Baraniuk, James N · The World Allergy Organization journal · 2009 · DOI
This study examines why some people develop chronic nasal symptoms like congestion and runny nose that don't have an obvious allergic cause. Researchers found that this condition may actually involve several different problems: structural issues in the nose, nerve sensitivity problems, and autonomic nervous system dysfunction—the same type of nervous system problem found in ME/CFS.
This study is significant for ME/CFS patients because it identifies autonomic dysfunction as a potential mechanism in iNAR—a symptom many ME/CFS patients experience. Understanding how autonomic dysregulation causes nasal symptoms may provide insights into broader ME/CFS pathophysiology and help explain overlapping symptoms in this patient population.
This study does not establish causation or prove that iNAR is present in ME/CFS patients—it only proposes mechanistic theories based on existing literature. It does not provide empirical data from a patient cohort and does not directly compare iNAR and ME/CFS populations. The heterogeneous nature of proposed mechanisms means no single finding is definitively proven.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Baraniuk, James N (2009). Pathogenic mechanisms of idiopathic nonallergic rhinitis.. The World Allergy Organization journal. https://doi.org/10.1097/WOX.0b013e3181aadb16
BibTeX
@article{mecfsatlas-baraniuk-2009-pathogenic-mechanisms,
author = {Baraniuk, James N},
title = {Pathogenic mechanisms of idiopathic nonallergic rhinitis.},
journal = {The World Allergy Organization journal},
year = {2009},
doi = {10.1097/WOX.0b013e3181aadb16},
note = {PubMed: 24229057},
url = {https://www.mecfsatlas.com/evidence/baraniuk-2009-pathogenic-mechanisms},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-25. https://www.mecfsatlas.com/evidence/baraniuk-2009-pathogenic-mechanisms
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