Bauermeister, C D, Wagner, C, Brede, H D · Medizinische Monatsschrift fur Pharmazeuten · 1992
This 1992 study investigated whether a common virus called human herpesvirus 6 (HHV-6) might be connected to ME/CFS. Researchers examined the relationship between this virus and chronic fatigue syndrome symptoms. While early research suggested a possible link, this study represents early work in understanding whether HHV-6 plays a role in the disease.
Understanding potential viral triggers for ME/CFS is crucial for developing targeted treatments and diagnostic approaches. HHV-6 was among the early suspected infectious agents in ME/CFS, making this historical examination relevant to how researchers have investigated the disease's origins. This work contributed to the broader investigation of viral reactivation as a mechanism in ME/CFS pathophysiology.
This study does not definitively establish that HHV-6 causes ME/CFS, nor does it provide conclusive evidence of the strength of any association. As a theoretical/commentary-level paper (E3), it reflects expert opinion and literature synthesis rather than empirical data proving causation. Subsequent research has shown the HHV-6 connection to be more complex than initially theorized.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Bauermeister, C D, Wagner, C, & Brede, H D (1992). [What is the relation of human herpesvirus 6 to chronic fatigue syndrome?].. Medizinische Monatsschrift fur Pharmazeuten. https://pubmed.ncbi.nlm.nih.gov/1319541/
BibTeX
@article{mecfsatlas-bauermeister-1992-what-relation,
author = {Bauermeister, C D and Wagner, C and Brede, H D},
title = {[What is the relation of human herpesvirus 6 to chronic fatigue syndrome?].},
journal = {Medizinische Monatsschrift fur Pharmazeuten},
year = {1992},
note = {PubMed: 1319541},
url = {https://www.mecfsatlas.com/evidence/bauermeister-1992-what-relation},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/bauermeister-1992-what-relation
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