Apel-Paz, M, Lior, B, Shemesh-Kigli, R · Harefuah · 2000
This review article examines ME/CFS, describing what the disease is and discussing different treatment approaches. The authors provide an overview of the condition and explore various ways doctors have tried to help patients manage their symptoms. This type of review helps bring together existing knowledge about the illness and its management.
Review articles play an important role in consolidating medical knowledge and helping clinicians and patients understand the current state of disease understanding and available treatment options. This work contributes to the historical record of how ME/CFS was conceptualized and managed in the year 2000, which helps researchers track the evolution of diagnostic criteria and therapeutic approaches.
As a review article rather than original research, this study does not present new experimental data or clinical trial results. It cannot prove the effectiveness of any specific treatment, nor can it establish causation for any aspect of ME/CFS. The findings represent a synthesis of previously published work and reflect the state of knowledge in 2000, which has since been substantially updated.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Apel-Paz, M, Lior, B, & Shemesh-Kigli, R (2000). [Chronic fatigue syndrome--the disease and approaches to treatment].. Harefuah. https://pubmed.ncbi.nlm.nih.gov/10979475/
BibTeX
@article{mecfsatlas-apel-paz-2000-chronic-fatigue,
author = {Apel-Paz, M and Lior, B and Shemesh-Kigli, R},
title = {[Chronic fatigue syndrome--the disease and approaches to treatment].},
journal = {Harefuah},
year = {2000},
note = {PubMed: 10979475},
url = {https://www.mecfsatlas.com/evidence/apel-paz-2000-chronic-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/apel-paz-2000-chronic-fatigue
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