiences of chronic fatigue syndrome.

Jelbert, Rebecca, Stedmon, Jacqui, Stephens, Alison·Clinical child psychology and psychiatry·2010

This study talked to five teenagers who had recovered from ME/CFS about what the illness was like for them. Through interviews and careful analysis of their stories, researchers found that teens experienced five common themes: trying to understand their illness, feeling a sense of loss, noticing things that seemed to make it better or worse, dealing with difficult emotions, and eventually recovering. The teens' own voices highlight that there is still much we need to learn about how this illness affects young people.

E3 PreliminaryReviewPEM unclearReview-Narrative

The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome.

Silverman, Robert H, Nguyen, Carvell, Weight, Christopher J et al.·Nature reviews. Urology·2010

This review examines XMRV, a newly discovered virus that has been found in some people with prostate cancer and some with ME/CFS. Researchers have found the virus at very different rates in different studies (0-27% in prostate cancer, 0-67% in ME/CFS patients). While some antiviral drugs appear to block this virus, scientists still do not know whether XMRV actually causes either disease.

Immune System

E3 PreliminaryReviewPEM requiredReview-Narrative

Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways.

Maes, Michael, Twisk, Frank N M·BMC medicine·2010

This study compares two different ways of understanding ME/CFS. One model suggests the illness is mainly caused by how the mind and behavior interact with the body, and proposes treatments like cognitive behavioral therapy and graded exercise. The other model focuses on biological problems like inflammation and oxidative stress in the body. The authors argue that the biological model better explains ME/CFS and that exercise-based treatments could actually make some patients worse.

Immune SystemPost-Exertional Malaise

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Exploring the feasibility of establishing a disease-specific post-mortem tissue bank in the UK: a case study in ME/CFS.

Lacerda, Eliana M, Nacul, Luis, Pheby, Derek et al.·Journal of clinical pathology·2010

This study explored whether it would be possible and acceptable to create a tissue bank in the UK specifically for ME/CFS—a place where donated tissues from people with ME/CFS could be studied after death to better understand the disease. Researchers interviewed patients, held discussion groups, and consulted experts to find out what people thought about this idea. The findings show that both patients and experts believe such a tissue bank would be valuable and could work in practice, as long as certain concerns were properly addressed.

E3 PreliminaryMechanismPEM not requiredMechanistic

Apobec 3G efficiently reduces infectivity of the human exogenous gammaretrovirus XMRV.

Stieler, Kristin, Fischer, Nicole·PloS one·2010

This study examined how a virus called XMRV (which has been suspected in ME/CFS) interacts with human immune defense proteins called Apobec3 proteins. Researchers found that one specific immune protein, called A3G, is very effective at stopping XMRV from infecting cells and spreading. Interestingly, cancer cells that are easily infected by XMRV don't produce much of this protective A3G protein.

Immune System

E3 PreliminaryCohortPEM not requiredObservational

Making the diagnosis of Chronic Fatigue Syndrome/Myalgic Encephalitis in primary care: a qualitative study.

Chew-Graham, Carolyn, Dowrick, Christopher, Wearden, Alison et al.·BMC family practice·2010

This study asked 22 general practitioners (GPs) about their experiences diagnosing ME/CFS in their clinics. GPs said they find it hard to understand what ME/CFS is, and they typically focus on ruling out other diseases rather than confidently saying a patient has ME/CFS. Many GPs worried that giving someone an ME/CFS diagnosis might actually harm them, and they weren't sure what to do to help these patients once diagnosed.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

The role of corticosteroids and stress in chronic pain conditions.

McEwen, Bruce S, Kalia, Madhu·Metabolism: clinical and experimental·2010

This review explores how stress hormones (corticosteroids) and the body's stress response system affect chronic pain conditions, including ME/CFS. The authors explain that these hormones can have surprising and contradictory effects—sometimes reducing pain, sometimes increasing it—depending on the dose and where they act in the body. They examine how chronic stress and nervous system changes in conditions like ME/CFS, fibromyalgia, and IBS may be linked to pain through brain changes and immune system activity.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

[Human herpesvirus 6].

Ongrádi, József, Kövesdi, Valéria, Medveczky, G Péter·Orvosi hetilap·2010

Human herpesvirus 6 (HHV-6) is a common virus that most people catch in early childhood, usually causing mild symptoms or no symptoms at all. The virus stays dormant in your body for life but can reactivate, especially if your immune system is weakened. Research suggests HHV-6 may play a role in ME/CFS and other serious conditions, possibly by changing how your immune system produces certain signaling molecules.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Idiopathic environmental intolerances (IEI): from molecular epidemiology to molecular medicine.

De Luca, C, Scordo, G, Cesareo, E et al.·Indian journal of experimental biology·2010

Some people with ME/CFS and related conditions may have difficulty processing chemicals, metals, and other substances they encounter in the environment because of inherited or acquired differences in how their bodies handle these toxins. This review suggests that genetic variations affecting enzymes responsible for detoxifying chemicals, combined with problems in the body's antioxidant systems, might explain why some people react strongly to very small amounts of environmental exposures. Understanding these biological mechanisms could help develop personalized treatments.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fibromyalgia syndrome: a discussion of the syndrome and pharmacotherapy.

