Craddock, R Cameron, Taylor, Renee, Broderick, Gordon et al. · Pharmacogenomics · 2006 · DOI
Researchers tested a new statistical method called the entropy correlation coefficient to identify which ME/CFS symptoms and test results are related to each other. They studied 130 women and found that fatigue-related measures were strongly connected to each other, as were general quality-of-life measures and depression scores. Importantly, they discovered some relationships between cognitive test results and ME/CFS that hadn't been found with traditional statistical methods.
This study demonstrates that advanced statistical tools like the entropy correlation coefficient may reveal hidden relationships in ME/CFS data that conventional methods miss. These newly identified correlations, particularly involving cognitive function and disease status, could generate new research hypotheses about ME/CFS mechanisms and inform future studies seeking biomarkers or disease subgroups.
This is a methodological study, not a clinical trial, so it does not prove that any identified correlations are causative or have biological significance. The study cannot establish why these variables are related, and findings from this single dataset require validation in independent populations. Correlation between two measures does not indicate that one causes the other or that either is a valid disease marker.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Craddock, R Cameron, Taylor, Renee, Broderick, Gordon, Whistler, Toni, Klimas, Nancy, & Unger, Elizabeth R (2006). Exploration of statistical dependence between illness parameters using the entropy correlation coefficient.. Pharmacogenomics. https://doi.org/10.2217/14622416.7.3.421
BibTeX
@article{mecfsatlas-craddock-2006-exploration-statistical,
author = {Craddock, R Cameron and Taylor, Renee and Broderick, Gordon and Whistler, Toni and Klimas, Nancy and Unger, Elizabeth R},
title = {Exploration of statistical dependence between illness parameters using the entropy correlation coefficient.},
journal = {Pharmacogenomics},
year = {2006},
doi = {10.2217/14622416.7.3.421},
note = {PubMed: 16610952},
url = {https://www.mecfsatlas.com/evidence/craddock-2006-exploration-statistical},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/craddock-2006-exploration-statistical
Contribute
Private, reviewed by a human. Not a public comment thread.