Brouillard, Franck, Fritsch, Janine, Edelman, Aleksander et al. · Proteomics. Clinical applications · 2008 · DOI
This review article discusses cytokeratins, which are structural proteins found in cells throughout the body. Researchers used advanced laboratory techniques called proteomics to study how these proteins are involved in various diseases, including chronic fatigue syndrome (ME/CFS). The article summarizes what scientists have learned about cytokeratins' roles in disease and suggests these proteins might be useful targets for developing new treatments.
This review is significant because it identifies cytokeratins as biomarkers associated with ME/CFS and suggests they may be involved in disease mechanisms. Understanding the molecular basis of ME/CFS through proteomics could lead to better diagnostic tools and potential therapeutic targets. The article highlights that proteomics techniques may help researchers uncover hidden cellular changes in ME/CFS patients.
This review does not demonstrate that cytokeratins directly cause ME/CFS or establish the specific mechanisms by which they contribute to disease pathophysiology. The article cannot prove that measuring cytokeratins would be clinically useful for diagnosing or treating ME/CFS specifically, as it primarily synthesizes literature across multiple diseases. Causation cannot be inferred from descriptive associations mentioned in a narrative review.
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Primary citation
Brouillard, Franck, Fritsch, Janine, Edelman, Aleksander, & Ollero, Mario (2008). Contribution of proteomics to the study of the role of cytokeratins in disease and physiopathology.. Proteomics. Clinical applications. https://doi.org/10.1002/prca.200780018
BibTeX
@article{mecfsatlas-brouillard-2008-contribution-proteomics,
author = {Brouillard, Franck and Fritsch, Janine and Edelman, Aleksander and Ollero, Mario},
title = {Contribution of proteomics to the study of the role of cytokeratins in disease and physiopathology.},
journal = {Proteomics. Clinical applications},
year = {2008},
doi = {10.1002/prca.200780018},
note = {PubMed: 21136830},
url = {https://www.mecfsatlas.com/evidence/brouillard-2008-contribution-proteomics},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/brouillard-2008-contribution-proteomics
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