Caccamo, Daniela, Cesareo, Eleonora, Mariani, Serena et al. · Oxidative medicine and cellular longevity · 2013 · DOI
This study looked at genetic differences in how people's bodies process certain chemicals, comparing patients with multiple chemical sensitivity (MCS), fibromyalgia, and chronic fatigue syndrome to healthy people. Researchers found that specific genetic variations related to chemical processing were more common in patients with these conditions, suggesting that how your body handles toxins may be linked to environmental sensitivity illnesses. These genetic markers could potentially help doctors diagnose these conditions more accurately in the future.
This research provides potential genetic biomarkers for diagnosing ME/CFS and related environmental sensitivity conditions, which currently lack objective diagnostic tests. Identifying genetic risk factors for abnormal chemical metabolism in ME/CFS patients could lead to better stratification of patients and personalized treatment approaches. The findings support the biological basis of these conditions and may reduce diagnostic delay and misattribution.
This study does not prove that these genetic variants *cause* ME/CFS or MCS—only that they are more frequently present in affected individuals. The association between genetic variants and disease does not establish mechanism or demonstrate that targeting these genes would improve outcomes. The study is limited to an Italian population and results may not apply equally to other ethnic or geographic groups.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Caccamo, Daniela, Cesareo, Eleonora, Mariani, Serena, Raskovic, Desanka, Ientile, Riccardo, Currò, Monica, et al. (2013). Xenobiotic sensor- and metabolism-related gene variants in environmental sensitivity-related illnesses: a survey on the Italian population.. Oxidative medicine and cellular longevity. https://doi.org/10.1155/2013/831969
BibTeX
@article{mecfsatlas-caccamo-2013-xenobiotic-sensor,
author = {Caccamo, Daniela and Cesareo, Eleonora and Mariani, Serena and Raskovic, Desanka and Ientile, Riccardo and Currò, Monica and Korkina, Liudmila and De Luca, Chiara},
title = {Xenobiotic sensor- and metabolism-related gene variants in environmental sensitivity-related illnesses: a survey on the Italian population.},
journal = {Oxidative medicine and cellular longevity},
year = {2013},
doi = {10.1155/2013/831969},
note = {PubMed: 23936614},
url = {https://www.mecfsatlas.com/evidence/caccamo-2013-xenobiotic-sensor},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/caccamo-2013-xenobiotic-sensor
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