ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

581–600 of 6,122 studies

E0 ConsensusReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Reid, Steven, Chalder, Trudie, Cleare, Anthony et al.·Clinical evidence·2002

This systematic review examined all available evidence about chronic fatigue syndrome (ME/CFS) to understand what treatments work best. The authors looked at multiple studies together to see what the overall evidence shows about managing this condition. This type of review helps doctors and patients understand which approaches have the strongest scientific support.

E0 ConsensusReviewPEM not requiredSystematic-Review

A review of the evidence for overlap among unexplained clinical conditions.

Aaron, L A, Buchwald, D·Annals of internal medicine·2001

This review examined eight unexplained illnesses—including ME/CFS, fibromyalgia, and irritable bowel syndrome—and found they share many similarities in symptoms (like fatigue and pain), how they affect daily life, and how they respond to laboratory tests. The researchers discovered that many patients have more than one of these conditions at the same time, suggesting they may be related or overlap in important ways.

Diagnostics

E0 ConsensusReviewPEM unclearSystematic-Review

Defining and managing chronic fatigue syndrome.

Mulrow, C D, Ramirez, G, Cornell, J E et al.·Evidence report/technology assessment (Summary)·2001

This 2001 review examined the medical literature on chronic fatigue syndrome to summarize what was known about how to define and manage the condition. The authors looked at existing research to identify consistent diagnostic criteria and treatment approaches. The goal was to create a clear picture of CFS based on the best available evidence at that time.

Diagnostics

E0 ConsensusReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome and fibromyalgia: clinical assessment and treatment.

Friedberg, F, Jason, L A·Journal of clinical psychology·2001

This review examines how ME/CFS and fibromyalgia are similar conditions that doctors don't fully understand yet. The authors looked at research on what causes these illnesses, how to diagnose them (including checking for depression and anxiety), and what treatments work—including medications, alternative therapies, and talking with a therapist. The study suggests that mental health professionals can play an important role in helping patients manage their symptoms.

Diagnostics

E0 ConsensusReviewPEM not requiredReview-Narrative

Controlled exposures to volatile organic compounds in sensitive groups.

Fiedler, N, Kipen, H M·Annals of the New York Academy of Sciences·2001

This review looked at studies where people with chemical sensitivities were exposed to different odors and chemical mixtures in controlled lab settings. Researchers found that people with chemical sensitivities did have real symptoms when exposed to certain chemicals, even at low levels, but these symptoms weren't always linked to measurable changes in heart rate, breathing, or other body functions that usually indicate stress.

Autonomic Nervous System

E0 ConsensusReviewPEM not requiredReview-Narrative

Fibromyalgia and other unexplained clinical conditions.

Aaron, L A, Buchwald, D·Current rheumatology reports·2001

This review examined research comparing fibromyalgia with ME/CFS and other related conditions like irritable bowel syndrome and migraines. The researchers looked at studies that measured how bodies of people with these conditions worked differently, trying to understand what might cause them. The goal was to see whether these conditions share common underlying problems.

E0 ConsensusReviewPEM not requiredSystematic-Review

Interventions for the treatment and management of chronic fatigue syndrome: a systematic review.

Whiting, P, Bagnall, A M, Sowden, A J et al.·JAMA·2001

This review looked at 44 studies testing different treatments for ME/CFS to see which ones actually work. The researchers found that cognitive behavioral therapy (talk-based therapy) and graded exercise therapy (gradually increasing activity) showed the most promise, while other treatments like supplements and immunological therapies had unclear or limited benefits. However, the studies used different measurements and methods, making it hard to draw firm conclusions.

Interventions

E0 ConsensusReviewPEM not requiredReview-Narrative

Neuropsychological functioning in chronic fatigue syndrome: a review.

Michiels, V, Cluydts, R·Acta psychiatrica Scandinavica·2001

This review looked at studies examining thinking and memory problems in ME/CFS patients. Researchers found that people with ME/CFS commonly experience slower thinking speed, difficulty holding information in working memory, and trouble learning new information. The study noted that brain scans haven't shown a consistent pattern that uniquely identifies ME/CFS patients, and that fatigue severity doesn't fully explain the cognitive problems.

