ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

81–100 of 1,202 studies

E0 ConsensusReviewPEM unclearSystematic-Review

A systematic review of natural killer cells profile and cytotoxic function in myalgic encephalomyelitis/chronic fatigue syndrome.

Eaton-Fitch, Natalie, du Preez, Stanley, Cabanas, Hélène et al.·Systematic reviews·2019

This review examined research on natural killer cells, which are immune cells that help fight infections and abnormal cells in the body. Scientists found that people with ME/CFS consistently have natural killer cells that don't work as well as they should. This discovery was the most reliable and consistent finding across all the studies reviewed, suggesting it could be an important marker for understanding ME/CFS.

Immune System

E0 ConsensusReviewPEM requiredReview-Narrative

[Myalgic encephalomyelitis or chronic fatigue syndrome].

Brinth, Louise, Nielsen, Henrik, Varming, Kim et al.·Ugeskrift for laeger·2019

ME/CFS is a serious condition that causes extreme tiredness affecting both mind and body, along with pain, sleep problems, difficulty thinking clearly, and a symptom called post-exertional malaise where activity makes symptoms worse. Research has found changes in patients' cells, hormones, immune systems, and how their bodies process energy, which could lead to better ways to diagnose and treat this condition.

BiomarkersEnergy MetabolismImmune SystemPost-Exertional Malaise

E0 ConsensusReviewPEM requiredReview-Narrative

[Neurologic Abnormalities in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review].

Komaroff, Anthony L, Takahashi, Ryosuke, Yamamura, Takashi et al.·Brain and nerve = Shinkei kenkyu no shinpo·2018

This review examines objective, measurable evidence that ME/CFS is a real physical illness, not just a psychological condition. Researchers looked at studies showing that ME/CFS involves problems with the brain, immune system, and how the body uses energy. They found that immune activation—where the body's defense system becomes overactive—may be a key driver of ME/CFS symptoms.

Immune SystemCognitive ImpairmentPost-Exertional Malaise

E0 ConsensusReviewPEM unclearReview-Narrative

Metabolic abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a mini-review.

Tomas, Cara, Newton, Julia·Biochemical Society transactions·2018

This review examines research showing that people with ME/CFS have problems with how their bodies use energy at a cellular level. Scientists have found several different metabolic abnormalities—issues with immune function, mitochondria (the cell's power plants), muscle acid buildup, and other energy-related problems—that could potentially be used as biomarkers (measurable signs) to diagnose the disease. However, no single test can yet reliably identify ME/CFS.

BiomarkersImmune System

E0 ConsensusReviewPEM unclearReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Evidence for an autoimmune disease.

Sotzny, Franziska, Blanco, Julià, Capelli, Enrica et al.·Autoimmunity reviews·2018

This review examines evidence that ME/CFS may be caused by the immune system attacking the body (autoimmune disease). Researchers found that people with ME/CFS have unusual immune patterns, including abnormal antibodies and changes in immune cells. Importantly, a treatment that removes certain immune cells (rituximab) helped about half of ME/CFS patients in clinical trials, suggesting an autoimmune mechanism in at least some people.

Energy MetabolismImmune System

E0 ConsensusReviewPEM unclearReview-Narrative

Recognizing the Leaky Gut as a Trans-diagnostic Target for Neuroimmune Disorders Using Clinical Chemistry and Molecular Immunology Assays.

Simeonova, Denitsa, Ivanovska, Mariya, Murdjeva, Mariana et al.·Current topics in medicinal chemistry·2018

This review examines how a condition called 'leaky gut'—where the intestinal barrier becomes too permeable, allowing harmful bacteria to enter the bloodstream—may contribute to ME/CFS and other conditions affecting mood and energy. The authors summarize available blood and stool tests that can help doctors recognize leaky gut in practice. They identify specific markers (like immune responses to bacterial toxins and inflammatory proteins) that could signal intestinal barrier problems.

Gut MicrobiomeImmune System

E0 ConsensusReviewPEM not requiredReview-Narrative

Antibodies Against GPCR.

Meyer, Carlotto, Heidecke, Harald·Frontiers in bioscience (Landmark edition)·2018

This review examines how the body's own antibodies (immune proteins) can mistakenly attack receptors on cell surfaces called GPCRs, which are involved in many bodily functions. The authors summarize evidence that these misdirected antibodies may play a role in several diseases, including chronic fatigue syndrome (ME/CFS), heart disease, and autoimmune conditions. Understanding these antibodies could help doctors develop better diagnostic tests and treatments.

Immune System

E0 ConsensusReviewPEM unclearReview-Narrative

The "Biology-First" Hypothesis: Functional disorders may begin and end with biology-A scoping review.

