ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5101–5120 of 6,164 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

What is fatigue? Pathological and nonpathological fatigue.

Jason, Leonard A, Evans, Meredyth, Brown, Molly et al.·PM & R : the journal of injury, function, and rehabilitation·2010

This article explores what fatigue really is and how doctors can tell the difference between normal tiredness and the severe, disabling fatigue that comes with illnesses like ME/CFS. Fatigue is common in many diseases and conditions, but researchers have had difficulty measuring it consistently and understanding why it happens. The authors review the scientific literature to help clarify these important questions.

E3 PreliminaryReviewPEM unclearReview-Narrative

The role of corticosteroids and stress in chronic pain conditions.

McEwen, Bruce S, Kalia, Madhu·Metabolism: clinical and experimental·2010

This review explores how stress hormones (corticosteroids) and the body's stress response system affect chronic pain conditions, including ME/CFS. The authors explain that these hormones can have surprising and contradictory effects—sometimes reducing pain, sometimes increasing it—depending on the dose and where they act in the body. They examine how chronic stress and nervous system changes in conditions like ME/CFS, fibromyalgia, and IBS may be linked to pain through brain changes and immune system activity.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

[Understanding chronic fatigue syndrome].

Rivera Redondo, Javier·Reumatologia clinica·2010

This article provides an overview of chronic fatigue syndrome (ME/CFS), explaining what the condition is and how it affects patients. The author discusses the main features of ME/CFS, including persistent exhaustion that doesn't improve with rest and other symptoms that can develop after infection or stress. The goal is to help readers understand this complex illness better.

E3 PreliminaryMechanismPEM unclearMechanistic

Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors.

Groom, Harriet C T, Yap, Melvyn W, Galão, Rui Pedro et al.·Proceedings of the National Academy of Sciences of the United States of America·2010

Scientists studied a virus called XMRV that had been linked to ME/CFS to understand how it survives in human cells. They discovered that the body's natural antiviral defense proteins can block this virus, but XMRV does not appear to have developed ways to escape these defenses like some other viruses do. This finding helps researchers understand which cells XMRV can infect and how to design better laboratory studies of this virus.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes.

Sperber, Ami D, Dekel, Roy·Journal of neurogastroenterology and motility·2010

Many people with irritable bowel syndrome (IBS) also experience other chronic conditions like fibromyalgia or chronic fatigue syndrome (ME/CFS). When patients have IBS plus another functional disorder, their symptoms tend to be worse, they report lower quality of life, and they miss more work. This suggests these conditions may share common underlying mechanisms rather than being completely separate diseases.

E3 PreliminaryCommentaryPEM not requiredEditorial

Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer.

Baraniuk, James N·Current allergy and asthma reports·2010

This study examined whether a virus called XMRV might be connected to ME/CFS. Researchers found this virus in about half to two-thirds of ME/CFS patients tested, compared to only about 4% of healthy people. The virus was able to spread from patient blood to laboratory cells, raising questions about whether it could be transmitted between people.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequences.

Oakes, Brendan, Tai, Albert K, Cingöz, Oya et al.·Retrovirology·2010

Researchers tested blood samples from ME/CFS patients and healthy people for a virus called XMRV. They discovered that when using very sensitive testing methods, they were getting false positive results because mouse DNA was contaminating the samples, not because patients actually had the virus. This study shows why careful testing procedures are essential when looking for viruses in patient samples.

E3 PreliminaryReviewPEM not requiredReview-Narrative

A new hypothesis of chronic fatigue syndrome: co-conditioning theory.

Tanaka, Masaaki, Watanabe, Yasuyoshi·Medical hypotheses·2010

This article proposes a new theory about how ME/CFS might develop: repeated overwork or stress could train your body and brain to respond with fatigue and an urge to rest, similar to how habits form. The authors suggest that once this pattern becomes established, your body may continue producing fatigue even when you're no longer overworking. This theory could eventually lead to new ways of treating ME/CFS.

Post-Exertional Malaise

E3 PreliminaryReviewPEM requiredReview-Narrative

Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways.

Maes, Michael, Twisk, Frank N M·BMC medicine·2010

This study compares two different ways of understanding ME/CFS. One model suggests the illness is mainly caused by how the mind and behavior interact with the body, and proposes treatments like cognitive behavioral therapy and graded exercise. The other model focuses on biological problems like inflammation and oxidative stress in the body. The authors argue that the biological model better explains ME/CFS and that exercise-based treatments could actually make some patients worse.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

Endometriosis-associated Lyme disease.

Matalliotakis, I M, Cakmak, H, Ziogos, M D E et al.·Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2010

This study looked at whether Lyme disease (an infection from tick bites) appears more often in women with endometriosis (a painful condition affecting the uterus). Researchers reviewed medical records from 605 women over 6 years and found that 3 women had both endometriosis and Lyme disease. The study suggests that women with endometriosis may be more likely to develop autoimmune and inflammatory conditions, including Lyme disease.

E3 PreliminaryMechanismPEM requiredMechanistic

Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study.

Van Oosterwijck, J, Nijs, J, Meeus, M et al.·Journal of internal medicine·2010

This study compared how the body's pain-relief systems work in people with ME/CFS versus healthy people during exercise. Researchers found that after exercise, people with ME/CFS became more sensitive to pain (their pain thresholds decreased), while healthy people became less sensitive to pain. The ME/CFS group also experienced worsening symptoms after both types of exercise they tried.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCross-Sectional

EEG findings in burnout patients.

van Luijtelaar, Gilles, Verbraak, Marc, van den Bunt, Martijn et al.·The Journal of neuropsychiatry and clinical neurosciences·2010

This study used brain wave recordings (EEG) to look for physical markers that could help identify burnout as a distinct condition. Researchers found that people with burnout showed different brain wave patterns compared to healthy people, including reduced activity in certain frequency bands. The findings suggest burnout may have measurable brain differences that set it apart from depression and chronic fatigue.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Exploring the feasibility of establishing a disease-specific post-mortem tissue bank in the UK: a case study in ME/CFS.