Cognitive Impairment

E0 ConsensusReviewPEM not requiredReview-Narrative

Coping and illness cognitions: chronic fatigue syndrome.

Ax, S, Gregg, V H, Jones, D·Clinical psychology review·2001

This study reviews what we know about how people with ME/CFS cope with their illness and how their beliefs about the condition affect their health. The researchers found that how patients think about and manage their illness may play an important role in their physical and mental well-being. The study suggests that understanding these coping strategies could help doctors develop better treatments for ME/CFS.

E0 ConsensusReviewPEM not requiredSystematic-Review

[What happens to the fibromyalgia syndrome?].

Maquet, D, Croisier, J L, Crielaard, J M·Annales de readaptation et de medecine physique : revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique·2001

This systematic review examined fibromyalgia research to understand its diagnostic criteria, how common it is, what causes it, and how it is treated. The authors reviewed 58 articles on fibromyalgia and 12 on related conditions. Fibromyalgia is characterized by widespread muscle and skeletal pain lasting at least three months, often with poor sleep quality and psychological changes, though the exact mechanisms remain unclear and likely involve multiple factors.

Pain and Sensitization

E0 ConsensusReviewPEM not requiredReview-Narrative

Autonomic nervous system derangement in fibromyalgia syndrome and related disorders.

Cohen, H, Neumann, L, Kotler, M et al.·The Israel Medical Association journal : IMAJ·2001

This review examined studies on how the autonomic nervous system (the part that controls heart rate, breathing, and other automatic functions) may be altered in fibromyalgia and related conditions including chronic fatigue syndrome. Researchers found evidence that autonomic nervous system changes were observed in these patient groups, though studies reported mixed results. The review suggests these changes might have long-term health implications, but the significance for individual patients remains unclear.

Autonomic Nervous System

E0 ConsensusReviewPEM not requiredReview-Narrative

The neuroendocrinology of chronic fatigue syndrome and fibromyalgia.

Parker, A J, Wessely, S, Cleare, A J·Psychological medicine·2001

This review examined how hormones and brain chemicals differ in ME/CFS patients. Researchers found that some patients have lower stress hormone (cortisol) levels, and their bodies show unusual patterns in serotonin and other brain chemical systems when tested. However, the findings were inconsistent across studies, and it's still unclear whether these changes cause ME/CFS symptoms or result from living with the illness.

Endocrine Disruption

E0 ConsensusReviewPEM not requiredSystematic-Review

Cognitive behaviour therapy for adults with chronic fatigue syndrome.

Price, J R, Couper, J·The Cochrane database of systematic reviews·2000

This review examined whether cognitive behaviour therapy (CBT)—a type of talk therapy that helps people change unhelpful thinking patterns and gradually return to activities—helps adults with ME/CFS. Researchers looked at three high-quality studies and found that CBT did improve physical functioning compared to standard medical care or relaxation therapy. However, the evidence was limited to people who could attend clinic appointments; more research is needed in people with milder or more severe forms of the illness.

Interventions

E0 ConsensusReviewPEM unclearSystematic-Review

The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders.

Heim, C, Ehlert, U, Hellhammer, D H·Psychoneuroendocrinology·2000

This review examines why some people under chronic stress or after trauma have abnormally low levels of the stress hormone cortisol—a condition called hypocortisolism. The authors found that low cortisol appears in several conditions including ME/CFS, fibromyalgia, and rheumatoid arthritis, not just in PTSD. They propose that persistently low cortisol may make people more vulnerable to developing stress-related illnesses.

Endocrine Disruption

E0 ConsensusReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Reid, S, Chalder, T, Cleare, A et al.·BMJ (Clinical research ed.)·2000

This was a systematic review that brought together existing research about chronic fatigue syndrome (ME/CFS) to understand what was known at the time. The researchers looked at multiple studies to summarize the current evidence about the condition. This type of overview helps doctors and patients understand the state of knowledge about ME/CFS.

Interventions

E0 ConsensusReviewPEM unclearReview-Narrative

Review of clinical and psychobiological dimensions of the chronic fatigue syndrome: differentiation from depression and contribution of sleep dysfunctions.

