Barbado Hernández, F J, Gómez Cerezo, J, López Rodríguez, M et al. · Anales de medicina interna (Madrid, Spain : 1984) · 2006 · DOI
This article reviews how chronic fatigue syndrome (ME/CFS) is diagnosed and understood within internal medicine practice. The authors discuss the clinical features, diagnostic criteria, and challenges that doctors face when identifying ME/CFS in patients. The paper helps physicians recognize and properly diagnose this condition in their everyday practice.
This article is important because it addresses a critical need in clinical practice: helping physicians recognize and diagnose ME/CFS accurately. Improved diagnostic understanding in internal medicine settings can reduce diagnostic delays and support patients in accessing appropriate care and recognition of their condition.
This review article does not provide original research data, does not establish cause-and-effect relationships, and does not validate new diagnostic tests or criteria. As a review published in 2006, it reflects the diagnostic understanding of that time and may not incorporate more recent research advances or proposed diagnostic updates.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Barbado Hernández, F J, Gómez Cerezo, J, López Rodríguez, M, & Vázquez Rodríguez, J J (2006). [The chronic fatigue syndrome and its diagnosis in internal medicine].. Anales de medicina interna (Madrid, Spain : 1984). https://doi.org/10.4321/s0212-71992006000500009
BibTeX
@article{mecfsatlas-barbado-hernndez-2006-chronic-fatigue,
author = {Barbado Hernández, F J and Gómez Cerezo, J and López Rodríguez, M and Vázquez Rodríguez, J J},
title = {[The chronic fatigue syndrome and its diagnosis in internal medicine].},
journal = {Anales de medicina interna (Madrid, Spain : 1984)},
year = {2006},
doi = {10.4321/s0212-71992006000500009},
note = {PubMed: 16817704},
url = {https://www.mecfsatlas.com/evidence/barbado-hernndez-2006-chronic-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/barbado-hernndez-2006-chronic-fatigue
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