ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

581–600 of 6,157 studies

A status report on chronic fatigue syndrome.

Natelson, Benjamin H, Lange, Gudrun·Environmental health perspectives·2002

This review examines why people develop ME/CFS, a condition marked by extreme tiredness and other symptoms that doctors struggle to explain. The authors suggest that ME/CFS likely isn't caused by a single thing, but rather by several different problems—including brain issues, difficulty handling stress, and concerns about making symptoms worse through activity. They note that while severe infections can trigger ME/CFS, the condition seems to persist through different biological mechanisms than the original infection itself.

Post-Exertional Malaise

E0 ConsensusReviewPEM unclearSystematic-Review

Systematic review of the current literature related to disability and chronic fatigue syndrome.

Ross, S D, Levine, C, Ganz, N et al.·Evidence report/technology assessment (Summary)·2002

This study reviewed all existing research about how ME/CFS affects a person's ability to work and function in daily life. The researchers looked at what scientists had already discovered about disability in ME/CFS to understand the bigger picture of how this illness impacts people. This type of comprehensive review helps identify what we know and what gaps still exist in our understanding.

E0 ConsensusReviewPEM not requiredReview-Narrative

Annotation: Chronic Fatigue Syndrome in children and adolescents.

Garralda, M Elena, Rangel, Luiza·Journal of child psychology and psychiatry, and allied disciplines·2002

This review looked at studies of ME/CFS (chronic fatigue syndrome) in children and teenagers over 20 years. The main symptom is severe tiredness along with other physical symptoms that stop children from doing normal activities. Most cases seem to start after an infection, and many children also have mood problems like depression. Treatment involving family support, gradual increases in activity, and help with mood disorders showed promise, with over two-thirds of children improving.

E0 ConsensusReviewPEM not requiredEditorial

Chronic fatigue syndrome: what role does the autonomic nervous system play in the pathophysiology of this complex illness?

Gerrity, Timothy R, Bates, Janet, Bell, David S et al.·Neuroimmunomodulation·2002

This paper brings together expert opinions about how the autonomic nervous system (the part of your nervous system that controls automatic functions like heart rate and breathing) may be involved in ME/CFS. The authors reviewed what was known in 2000 about connections between autonomic nervous system problems and other system dysfunctions seen in ME/CFS, including immune and hormone abnormalities.

Autonomic Nervous System

E0 ConsensusReviewPEM not requiredSystematic-Review

Systematic review of mental health interventions for patients with common somatic symptoms: can research evidence from secondary care be extrapolated to primary care?

Raine, Rosalind, Haines, Andy, Sensky, Tom et al.·BMJ (Clinical research ed.)·2002

Researchers reviewed 61 studies testing mental health treatments for ME/CFS, irritable bowel syndrome, and chronic back pain. They found that cognitive behavioural therapy and behaviour therapy helped with ME/CFS and back pain, while antidepressants helped with irritable bowel syndrome. Treatments worked better when delivered in hospital settings than in GP surgeries, possibly because hospital patients had more severe illness or received closer supervision.

E0 ConsensusReviewPEM not requiredReview-Narrative

Dysautonomias: clinical disorders of the autonomic nervous system.

Goldstein, David S, Robertson, David, Esler, Murray et al.·Annals of internal medicine·2002

This review examines dysautonomias—conditions where the autonomic nervous system (the part of your body that controls heart rate, blood pressure, and other automatic functions) stops working properly. The authors discuss how these problems can range from occasional fainting spells to serious nerve damage. Importantly, they note that ME/CFS patients often show signs of orthostatic intolerance (difficulty maintaining blood pressure when standing), but a common treatment that works for other autonomic conditions does not appear to help ME/CFS patients.

Autonomic Nervous System

E0 ConsensusReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Reid, Steven, Chalder, Trudie, Cleare, Anthony et al.·Clinical evidence·2002

This systematic review examined all available evidence about chronic fatigue syndrome (ME/CFS) to understand what treatments work best. The authors looked at multiple studies together to see what the overall evidence shows about managing this condition. This type of review helps doctors and patients understand which approaches have the strongest scientific support.

E0 ConsensusReviewPEM unclearSystematic-Review

Interventions for the treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis.