Smith, Howard S, Barkin, Robert L·American journal of therapeutics·2010

Fibromyalgia is a condition that causes widespread pain throughout the body, along with fatigue, sleep problems, brain fog, and mood changes. This article explains that fibromyalgia may share common features with ME/CFS and other conditions involving heightened pain sensitivity. While there is no cure, doctors can help manage symptoms through exercise, therapy, patient education, and specific medications.

Pain and SensitizationSleepCognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Implications of forgiveness enhancement in patients with fibromyalgia and chronic fatigue syndrome.

Toussaint, Loren, Overvold-Ronningen, Mary, Vincent, Ann et al.·Journal of health care chaplaincy·2010

This review examines whether learning to forgive—others and ourselves—might help people with ME/CFS and fibromyalgia cope better with the anger, stress, fear, and depression that often come with these conditions. The authors suggest that forgiveness could be a helpful complementary approach, alongside other treatments, to reduce the emotional burden of living with these chronic illnesses. They propose a model to guide future research on how forgiveness might improve well-being in these patient populations.

E3 PreliminaryMechanismPEM unclearMechanistic

Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity.

Vermeulen, Ruud C W, Kurk, Ruud M, Visser, Frans C et al.·Journal of translational medicine·2010

This study compared how well people with ME/CFS and healthy controls performed during two exercise tests done 24 hours apart. Patients became exhausted at much lower exercise levels than controls, and performed even worse on the second test. Surprisingly, when researchers tested the energy-producing structures (mitochondria) in patients' blood cells, they appeared to work normally, suggesting the problem may lie elsewhere in the energy production process.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Host range and cellular tropism of the human exogenous gammaretrovirus XMRV.

Stieler, Kristin, Schulz, Claudia, Lavanya, Madakasira et al.·Virology·2010

This study examined how XMRV, a virus found in some ME/CFS patients' blood cells, infects different types of human cells. Researchers tested which cells the virus could enter and grow in, finding that it could infect various cell types including immune cells and prostate cells. The virus appeared to replicate most efficiently in prostate tissue, suggesting the virus may have preferred targets in the body.

E3 PreliminaryMechanismPEM not requiredMechanistic

Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.

Paprotka, Tobias, Venkatachari, Narasimhan J, Chaipan, Chawaree et al.·Journal of virology·2010

This study investigated how a virus called XMRV, which has been found in some ME/CFS patients, survives and spreads in human cells. Researchers discovered that the virus can replicate more easily in certain cells that have low levels of natural antiviral proteins called APOBEC3. The study also found that some HIV medications (AZT, tenofovir, and raltegravir) can block XMRV replication in laboratory tests.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Short QT interval in clinical practice.

Bjerregaard, Preben, Nallapaneni, Hari, Gussak, Ihor·Journal of electrocardiology·2010

This review article discusses a heart rhythm pattern called a 'short QT interval' that doctors can see on heart electrical recordings (EKGs). The authors note that while this pattern is rare, it can sometimes be dangerous and increase the risk of sudden cardiac death. They found that short QT intervals have been reported in patients with ME/CFS, along with several other medical conditions, though we still don't fully understand what it means or how to best manage patients who have it.

E3 PreliminaryReviewPEM unclearReview-Narrative

Gut inflammation in chronic fatigue syndrome.

Lakhan, Shaheen E, Kirchgessner, Annette·Nutrition & metabolism·2010

Many ME/CFS patients experience gut problems similar to irritable bowel syndrome. This review discusses how three interconnected gut issues—changes in the bacteria that live in your intestines, a weakened intestinal lining, and an altered immune response in the gut—may contribute to ME/CFS. The authors suggest that treatments like probiotics (beneficial bacteria) might help by restoring healthy gut bacteria and reducing inflammation.

Immune System

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Endometriosis-associated Lyme disease.

Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequences.

Frequency and content analysis of chronic fatigue syndrome in medical text books.

[The cerebralization of fatigue: an analysis of the cerebral hypothesis in the case of chronic fatigue syndrome].

A qualitative exploration of adolescents' experiences of chronic fatigue syndrome.

The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome.

Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways.

Exploring the feasibility of establishing a disease-specific post-mortem tissue bank in the UK: a case study in ME/CFS.

Apobec 3G efficiently reduces infectivity of the human exogenous gammaretrovirus XMRV.

Making the diagnosis of Chronic Fatigue Syndrome/Myalgic Encephalitis in primary care: a qualitative study.

The role of corticosteroids and stress in chronic pain conditions.

[Human herpesvirus 6].

Idiopathic environmental intolerances (IEI): from molecular epidemiology to molecular medicine.

Fibromyalgia syndrome: a discussion of the syndrome and pharmacotherapy.

Implications of forgiveness enhancement in patients with fibromyalgia and chronic fatigue syndrome.

Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity.

Host range and cellular tropism of the human exogenous gammaretrovirus XMRV.

Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.

Short QT interval in clinical practice.

Gut inflammation in chronic fatigue syndrome.

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