Enck, P, Mazurak, N·Neurogastroenterology and motility·2018

This study reviewed research showing that infections can trigger long-lasting functional disorders—conditions where the body doesn't work properly but standard tests appear normal. The authors propose that these disorders start from biological changes (like immune dysfunction or altered gut bacteria) caused by the infection, and that psychological factors develop as a result rather than being the root cause. This challenges the common belief that such conditions are mainly psychological or social in nature.

Immune System

E0 ConsensusReviewPEM unclearReview-Narrative

Nutritional modulation of the intestinal microbiota; future opportunities for the prevention and treatment of neuroimmune and neuroinflammatory disease.

Lombardi, Vincent C, De Meirleir, Kenny L, Subramanian, Krishnamurthy et al.·The Journal of nutritional biochemistry·2018

Your gut bacteria and brain communicate constantly with each other in ways that affect your immune system and inflammation levels. This review looks at how diet and nutrition can change your gut bacteria in ways that might help prevent or treat brain-related diseases that involve immune problems. The authors suggest that maintaining healthy gut bacteria through food choices could be an important treatment strategy.

NeuroinflammationImmune System

E0 ConsensusReviewPEM unclearReview-Narrative

Does the microbiome and virome contribute to myalgic encephalomyelitis/chronic fatigue syndrome?

Newberry, Fiona, Hsieh, Shen-Yuan, Wileman, Tom et al.·Clinical science (London, England : 1979)·2018

This review examines whether changes in the bacteria living in our gut and the viruses that affect those bacteria might contribute to ME/CFS. While previous studies have focused mainly on bacterial changes, this paper points out that viruses—especially those that attack bacteria—are equally important to understand. The authors explain that inconsistencies between different microbiome studies make it hard to draw clear conclusions, and call for more standardized research methods.

Immune System

E0 ConsensusReviewPEM unclearReview-Narrative

Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities.

Slyepchenko, Anastasiya, Maes, Michael, Jacka, Felice N et al.·Psychotherapy and psychosomatics·2017

This review examines how changes in gut bacteria and a 'leaky gut' (where bacteria can cross the intestinal barrier) may contribute to depression and related conditions like ME/CFS. The authors found evidence that diet, gut bacteria composition, and immune system activation are interconnected, and that these connections may explain why depression often occurs alongside conditions like irritable bowel syndrome, ME/CFS, obesity, and diabetes.

Immune System

E0 ConsensusReviewPEM unclearSystematic-Review

A systematic review of the association between fatigue and genetic polymorphisms.

Wang, Tengteng, Yin, Jie, Miller, Andrew H et al.·Brain, behavior, and immunity·2017

Researchers reviewed 50 studies to understand whether differences in our genes (called genetic polymorphisms) might make some people more likely to experience severe fatigue. They found that certain genetic variations in immune system and brain chemistry genes were linked to fatigue across different diseases, including ME/CFS. This suggests that our genes may play a role in determining how tired we become.

Immune System

E0 ConsensusReviewPEM unclearReview-Narrative

Hypothalamic-Pituitary-Adrenal Hypofunction in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) as a Consequence of Activated Immune-Inflammatory and Oxidative and Nitrosative Pathways.

Morris, Gerwyn, Anderson, George, Maes, Michael·Molecular neurobiology·2017

This review examines why people with ME/CFS often have low cortisol levels (a stress hormone). The researchers found that the problem likely starts with an overactive immune system producing excessive inflammatory markers, which then damages the body's stress-hormone system. This is important because it suggests the low cortisol is a consequence of the disease, not its cause.

Immune System

E0 ConsensusReviewPEM unclearReview-Narrative

Chronic fatigue syndrome and the immune system: Where are we now?

Mensah, Fane Kojo Fosu, Bansal, Amolak Singh, Ford, Brian et al.·Neurophysiologie clinique = Clinical neurophysiology·2017

ME/CFS is a complex illness that causes exhaustion, headaches, and thinking problems, and gets worse with activity. Researchers have suspected for years that the immune system plays a role in ME/CFS, but studies have produced confusing and sometimes contradictory results. This review examines what we currently know about immune system changes in ME/CFS and discusses promising new research directions, including the possibility that certain immune-targeting treatments might help patients improve.

Immune System

E0 ConsensusReviewPEM not requiredEditorial

Evidence Refuting the Existence of Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA).

Ameratunga, Rohan, Gillis, David, Gold, Michael et al.·The journal of allergy and clinical immunology. In practice·2017

This study examined whether a theory called ASIA (a proposed condition blamed on vaccine adjuvants like aluminum) is supported by scientific evidence. Researchers looked at data from people who received allergen immunotherapy, which contains much more aluminum than vaccines, and found they actually had fewer autoimmune diseases, not more. The study concludes that current evidence does not support the idea that aluminum in vaccines causes autoimmune problems.