Bagnall, A M, Whiting, P, Richardson, R et al.·Quality & safety in health care·2002

This review looked at all the available research studies about treatments for ME/CFS to understand which approaches actually work. The authors examined evidence from previously published studies to summarize what we know about managing this condition. This type of review helps doctors and patients understand the current state of treatment options based on the best available evidence.

E0 ConsensusReviewPEM unclearReview-Narrative

Fibromyalgia syndrome, idiopathic widespread persistent pain or syndrome of myalgic encephalomyelopathy (SME): what is its nature?

Mehendale, Anand W, Goldman, Mark P·Pain practice : the official journal of World Institute of Pain·2002

This review summarizes what scientists and doctors know about fibromyalgia and ME/CFS by examining research from the past 25 years. The authors looked at studies on symptoms, causes, blood test findings, brain imaging, and what patients reported about their experiences. They propose that these conditions may need to be understood in an entirely new way.

Pain and Sensitization

E0 ConsensusGuidelinePEM unclearGuideline

Chronic fatigue syndrome. Clinical practice guidelines--2002.

Working Group of the Royal Australasian College of Physicians·The Medical journal of Australia·2002

These guidelines were created by Australian medical experts in 2002 to help doctors recognize, diagnose, and treat ME/CFS (a condition also called chronic fatigue syndrome). The guidelines set standards for how patients should be evaluated and managed, based on the best medical knowledge available at that time. They aim to improve the quality of care patients receive and reduce confusion about how to properly approach this illness.

Diagnostics

E0 ConsensusGuidelinePEM unclearGuideline

Chronic fatigue syndrome: a step towards agreement.

Clark, Christopher, Buchwald, Dedra, MacIntyre, Anne et al.·Lancet (London, England)·2002

This 2002 guideline paper from leading ME/CFS researchers brought together different international perspectives on how to define and diagnose chronic fatigue syndrome, aiming to reduce confusion among doctors. The authors reviewed existing diagnostic criteria and clinical approaches to help create more consistent standards for identifying the condition. This work was an important step toward getting doctors and researchers to agree on what ME/CFS actually is.

Diagnostics

E0 ConsensusReviewPEM not requiredReview-Narrative

Behavioral medicine approaches to somatoform disorders.

Looper, Karl J, Kirmayer, Laurence J·Journal of consulting and clinical psychology·2002

This review looked at research studies testing whether cognitive-behavioral therapy (CBT)—a type of talk therapy that helps people change unhelpful thinking patterns—works for conditions where people have physical symptoms that doctors cannot fully explain. The review found that CBT appears helpful for several conditions including chronic fatigue syndrome, though the quality and amount of evidence varies.

E0 ConsensusReviewPEM not requiredSystematic-Review

Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?

Whitehead, William E, Palsson, Olafur, Jones, Kenneth R·Gastroenterology·2002

This review examined how irritable bowel syndrome (IBS) often occurs together with other conditions like fibromyalgia, chronic fatigue syndrome, anxiety, and depression. Researchers found that patients with IBS frequently have multiple other health problems at the same time, suggesting these conditions may share common underlying mechanisms rather than being completely separate disorders.

E0 ConsensusReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome and fibromyalgia: clinical assessment and treatment.

Friedberg, F, Jason, L A·Journal of clinical psychology·2001

This review examines how ME/CFS and fibromyalgia are similar conditions that doctors don't fully understand yet. The authors looked at research on what causes these illnesses, how to diagnose them (including checking for depression and anxiety), and what treatments work—including medications, alternative therapies, and talking with a therapist. The study suggests that mental health professionals can play an important role in helping patients manage their symptoms.

Diagnostics

E0 ConsensusReviewPEM not requiredReview-Narrative

Coping and illness cognitions: chronic fatigue syndrome.

Ax, S, Gregg, V H, Jones, D·Clinical psychology review·2001

This study reviews what we know about how people with ME/CFS cope with their illness and how their beliefs about the condition affect their health. The researchers found that how patients think about and manage their illness may play an important role in their physical and mental well-being. The study suggests that understanding these coping strategies could help doctors develop better treatments for ME/CFS.

