Belcaro, G, Cornelli, U, Luzzi, R et al. · Journal of neurosurgical sciences · 2015
This study tested whether a natural plant extract called Robuvit (made from oak wood) might help people with ME/CFS who had signs of increased oxidative stress—a type of cellular damage. Thirty-eight people with ME/CFS took Robuvit supplements for 6 months while also following a structured lifestyle plan (better sleep, exercise, diet, and relaxation), and they were compared to 42 similar people who followed the plan without the supplement. The group taking Robuvit reported more improvement in fatigue symptoms and had lower markers of oxidative stress in their blood.
ME/CFS patients often experience persistent fatigue with limited treatment options. This study explores whether addressing oxidative stress—a plausible biological mechanism in some ME/CFS cases—might improve outcomes. The suggestion that a natural supplement could reduce both fatigue symptoms and cellular damage markers offers a potential avenue worth investigating further with more rigorous methodology.
This study cannot establish that Robuvit caused the improvements, because all participants also received intensive lifestyle modifications (sleep, exercise, diet, relaxation), which likely contributed substantially to outcomes. The lack of a placebo control group means improvement could reflect placebo effect, natural recovery, or the lifestyle intervention alone rather than the supplement. Registry studies generate preliminary signals but cannot prove efficacy or determine whether effects are due to the supplement or other concurrent interventions.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Belcaro, G, Cornelli, U, Luzzi, R, Ledda, A, Cacchio, M, Saggino, A, et al. (2015). Robuvit® (Quercus robur extract) supplementation in subjects with chronic fatigue syndrome and increased oxidative stress. A pilot registry study.. Journal of neurosurgical sciences. https://pubmed.ncbi.nlm.nih.gov/25394351/
BibTeX
@article{mecfsatlas-belcaro-2015-robuvit-quercus,
author = {Belcaro, G and Cornelli, U and Luzzi, R and Ledda, A and Cacchio, M and Saggino, A and Cesarone, M R and Dugall, M and Feragalli, B and Hu, S and Pellegrini, L and Ippolito, E},
title = {Robuvit® (Quercus robur extract) supplementation in subjects with chronic fatigue syndrome and increased oxidative stress. A pilot registry study.},
journal = {Journal of neurosurgical sciences},
year = {2015},
note = {PubMed: 25394351},
url = {https://www.mecfsatlas.com/evidence/belcaro-2015-robuvit-quercus},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-27. https://www.mecfsatlas.com/evidence/belcaro-2015-robuvit-quercus
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