Fischler, B·Sleep medicine reviews·1999

This review examined how ME/CFS differs from depression and what role sleep problems play in the condition. The researchers found that ME/CFS is a distinct illness with its own biological features—not just depression wearing a different mask. While sleep problems are common in ME/CFS, they don't fully explain why patients feel so exhausted and unwell.

Sleep

E0 ConsensusReviewPEM not requiredReview-Narrative

Functional somatic syndromes: one or many?

Wessely, S, Nimnuan, C, Sharpe, M·Lancet (London, England)·1999

This study looked at several long-term illnesses that cause many physical symptoms but don't show obvious damage on standard medical tests, including ME/CFS and irritable bowel syndrome. The researchers found that these conditions have much more in common with each other than previously thought—they affect similar types of patients, cause overlapping symptoms, and respond to treatment in similar ways. Rather than treating each condition as completely separate, the authors suggest doctors and researchers should think of them as related conditions on a spectrum.

Diagnostics

E0 ConsensusReviewPEM not requiredReview-Narrative

Review of juvenile primary fibromyalgia and chronic fatigue syndrome.

Breau, L M, McGrath, P J, Ju, L H·Journal of developmental and behavioral pediatrics : JDBP·1999

This review examined research on fibromyalgia and chronic fatigue syndrome (ME/CFS) in children. The authors found that these conditions in young people may work differently than they do in adults, and that they might be more closely related to each other than previously thought. The review suggests that these illnesses are likely caused by biological and genetic factors rather than psychological problems.

Diagnostics

E0 ConsensusReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: reviewing the research findings.

Johnson, S K, DeLuca, J, Natelson, B H·Annals of behavioral medicine : a publication of the Society of Behavioral Medicine·1999

This 1999 review summarizes what researchers had learned about ME/CFS up to that point, covering theories about its causes, how common it is, and what treatments were being studied. The authors found that ME/CFS appears to involve multiple factors—psychiatric, immune, neurological, and hormonal—rather than a single cause, and that patients may represent different subgroups. However, as a review of existing literature rather than a new study, it reports on what other researchers had observed rather than providing definitive answers about the illness itself.

Immune System

E0 ConsensusReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: an immunological perspective.

Vollmer-Conna, U, Lloyd, A, Hickie, I et al.·The Australian and New Zealand journal of psychiatry·1998

This review examines whether immune system problems might cause ME/CFS symptoms, particularly in the brain. The researchers found that while immune chemicals called cytokines are likely involved in ME/CFS, the results from studies measuring these chemicals in the blood have been mixed and unclear. They suggest that abnormal cytokine activity happening directly inside the brain—rather than in the bloodstream—may be more important for explaining the neurological symptoms patients experience.

Immune System

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Evidence Atlas

Evidence browser

Chronic fatigue syndrome.

A review of the evidence for overlap among unexplained clinical conditions.

Defining and managing chronic fatigue syndrome.

Chronic fatigue syndrome and fibromyalgia: clinical assessment and treatment.

Controlled exposures to volatile organic compounds in sensitive groups.

Fibromyalgia and other unexplained clinical conditions.

Interventions for the treatment and management of chronic fatigue syndrome: a systematic review.

Neuropsychological functioning in chronic fatigue syndrome: a review.

Coping and illness cognitions: chronic fatigue syndrome.

[What happens to the fibromyalgia syndrome?].

Autonomic nervous system derangement in fibromyalgia syndrome and related disorders.

The neuroendocrinology of chronic fatigue syndrome and fibromyalgia.

Cognitive behaviour therapy for adults with chronic fatigue syndrome.

The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders.

Chronic fatigue syndrome.

Review of clinical and psychobiological dimensions of the chronic fatigue syndrome: differentiation from depression and contribution of sleep dysfunctions.

Functional somatic syndromes: one or many?

Review of juvenile primary fibromyalgia and chronic fatigue syndrome.

Chronic fatigue syndrome: reviewing the research findings.

Chronic fatigue syndrome: an immunological perspective.

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