E0 ConsensusReviewPEM not requiredSystematic-Review

A review of the evidence for overlap among unexplained clinical conditions.

Aaron, L A, Buchwald, D·Annals of internal medicine·2001

This review examined eight unexplained illnesses—including ME/CFS, fibromyalgia, and irritable bowel syndrome—and found they share many similarities in symptoms (like fatigue and pain), how they affect daily life, and how they respond to laboratory tests. The researchers discovered that many patients have more than one of these conditions at the same time, suggesting they may be related or overlap in important ways.

Diagnostics

E0 ConsensusReviewPEM not requiredSystematic-Review

Interventions for the treatment and management of chronic fatigue syndrome: a systematic review.

Whiting, P, Bagnall, A M, Sowden, A J et al.·JAMA·2001

This review looked at 44 studies testing different treatments for ME/CFS to see which ones actually work. The researchers found that cognitive behavioral therapy (talk-based therapy) and graded exercise therapy (gradually increasing activity) showed the most promise, while other treatments like supplements and immunological therapies had unclear or limited benefits. However, the studies used different measurements and methods, making it hard to draw firm conclusions.

Interventions

E0 ConsensusReviewPEM not requiredReview-Narrative

Fibromyalgia and other unexplained clinical conditions.

Aaron, L A, Buchwald, D·Current rheumatology reports·2001

This review examined research comparing fibromyalgia with ME/CFS and other related conditions like irritable bowel syndrome and migraines. The researchers looked at studies that measured how bodies of people with these conditions worked differently, trying to understand what might cause them. The goal was to see whether these conditions share common underlying problems.

E0 ConsensusReviewPEM not requiredReview-Narrative

Controlled exposures to volatile organic compounds in sensitive groups.

Fiedler, N, Kipen, H M·Annals of the New York Academy of Sciences·2001

This review looked at studies where people with chemical sensitivities were exposed to different odors and chemical mixtures in controlled lab settings. Researchers found that people with chemical sensitivities did have real symptoms when exposed to certain chemicals, even at low levels, but these symptoms weren't always linked to measurable changes in heart rate, breathing, or other body functions that usually indicate stress.

Autonomic Nervous System

E0 ConsensusReviewPEM not requiredReview-Narrative

Autonomic nervous system derangement in fibromyalgia syndrome and related disorders.

Cohen, H, Neumann, L, Kotler, M et al.·The Israel Medical Association journal : IMAJ·2001

This review examines how the autonomic nervous system—the part of your nervous system that controls heart rate, breathing, and digestion automatically—may not work properly in fibromyalgia and related conditions like ME/CFS and irritable bowel syndrome. Researchers found evidence that this system dysfunction could have important health consequences, including increased risk of heart problems. However, studies on this topic have produced mixed and sometimes contradictory results.

Autonomic Nervous System

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Evidence browser

A status report on chronic fatigue syndrome.

Systematic review of the current literature related to disability and chronic fatigue syndrome.

Annotation: Chronic Fatigue Syndrome in children and adolescents.

Chronic fatigue syndrome: what role does the autonomic nervous system play in the pathophysiology of this complex illness?

Systematic review of mental health interventions for patients with common somatic symptoms: can research evidence from secondary care be extrapolated to primary care?

Dysautonomias: clinical disorders of the autonomic nervous system.

Chronic fatigue syndrome.

Interventions for the treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis.

Fibromyalgia syndrome, idiopathic widespread persistent pain or syndrome of myalgic encephalomyelopathy (SME): what is its nature?

Chronic fatigue syndrome. Clinical practice guidelines--2002.

Chronic fatigue syndrome: a step towards agreement.

Behavioral medicine approaches to somatoform disorders.

Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?

Chronic fatigue syndrome and fibromyalgia: clinical assessment and treatment.

Coping and illness cognitions: chronic fatigue syndrome.

A review of the evidence for overlap among unexplained clinical conditions.

Interventions for the treatment and management of chronic fatigue syndrome: a systematic review.

Fibromyalgia and other unexplained clinical conditions.

Controlled exposures to volatile organic compounds in sensitive groups.

Autonomic nervous system derangement in fibromyalgia syndrome and related disorders.

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