Chacko, Anu, Staines, Donald R, Johnston, Samantha C et al. · Gene regulation and systems biology · 2016 · DOI
This study looked at immune cells called NK cells in people with ME/CFS to understand why they don't work properly. Researchers examined the activity of hundreds of genes that control how these immune cells function and found that many genes were turned on or off abnormally in severely ill patients compared to healthy people. This suggests that problems with how these genes are regulated may explain why NK cells cannot fight infections effectively in ME/CFS.
Identifying specific genes that malfunction in ME/CFS immune cells is crucial for understanding disease mechanisms and developing targeted treatments. This work provides molecular evidence linking NK cell dysfunction to gene expression abnormalities, offering potential biomarkers for diagnosis and treatment monitoring. Finding these dysregulated genes could lead to therapeutic interventions that restore normal immune function.
This study does not establish that these gene expression changes cause ME/CFS or prove causation—correlation alone cannot determine direction of effect. It does not demonstrate whether these changes occur in other immune cells or tissues, limiting conclusions about disease-wide mechanisms. It also does not show whether correcting these gene expression abnormalities would improve patient symptoms or NK cell function.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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Primary citation
Chacko, Anu, Staines, Donald R, Johnston, Samantha C, & Marshall-Gradisnik, Sonya M (2016). Dysregulation of Protein Kinase Gene Expression in NK Cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients.. Gene regulation and systems biology. https://doi.org/10.4137/GRSB.S40036
BibTeX
@article{mecfsatlas-chacko-2016-dysregulation-protein,
author = {Chacko, Anu and Staines, Donald R and Johnston, Samantha C and Marshall-Gradisnik, Sonya M},
title = {Dysregulation of Protein Kinase Gene Expression in NK Cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients.},
journal = {Gene regulation and systems biology},
year = {2016},
doi = {10.4137/GRSB.S40036},
note = {PubMed: 27594784},
url = {https://www.mecfsatlas.com/evidence/chacko-2016-dysregulation-protein},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/chacko-2016-dysregulation-protein
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