Lacerda, Eliana M, Nacul, Luis, Pheby, Derek et al.·Journal of clinical pathology·2010

This study explored whether it would be possible and acceptable to create a tissue bank in the UK specifically for ME/CFS—a place where donated tissues from people with ME/CFS could be studied after death to better understand the disease. Researchers interviewed patients, held discussion groups, and consulted experts to find out what people thought about this idea. The findings show that both patients and experts believe such a tissue bank would be valuable and could work in practice, as long as certain concerns were properly addressed.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

The PRIME project: developing a patient evidence-base.

Staniszewska, Sophie, Crowe, Sally, Badenoch, Douglas et al.·Health expectations : an international journal of public participation in health care and health policy·2010

The PRIME project created a collection of stories and experiences from 40 people with ME/CFS to help researchers and doctors better understand what it's really like to live with this condition. Instead of just looking at test results and medical costs, this study captured patients' own descriptions of their symptoms, daily challenges, and how the illness affects their lives. The researchers organized all these personal experiences into themes that can be used to guide future ME/CFS research in ways that matter most to patients.

E3 PreliminaryCommentaryPEM unclearEditorial

Chronic fatigue syndrome/myalgic encephalomyelitis: an update.

Capelli, E, Zola, R, Lorusso, L et al.·International journal of immunopathology and pharmacology·2010

ME/CFS is a serious illness of unknown cause that affects about 1 in every 100 people worldwide, with women affected six times more often than men. Most people develop it between ages 20-40, and symptoms typically last several years. While doctors don't yet have a cure, treatment focuses on managing individual symptoms to help patients improve their quality of life.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in adults: a qualitative study of perspectives from professional practice.

Horton, Simon M C, Poland, Fiona, Kale, Swati et al.·BMC family practice·2010

This study spoke with six healthcare providers who were praised by ME/CFS patients for being helpful and understanding. The researchers asked these doctors and specialists what they thought worked best when treating ME/CFS. The key finding was that patients benefit most from doctors who truly listen, show respect, build trust, and recognize how serious and complex the condition is—rather than those who dismiss or minimize ME/CFS.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neuroendocrine and immune contributors to fatigue.

Silverman, Marni N, Heim, Christine M, Nater, Urs M et al.·PM & R : the journal of injury, function, and rehabilitation·2010

This review explores how three body systems—the stress response system, the nervous system, and the immune system—may work together to cause the overwhelming tiredness experienced in ME/CFS. The researchers found that people with chronic fatigue often have an underactive stress-response system, an overactive fight-or-flight response, and immune system imbalances. Understanding how these systems interact may help explain why rest alone doesn't always resolve the fatigue.

Autonomic Nervous SystemImmune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

A qualitative exploration of adolescents' experiences of chronic fatigue syndrome.

Jelbert, Rebecca, Stedmon, Jacqui, Stephens, Alison·Clinical child psychology and psychiatry·2010

This study talked to five teenagers who had recovered from ME/CFS about what the illness was like for them. Through interviews and careful analysis of their stories, researchers found that teens experienced five common themes: trying to understand their illness, feeling a sense of loss, noticing things that seemed to make it better or worse, dealing with difficult emotions, and eventually recovering. The teens' own voices highlight that there is still much we need to learn about how this illness affects young people.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Readability of patient and health care professional targeted dietary supplement leaflets used for diabetes and chronic fatigue syndrome.

Clauson, Kevin A, Zeng-Treitler, Qing, Kandula, Sasikiran·Journal of alternative and complementary medicine (New York, N.Y.)·2010

This study examined whether instruction sheets about dietary supplements for diabetes and ME/CFS are written in a way that patients can easily understand. Researchers found that most of these leaflets are written at a college level (13th grade), far harder than the recommended 6th-grade level. This difficulty may make it harder for patients to understand important information and follow recommendations.

E3 PreliminaryReviewPEM unclearReview-Narrative

The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome.

Silverman, Robert H, Nguyen, Carvell, Weight, Christopher J et al.·Nature reviews. Urology·2010

This review examines XMRV, a newly discovered virus that has been found in some people with prostate cancer and some with ME/CFS. Researchers have found the virus at very different rates in different studies (0-27% in prostate cancer, 0-67% in ME/CFS patients). While some antiviral drugs appear to block this virus, scientists still do not know whether XMRV actually causes either disease.

Immune System

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Evidence browser

What is fatigue? Pathological and nonpathological fatigue.

The role of corticosteroids and stress in chronic pain conditions.

[Understanding chronic fatigue syndrome].

Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors.

Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes.

Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer.

Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequences.

A new hypothesis of chronic fatigue syndrome: co-conditioning theory.

Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways.

Endometriosis-associated Lyme disease.

Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study.

EEG findings in burnout patients.

Exploring the feasibility of establishing a disease-specific post-mortem tissue bank in the UK: a case study in ME/CFS.

The PRIME project: developing a patient evidence-base.

Chronic fatigue syndrome/myalgic encephalomyelitis: an update.

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in adults: a qualitative study of perspectives from professional practice.

Neuroendocrine and immune contributors to fatigue.

A qualitative exploration of adolescents' experiences of chronic fatigue syndrome.

Readability of patient and health care professional targeted dietary supplement leaflets used for diabetes and chronic fatigue syndrome.

The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome.

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