Aspler, Anne L, Bolshin, Carly, Vernon, Suzanne D et al. · Behavioral and brain functions : BBF · 2008 · DOI
This study looked at blood samples from 111 women to see if people with ME/CFS have different patterns of immune cell activity compared to healthy controls. Researchers found that certain immune cells—particularly B cells and neutrophils—showed unusual patterns of communication with each other in ME/CFS patients. These findings suggest the body's immune system is stuck in an activated state, which could explain why people with ME/CFS experience persistent fatigue and symptoms.
This study provides molecular evidence that ME/CFS involves distinct patterns of immune dysregulation—specifically aberrant communication between B cells, monocytes, and neutrophils—rather than simple up- or downregulation of individual immune components. Identifying these co-expression network signatures could enable earlier, more accurate diagnosis and reveal potential therapeutic targets for reducing persistent immune activation in ME/CFS.
This study does not prove that the identified immune patterns cause ME/CFS symptoms or that correcting these patterns would improve outcomes. The cross-sectional design cannot establish whether immune dysregulation precedes or results from illness. Additionally, these findings describe correlation patterns in gene expression but do not demonstrate the functional consequences of these altered networks or their relationship to clinical severity.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Aspler, Anne L, Bolshin, Carly, Vernon, Suzanne D, & Broderick, Gordon (2008). Evidence of inflammatory immune signaling in chronic fatigue syndrome: A pilot study of gene expression in peripheral blood.. Behavioral and brain functions : BBF. https://doi.org/10.1186/1744-9081-4-44
BibTeX
@article{mecfsatlas-aspler-2008-evidence-inflammatory,
author = {Aspler, Anne L and Bolshin, Carly and Vernon, Suzanne D and Broderick, Gordon},
title = {Evidence of inflammatory immune signaling in chronic fatigue syndrome: A pilot study of gene expression in peripheral blood.},
journal = {Behavioral and brain functions : BBF},
year = {2008},
doi = {10.1186/1744-9081-4-44},
note = {PubMed: 18822143},
url = {https://www.mecfsatlas.com/evidence/aspler-2008-evidence-inflammatory},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/aspler-2008-evidence-inflammatory
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