Immune System

E0 ConsensusReviewPEM unclearSystematic-Review

Serious adverse events after HPV vaccination: a critical review of randomized trials and post-marketing case series.

Martínez-Lavín, Manuel, Amezcua-Guerra, Luis·Clinical rheumatology·2017

This review examined safety reports from HPV vaccine studies and medical databases. The authors found that some large vaccine trials reported more serious side effects in vaccinated groups than in control groups, though researchers did not conclude these were caused by the vaccine. The study raises questions about how thoroughly vaccine safety is monitored and reported.

Immune System

E0 ConsensusReviewPEM unclearReview-Narrative

A Role for the Intestinal Microbiota and Virome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)?

Navaneetharaja, Navena, Griffiths, Verity, Wileman, Tom et al.·Journal of clinical medicine·2016

This review examines whether infections—particularly viruses in the gut—might trigger ME/CFS. The authors suggest that an imbalance in the gut's microbial and viral communities could be a key factor in developing the disease. They propose that understanding these gut infections could help identify better treatments and ways to prevent ME/CFS.

Immune System

E0 ConsensusReviewPEM not requiredSystematic-Review

Chronic fatigue syndrome and circulating cytokines: A systematic review.

Blundell, S, Ray, K K, Buckland, M et al.·Brain, behavior, and immunity·2015

Researchers reviewed 38 studies looking at whether immune proteins called cytokines are elevated in people with ME/CFS. They found that one specific cytokine, TGF-β, was consistently higher in people with ME/CFS compared to healthy people in about 63% of studies. However, most other immune proteins measured were normal, and exercise did not change cytokine levels differently between people with ME/CFS and healthy controls.

Immune SystemPost-Exertional Malaise

E0 ConsensusReviewPEM not requiredReview-Narrative

Fecal microbiota transplantation broadening its application beyond intestinal disorders.

Xu, Meng-Que, Cao, Hai-Long, Wang, Wei-Qiang et al.·World journal of gastroenterology·2015

This review explores how fecal microbiota transplantation (FMT)—transferring healthy gut bacteria from donors to patients—might help treat conditions beyond intestinal diseases, including chronic fatigue syndrome. The authors found that FMT has shown promise in improving insulin sensitivity in metabolic disease and has produced favorable results in case reports of patients with Parkinson's disease, multiple sclerosis, and chronic fatigue syndrome, suggesting that gut bacteria imbalance may contribute to these conditions.

Immune System

E0 ConsensusReviewPEM not requiredReview-Narrative

The inflammatory hypothesis of mood spectrum broadened to fibromyalgia and chronic fatigue syndrome.

Dell'Osso, Liliana, Bazzichi, Laura, Baroni, Stefano et al.·Clinical and experimental rheumatology·2015

This review examined whether ME/CFS, fibromyalgia, and mood disorders like depression might share similar root causes involving inflammation and immune system dysfunction. Researchers looked at scientific papers from 2000-2014 and found striking similarities in how these conditions affect the brain, nervous system, and immune system. The findings suggest these seemingly different conditions may be connected through common biological mechanisms rather than being completely separate diseases.

NeuroinflammationImmune System

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A systematic review of natural killer cells profile and cytotoxic function in myalgic encephalomyelitis/chronic fatigue syndrome.

[Myalgic encephalomyelitis or chronic fatigue syndrome].

[Neurologic Abnormalities in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review].

Metabolic abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a mini-review.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Evidence for an autoimmune disease.

Recognizing the Leaky Gut as a Trans-diagnostic Target for Neuroimmune Disorders Using Clinical Chemistry and Molecular Immunology Assays.

Antibodies Against GPCR.

The "Biology-First" Hypothesis: Functional disorders may begin and end with biology-A scoping review.

Nutritional modulation of the intestinal microbiota; future opportunities for the prevention and treatment of neuroimmune and neuroinflammatory disease.

Does the microbiome and virome contribute to myalgic encephalomyelitis/chronic fatigue syndrome?

Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities.

A systematic review of the association between fatigue and genetic polymorphisms.

Hypothalamic-Pituitary-Adrenal Hypofunction in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) as a Consequence of Activated Immune-Inflammatory and Oxidative and Nitrosative Pathways.

Chronic fatigue syndrome and the immune system: Where are we now?

Evidence Refuting the Existence of Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA).

Serious adverse events after HPV vaccination: a critical review of randomized trials and post-marketing case series.

A Role for the Intestinal Microbiota and Virome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)?

Chronic fatigue syndrome and circulating cytokines: A systematic review.

Fecal microbiota transplantation broadening its application beyond intestinal disorders.

The inflammatory hypothesis of mood spectrum broadened to fibromyalgia and chronic fatigue syndrome.

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