Chi, Aiping, Kang, Chenzhe, Zhang, Yan et al. · Carbohydrate polymers · 2015 · DOI
Researchers tested whether jujube fruit extract could help rats with an artificially induced chronic fatigue condition. The extract appeared to reduce oxidative stress (cellular damage) and boost immune function in these rats, including improving the activity of natural killer cells that help fight infections. While these results are encouraging, this is animal research and much more work is needed to determine if similar benefits would occur in people with ME/CFS.
If jujube polysaccharides can reduce oxidative stress and restore immune function—two pathological hallmarks implicated in ME/CFS—this could represent a novel therapeutic avenue worth further investigation. Understanding how natural compounds might modulate immune and antioxidant systems is valuable for developing safer, tolerable treatments that target underlying disease mechanisms rather than just symptoms.
This study does not prove that jujube extract will be effective in humans with ME/CFS, as animal models often fail to translate to clinical efficacy. The research does not establish whether the immune and antioxidant improvements are causally responsible for behavioral recovery, nor does it clarify which specific polysaccharide components are active. The study also cannot determine optimal dosing, duration, or safety in human patients.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Chi, Aiping, Kang, Chenzhe, Zhang, Yan, Tang, Liang, Guo, Huanhuan, Li, Hong, et al. (2015). Immunomodulating and antioxidant effects of polysaccharide conjugates from the fruits of Ziziphus Jujube on Chronic Fatigue Syndrome rats.. Carbohydrate polymers. https://doi.org/10.1016/j.carbpol.2014.12.082
BibTeX
@article{mecfsatlas-chi-2015-immunomodulating-antioxidant,
author = {Chi, Aiping and Kang, Chenzhe and Zhang, Yan and Tang, Liang and Guo, Huanhuan and Li, Hong and Zhang, Kunru},
title = {Immunomodulating and antioxidant effects of polysaccharide conjugates from the fruits of Ziziphus Jujube on Chronic Fatigue Syndrome rats.},
journal = {Carbohydrate polymers},
year = {2015},
doi = {10.1016/j.carbpol.2014.12.082},
note = {PubMed: 25817658},
url = {https://www.mecfsatlas.com/evidence/chi-2015-immunomodulating-antioxidant},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/chi-2015-immunomodulating-antioxidant
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