Brenu, Ekua Weba, Huth, Teilah K, Hardcastle, Sharni L et al. · International immunology · 2014 · DOI
This study compared immune system cells in 30 people with ME/CFS and 25 healthy controls to identify which immune cells are abnormal in ME/CFS. Researchers found several key differences: patients with ME/CFS had unusual numbers and activity levels of immune cells called B cells, regulatory T cells, and neutrophils. These findings suggest that ME/CFS involves problems with how the immune system regulates itself, similar to autoimmune diseases.
Understanding which specific immune cells are abnormal in ME/CFS is critical for developing targeted treatments and biomarkers. This study provides detailed cellular fingerprinting that moves beyond general inflammatory markers, potentially enabling future diagnostic tests and mechanistic insights into whether immune dysregulation drives symptoms or is secondary to disease pathology.
This study does not prove that abnormal immune cells cause ME/CFS symptoms—it only documents that differences exist at one point in time. It cannot show whether these immune changes occur before symptom onset, whether they persist or fluctuate over time, or whether correcting them would improve patient outcomes. The small sample size and cross-sectional design limit generalizability.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Brenu, Ekua Weba, Huth, Teilah K, Hardcastle, Sharni L, Fuller, Kirsty, Kaur, Manprit, Johnston, Samantha, et al. (2014). Role of adaptive and innate immune cells in chronic fatigue syndrome/myalgic encephalomyelitis.. International immunology. https://doi.org/10.1093/intimm/dxt068
BibTeX
@article{mecfsatlas-brenu-2014-role-adaptive,
author = {Brenu, Ekua Weba and Huth, Teilah K and Hardcastle, Sharni L and Fuller, Kirsty and Kaur, Manprit and Johnston, Samantha and Ramos, Sandra B and Staines, Don R and Marshall-Gradisnik, Sonya M},
title = {Role of adaptive and innate immune cells in chronic fatigue syndrome/myalgic encephalomyelitis.},
journal = {International immunology},
year = {2014},
doi = {10.1093/intimm/dxt068},
note = {PubMed: 24343819},
url = {https://www.mecfsatlas.com/evidence/brenu-2014-role-adaptive},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/brenu-2014-role-adaptive
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